Details of the Target

General Information of Target

Target ID LDTP02146
Target Name Retinoblastoma-associated protein (RB1)
Gene Name RB1
Gene ID 5925
Synonyms
Retinoblastoma-associated protein; p105-Rb; p110-RB1; pRb; Rb; pp110
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTAL
CQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTEL
QKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYK
TAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM
NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
NLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVK
DIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDN
IFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEG
NLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNH
TAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYL
RLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLK
FKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLS
PIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG
TSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQK
LAEMTSTRTRMQKQKMNDSMDTSNKEEK
Target Bioclass
Other
Family
Retinoblastoma protein (RB) family
Subcellular location
Nucleus
Function
Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex.; (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Uniprot ID
P06400
Ensemble ID
ENST00000267163.6
HGNC ID
HGNC:9884
ChEMBL ID
CHEMBL5288

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y790(20.00); Y424(15.26)  LDD0260  [3]
C-Sul
 Probe Info  		2.45  LDD0066  [4]
STPyne
 Probe Info  		K265(9.09); K279(3.33); K427(9.63); K429(9.09)  LDD0277  [5]
Probe 1
 Probe Info  		Y325(31.86)  LDD3495  [6]
BTD
 Probe Info  		C666(3.30); C853(1.79)  LDD1700  [7]
AHL-Pu-1
 Probe Info  		C853(2.06); C438(20.00)  LDD0171  [8]
HHS-482
 Probe Info  		Y790(0.63)  LDD0285  [9]
HHS-475
 Probe Info  		Y91(0.40); Y790(0.57)  LDD0264  [10]
HHS-465
 Probe Info  		Y790(5.85)  LDD2237  [11]
DBIA
 Probe Info  		C438(2.76)  LDD0080  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C438(0.00); C590(0.00); C283(0.00); C278(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C438(0.00); C283(0.00); C278(0.00); C853(0.00)  LDD0036  [13]
IPIAA_L
 Probe Info  		C283(0.00); C61(0.00); C438(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C438(0.00); C283(0.00); C853(0.00); C61(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		C438(0.00); C590(0.00); C853(0.00)  LDD2226  [15]
NAIA_5
 Probe Info  		C438(0.00); C853(0.00)  LDD2224  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
WYneO
 Probe Info  		C438(0.00); C853(0.00)  LDD0022  [16]
Compound 10
 Probe Info  		C590(0.00); C853(0.00)  LDD2216  [17]
Compound 11
 Probe Info  		C590(0.00); C853(0.00)  LDD2213  [17]
ENE
 Probe Info  		C438(0.00); C853(0.00)  LDD0006  [16]
IPM
 Probe Info  		C438(0.00); C853(0.00)  LDD0005  [16]
SF
 Probe Info  		N.A.  LDD0028  [18]
VSF
 Probe Info  		N.A.  LDD0007  [16]
W1
 Probe Info  		C283(0.00); C853(0.00); C438(0.00)  LDD0236  [19]
AOyne
 Probe Info  		15.00  LDD0443  [20]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C283(0.93)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C438(1.04); C283(1.20); C278(1.05); C853(0.98)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C438(0.97); C666(1.45); C278(1.09); C853(0.92)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C283(0.55)  LDD2132  [7]
 LDCM0025  4SU-RNA HEK-293T C590(2.64)  LDD0172  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C853(2.06); C438(20.00)  LDD0171  [8]
 LDCM0214  AC1 HCT 116 C278(1.11); C283(0.85); C438(1.06); C666(1.17)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C278(1.07); C438(1.02); C706(0.81); C712(0.81)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C278(0.90); C283(0.77); C706(1.01); C712(1.05)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C278(0.72); C283(0.70); C706(1.04); C712(1.00)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C278(0.81); C283(0.51); C706(1.07); C712(1.11)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C278(0.80); C283(0.64); C706(0.87); C712(0.84)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C278(0.81); C283(1.18); C706(1.06); C712(1.06)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C278(0.78); C283(1.03); C706(1.00); C712(1.01)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C278(0.87); C283(1.00); C706(0.97); C712(0.97)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C278(0.91); C283(1.04); C706(1.02); C712(1.07)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C278(0.89); C283(1.04); C706(1.01); C712(1.04)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C278(0.87); C283(1.15); C706(1.19); C712(1.28)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C278(1.36); C438(0.97); C706(0.86); C712(0.86)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C278(0.87); C283(1.01); C706(1.03); C712(1.05)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C278(0.80); C283(0.98); C706(1.11); C712(1.18)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C278(0.79); C283(0.94); C706(0.98); C712(0.98)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C278(0.93); C283(0.95); C438(1.05); C61(1.10)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C278(1.12); C283(0.96); C438(1.02); C61(1.06)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C278(1.26); C283(0.92); C438(1.07); C61(1.05)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C278(0.83); C283(0.82); C438(1.17); C61(1.08)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C278(0.88); C283(0.88); C438(1.20); C61(1.16)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C278(1.15); C283(0.91); C438(1.05); C61(1.06)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C278(1.06); C283(0.95); C438(1.01); C61(1.11)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C278(1.44); C438(0.75); C706(0.89); C712(0.89)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C278(2.29); C283(0.92); C438(0.93); C61(0.98)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C278(1.16); C283(1.01); C438(1.09); C61(1.02)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C278(1.37); C283(1.00); C438(1.01); C61(0.98)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C278(1.31); C283(0.87); C438(0.96); C61(0.96)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C278(1.13); C283(1.05); C438(1.04); C61(1.08)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C278(1.42); C283(0.92); C438(0.90); C61(0.97)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C278(1.26); C283(0.96); C438(1.17); C61(0.97)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C278(1.43); C283(0.96); C438(1.11); C61(1.00)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C278(1.09); C438(1.29); C706(1.56); C712(1.56)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C278(0.96); C438(1.59); C706(1.12); C712(1.12)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C278(0.91); C438(1.52); C706(1.01); C712(1.01)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C278(0.98); C438(1.15); C706(1.66); C712(1.66)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C278(0.98); C438(1.37); C706(1.10); C712(1.10)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C278(0.94); C438(1.39); C706(1.03); C712(1.03)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C278(0.91); C438(1.38); C706(1.35); C712(1.35)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C278(0.94); C438(1.27); C706(1.08); C712(1.08)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C278(0.94); C438(1.41); C706(1.09); C712(1.09)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C278(0.98); C438(1.58); C706(1.16); C712(1.16)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C278(0.94); C438(2.03); C706(1.86); C712(1.86)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C278(0.95); C438(2.02); C706(1.07); C712(1.07)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C278(1.13); C438(0.92); C706(0.91); C712(0.91)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C278(1.00); C438(2.16); C706(1.29); C712(1.29)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C278(0.95); C438(1.94); C706(1.61); C712(1.61)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C278(0.91); C438(1.56); C706(1.01); C712(1.01)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C283(0.55); C438(0.96); C706(1.01); C712(1.01)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C706(0.76); C283(0.81); C712(0.96); C438(1.00)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C706(0.84); C438(0.93); C853(0.97); C283(1.00)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C283(0.63); C706(0.78); C712(0.94); C278(1.09)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C283(0.84); C706(0.87); C712(1.18); C438(1.20)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C283(0.69); C712(1.05); C706(1.05); C438(1.25)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C283(0.68); C712(0.89); C706(0.91); C278(0.95)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C706(1.03); C712(1.03); C278(1.08); C438(1.15)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C283(0.61); C706(0.90); C853(1.13); C438(1.17)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C283(0.59); C706(0.85); C278(0.97); C438(0.99)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C283(0.84); C706(0.91); C712(1.15); C438(1.23)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C283(0.50); C706(0.92); C712(1.27); C278(1.35)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C278(1.81); C283(0.63); C438(1.07); C706(1.04)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C278(1.30); C283(0.83); C438(1.00); C706(1.15)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C278(1.18); C283(0.63); C438(1.23); C706(1.02)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C278(1.80); C283(0.57); C438(0.83); C706(0.96)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C706(0.98); C712(0.98); C278(1.09); C853(1.20)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C853(0.91); C706(0.96); C712(0.96); C278(1.13)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C706(0.93); C712(0.93); C853(0.93); C278(1.06)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C706(0.66); C712(0.66); C278(0.95); C283(0.98)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C853(0.95); C706(1.22); C712(1.22); C278(1.30)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C853(0.95); C706(1.15); C712(1.15); C278(1.35)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C706(0.92); C712(0.92); C853(1.01); C278(1.20)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C853(0.88); C706(0.95); C712(0.95); C278(1.32)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C853(1.04); C278(1.24); C706(1.43); C712(1.43)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C706(0.88); C712(0.88); C438(0.96); C853(1.05)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C706(0.73); C712(0.73); C61(0.85); C438(0.94)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C706(0.76); C712(0.76); C61(0.90); C278(0.93)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C706(0.79); C712(0.79); C278(1.10); C853(1.12)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C706(0.69); C712(0.69); C278(0.93); C61(0.96)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C706(0.76); C712(0.76); C283(0.87); C278(0.90)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C61(0.86); C706(0.90); C712(0.90); C278(0.91)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C706(0.74); C712(0.74); C61(0.81); C278(0.97)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C706(0.67); C712(0.67); C61(0.80); C278(1.07)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C706(0.83); C712(0.83); C61(0.84); C438(0.96)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C438(0.84); C61(0.87); C706(0.96); C712(0.96)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C438(0.93); C853(0.95); C278(1.48)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C438(0.83); C853(1.17); C278(1.27)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C438(0.91); C278(1.10); C853(1.13)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C438(0.97); C278(1.17); C853(1.19)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C438(1.02); C853(1.17); C278(1.72)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C706(0.61); C712(0.61); C283(0.95); C278(1.04)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C438(0.91); C853(1.15); C278(1.29)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C278(0.90); C438(0.95); C853(1.44)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C438(0.98); C278(1.09); C853(1.23)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C278(1.01); C438(1.02); C853(1.50)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C438(0.94); C278(1.09); C853(1.15)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C438(0.86); C278(1.21); C853(1.22)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C706(0.92); C712(0.92); C283(0.97); C278(1.02)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C283(0.94); C278(1.14); C438(1.16); C706(1.18)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C283(1.02); C706(1.23); C712(1.23); C278(1.28)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C283(0.86); C278(0.95); C706(0.95); C712(0.95)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C706(0.70); C712(0.70); C283(0.85); C278(1.04)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C283(0.85); C278(0.92); C706(1.39); C712(1.39)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C283(0.88); C278(1.05); C853(1.13); C438(1.26)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C283(0.98); C706(1.08); C712(1.08); C278(1.09)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C283(0.87); C438(1.02); C278(1.15); C706(1.52)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C438(1.12); C283(1.18); C853(1.36); C278(1.39)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C283(0.82); C706(0.95); C712(0.95); C438(1.09)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C283(0.85); C706(1.09); C712(1.09); C278(1.27)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C706(0.76); C712(0.76); C278(0.79); C853(0.93)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C278(0.78); C438(0.96); C706(0.96); C712(0.96)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C278(0.72); C61(0.73); C853(0.97); C666(1.00)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C706(0.89); C712(0.89); C278(0.95); C438(1.08)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C278(0.65); C706(0.68); C712(0.68); C61(0.71)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C706(0.64); C712(0.64); C278(0.76); C61(0.89)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C278(0.76); C61(0.78); C853(0.95); C706(1.06)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C61(0.65); C706(0.72); C712(0.72); C278(0.76)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C61(0.72); C278(0.81); C853(0.83); C706(0.85)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C706(0.64); C712(0.64); C278(0.70); C61(0.76)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C278(0.72); C706(0.76); C712(0.76); C853(0.90)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C706(0.69); C712(0.69); C278(0.69); C61(0.74)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C666(0.67); C706(0.77); C712(0.77); C438(0.79)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C666(0.73); C438(0.76); C706(0.84); C712(0.84)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C438(0.87); C706(0.90); C712(0.90); C278(0.92)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C666(0.72); C438(0.77); C706(0.82); C712(0.82)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C438(0.76); C666(0.77); C706(0.94); C712(0.94)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C666(0.75); C438(0.82); C278(0.98); C706(0.99)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C666(0.70); C438(0.82); C706(1.01); C712(1.01)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C438(0.74); C666(0.76); C706(0.96); C712(0.96)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C666(0.79); C438(0.86); C278(1.12); C706(1.27)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C438(0.61); C666(0.79); C278(1.07); C853(1.25)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C438(0.70); C666(0.81); C706(0.91); C712(0.91)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C706(0.72); C712(0.72); C666(0.75); C438(0.84)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C666(0.72); C438(0.80); C706(0.85); C712(0.85)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C438(0.87); C706(0.93); C712(0.93); C278(0.98)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C438(0.66); C666(1.10); C853(1.12); C706(1.13)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C438(0.69); C706(0.87); C712(0.87); C666(0.95)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C666(0.70); C438(0.72); C706(1.05); C712(1.05)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C706(0.40); C712(0.40); C278(0.84); C438(1.38)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C706(0.43); C712(0.43); C278(0.88); C438(1.68)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C706(0.38); C712(0.38); C278(0.85); C853(1.57)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C706(0.52); C712(0.52); C278(0.86); C438(1.16)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C706(0.48); C712(0.48); C278(1.12); C853(1.19)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C706(0.46); C712(0.46); C278(1.09); C853(1.24)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C706(0.48); C712(0.48); C278(0.88); C438(1.13)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C706(0.43); C712(0.43); C278(0.96); C853(1.09)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C706(0.43); C712(0.43); C278(1.02); C438(1.25)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C706(0.42); C712(0.42); C278(0.91); C438(1.22)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C706(0.34); C712(0.34); C278(0.91); C438(1.15)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C706(0.38); C712(0.38); C278(1.20); C438(1.24)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C706(0.38); C712(0.38); C278(0.95); C853(1.33)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C706(0.39); C712(0.39); C438(1.07); C278(1.14)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C706(0.33); C712(0.33); C278(0.80); C438(1.34)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C283(0.65); C278(0.75); C712(0.86); C706(0.86)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C278(0.86); C283(0.91); C706(0.98); C712(1.02)  LDD0683  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C666(1.67); C283(0.72); C278(0.79)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C278(1.20); C438(0.98); C706(0.94); C712(0.94)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C706(0.77); C712(0.77); C278(0.97); C438(1.15)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C706(0.92); C712(0.92); C278(1.02); C438(1.35)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 12.11  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C853(1.04)  LDD2171  [12]
 LDCM0498  BS-3668 MDA-MB-231 C666(0.49); C853(0.88)  LDD2091  [7]
 LDCM0630  CCW28-3 231MFP C853(1.79)  LDD2214  [22]
 LDCM0367  CL1 HCT 116 C61(0.81); C278(0.82); C438(0.91); C706(1.03)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C278(0.85); C61(0.92); C706(0.92); C712(0.92)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C706(0.65); C712(0.65); C283(0.91); C438(0.94)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C278(0.99); C438(0.99); C706(1.25); C712(1.25)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C278(0.90); C853(1.02); C438(1.08); C706(1.19)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C706(0.98); C712(0.98); C438(1.01); C853(1.01)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C706(0.91); C712(0.91); C278(0.94); C438(0.95)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C706(0.69); C712(0.69); C278(1.08); C853(1.09)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C706(0.82); C712(0.82); C853(0.94); C278(1.55)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C706(0.65); C712(0.65); C853(1.04); C278(1.14)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C706(0.88); C712(0.88); C853(0.99); C278(1.18)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C706(0.62); C712(0.62); C278(1.05); C853(1.06)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C61(0.80); C706(0.83); C712(0.83); C278(0.93)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C706(0.77); C712(0.77); C853(0.93); C278(1.27)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C706(0.73); C712(0.73); C853(1.05); C278(1.08)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C706(0.82); C712(0.82); C61(0.87); C278(1.09)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C706(0.94); C712(0.94); C61(0.99); C438(1.03)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C61(0.87); C706(0.90); C712(0.90); C278(0.93)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C706(0.77); C712(0.77); C438(0.88); C278(0.97)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C706(0.69); C712(0.69); C61(0.86); C438(1.00)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C438(0.88); C853(1.31); C278(2.10)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C278(0.81); C438(1.10); C853(1.29)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C278(0.88); C438(1.07); C853(1.23)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C278(0.82); C853(0.97); C706(1.04); C712(1.04)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C278(0.96); C853(1.34); C438(1.34)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C706(0.95); C712(0.95); C283(0.95); C438(0.99)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C283(0.84); C278(1.04); C438(1.10); C706(1.24)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C283(0.97); C706(1.04); C712(1.04); C438(1.17)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C706(0.92); C712(0.92); C438(1.08); C283(1.19)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C61(0.72); C706(0.81); C712(0.81); C278(0.83)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C278(0.73); C61(0.80); C438(0.95); C666(0.96)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C278(0.72); C61(0.77); C706(0.91); C712(0.91)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C278(0.81); C706(0.88); C712(0.88); C61(0.92)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C278(0.81); C706(0.90); C712(0.90); C61(0.95)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C278(0.70); C706(0.83); C712(0.83); C61(0.98)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C278(0.72); C706(0.80); C712(0.80); C853(0.82)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C438(0.59); C61(0.73); C278(0.81); C853(1.13)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C438(0.69); C278(1.02); C853(1.04)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C278(0.89); C853(1.03); C438(1.19)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C853(0.96); C278(1.08); C438(1.14)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C278(0.75); C438(0.81); C706(0.88); C712(0.88)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C278(0.76); C438(0.79); C853(1.15)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C438(0.76); C278(0.82); C853(0.92)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C278(0.79); C853(0.87); C438(0.99)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C278(0.88); C853(0.98); C438(1.06)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C278(0.89); C438(1.18); C853(1.07)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C278(0.90); C438(0.74); C853(1.20)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C278(0.83); C438(1.04); C853(1.16)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C278(0.86); C438(1.09); C853(0.80)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C278(0.83); C438(0.71); C853(1.06)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C278(0.75); C438(1.07); C853(0.88)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C278(0.83); C438(0.92); C61(0.75); C706(1.16)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C278(0.97); C438(0.84); C853(0.85)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C278(0.86); C61(1.01); C666(0.83); C706(1.09)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C278(0.78); C61(0.97); C666(0.80); C706(0.73)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C278(0.69); C61(0.86); C666(1.32); C706(0.87)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C278(0.80); C61(0.83); C666(1.39); C706(1.41)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C278(0.83); C61(0.81); C666(0.65); C706(1.74)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C278(0.83); C61(0.84); C666(1.06); C706(1.35)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C278(0.86); C61(0.99); C666(0.70); C706(1.45)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C278(0.95); C61(1.07); C666(0.68); C706(1.26)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C278(0.88); C438(0.91); C61(1.06); C706(0.85)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C278(0.90); C61(0.84); C666(1.74); C706(1.25)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C278(0.82); C61(0.82); C666(0.77); C706(1.28)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C278(1.11); C61(1.03); C666(0.64); C706(1.47)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C278(0.92); C61(0.92); C666(0.82); C706(1.44)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C278(0.81); C61(0.92); C666(0.68); C706(1.07)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C278(0.87); C61(0.92); C666(0.62); C706(1.00)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C278(0.68); C438(1.08); C61(1.08); C666(1.02)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C278(0.71); C438(0.95); C61(1.00); C666(1.11)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C278(0.80); C438(0.94); C61(1.03); C666(1.09)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C278(0.97); C438(1.13); C61(1.04); C666(1.19)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C278(0.88); C438(0.93); C61(1.08); C706(0.94)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C278(1.12); C438(0.93); C61(1.06); C666(1.19)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C278(0.93); C438(0.94); C61(1.08); C666(1.22)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C278(0.96); C438(1.20); C61(0.99); C666(1.07)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C278(0.78); C438(0.78); C61(1.00); C666(0.76)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C278(0.80); C438(0.97); C61(1.13); C666(1.25)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C278(1.02); C438(1.14); C61(1.25); C666(1.20)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C278(0.79); C438(0.89); C61(1.10); C666(1.13)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C278(0.75); C438(0.79); C61(1.09); C666(0.68)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C278(0.96); C438(1.00); C61(1.09); C666(0.98)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C278(0.90); C438(1.06); C61(1.05); C666(1.40)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C278(0.66); C438(0.95); C61(0.73); C706(0.64)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C278(0.90); C438(1.07); C61(0.89); C666(0.95)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C278(0.73); C438(1.24); C706(0.69); C712(0.69)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C278(0.81); C438(0.96); C706(0.78); C712(0.78)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C278(0.75); C438(0.95); C706(0.80); C712(0.80)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C278(0.84); C438(1.02); C706(0.86); C712(0.86)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C278(1.00); C438(1.07); C706(0.94); C712(0.94)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C278(0.91); C438(0.90); C706(0.80); C712(0.80)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C278(1.05); C438(0.99); C706(0.98); C712(0.98)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C278(0.86); C438(1.17); C706(0.93); C712(0.93)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C278(0.78); C438(0.94); C706(0.68); C712(0.68)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C278(0.80); C438(1.04); C61(0.90); C706(0.90)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C278(0.95); C438(1.17); C706(0.98); C712(0.98)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C278(0.94); C438(1.11); C706(0.84); C712(0.84)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C278(0.89); C438(1.14); C706(0.82); C712(0.82)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C278(0.93); C438(0.97); C706(1.15); C712(1.15)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C278(1.13); C438(0.98); C706(1.14); C712(1.14)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C278(0.91); C438(0.86); C853(0.76)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C278(0.97); C438(0.79); C853(0.82)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C278(1.12); C438(1.13); C853(1.07)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C278(0.96); C438(0.92); C853(1.11)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C278(0.61); C438(0.90); C61(0.89); C706(1.12)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C278(1.09); C438(0.98); C853(0.86)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C278(0.94); C438(0.97); C853(0.87)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C278(0.95); C438(0.97); C853(0.92)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C278(0.97); C438(0.93); C853(0.94)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C278(0.87); C438(0.87); C853(1.07)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C278(0.95); C438(0.94); C853(0.99)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C278(1.10); C438(0.86); C853(0.74)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C278(1.10); C438(0.78); C853(0.96)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C278(1.33); C438(0.82); C853(1.28)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C278(1.67); C438(1.01); C853(1.16)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C278(0.79); C438(1.05); C61(0.92); C706(1.18)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C278(1.07); C438(0.70); C853(0.90)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C278(0.94); C283(0.80); C438(0.79); C666(1.12)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C278(1.12); C283(0.96); C438(0.94); C666(0.93)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C278(1.19); C283(1.19); C438(1.39); C666(0.88)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C278(0.94); C283(0.84); C438(0.93); C666(0.94)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C278(0.93); C283(0.88); C438(0.94); C666(0.99)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C278(0.90); C283(0.88); C438(0.98); C666(0.93)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C278(0.84); C283(0.74); C438(0.88); C666(1.06)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C278(0.87); C283(0.91); C438(1.03); C666(1.05)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C278(0.98); C283(0.77); C438(0.95); C666(1.18)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C283(0.97); C438(0.95); C278(1.20); C61(1.05)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C666(2.14); C853(1.84)  LDD1702  [7]
 LDCM0625  F8 Ramos C853(0.73); C438(1.13); C666(0.63); C61(0.58)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C853(1.49); C438(0.86); C666(0.78); C61(0.81)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C853(11.99); C438(1.37)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C853(0.51); C438(0.84); C666(0.89); C61(1.02)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C853(0.85); C438(0.98); C666(1.00); C61(0.95)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C853(0.67); C438(1.43); C666(0.79); C61(1.44)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C853(0.57); C438(0.70); C666(0.73); C61(0.94)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C853(0.99); C438(0.94); C666(0.96); C61(0.81)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C853(0.93); C438(0.97); C666(1.11); C61(0.98)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C853(0.87); C438(0.86); C666(1.00); C61(0.82)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C853(0.75); C438(0.88); C666(0.69); C61(0.75)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C853(1.53); C438(0.98); C666(1.10); C61(0.93)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C853(0.95); C438(0.94); C666(1.01); C61(1.00)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C853(1.10); C438(1.05); C666(0.75); C61(0.80)  LDD2201  [24]
 LDCM0468  Fragment33 HCT 116 C278(0.69); C438(1.10); C706(0.86); C712(0.86)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C853(0.87); C438(0.89); C666(1.01); C61(0.79)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C853(0.82); C438(0.79); C666(0.86); C61(0.48)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C278(1.00); C61(0.91); C666(1.90); C706(1.48)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C853(0.78); C438(1.25); C666(1.35); C61(0.86)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C853(0.91); C438(1.25); C666(1.22); C61(0.91)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C853(0.55); C438(1.09); C666(0.83); C61(0.66)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C853(0.71); C438(0.96); C666(0.94); C61(1.17)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y91(0.40); Y790(0.57)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y790(0.80)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y790(0.36); Y91(9.21)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y790(0.41)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y790(0.87); Y91(5.20)  LDD0268  [10]
 LDCM0123  JWB131 DM93 Y790(0.63)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y790(0.77)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y790(0.64)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y790(2.76)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y790(1.97)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y790(0.18)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y790(0.33)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y790(0.70)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C438(2.76)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C438(2.15)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C438(1.53)  LDD0082  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C283(1.09); C853(3.04)  LDD2121  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C438(0.96); C666(1.03); C278(0.87)  LDD2093  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C438(1.00); C666(1.11); C283(1.00); C278(0.97)  LDD2099  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C666(0.72); C278(0.65); C853(0.92)  LDD2101  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C853(0.90)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C438(0.95); C853(0.89)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C438(0.51); C666(0.42); C283(0.92); C278(0.76)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C438(0.82); C853(0.90)  LDD2111  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C853(0.58)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C438(0.98); C666(2.18); C278(1.43)  LDD2119  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C438(0.73); C283(1.02); C278(0.79); C853(0.66)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C438(0.73); C283(1.07); C853(0.75)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C853(0.51)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C438(0.98); C666(1.15); C283(1.42); C278(1.17)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C438(0.92); C666(0.82)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C666(0.65); C278(0.50)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C278(2.58)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C438(1.05); C666(1.17); C278(1.82); C853(0.90)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C438(1.03); C666(1.29); C278(1.61); C853(1.10)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C438(0.84); C666(0.91); C283(0.99); C278(0.86)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C666(3.30); C853(1.79)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C438(0.70); C666(0.88); C278(0.99); C853(0.66)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C283(1.71); C853(0.40)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C853(1.43)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C278(1.54)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C666(0.81)  LDD2146  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C666(0.55); C278(0.50)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C283(0.78); C853(3.15)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C853(0.98); C438(0.85)  LDD2206  [25]
 LDCM0628  OTUB2-COV-1 HEK-293T C853(2.86)  LDD2207  [25]
 LDCM0021  THZ1 HCT 116 C853(1.04)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
E3 ubiquitin-protein ligase BRE1B (RNF40) BRE1 family O75150
Protein arginine N-methyltransferase 2 (PRMT2) Protein arginine N-methyltransferase family P55345
Histone-lysine N-methyltransferase SETD7 (SETD7) Histone-lysine methyltransferase family Q8WTS6
DNA endonuclease RBBP8 (RBBP8) COM1/SAE2/CtIP family Q99708
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Lysine-specific demethylase 5A (KDM5A) JARID1 histone demethylase family P29375
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Proliferation-associated protein 2G4 (PA2G4) Peptidase M24 family Q9UQ80
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein kinase Chk2 (CHEK2) CAMK Ser/Thr protein kinase family O96017
Serine/threonine-protein kinase Chk1 (CHEK1) CAMK Ser/Thr protein kinase family O14757
Cyclin-dependent kinase 2 (CDK2) CMGC Ser/Thr protein kinase family P24941
Mitogen-activated protein kinase 14 (MAPK14) CMGC Ser/Thr protein kinase family Q16539
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) CMGC Ser/Thr protein kinase family Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) CMGC Ser/Thr protein kinase family Q9Y463
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Tyrosine-protein kinase FRK (FRK) Tyr protein kinase family P42685
E3 ubiquitin-protein ligase UHRF2 (UHRF2) . Q96PU4
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor E2F1 (E2F1) E2F/DP family Q01094
Transcription factor E2F2 (E2F2) E2F/DP family Q14209
Transcription factor E2F3 (E2F3) E2F/DP family O00716
Transcription factor E2F5 (E2F5) E2F/DP family Q15329
Interferon regulatory factor 3 (IRF3) IRF family Q14653
Transcriptional activator protein Pur-alpha (PURA) PUR DNA-binding protein family Q00577
Erythroid transcription factor (GATA1) . P15976
Forkhead box protein O3 (FOXO3) . O43524
HMG box-containing protein 1 (HBP1) . O60381
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein mS40 (MRPS18B) Bacterial ribosomal protein bS18 family Q9Y676
Cyclin-C (CCNC) Cyclin family P24863
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Neurofilament medium polypeptide (NEFM) Intermediate filament family P07197
Protein Mdm4 (MDM4) MDM2/MDM4 family O15151
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400
Nuclear receptor coactivator 6 (NCOA6) . Q14686

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.