General Information of Experiment

Probe Name EA-probe  Probe Info 
Probe concentration 40 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Ethacrynic acid  Competitor Info 
Competitor Concentration 40 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 179 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 15.0
 LDTP14214  Dolichyl-phosphate beta-glucosyltransferase (ALG5) C194 15.0
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C363 15.0
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 15.0
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) C185 15.0
 LDTP08217  Threonylcarbamoyl-AMP synthase (YRDC) C95 15.0
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 15.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C166 15.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 13.7
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) C304 12.9
 LDTP06885  Glycerol-3-phosphate acyltransferase 3 (GPAT3) C306 11.7
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C166 10.0
 LDTP10049  FAST kinase domain-containing protein 4 (TBRG4) C335 9.9
 LDTP10049  FAST kinase domain-containing protein 4 (TBRG4) C335 9.1
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C42 8.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 7.6
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C23 7.6
 LDTP07967  Lysophosphatidylcholine acyltransferase 2 (LPCAT2) C223 5.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 5.0
 LDTP02506  Microsomal glutathione S-transferase 1 (MGST1) C50 5.0
 LDTP00492  Ras-related protein Rab-7L1 (RAB29) C120 4.5
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) . 4.4
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) C335 4.3
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C376 4.0
 LDTP09939  Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) C289 3.9
 LDTP03726  Replication factor C subunit 2 (RFC2) C88 3.8
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 3.8
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C164 3.8
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 3.6
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C343 3.5
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C360 3.3
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) C163 3.3
 LDTP04243  Fatty acid synthase (FASN) C1448 3.3
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C237 3.2
 LDTP03770  Alpha-adducin (ADD1) C68 3.0
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 2.9
 LDTP00492  Ras-related protein Rab-7L1 (RAB29) C120 2.7
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 2.7
 LDTP00293  Cytochrome c oxidase subunit NDUFA4 (NDUFA4) C44 2.6
 LDTP15219  Diphthine--ammonia ligase (DPH6) C88 2.6
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C376 2.5
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) C18 2.5
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 2.4
 LDTP00293  Cytochrome c oxidase subunit NDUFA4 (NDUFA4) C44 2.4
 LDTP13285  Probable ATP-dependent RNA helicase DDX20 (DDX20) C577 2.3
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) C18 2.3
 LDTP11311  Very long chain fatty acid elongase 1 (ELOVL1) C93 2.2
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 2.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 2.1
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) C1076 2.0
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C411 2.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) C499 2.0
 LDTP10286  Corrinoid adenosyltransferase MMAB (MMAB) C119 2.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 2.0
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.9
 LDTP09396  Minor histocompatibility antigen H13 (HM13) C326 1.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C4 1.8
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.8
 LDTP04874  Ubiquitin-conjugating enzyme E2 G2 (UBE2G2) C89 1.8
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) C640 1.7
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.7
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C579 1.7
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C215 1.7
 LDTP02279  Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) C181 1.7
 LDTP05289  AMP deaminase 2 (AMPD2) C230 1.7
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C467 1.6
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) C705 1.6
 LDTP03688  Serine hydroxymethyltransferase, cytosolic (SHMT1) C68 1.6
 LDTP09396  Minor histocompatibility antigen H13 (HM13) C326 1.6
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C329 1.6
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.6
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C62 1.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.5
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.5
 LDTP03401  Multifunctional protein CAD (CAD) C73 1.5
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C411 1.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.5
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.5
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.5
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 1.5
 LDTP01984  NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) C39 1.5
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.4
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) C53 1.4
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C4106 1.4
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) C155 1.4
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C143 1.4
 LDTP05503  Peroxiredoxin-1 (PRDX1) C71 1.4
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C225 1.4
 LDTP01634  Fatty acid CoA ligase Acsl3 (ACSL3) C429 1.4
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.3
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C257 1.3
 LDTP00192  ATP-dependent RNA helicase DDX39A (DDX39A) C62 1.3
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 1.3
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) C131 1.3
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.3
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C62 1.3
 LDTP01772  Cytochrome c oxidase subunit 1 (MT-CO1) C498 1.3
 LDTP03849  Electron transfer flavoprotein subunit beta (ETFB) C42 1.3
 LDTP02261  ATP-dependent 6-phosphofructokinase, muscle type (PFKM) C334 1.3
 LDTP04986  ADP-ribosylation factor 6 (ARF6) C155 1.3
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) C330 1.3
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C447 1.2
 LDTP03411  Proteasome subunit beta type-8 (PSMB8) C120 1.2
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C150 1.2
 LDTP03220  NAD-dependent malic enzyme, mitochondrial (ME2) C120 1.2
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 1.2
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.2
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C159 1.2
 LDTP11090  Mitochondrial genome maintenance exonuclease 1 (MGME1) C79 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.2
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C257 1.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C247 1.2
 LDTP13814  Phospholipase A-2-activating protein (PLAA) C605 1.2
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.2
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C196 1.2
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) C374 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.2
 LDTP02672  Elongation factor 2 (EEF2) C131 1.2
 LDTP01664  Serine/threonine-protein kinase OSR1 (OXSR1) C191 1.2
 LDTP03411  Proteasome subunit beta type-8 (PSMB8) C120 1.2
 LDTP03849  Electron transfer flavoprotein subunit beta (ETFB) C42 1.1
 LDTP11432  Inosine triphosphate pyrophosphatase (ITPA) C146 1.1
 LDTP03333  Proteasome subunit alpha type-4 (PSMA4) C107 1.1
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.1
 LDTP03808  Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) C211 1.1
 LDTP00225  26S proteasome non-ATPase regulatory subunit 9 (PSMD9) C59 1.1
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C81 1.1
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C377 1.1
 LDTP02672  Elongation factor 2 (EEF2) C466 1.1
 LDTP10500  Lymphokine-activated killer T-cell-originated protein kinase (PBK) C22 1.1
 LDTP03008  Spermidine synthase (SRM) C25 1.1
 LDTP02672  Elongation factor 2 (EEF2) C131 1.1
 LDTP03510  Peroxiredoxin-6 (PRDX6) C47 1.1
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C159 1.1
 LDTP00273  Dynamin-1-like protein (DNM1L) C361 1.1
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) C145 1.1
 LDTP13814  Phospholipase A-2-activating protein (PLAA) C605 1.1
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C390 1.1
 LDTP03145  Catechol O-methyltransferase (COMT) C119 1.1
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C225 1.1
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C496 1.0
 LDTP12646  ATP-dependent RNA helicase DDX19A (DDX19A) C392 1.0
 LDTP14083  E3 ubiquitin-protein ligase RNF114 (RNF114) C8 1.0
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C62 1.0
 LDTP03518  Enoyl-CoA hydratase, mitochondrial (ECHS1) C62 1.0
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) C111 1.0
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 1.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) C195 1.0
 LDTP02502  Thioredoxin (TXN) C73 1.0
 LDTP02521  S-formylglutathione hydrolase (ESD) C45 1.0
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C377 1.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.0
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C217 1.0
 LDTP02220  Adenine phosphoribosyltransferase (APRT) C140 1.0
 LDTP01634  Fatty acid CoA ligase Acsl3 (ACSL3) C450 0.9
 LDTP00192  ATP-dependent RNA helicase DDX39A (DDX39A) C197 0.9
 LDTP11127  ADP-dependent glucokinase (ADPGK) C40 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C119 0.9
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C62 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.9
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C159 0.9
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) C453 0.9
 LDTP00527  Phosphoribosylformylglycinamidine synthase (PFAS) C66 0.9
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.8
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.8
 LDTP04561  ATP-citrate synthase (ACLY) C20 0.8
 LDTP03145  Catechol O-methyltransferase (COMT) C223 0.8
 LDTP04441  26S proteasome non-ATPase regulatory subunit 7 (PSMD7) C116 0.8
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C230 0.8
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) C321 0.8
 LDTP05503  Peroxiredoxin-1 (PRDX1) C173 0.8
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C234 0.7
 LDTP14141  Mannose-1-phosphate guanyltransferase beta (GMPPB) C245 0.5
Transporter and channel
Click to Show/Hide to Show 92 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C160 15.0
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C257 15.0
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) C257 15.0
 LDTP04787  Transmembrane protein 33 (TMEM33) C224 15.0
 LDTP09949  Transportin-1 (TNPO1) C386 15.0
 LDTP00434  Transportin-2 (TNPO2) . 15.0
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) C257 14.8
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C257 14.7
 LDTP03869  Protein Mpv17 (MPV17) C59 13.7
 LDTP12078  Mitochondrial glutamate carrier 1 (SLC25A22) C233 10.7
 LDTP00810  Exportin-T (XPOT) C915 7.6
 LDTP04749  Peroxisomal biogenesis factor 3 (PEX3) C65 7.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) C428 7.2
 LDTP04082  Ran GTPase-activating protein 1 (RANGAP1) C573 6.0
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 5.5
 LDTP04801  Gasdermin-D (GSDMD) C268 5.5
 LDTP06242  Importin subunit beta-1 (KPNB1) C585 5.5
 LDTP00501  Exportin-1 (XPO1) C164 5.3
 LDTP09515  Importin-4 (IPO4) C350 4.9
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) C477 4.9
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C129 4.8
 LDTP03869  Protein Mpv17 (MPV17) C59 4.8
 LDTP04553  Tricarboxylate transport protein, mitochondrial (SLC25A1) C127 4.8
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) C136 4.3
 LDTP11213  Nucleoporin NDC1 (NDC1) C468 4.3
 LDTP15898  HIG1 domain family member 2A, mitochondrial (HIGD2A) C53 4.2
 LDTP09949  Transportin-1 (TNPO1) C103 4.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C210 3.9
 LDTP11292  BOS complex subunit TMEM147 (TMEM147) C23 3.8
 LDTP00592  Surfeit locus protein 4 (SURF4) C32 3.8
 LDTP06242  Importin subunit beta-1 (KPNB1) C585 3.7
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) C136 3.7
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C39 3.5
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) C13 3.5
 LDTP00592  Surfeit locus protein 4 (SURF4) C32 3.4
 LDTP09949  Transportin-1 (TNPO1) C142 3.2
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C129 3.0
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) C13 2.8
 LDTP11310  Nuclear pore complex protein Nup85 (NUP85) C51 2.7
 LDTP09949  Transportin-1 (TNPO1) C103 2.6
 LDTP05305  Large neutral amino acids transporter small subunit 1 (SLC7A5) C496 2.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) C23 2.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C47 2.5
 LDTP00434  Transportin-2 (TNPO2) C789 2.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C47 2.3
 LDTP00501  Exportin-1 (XPO1) C34 2.3
 LDTP09825  Nuclear pore complex protein Nup205 (NUP205) C1662 2.3
 LDTP09515  Importin-4 (IPO4) C42 2.3
 LDTP00434  Transportin-2 (TNPO2) C93 2.2
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) . 2.2
 LDTP11292  BOS complex subunit TMEM147 (TMEM147) C23 2.2
 LDTP01574  Importin-7 (IPO7) C757 2.1
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) C58 2.1
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) C330 2.1
 LDTP00434  Transportin-2 (TNPO2) C805 2.1
 LDTP01574  Importin-7 (IPO7) C401 2.0
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C467 1.9
 LDTP00810  Exportin-T (XPOT) C38 1.9
 LDTP12526  Oligosaccharyltransferase complex subunit OSTC (OSTC) C14 1.9
 LDTP00501  Exportin-1 (XPO1) C34 1.7
 LDTP04501  Importin subunit alpha-1 (KPNA2) C223 1.6
 LDTP09949  Transportin-1 (TNPO1) C683 1.6
 LDTP01060  PRA1 family protein 2 (PRAF2) C28 1.5
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 1.5
 LDTP12526  Oligosaccharyltransferase complex subunit OSTC (OSTC) C14 1.5
 LDTP01037  Catenin delta-1 (CTNND1) C692 1.5
 LDTP04662  Exportin-2 (CSE1L) C344 1.4
 LDTP09949  Transportin-1 (TNPO1) C683 1.4
 LDTP14952  Mpv17-like protein 2 (MPV17L2) C198 1.4
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C76 1.4
 LDTP01988  ATP synthase protein 8 (MT-ATP8) C59 1.4
 LDTP04662  Exportin-2 (CSE1L) C853 1.4
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) C23 1.4
 LDTP04662  Exportin-2 (CSE1L) C853 1.4
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C467 1.4
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) C704 1.4
 LDTP04662  Exportin-2 (CSE1L) C325 1.3
 LDTP11934  EH domain-containing protein 1 (EHD1) C138 1.3
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.3
 LDTP04501  Importin subunit alpha-1 (KPNA2) C223 1.3
 LDTP01631  Mitochondrial pyruvate carrier 2 (MPC2) C54 1.2
 LDTP06242  Importin subunit beta-1 (KPNB1) C436 1.2
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) C199 1.2
 LDTP04662  Exportin-2 (CSE1L) C344 1.1
 LDTP06554  Dihydropyrimidinase-related protein 2 (DPYSL2) C179 1.1
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) C366 1.0
 LDTP02010  Annexin A1 (ANXA1) C324 1.0
 LDTP02010  Annexin A1 (ANXA1) C324 1.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) C49 1.0
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) C589 0.9
 LDTP01133  Copine-3 (CPNE3) C54 0.9
 LDTP00266  Importin-5 (IPO5) C733 0.8
Transcription factor
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP14241  eIF5-mimic protein 1 (BZW2) C97 15.0
 LDTP04752  Transcription factor SOX-10 (SOX10) C71 15.0
 LDTP07940  eIF5-mimic protein 2 (BZW1) C96 9.0
 LDTP02500  Nuclear receptor subfamily 2 group F member 6 (NR2F6) C316 3.4
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 2.7
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 2.1
 LDTP04752  Transcription factor SOX-10 (SOX10) C190 1.2
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.9
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00671  Tapasin (TAPBP) C115 1.7
Cytokine and receptor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10323  CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) C12 1.5
 LDTP10323  CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) C12 1.4
Other
Click to Show/Hide to Show 121 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C673 15.0
 LDTP00313  Nucleolar protein 56 (NOP56) C112 15.0
 LDTP00313  Nucleolar protein 56 (NOP56) C142 15.0
 LDTP00313  Nucleolar protein 56 (NOP56) C211 15.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 15.0
 LDTP13925  Nucleolar protein 58 (NOP58) C205 9.0
 LDTP00313  Nucleolar protein 56 (NOP56) C52 7.6
 LDTP11331  Sideroflexin-3 (SFXN3) C234 5.2
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C397 4.8
 LDTP03367  Elongation factor 1-gamma (EEF1G) C68 4.7
 LDTP05867  Treacle protein (TCOF1) C38 4.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 4.0
 LDTP03773  Metalloproteinase inhibitor 3 (TIMP3) C163 3.9
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C325 3.5
 LDTP05867  Treacle protein (TCOF1) C38 3.4
 LDTP14153  Trafficking protein particle complex subunit 1 (TRAPPC1) C115 3.3
 LDTP05025  Large ribosomal subunit protein eL32 (RPL32) C91 3.1
 LDTP07718  MICOS complex subunit MIC27 (APOOL) C152 3.1
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 3.0
 LDTP15947  Mitochondrial fission regulator 1-like (MTFR1L) C52 3.0
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C49 2.8
 LDTP14069  WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) C393 2.7
 LDTP06383  Calponin-3 (CNN3) C173 2.7
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C196 2.7
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C196 2.6
 LDTP14980  RRP12-like protein (RRP12) C763 2.6
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) C111 2.6
 LDTP00720  Centromere/kinetochore protein zw10 homolog (ZW10) C568 2.6
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) C10 2.6
 LDTP10864  Calponin-2 (CNN2) C175 2.5
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) C363 2.4
 LDTP06383  Calponin-3 (CNN3) C173 2.4
 LDTP08387  Dynein axonemal assembly factor 5 (DNAAF5) C173 2.3
 LDTP00313  Nucleolar protein 56 (NOP56) C384 2.3
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) C180 2.3
 LDTP02205  Tubulin beta chain (TUBB) C303 2.2
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) C615 2.2
 LDTP01285  TIP41-like protein (TIPRL) C87 2.1
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.1
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 2.1
 LDTP15101  Armadillo repeat-containing protein 6 (ARMC6) C297 2.0
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 2.0
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) C111 1.9
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) C60 1.9
 LDTP05778  Chromobox protein homolog 3 (CBX3) C177 1.9
 LDTP04504  Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) C85 1.9
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) C60 1.9
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.9
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.9
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 1.8
 LDTP19499  UPF0598 protein C8orf82 (C8orf82) C98 1.8
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.8
 LDTP02205  Tubulin beta chain (TUBB) C201 1.8
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) C363 1.7
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 1.7
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) C33 1.7
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C450 1.7
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) C468 1.7
 LDTP02809  Small ribosomal subunit protein uS5 (RPS2) C229 1.7
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) C70 1.6
 LDTP05049  Dynein light chain 1, cytoplasmic (DYNLL1) C56 1.6
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 1.6
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C175 1.6
 LDTP06367  Poly(rC)-binding protein 2 (PCBP2) C217 1.6
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.5
 LDTP13424  Vacuolar protein sorting-associated protein 28 homolog (VPS28) C128 1.5
 LDTP04249  T-complex protein 1 subunit gamma (CCT3) C455 1.5
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14) C42 1.5
 LDTP02205  Tubulin beta chain (TUBB) C354 1.5
 LDTP13170  COP9 signalosome complex subunit 7a (COPS7A) C110 1.5
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.5
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) C468 1.4
 LDTP02205  Tubulin beta chain (TUBB) C239 1.4
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 1.4
 LDTP05049  Dynein light chain 1, cytoplasmic (DYNLL1) C56 1.4
 LDTP02107  Large ribosomal subunit protein P1 (RPLP1) C61 1.4
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C511 1.4
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C54 1.4
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.3
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C175 1.3
 LDTP11331  Sideroflexin-3 (SFXN3) C189 1.3
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C205 1.3
 LDTP03888  T-complex protein 1 subunit zeta (CCT6A) C406 1.3
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C172 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.3
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) C92 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.3
 LDTP05002  Small ribosomal subunit protein eS6 (RPS6) C12 1.3
 LDTP04504  Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) C85 1.2
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.2
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) C119 1.2
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.2
 LDTP02059  Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) C112 1.1
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) C70 1.1
 LDTP00619  Eukaryotic translation initiation factor 3 subunit D (EIF3D) C19 1.1
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) C119 1.1
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) C33 1.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C155 1.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C155 1.1
 LDTP02596  Proliferating cell nuclear antigen (PCNA) C81 1.1
 LDTP16107  TBC1 domain family member 13 (TBC1D13) C145 1.0
 LDTP03367  Elongation factor 1-gamma (EEF1G) C266 1.0
 LDTP09811  Heat shock protein 105 kDa (HSPH1) C34 1.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.0
 LDTP03244  Cofilin-1 (CFL1) C139 1.0
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 1.0
 LDTP03244  Cofilin-1 (CFL1) C139 0.9
 LDTP05697  Heat shock protein 75 kDa, mitochondrial (TRAP1) C573 0.9
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.9
 LDTP13991  Serine-threonine kinase receptor-associated protein (STRAP) C340 0.9
 LDTP04708  NHP2-like protein 1 (SNU13) C30 0.9
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.9
 LDTP10071  Protein mago nashi homolog 2 (MAGOHB) C133 0.9
 LDTP05055  Small ribosomal subunit protein eS21 (RPS21) C56 0.9
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.9
 LDTP04887  Destrin (DSTN) C163 0.8
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.8
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C269 0.8
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.7

References

1 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.