General Information of Experiment

Probe Name EA-probe  Probe Info 
Probe concentration 40 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Ethacrynic acid  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 180 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP14214  Dolichyl-phosphate beta-glucosyltransferase (ALG5) C194 15.0
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 15.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 10.1
 LDTP14214  Dolichyl-phosphate beta-glucosyltransferase (ALG5) C194 9.0
 LDTP08217  Threonylcarbamoyl-AMP synthase (YRDC) C95 8.2
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 5.9
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) C185 5.4
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) C304 5.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 4.1
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 3.3
 LDTP06885  Glycerol-3-phosphate acyltransferase 3 (GPAT3) C306 3.1
 LDTP07967  Lysophosphatidylcholine acyltransferase 2 (LPCAT2) C223 2.9
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C166 2.8
 LDTP10049  FAST kinase domain-containing protein 4 (TBRG4) C335 2.5
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.5
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C42 2.5
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C363 2.3
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) . 2.3
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C376 2.3
 LDTP00492  Ras-related protein Rab-7L1 (RAB29) C120 2.3
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) C335 2.3
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C166 2.2
 LDTP09939  Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) C289 2.2
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 2.1
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 2.1
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C23 2.0
 LDTP03726  Replication factor C subunit 2 (RFC2) C88 2.0
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C360 1.9
 LDTP02506  Microsomal glutathione S-transferase 1 (MGST1) C50 1.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C237 1.9
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 1.9
 LDTP10049  FAST kinase domain-containing protein 4 (TBRG4) C335 1.9
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C164 1.9
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 1.9
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C343 1.9
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.8
 LDTP15219  Diphthine--ammonia ligase (DPH6) C88 1.8
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) C163 1.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.7
 LDTP11311  Very long chain fatty acid elongase 1 (ELOVL1) C93 1.7
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) C1076 1.6
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C376 1.6
 LDTP04243  Fatty acid synthase (FASN) C1448 1.6
 LDTP00492  Ras-related protein Rab-7L1 (RAB29) C120 1.5
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) C18 1.5
 LDTP00293  Cytochrome c oxidase subunit NDUFA4 (NDUFA4) C44 1.4
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) C18 1.4
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.4
 LDTP06375  Delta(24)-sterol reductase (DHCR24) C499 1.4
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.4
 LDTP00293  Cytochrome c oxidase subunit NDUFA4 (NDUFA4) C44 1.3
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.3
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C143 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C4 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.3
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.3
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.3
 LDTP13285  Probable ATP-dependent RNA helicase DDX20 (DDX20) C577 1.2
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C579 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.2
 LDTP03401  Multifunctional protein CAD (CAD) C73 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.2
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) C640 1.2
 LDTP05289  AMP deaminase 2 (AMPD2) C230 1.2
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.2
 LDTP03220  NAD-dependent malic enzyme, mitochondrial (ME2) C120 1.2
 LDTP01984  NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) C39 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.2
 LDTP04874  Ubiquitin-conjugating enzyme E2 G2 (UBE2G2) C89 1.2
 LDTP10286  Corrinoid adenosyltransferase MMAB (MMAB) C119 1.2
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.2
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.2
 LDTP09396  Minor histocompatibility antigen H13 (HM13) C326 1.2
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C467 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.2
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C62 1.1
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C159 1.1
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.1
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.1
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C411 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.1
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) C705 1.1
 LDTP02279  Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) C181 1.1
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) C53 1.1
 LDTP00273  Dynamin-1-like protein (DNM1L) C361 1.1
 LDTP09396  Minor histocompatibility antigen H13 (HM13) C326 1.1
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C215 1.1
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C447 1.1
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C4106 1.1
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) C131 1.1
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C257 1.1
 LDTP01664  Serine/threonine-protein kinase OSR1 (OXSR1) C191 1.1
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C329 1.1
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.0
 LDTP01772  Cytochrome c oxidase subunit 1 (MT-CO1) C498 1.0
 LDTP03849  Electron transfer flavoprotein subunit beta (ETFB) C42 1.0
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C411 1.0
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C196 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C390 1.0
 LDTP05503  Peroxiredoxin-1 (PRDX1) C71 1.0
 LDTP03849  Electron transfer flavoprotein subunit beta (ETFB) C42 1.0
 LDTP03333  Proteasome subunit alpha type-4 (PSMA4) C107 1.0
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C62 1.0
 LDTP14083  E3 ubiquitin-protein ligase RNF114 (RNF114) C8 1.0
 LDTP02672  Elongation factor 2 (EEF2) C131 1.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C225 1.0
 LDTP11090  Mitochondrial genome maintenance exonuclease 1 (MGME1) C79 1.0
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.0
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 1.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C225 1.0
 LDTP03518  Enoyl-CoA hydratase, mitochondrial (ECHS1) C62 1.0
 LDTP11432  Inosine triphosphate pyrophosphatase (ITPA) C146 1.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C150 1.0
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) C330 1.0
 LDTP03510  Peroxiredoxin-6 (PRDX6) C47 1.0
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) C111 1.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.0
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C257 1.0
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.0
 LDTP03770  Alpha-adducin (ADD1) C68 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C247 1.0
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) C374 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP03411  Proteasome subunit beta type-8 (PSMB8) C120 0.9
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C377 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.9
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 0.9
 LDTP03808  Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) C211 0.9
 LDTP02672  Elongation factor 2 (EEF2) C131 0.9
 LDTP02672  Elongation factor 2 (EEF2) C466 0.9
 LDTP02502  Thioredoxin (TXN) C73 0.9
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C496 0.9
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C377 0.9
 LDTP00225  26S proteasome non-ATPase regulatory subunit 9 (PSMD9) C59 0.9
 LDTP04986  ADP-ribosylation factor 6 (ARF6) C155 0.9
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) C195 0.9
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C119 0.9
 LDTP00192  ATP-dependent RNA helicase DDX39A (DDX39A) C62 0.9
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C81 0.9
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP03411  Proteasome subunit beta type-8 (PSMB8) C120 0.9
 LDTP03008  Spermidine synthase (SRM) C25 0.9
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) C155 0.9
 LDTP13814  Phospholipase A-2-activating protein (PLAA) C605 0.9
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C217 0.9
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C159 0.9
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C62 0.9
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) C453 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.9
 LDTP03688  Serine hydroxymethyltransferase, cytosolic (SHMT1) C68 0.9
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.9
 LDTP02220  Adenine phosphoribosyltransferase (APRT) C140 0.9
 LDTP12646  ATP-dependent RNA helicase DDX19A (DDX19A) C392 0.9
 LDTP01634  Fatty acid CoA ligase Acsl3 (ACSL3) C429 0.9
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C62 0.8
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) C145 0.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) C40 0.8
 LDTP04561  ATP-citrate synthase (ACLY) C20 0.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.8
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.8
 LDTP10500  Lymphokine-activated killer T-cell-originated protein kinase (PBK) C22 0.8
 LDTP00527  Phosphoribosylformylglycinamidine synthase (PFAS) C66 0.8
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C230 0.8
 LDTP04441  26S proteasome non-ATPase regulatory subunit 7 (PSMD7) C116 0.8
 LDTP03145  Catechol O-methyltransferase (COMT) C119 0.8
 LDTP02521  S-formylglutathione hydrolase (ESD) C45 0.8
 LDTP02261  ATP-dependent 6-phosphofructokinase, muscle type (PFKM) C334 0.7
 LDTP01634  Fatty acid CoA ligase Acsl3 (ACSL3) C450 0.7
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C159 0.7
 LDTP03145  Catechol O-methyltransferase (COMT) C223 0.7
 LDTP00192  ATP-dependent RNA helicase DDX39A (DDX39A) C197 0.6
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) C321 0.6
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C234 0.6
 LDTP05503  Peroxiredoxin-1 (PRDX1) C173 0.6
 LDTP14141  Mannose-1-phosphate guanyltransferase beta (GMPPB) C245 0.5
Transporter and channel
Click to Show/Hide to Show 91 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C160 15.0
 LDTP04787  Transmembrane protein 33 (TMEM33) C224 11.6
 LDTP00434  Transportin-2 (TNPO2) . 7.7
 LDTP04749  Peroxisomal biogenesis factor 3 (PEX3) C65 7.1
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) C257 7.0
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C257 6.6
 LDTP09949  Transportin-1 (TNPO1) C386 5.3
 LDTP03869  Protein Mpv17 (MPV17) C59 4.1
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) C257 4.0
 LDTP12078  Mitochondrial glutamate carrier 1 (SLC25A22) C233 3.8
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C257 3.5
 LDTP09515  Importin-4 (IPO4) C350 3.4
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C210 3.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) C428 2.8
 LDTP03869  Protein Mpv17 (MPV17) C59 2.7
 LDTP15898  HIG1 domain family member 2A, mitochondrial (HIGD2A) C53 2.6
 LDTP04553  Tricarboxylate transport protein, mitochondrial (SLC25A1) C127 2.3
 LDTP06242  Importin subunit beta-1 (KPNB1) C585 2.3
 LDTP06242  Importin subunit beta-1 (KPNB1) C585 2.2
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) C136 2.1
 LDTP00501  Exportin-1 (XPO1) C164 2.0
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) C477 2.0
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C129 1.9
 LDTP11213  Nucleoporin NDC1 (NDC1) C468 1.9
 LDTP04801  Gasdermin-D (GSDMD) C268 1.9
 LDTP00810  Exportin-T (XPOT) C915 1.9
 LDTP09949  Transportin-1 (TNPO1) C142 1.9
 LDTP11292  BOS complex subunit TMEM147 (TMEM147) C23 1.9
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) C136 1.8
 LDTP01574  Importin-7 (IPO7) C401 1.8
 LDTP11310  Nuclear pore complex protein Nup85 (NUP85) C51 1.8
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) C13 1.8
 LDTP00592  Surfeit locus protein 4 (SURF4) C32 1.7
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) C58 1.7
 LDTP09949  Transportin-1 (TNPO1) C103 1.7
 LDTP00592  Surfeit locus protein 4 (SURF4) C32 1.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C47 1.7
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C129 1.6
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C39 1.6
 LDTP00434  Transportin-2 (TNPO2) C805 1.6
 LDTP00434  Transportin-2 (TNPO2) C789 1.6
 LDTP04082  Ran GTPase-activating protein 1 (RANGAP1) C573 1.6
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.5
 LDTP04501  Importin subunit alpha-1 (KPNA2) C223 1.5
 LDTP05305  Large neutral amino acids transporter small subunit 1 (SLC7A5) C496 1.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C47 1.5
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) . 1.5
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) C13 1.5
 LDTP09515  Importin-4 (IPO4) C42 1.4
 LDTP11292  BOS complex subunit TMEM147 (TMEM147) C23 1.4
 LDTP00434  Transportin-2 (TNPO2) C93 1.4
 LDTP09949  Transportin-1 (TNPO1) C103 1.4
 LDTP00501  Exportin-1 (XPO1) C34 1.3
 LDTP09825  Nuclear pore complex protein Nup205 (NUP205) C1662 1.3
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) C330 1.3
 LDTP12526  Oligosaccharyltransferase complex subunit OSTC (OSTC) C14 1.3
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) C704 1.3
 LDTP00501  Exportin-1 (XPO1) C34 1.3
 LDTP01574  Importin-7 (IPO7) C757 1.3
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) C23 1.3
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C467 1.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) C198 1.3
 LDTP04662  Exportin-2 (CSE1L) C853 1.2
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C76 1.2
 LDTP00810  Exportin-T (XPOT) C38 1.2
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) C23 1.2
 LDTP12526  Oligosaccharyltransferase complex subunit OSTC (OSTC) C14 1.2
 LDTP01060  PRA1 family protein 2 (PRAF2) C28 1.2
 LDTP04662  Exportin-2 (CSE1L) C344 1.1
 LDTP04501  Importin subunit alpha-1 (KPNA2) C223 1.1
 LDTP04662  Exportin-2 (CSE1L) C853 1.1
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C467 1.1
 LDTP01037  Catenin delta-1 (CTNND1) C692 1.1
 LDTP01988  ATP synthase protein 8 (MT-ATP8) C59 1.1
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.0
 LDTP09949  Transportin-1 (TNPO1) C683 1.0
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) C366 1.0
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 1.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) C49 1.0
 LDTP11934  EH domain-containing protein 1 (EHD1) C138 0.9
 LDTP06242  Importin subunit beta-1 (KPNB1) C436 0.9
 LDTP06554  Dihydropyrimidinase-related protein 2 (DPYSL2) C179 0.9
 LDTP04662  Exportin-2 (CSE1L) C325 0.9
 LDTP01631  Mitochondrial pyruvate carrier 2 (MPC2) C54 0.9
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) C199 0.9
 LDTP02010  Annexin A1 (ANXA1) C324 0.9
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) C589 0.9
 LDTP02010  Annexin A1 (ANXA1) C324 0.8
 LDTP00266  Importin-5 (IPO5) C733 0.8
 LDTP01133  Copine-3 (CPNE3) C54 0.7
 LDTP04662  Exportin-2 (CSE1L) C344 0.5
Transcription factor
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04752  Transcription factor SOX-10 (SOX10) C71 7.0
 LDTP14241  eIF5-mimic protein 1 (BZW2) C97 3.7
 LDTP07940  eIF5-mimic protein 2 (BZW1) C96 2.4
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.9
 LDTP02500  Nuclear receptor subfamily 2 group F member 6 (NR2F6) C316 1.8
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.3
 LDTP04752  Transcription factor SOX-10 (SOX10) C190 1.0
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.8
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00671  Tapasin (TAPBP) C115 1.3
Cytokine and receptor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10323  CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) C12 1.1
 LDTP10323  CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) C12 1.1
Other
Click to Show/Hide to Show 122 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 15.0
 LDTP00313  Nucleolar protein 56 (NOP56) C112 4.0
 LDTP00313  Nucleolar protein 56 (NOP56) C52 3.9
 LDTP13925  Nucleolar protein 58 (NOP58) C205 3.4
 LDTP05867  Treacle protein (TCOF1) C38 3.4
 LDTP00313  Nucleolar protein 56 (NOP56) C142 3.3
 LDTP00313  Nucleolar protein 56 (NOP56) C211 3.2
 LDTP03367  Elongation factor 1-gamma (EEF1G) C68 2.6
 LDTP11331  Sideroflexin-3 (SFXN3) C234 2.4
 LDTP05867  Treacle protein (TCOF1) C38 2.2
 LDTP03773  Metalloproteinase inhibitor 3 (TIMP3) C163 2.2
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C673 2.1
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C397 1.9
 LDTP14153  Trafficking protein particle complex subunit 1 (TRAPPC1) C115 1.9
 LDTP10864  Calponin-2 (CNN2) C175 1.8
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C196 1.8
 LDTP00720  Centromere/kinetochore protein zw10 homolog (ZW10) C568 1.7
 LDTP01285  TIP41-like protein (TIPRL) C87 1.6
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C325 1.6
 LDTP07718  MICOS complex subunit MIC27 (APOOL) C152 1.6
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.5
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C196 1.5
 LDTP06383  Calponin-3 (CNN3) C173 1.5
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 1.5
 LDTP05025  Large ribosomal subunit protein eL32 (RPL32) C91 1.5
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C49 1.5
 LDTP02809  Small ribosomal subunit protein uS5 (RPS2) C229 1.5
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) C111 1.4
 LDTP06383  Calponin-3 (CNN3) C173 1.4
 LDTP00313  Nucleolar protein 56 (NOP56) C384 1.4
 LDTP14980  RRP12-like protein (RRP12) C763 1.4
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) C111 1.4
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.4
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 1.4
 LDTP08387  Dynein axonemal assembly factor 5 (DNAAF5) C173 1.4
 LDTP15947  Mitochondrial fission regulator 1-like (MTFR1L) C52 1.4
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) C180 1.3
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) C60 1.3
 LDTP02205  Tubulin beta chain (TUBB) C303 1.3
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) C615 1.3
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.3
 LDTP14069  WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) C393 1.3
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) C60 1.3
 LDTP02205  Tubulin beta chain (TUBB) C201 1.3
 LDTP15101  Armadillo repeat-containing protein 6 (ARMC6) C297 1.3
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.3
 LDTP13170  COP9 signalosome complex subunit 7a (COPS7A) C110 1.3
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 1.3
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) C363 1.3
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) C10 1.2
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.2
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) C363 1.2
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C450 1.2
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) C468 1.2
 LDTP05049  Dynein light chain 1, cytoplasmic (DYNLL1) C56 1.2
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.2
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) C33 1.2
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 1.2
 LDTP13424  Vacuolar protein sorting-associated protein 28 homolog (VPS28) C128 1.2
 LDTP04504  Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) C85 1.2
 LDTP02205  Tubulin beta chain (TUBB) C239 1.2
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) C468 1.2
 LDTP05778  Chromobox protein homolog 3 (CBX3) C177 1.2
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.1
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C511 1.1
 LDTP05049  Dynein light chain 1, cytoplasmic (DYNLL1) C56 1.1
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.1
 LDTP19499  UPF0598 protein C8orf82 (C8orf82) C98 1.1
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.1
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14) C42 1.1
 LDTP06367  Poly(rC)-binding protein 2 (PCBP2) C217 1.1
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 1.1
 LDTP04249  T-complex protein 1 subunit gamma (CCT3) C455 1.1
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) C92 1.0
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) C119 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.0
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) C33 1.0
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C155 1.0
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C175 1.0
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) C70 1.0
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.0
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C175 1.0
 LDTP02059  Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) C112 1.0
 LDTP11331  Sideroflexin-3 (SFXN3) C189 1.0
 LDTP03888  T-complex protein 1 subunit zeta (CCT6A) C406 1.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C205 1.0
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) C119 1.0
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) C70 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.0
 LDTP02107  Large ribosomal subunit protein P1 (RPLP1) C61 1.0
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C172 1.0
 LDTP02205  Tubulin beta chain (TUBB) C354 1.0
 LDTP03244  Cofilin-1 (CFL1) C139 0.9
 LDTP00619  Eukaryotic translation initiation factor 3 subunit D (EIF3D) C19 0.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.9
 LDTP02596  Proliferating cell nuclear antigen (PCNA) C81 0.9
 LDTP03367  Elongation factor 1-gamma (EEF1G) C266 0.9
 LDTP03244  Cofilin-1 (CFL1) C139 0.9
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C54 0.9
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 0.9
 LDTP05697  Heat shock protein 75 kDa, mitochondrial (TRAP1) C573 0.9
 LDTP10071  Protein mago nashi homolog 2 (MAGOHB) C133 0.9
 LDTP13991  Serine-threonine kinase receptor-associated protein (STRAP) C340 0.9
 LDTP05002  Small ribosomal subunit protein eS6 (RPS6) C12 0.9
 LDTP09811  Heat shock protein 105 kDa (HSPH1) C34 0.9
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.9
 LDTP04504  Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) C85 0.8
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C155 0.8
 LDTP16107  TBC1 domain family member 13 (TBC1D13) C145 0.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.8
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.8
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 0.8
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.8
 LDTP04708  NHP2-like protein 1 (SNU13) C30 0.8
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.8
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.8
 LDTP04887  Destrin (DSTN) C163 0.8
 LDTP05055  Small ribosomal subunit protein eS21 (RPS21) C56 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.7
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.7
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C269 0.6

References

1 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.