Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	KB02					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	20.0
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	20.0
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	20.0
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	20.0
LDTP13663	Dual specificity protein phosphatase 12 (DUSP12)				C265	20.0
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	20.0
LDTP08135	E3 ubiquitin-protein ligase HUWE1 (HUWE1)				C4367	20.0
LDTP10774	Elongation factor G, mitochondrial (GFM1)				C153	20.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	20.0
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	20.0
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	20.0
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	20.0
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	20.0
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	20.0
LDTP14888	Pre-rRNA-processing protein TSR1 homolog (TSR1)				C126	20.0
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	20.0
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C453	20.0
LDTP12166	Ras-related GTP-binding protein C (RRAGC)				C358	20.0
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	20.0
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	20.0
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	20.0
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	17.6
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	17.1
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	15.6
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	14.8
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	14.0
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	14.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	13.8
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	13.8
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	13.8
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	13.6
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	13.3
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	13.1
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	12.9
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	12.6
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	12.5
LDTP03786	Glutaredoxin-1 (GLRX)				C23	12.1
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	11.9
LDTP14036	Helicase ARIP4 (RAD54L2)				C820	10.7
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	9.5
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	9.3
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	8.6
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	7.1
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	6.9
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	6.1
LDTP04374	Dynamin-2 (DNM2)				C27	5.5
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	5.1
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	4.9
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	4.3
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	4.1
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	4.0
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	4.0
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	3.9
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	3.9
LDTP02502	Thioredoxin (TXN)				C32	3.9
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	3.8
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	3.7
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	3.6
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	3.5
LDTP04424	Galactokinase (GALK1)				C182	3.4
LDTP04689	Adenosine kinase (ADK)				C353	3.2
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	3.2
LDTP03400	Deoxycytidine kinase (DCK)				C9	3.1
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	2.9
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	2.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	2.6
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	2.5
LDTP09912	DNA repair protein RAD50 (RAD50)				C1302	2.4
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	2.3
LDTP02672	Elongation factor 2 (EEF2)				C41	2.2
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	2.2
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	2.2
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	2.2
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	2.1
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	2.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.8
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.7
LDTP05992	Bleomycin hydrolase (BLMH)				C73	1.7
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	1.6
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.6
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.6
LDTP04103	Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)				C207	1.6
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	1.5
LDTP02672	Elongation factor 2 (EEF2)				C136	1.4
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.4
LDTP03400	Deoxycytidine kinase (DCK)				C45	1.3
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.2
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.0
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C641	1.0
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C170	0.9
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	0.8
LDTP04061	26S proteasome regulatory subunit 6B (PSMC4)				C210	0.8
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C193	0.7
LDTP04306	Adenosine 5'-monophosphoramidase HINT1 (HINT1)				C84	0.6
LDTP04251	Elongation factor Tu, mitochondrial (TUFM)				C147	0.5

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	20.0
LDTP04801	Gasdermin-D (GSDMD)				C268	20.0
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	20.0
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	20.0
LDTP04707	Protein SEC13 homolog (SEC13)				C187	13.1
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)				C1223	6.9
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	6.9
LDTP09204	Nucleoporin NUP35 (NUP35)				C255	5.0
LDTP00501	Exportin-1 (XPO1)				C34	4.6
LDTP13661	Sorting nexin-6 (SNX6)				C264	3.8
LDTP00501	Exportin-1 (XPO1)				C528	3.1
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	1.6
LDTP01574	Importin-7 (IPO7)				C757	1.4
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	1.2
LDTP04662	Exportin-2 (CSE1L)				C842	0.9

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	20.0
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	20.0
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	20.0
LDTP05284	Transcription factor RelB (RELB)				C109	20.0
LDTP01191	Zinc finger protein 217 (ZNF217)				C286	20.0
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	14.0
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.2

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	20.0
LDTP08573	Ankyrin repeat and KH domain-containing protein 1 (ANKHD1)				C615	20.0
LDTP04092	Crk-like protein (CRKL)				C249	20.0
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1059	20.0
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	20.0
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	20.0
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	20.0
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	20.0
LDTP14195	FH1/FH2 domain-containing protein 1 (FHOD1)				C502	20.0
LDTP12571	LanC-like protein 2 (LANCL2)				C187	20.0
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	20.0
LDTP06244	Nuclear mitotic apparatus protein 1 (NUMA1)				C961	20.0
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	20.0
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	20.0
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	20.0
LDTP07755	Dynamin-binding protein (DNMBP)				C691	18.6
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	17.3
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	12.0
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	9.3
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	9.1
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	8.4
LDTP04487	Cyclin-H (CCNH)				C244	7.3
LDTP00202	AH receptor-interacting protein (AIP)				C122	6.7
LDTP04517	Transcription initiation factor IIA subunit 2 (GTF2A2)				C68	6.5
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C660	6.3
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	5.7
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	5.3
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	5.3
LDTP09549	Conserved oligomeric Golgi complex subunit 1 (COG1)				C513	5.1
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	4.9
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	4.8
LDTP11239	Protein misato homolog 1 (MSTO1)				C485	4.7
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	4.5
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	4.5
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	4.4
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	4.3
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	4.1
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	4.1
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	4.0
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	4.0
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	4.0
LDTP10700	KH domain-containing RNA-binding protein QKI (QKI)				C35	3.8
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	3.7
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	3.6
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	3.6
LDTP13964	MOB-like protein phocein (MOB4)				C134	3.4
LDTP14337	Protein strawberry notch homolog 1 (SBNO1)				C445	3.4
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C684	3.2
LDTP02205	Tubulin beta chain (TUBB)				C239	3.2
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	3.2
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	2.9
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	2.9
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	2.8
LDTP05867	Treacle protein (TCOF1)				C38	2.7
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	2.6
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	2.5
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	2.5
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	2.5
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	2.4
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	2.4
LDTP13580	Coronin-1C (CORO1C)				C420	2.3
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	2.3
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	2.3
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	2.1
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	2.1
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	2.0
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	1.9
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.9
LDTP04117	Ras GTPase-activating-like protein IQGAP1 (IQGAP1)				C781	1.9
LDTP13580	Coronin-1C (CORO1C)				C456	1.8
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	1.8
LDTP02205	Tubulin beta chain (TUBB)				C354	1.8
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	1.8
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	1.7
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	1.7
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	1.7
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	1.7
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.6
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	1.6
LDTP05076	Tubulin beta-4B chain (TUBB4B)				C213	1.6
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	1.5
LDTP10864	Calponin-2 (CNN2)				C215	1.5
LDTP04902	Actin-related protein 3 (ACTR3)				C235	1.5
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.4
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	1.2
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	1.2
LDTP10864	Calponin-2 (CNN2)				C164	1.0
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	1.0
LDTP01320	Eukaryotic translation initiation factor 3 subunit J (EIF3J)				C207	1.0
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	0.9
LDTP00430	Transcription elongation regulator 1 (TCERG1)				C1062	0.9
LDTP03244	Cofilin-1 (CFL1)				C80	0.9
LDTP04518	DNA mismatch repair protein Msh6 (MSH6)				C1117	0.8
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C122	0.6
LDTP03860	Stress-70 protein, mitochondrial (HSPA9)				C317	0.4

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.