Details of the Target

General Information of Target

Target ID LDTP05855
Target Name Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2)
Gene Name DYNC1I2
Gene ID 1781
Synonyms
DNCI2; DNCIC2; Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; Dynein intermediate chain 2, cytosolic; DH IC-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDP
SVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVA
PKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQ
INIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYN
NNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQD
SMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPIT
GIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPALF
ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG
EQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA
Target Bioclass
Other
Family
Dynein intermediate chain family
Subcellular location
Cytoplasm, cytoskeleton
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Uniprot ID
Q13409
Ensemble ID
ENST00000340296.8
HGNC ID
HGNC:2964
ChEMBL ID
CHEMBL4295815

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.I143F .
HCT116 Deletion: p.R57EfsTer4 DBIA    Probe Info 
MDAMB453 SNV: p.E207Ter DBIA    Probe Info 
RL952 SNV: p.D52N DBIA    Probe Info 
SBC5 SNV: p.C331Ter DBIA    Probe Info 
WM1552C SNV: p.G615C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		4.47  LDD0215  [1]
ONAyne
 Probe Info  		K213(8.33)  LDD0274  [2]
STPyne
 Probe Info  		K25(10.00)  LDD0277  [2]
m-APA
 Probe Info  		10.95  LDD0403  [3]
HHS-482
 Probe Info  		Y291(0.81)  LDD0286  [4]
HHS-475
 Probe Info  		Y291(2.76)  LDD0264  [5]
HHS-465
 Probe Info  		Y291(4.46)  LDD2237  [6]
DBIA
 Probe Info  		C408(1.23)  LDD0531  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C408(0.00); C542(0.00); C331(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
Lodoacetamide azide
 Probe Info  		C408(0.00); C542(0.00); C331(0.00)  LDD0037  [9]
NHS
 Probe Info  		N.A.  LDD0010  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
AOyne
 Probe Info  		11.20  LDD0443  [14]
NAIA_5
 Probe Info  		C408(0.00); C386(0.00); C331(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C206
 Probe Info  		45.89  LDD1881  [16]
C243
 Probe Info  		10.70  LDD1916  [16]
C293
 Probe Info  		15.89  LDD1963  [16]
FFF probe13
 Probe Info  		11.66  LDD0475  [17]
STS-2
 Probe Info  		N.A.  LDD0138  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C408(1.23)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C408(0.90)  LDD0532  [7]
 LDCM0216  AC100 HEK-293T C460(1.35)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C460(1.55)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C460(1.36)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C460(1.55)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C460(1.21)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C460(1.13)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C460(0.99)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C460(1.31)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C460(1.19)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C460(1.22)  LDD0823  [7]
 LDCM0226  AC11 HCT 116 C408(0.87)  LDD0543  [7]
 LDCM0227  AC110 HEK-293T C460(1.68)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C460(1.80)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C460(1.67)  LDD0827  [7]
 LDCM0230  AC113 HCT 116 C408(1.05)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C408(1.04)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C408(1.02)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C408(0.93)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C408(0.95)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C408(0.96)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C408(0.91)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C408(0.96)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C408(0.97)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C408(0.85)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C408(0.90)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C408(1.07)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C408(0.93)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C408(0.87)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C408(0.99)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C408(0.97)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C408(0.92)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C408(1.01)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C408(0.91)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C408(0.93)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C408(1.08)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C408(1.07)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C408(0.93)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C408(0.92)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C408(0.98)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C408(0.97)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C408(0.88)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C408(1.00)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C408(1.09)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C408(0.93)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C408(0.96)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C408(1.19)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C408(0.90)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C408(0.86)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C408(0.85)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C408(0.87)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C408(1.00)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C408(0.91)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C408(0.89)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C408(0.95)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C408(0.88)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C408(0.83)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C408(0.90)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C408(0.81)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C408(0.87)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C408(0.85)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C408(0.86)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C408(0.74)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C408(0.91)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C408(0.87)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C408(0.87)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C408(1.05)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C408(0.89)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C408(0.90)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C408(0.87)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C408(0.79)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C408(0.92)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C408(0.99)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C408(0.81)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C408(1.10)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C408(0.88)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C408(0.80)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C408(0.93)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C408(0.80)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C408(1.01)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C408(0.73)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C408(1.00)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C408(1.02)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C408(0.92)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C408(0.72)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C408(0.77)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C408(0.91)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C408(0.91)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C408(1.00)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C408(0.80)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C408(0.75)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C408(0.82)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C408(0.84)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C408(0.90)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C408(0.83)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C408(0.72)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C408(0.75)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C408(0.74)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C408(0.67)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C408(0.95)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C408(0.66)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C408(0.60)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C408(0.62)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C408(0.80)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C408(0.69)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C408(0.90)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C408(0.70)  LDD0636  [7]
 LDCM0320  AC57 HEK-293T C460(1.02)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C460(1.09)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C460(1.03)  LDD0920  [7]
 LDCM0323  AC6 HCT 116 C408(0.88)  LDD0640  [7]
 LDCM0324  AC60 HEK-293T C460(1.03)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C460(1.27)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C460(1.26)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C460(1.47)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C460(1.16)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C460(1.48)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C460(1.18)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C460(1.26)  LDD0929  [7]
 LDCM0332  AC68 HCT 116 C408(1.02)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C408(0.97)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C408(0.96)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C408(0.81)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C408(1.20)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C408(0.87)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C408(0.94)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C408(1.14)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C408(0.92)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C408(0.99)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C408(0.97)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C408(1.00)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C408(0.97)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C408(0.94)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C408(1.05)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C408(1.01)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C408(0.88)  LDD0665  [7]
 LDCM0349  AC83 HEK-293T C460(1.06)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C460(1.52)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C460(1.16)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C460(1.27)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C460(1.28)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C460(1.35)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C460(1.28)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C460(1.10)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C460(1.35)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C460(1.11)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C460(0.93)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C460(1.46)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C460(1.31)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C460(1.35)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C460(2.07)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C460(1.05)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C460(0.93)  LDD0964  [7]
 LDCM0248  AKOS034007472 HCT 116 C408(1.02)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C408(0.95)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C408(0.88)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 10.95  LDD0403  [3]
 LDCM0108  Chloroacetamide HeLa C386(0.00); H580(0.00); H206(0.00)  LDD0222  [13]
 LDCM0367  CL1 PaTu 8988t C408(0.95)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C408(0.83)  LDD1247  [7]
 LDCM0369  CL100 HCT 116 C408(1.01)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C408(1.02)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C408(0.98)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C408(0.93)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C408(0.97)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C408(0.77)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C408(1.01)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C408(0.88)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C408(1.03)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C408(0.82)  LDD0695  [7]
 LDCM0379  CL11 PaTu 8988t C408(0.93)  LDD1258  [7]
 LDCM0380  CL110 HCT 116 C408(0.76)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C408(0.76)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C408(0.99)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C408(0.79)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C408(0.78)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C408(0.87)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C408(0.90)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C408(0.90)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C408(0.86)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C408(0.84)  LDD0706  [7]
 LDCM0390  CL12 PaTu 8988t C408(0.92)  LDD1269  [7]
 LDCM0391  CL120 HCT 116 C408(0.80)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C408(0.88)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C408(0.80)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C408(0.86)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C408(0.64)  LDD0712  [7]
 LDCM0396  CL125 HEK-293T C460(1.14)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C460(1.12)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C460(1.13)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C460(1.03)  LDD0997  [7]
 LDCM0400  CL13 PaTu 8988t C408(0.91)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C408(0.87)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C408(0.79)  LDD1281  [7]
 LDCM0403  CL16 HCT 116 C408(0.90)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C408(0.97)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C408(1.32)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C408(1.02)  LDD0723  [7]
 LDCM0407  CL2 PaTu 8988t C408(0.87)  LDD1286  [7]
 LDCM0408  CL20 HCT 116 C408(0.87)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C408(0.97)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C408(0.93)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C408(0.87)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C408(1.01)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C408(0.82)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C408(0.86)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C408(0.87)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C408(0.83)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C408(0.94)  LDD0734  [7]
 LDCM0418  CL3 PaTu 8988t C408(1.03)  LDD1297  [7]
 LDCM0419  CL30 HCT 116 C408(0.94)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C408(0.99)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C408(1.43)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C408(0.91)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C408(1.01)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C408(1.06)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C408(0.91)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C408(0.97)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C408(0.95)  LDD0745  [7]
 LDCM0429  CL4 PaTu 8988t C408(1.36)  LDD1308  [7]
 LDCM0430  CL40 HCT 116 C408(0.99)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C408(0.98)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C408(0.87)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C408(1.16)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C408(1.14)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C408(0.94)  LDD0752  [7]
 LDCM0436  CL46 PaTu 8988t C408(0.89)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C408(0.97)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C408(0.88)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C408(0.89)  LDD1318  [7]
 LDCM0440  CL5 PaTu 8988t C408(0.89)  LDD1319  [7]
 LDCM0441  CL50 PaTu 8988t C408(0.82)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C408(0.78)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C408(0.86)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C408(0.95)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C408(1.00)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C408(1.09)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C408(0.62)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C408(0.78)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C408(0.91)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C408(0.83)  LDD1329  [7]
 LDCM0451  CL6 PaTu 8988t C408(0.88)  LDD1330  [7]
 LDCM0452  CL60 PaTu 8988t C408(0.88)  LDD1331  [7]
 LDCM0453  CL61 HCT 116 C408(1.01)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C408(1.08)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C408(1.12)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C408(1.02)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C408(1.10)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C408(1.17)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C408(1.16)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C408(1.11)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C408(1.81)  LDD0778  [7]
 LDCM0462  CL7 PaTu 8988t C408(0.90)  LDD1341  [7]
 LDCM0463  CL70 HCT 116 C408(1.08)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C408(1.12)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C408(1.09)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C408(1.00)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C408(1.05)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C408(1.22)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C408(0.92)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C408(0.94)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C408(1.03)  LDD0789  [7]
 LDCM0473  CL8 PaTu 8988t C408(0.84)  LDD1352  [7]
 LDCM0474  CL80 HCT 116 C408(1.62)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C408(0.85)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C408(1.06)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C408(1.10)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C408(1.16)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C408(1.04)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C408(1.07)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C408(1.03)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C408(1.05)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C408(1.14)  LDD0800  [7]
 LDCM0484  CL9 PaTu 8988t C408(0.93)  LDD1363  [7]
 LDCM0485  CL90 HCT 116 C408(0.89)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C408(1.01)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C408(0.97)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C408(0.91)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C408(0.96)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C408(0.92)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C408(0.95)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C408(1.02)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C408(0.97)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C408(0.96)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C408(0.97); C460(0.87); C284(1.01); C542(0.94)  LDD1698  [19]
 LDCM0625  F8 Ramos C408(0.84)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C408(0.60)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C408(2.33)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C408(0.75)  LDD2191  [20]
 LDCM0576  Fragment14 Ramos C408(1.06)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C408(0.80)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C408(1.71)  LDD2195  [20]
 LDCM0588  Fragment30 Ramos C408(1.10)  LDD2199  [20]
 LDCM0468  Fragment33 HCT 116 C408(1.10)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C408(1.69)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C408(0.86)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C408(0.95)  LDD0744  [7]
 LDCM0614  Fragment56 Ramos C408(0.88)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C408(1.42)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C408(0.60)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y291(2.76)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y291(1.25)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y291(0.54)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y291(0.94)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y291(1.04)  LDD0268  [5]
 LDCM0107  IAA HeLa H580(0.00); H206(0.00)  LDD0221  [13]
 LDCM0124  JWB142 DM93 Y291(0.81)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y291(1.35)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y291(5.96)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y291(3.81)  LDD0289  [4]
 LDCM0022  KB02 HEK-293T C408(0.96); C542(0.96); C331(1.02); C284(0.95)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C408(0.92); C542(0.99); C331(0.95); C284(1.01)  LDD1497  [19]
 LDCM0024  KB05 HMCB C408(1.82)  LDD3312  [21]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain Tctex-type 1 (DYNLT1) Dynein light chain Tctex-type family P63172
Dynein light chain Tctex-type 3 (DYNLT3) Dynein light chain Tctex-type family P51808
Dynein light chain roadblock-type 1 (DYNLRB1) GAMAD family Q9NP97
Liprin-alpha-1 (PPFIA1) Liprin family Q13136

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840