Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe14  Probe Info 
Probe concentration Probe:20uM; negative probe:20uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 20.0
 LDTP02837  Beta-galactosidase (GLB1) 20.0
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 20.0
 LDTP05992  Bleomycin hydrolase (BLMH) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP01769  Dihydrofolate reductase (DHFR) 20.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 20.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.0
 LDTP04183  Lanosterol synthase (LSS) 20.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 20.0
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 20.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 20.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 16.9
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 16.7
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 15.6
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 13.4
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 11.0
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 9.5
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 9.0
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 7.5
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 6.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 5.9
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 5.7
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 5.6
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 5.5
Transporter and channel
Click to Show/Hide to Show 24 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10036  BOS complex subunit NCLN (NCLN) 20.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP09515  Importin-4 (IPO4) 20.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 20.0
 LDTP05900  Metaxin-1 (MTX1) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 20.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 20.0
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 20.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 20.0
 LDTP11213  Nucleoporin NDC1 (NDC1) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP07236  Protein GPR107 (GPR107) 20.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP07531  Sideroflexin-4 (SFXN4) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 19.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 14.1
 LDTP09949  Transportin-1 (TNPO1) 14.0
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 12.8
 LDTP06242  Importin subunit beta-1 (KPNB1) 5.5
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 12.9
Other
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 20.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 20.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP09787  Nicastrin (NCSTN) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP05160  Nucleobindin-2 (NUCB2) 20.0
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 20.0
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 9.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 7.4
 LDTP02297  Vimentin (VIM) 7.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 5.8

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.