Details of the Target

General Information of Target

Target ID LDTP18768
Target Name Pleckstrin homology domain-containing family D member 1 (PLEKHD1)
Gene Name PLEKHD1
Gene ID 400224
Synonyms
Pleckstrin homology domain-containing family D member 1; PH domain-containing family D member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEPAFTSFPSPPVLGKLKRNMMPWALQKKREIHMAKAHRRRAARSALPMRLTSCIFRRP
VTRIRSHPDNQVRRRKGDEHLEKPQQLCAYRRLQALQPCSSQGEGSSPLHLESVLSILAP
GTAGESLDRAGAERVRSPLEPTPGRFPAVAGGPTPGMGCQLPPPLSGQLVTPADIRRQAR
RVKKARERLAKALQADRLARQAEMLTCR
Target Bioclass
Other
Family
PLEKHD1 family
Uniprot ID
A6NEE1
Ensemble ID
ENST00000322564.9
HGNC ID
HGNC:20148

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C406(2.41)  LDD2267  [1]
YY4-yne
 Probe Info  		5.04  LDD0400  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX142 C406(2.41)  LDD2267  [1]
 LDCM0023  KB03 BRX142 C406(3.17)  LDD2684  [1]
 LDCM0024  KB05 BRX142 C406(4.80)  LDD3101  [1]
 LDCM0154  YY4 T cell 5.04  LDD0400  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.