Details of the Target

General Information of Target

Target ID LDTP02684
Target Name Delta-aminolevulinic acid dehydratase (ALAD)
Gene Name ALAD
Gene ID 210
Synonyms
Delta-aminolevulinic acid dehydratase; ALADH; EC 4.2.1.24; Porphobilinogen synthase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKR
LEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACD
VCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKE
ALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDR
DVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAV
LEAMTAFRRAGADIIITYYTPQLLQWLKEE
Target Type
Successful
Target Bioclass
Enzyme
Family
ALAD family
Function Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
TTD ID
T20514
Uniprot ID
P13716
DrugMap ID
TTJHKYD
Ensemble ID
ENST00000409155.8
HGNC ID
HGNC:395
ChEMBL ID
CHEMBL3126

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KELLY SNV: p.R147L .
MCC13 SNV: p.Q290P .
NCIH1792 Deletion: p.L108Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.14  LDD0402  [1]
STPyne
 Probe Info  		K213(0.23); K252(5.97)  LDD0277  [2]
BTD
 Probe Info  		C162(3.69)  LDD1699  [3]
DBIA
 Probe Info  		C75(1.15)  LDD3316  [4]
YY4-yne
 Probe Info  		3.17  LDD0400  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
WYneN
 Probe Info  		C223(0.00); C75(0.00)  LDD0021  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
IPM
 Probe Info  		N.A.  LDD0005  [7]
MPP-AC
 Probe Info  		N.A.  LDD0428  [9]
NAIA_5
 Probe Info  		C75(0.00); C203(0.00)  LDD2223  [10]
TER-AC
 Probe Info  		N.A.  LDD0426  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C223(1.09)  LDD1507  [12]
 LDCM0237  AC12 HEK-293T C223(1.06)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C75(0.91); C223(1.06)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C223(0.97)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C223(1.01)  LDD1515  [12]
 LDCM0280  AC20 HEK-293T C223(1.04)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C75(0.98); C223(0.97)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C75(1.02); C223(0.96)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C223(1.04)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C223(1.02)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C223(1.01)  LDD1524  [12]
 LDCM0288  AC28 HEK-293T C223(0.95)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C75(1.21); C223(1.01)  LDD1528  [12]
 LDCM0291  AC30 HEK-293T C75(0.95); C223(0.95)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C223(0.99)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C223(1.02)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C223(1.08)  LDD1533  [12]
 LDCM0297  AC36 HEK-293T C223(0.96)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C75(1.12); C223(0.98)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C75(0.94); C223(1.00)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C223(0.89)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C223(0.97)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C223(1.10)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C223(1.09)  LDD1542  [12]
 LDCM0306  AC44 HEK-293T C223(1.08)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C75(0.89); C223(1.03)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C75(0.88); C223(0.95)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C223(0.99)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C223(1.15)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C223(1.07)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C75(1.09); C223(1.01)  LDD1551  [12]
 LDCM0315  AC52 HEK-293T C223(0.98)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C75(1.02); C223(1.09)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C75(0.90); C223(1.01)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C223(1.06)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C223(1.06)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C223(1.06)  LDD1559  [12]
 LDCM0323  AC6 HEK-293T C75(0.90); C223(0.96)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C223(1.00)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C75(0.97); C223(1.05)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C75(0.86); C223(0.94)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C223(1.01)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C223(1.07)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C223(0.94)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C223(1.04)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C75(1.21); C223(1.03)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C223(1.02)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C223(1.04)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 12.38  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C75(1.03); C223(1.00)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C75(0.81); C223(1.08)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C223(1.21)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C75(1.07); C223(1.35)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C223(1.63)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C223(1.02)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C223(1.13)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C75(0.95); C223(0.98)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C223(1.02)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C223(0.98)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C223(1.04)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C75(0.99); C223(0.94)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C223(1.03)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C223(1.62)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C223(0.97)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C223(2.84)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C75(0.89); C223(1.04)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C223(1.64)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C223(1.03)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C223(1.26)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C75(0.75); C223(1.07)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C223(1.12)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C223(1.09)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C223(1.39)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C223(1.12)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C75(0.99); C223(1.28)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C223(1.00)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C223(0.99)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C223(1.98)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C75(0.93); C223(0.94)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C223(0.98)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C223(1.00)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C223(0.98)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C75(0.72); C223(1.17)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C223(1.10)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C223(1.11)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C223(1.03)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C223(1.64)  LDD1608  [12]
 LDCM0407  CL2 HEK-293T C223(1.02)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C223(1.19)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C75(0.88); C223(1.21)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C75(0.88); C223(1.10)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C223(1.04)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C223(1.14)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C75(1.47); C223(0.88)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C223(1.00)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C223(1.05)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C223(1.01)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C223(1.02)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C223(1.11)  LDD1622  [12]
 LDCM0421  CL32 HEK-293T C223(1.21)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C75(1.02); C223(1.22)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C75(0.86); C223(1.02)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C223(1.01)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C223(1.00)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C75(1.28); C223(1.72)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C223(1.13)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C223(1.11)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C223(1.18)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C223(1.14)  LDD1635  [12]
 LDCM0434  CL44 HEK-293T C223(0.97)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C75(1.11); C223(1.02)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C75(0.95); C223(1.07)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C223(1.01)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C223(1.18)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C75(0.84); C223(1.03)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C223(1.27)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C223(1.27)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C223(1.12)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C223(1.57)  LDD1647  [12]
 LDCM0447  CL56 HEK-293T C223(1.17)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C75(0.76); C223(1.14)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C75(1.04); C223(1.14)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C223(1.16)  LDD1653  [12]
 LDCM0452  CL60 HEK-293T C223(1.13)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C75(0.94); C223(0.93)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C223(0.99)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C223(1.10)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C223(1.25)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C223(1.22)  LDD1660  [12]
 LDCM0460  CL68 HEK-293T C223(1.23)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C75(1.30); C223(1.15)  LDD1664  [12]
 LDCM0463  CL70 HEK-293T C75(1.00); C223(1.03)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C223(1.19)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C223(1.06)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C75(0.97); C223(1.09)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C223(1.00)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C223(1.02)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C223(1.97)  LDD1673  [12]
 LDCM0473  CL8 HEK-293T C223(1.03)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C223(1.01)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C75(1.39); C223(1.08)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C75(1.05); C223(1.01)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C223(1.01)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C223(1.23)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C75(1.11); C223(1.02)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C223(0.93)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C223(1.03)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C223(1.07)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C223(1.08)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C75(1.05); C223(1.15)  LDD1687  [12]
 LDCM0487  CL92 HEK-293T C223(1.05)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C75(0.89); C223(1.11)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C75(1.02); C223(1.08)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C223(1.42)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C223(1.59)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C75(0.69); C223(1.02)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C223(1.01)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C223(0.96)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C223(1.05)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C75(2.15); C223(0.91)  LDD1702  [3]
 LDCM0625  F8 Ramos C75(0.84); C223(2.36); C203(2.13)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C75(0.60); C203(0.27)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C75(11.10); C223(0.28)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C75(0.73); C223(0.39); C203(0.33)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C75(0.97); C203(0.75)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C75(0.86); C223(0.51)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C75(0.65); C223(0.61); C203(0.35)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C75(0.76); C203(0.51)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C75(1.08); C223(0.27); C203(0.26)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C75(0.90); C223(0.43); C203(0.65)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C75(1.14); C223(0.97); C203(0.54)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C75(1.01); C223(2.09); C203(0.47)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C75(1.55); C223(0.34); C203(0.58)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C75(0.48); C223(0.54); C203(0.34)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C223(1.00)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C75(0.89); C223(0.31); C203(5.88)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C75(0.65); C223(1.26); C203(0.95)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C223(1.12)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C75(1.61); C223(1.00)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C75(1.18); C223(1.06); C203(0.36)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C75(0.64); C223(6.36); C203(0.77)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C75(0.59); C203(0.36)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C223(0.85)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C223(1.01)  LDD1497  [12]
 LDCM0024  KB05 MEL167 C75(1.15)  LDD3316  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C223(1.19)  LDD2094  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C223(1.19)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C223(0.94)  LDD2098  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C162(0.37)  LDD2115  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C162(0.60)  LDD2148  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C223(0.95)  LDD2207  [14]
 LDCM0154  YY4 T cell 3.17  LDD0400  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aminolevulinic Acid Small molecular drug DB00855
Aminolevulinic Acid Hci Small molecular drug D0Y7ZD
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Porphobilinogen Small molecular drug D0U6QC
Investigative
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-sulfhydryl-ethanol Small molecular drug D0Q5FV
3-(2-aminoethyl)-4-(Aminomethyl)Heptanedioic Acid Small molecular drug D0MD4U
4-oxosebacic Acid Small molecular drug D0VG6L
5-fluorolevulinic Acid Small molecular drug D0NV2V
5-hydroxyvaleric Acid Small molecular drug D0Y4TF
Delta-amino Valeric Acid Small molecular drug D06KOT
Formic Acid Small molecular drug D06EWG
Laevulinic Acid Small molecular drug D0A1PW
S,S-(2-hydroxyethyl)Thiocysteine Small molecular drug D0P7JE
4,7-dioxosebacic Acid . D06UYC
47-dioxosebacic Acid . DB04560

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.