Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name KB05  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 85 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 20.0
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 20.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 20.0
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 20.0
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 20.0
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 20.0
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 20.0
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 20.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 20.0
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 20.0
 LDTP03400  Deoxycytidine kinase (DCK) C45 16.7
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 15.3
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 15.2
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 12.5
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 8.0
 LDTP05859  Integrin-linked protein kinase (ILK) C346 7.8
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 6.8
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 5.8
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 5.7
 LDTP04689  Adenosine kinase (ADK) C353 5.4
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 4.9
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 4.8
 LDTP02672  Elongation factor 2 (EEF2) C41 4.6
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 4.2
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 4.1
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 4.0
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 3.8
 LDTP04374  Dynamin-2 (DNM2) C27 3.7
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 3.6
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 3.4
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 3.3
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 3.0
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 3.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 2.8
 LDTP05289  AMP deaminase 2 (AMPD2) C107 2.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 2.7
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 2.5
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 2.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 2.4
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 2.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 2.4
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 2.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 2.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 2.2
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.8
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 1.8
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 1.8
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.7
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.4
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.4
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 1.3
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.3
 LDTP06211  Caspase-8 (CASP8) C360 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.3
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.3
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 1.3
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 1.3
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.3
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.2
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 1.2
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.2
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.2
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.2
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.1
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.1
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 1.1
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.1
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 1.1
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.0
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.9
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 0.9
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.9
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 0.9
 LDTP02672  Elongation factor 2 (EEF2) C136 0.8
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 0.8
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 0.7
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04801  Gasdermin-D (GSDMD) C268 20.0
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 3.3
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 2.4
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.4
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.4
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.3
 LDTP00501  Exportin-1 (XPO1) C34 1.2
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.2
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.2
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.1
 LDTP01574  Importin-7 (IPO7) C757 1.1
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.1
 LDTP04662  Exportin-2 (CSE1L) C842 1.0
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 2.8
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 2.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 2.0
Other
Click to Show/Hide to Show 65 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 20.0
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 20.0
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 20.0
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 20.0
 LDTP13580  Coronin-1C (CORO1C) C456 20.0
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 20.0
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 20.0
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 20.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 20.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 20.0
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 20.0
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 20.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 11.1
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 10.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 8.5
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) C615 8.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 8.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 7.6
 LDTP07755  Dynamin-binding protein (DNMBP) C691 7.3
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 6.9
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 5.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 4.5
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 4.4
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 4.4
 LDTP04092  Crk-like protein (CRKL) C249 4.3
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 4.2
 LDTP12571  LanC-like protein 2 (LANCL2) C187 3.6
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 3.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 3.4
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 3.3
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 3.2
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 3.1
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 2.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 2.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.8
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 2.7
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 2.7
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 2.5
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 2.5
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 2.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C280 2.3
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 2.3
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 2.2
 LDTP10864  Calponin-2 (CNN2) C215 2.2
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 2.2
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 2.2
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 2.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.0
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.8
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.8
 LDTP10864  Calponin-2 (CNN2) C164 1.8
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.7
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.7
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.6
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.6
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.5
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.4
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 1.4
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.3
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.2
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 1.2
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.1
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 1.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.0
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.0

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.