Details of the Target

General Information of Target

Target ID LDTP05301
Target Name Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
Gene Name HMGCS1
Gene ID 3157
Synonyms
HMGCS; Hydroxymethylglutaryl-CoA synthase, cytoplasmic; HMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Thiolase-like superfamily, HMG-CoA synthase family
Subcellular location
Cytoplasm
Function Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.
TTD ID
T41195
Uniprot ID
Q01581
DrugMap ID
TTQF4TK
Ensemble ID
ENST00000325110.11
HGNC ID
HGNC:5007

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.04  LDD0402  [1]
A-EBA
 Probe Info  		3.55  LDD0215  [2]
TH211
 Probe Info  		Y375(20.00)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
Probe 1
 Probe Info  		Y310(40.08)  LDD3495  [5]
BTD
 Probe Info  		C406(0.77)  LDD2089  [6]
AHL-Pu-1
 Probe Info  		C406(11.75)  LDD0168  [7]
HHS-465
 Probe Info  		Y267(5.41)  LDD2237  [8]
DBIA
 Probe Info  		C86(1.15); C224(1.02); C406(0.86)  LDD0078  [9]
5E-2FA
 Probe Info  		H485(0.00); H492(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K46(0.00); K409(0.00); K100(0.00); K102(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C268(0.00); C69(0.00); C406(0.00); C224(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C59(0.00); C406(0.00); C224(0.00); C12(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C268(0.00); C406(0.00); C224(0.00); C86(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
NAIA_4
 Probe Info  		C12(0.00); C268(0.00)  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		C86(0.00); C406(0.00)  LDD0021  [16]
WYneO
 Probe Info  		C86(0.00); C406(0.00)  LDD0022  [16]
Compound 10
 Probe Info  		C12(0.00); C86(0.00)  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
IPM
 Probe Info  		N.A.  LDD0147  [14]
PF-06672131
 Probe Info  		C12(0.00); C406(0.00)  LDD0017  [18]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
VSF
 Probe Info  		N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info  		C224(0.00); C86(0.00); C268(0.00)  LDD0018  [19]
Acrolein
 Probe Info  		C12(0.00); C406(0.00); C86(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
W1
 Probe Info  		C12(0.00); C406(0.00)  LDD0236  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		C69(0.00); C268(0.00); C406(0.00); C224(0.00)  LDD2223  [15]
HHS-482
 Probe Info  		Y267(2.87); Y345(3.06)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe15
 Probe Info  		12.12  LDD0478  [23]
FFF probe3
 Probe Info  		6.60  LDD0465  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]
A-DA
 Probe Info  		3.78  LDD0335  [25]
STS-1
 Probe Info  		N.A.  LDD0068  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C86(1.16)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C86(1.15)  LDD2152  [6]
 LDCM0025  4SU-RNA HEK-293T C406(11.75)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C69(2.43); C59(2.45); C86(2.38); C406(13.82)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C224(1.08); C406(1.30); C86(1.04)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C224(0.89); C406(0.99); C86(1.35)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C224(0.74); C232(0.34); C237(0.34); C406(0.88)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C224(0.83); C232(0.38); C237(0.38); C406(0.89)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C224(0.74); C232(0.71); C237(0.71); C406(0.89)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C224(0.72); C232(0.36); C237(0.36); C406(0.82)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C224(0.83); C232(0.94); C237(0.94); C406(0.92)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C224(0.72); C232(0.37); C237(0.37); C406(0.89)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C224(0.66); C232(0.26); C237(0.26); C406(0.82)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C224(0.72); C232(0.38); C237(0.38); C406(0.96)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C224(0.64); C232(0.28); C237(0.28); C406(0.71)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C224(0.65); C232(0.87); C237(0.87); C406(0.90)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C224(0.83); C406(0.98); C86(1.14)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C224(0.74); C232(0.31); C237(0.31); C406(0.80)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C224(0.56); C232(0.30); C237(0.30); C406(0.76)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C224(0.78); C232(0.32); C237(0.32); C406(0.81)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C224(1.06); C406(1.24); C86(1.02)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C224(0.83); C406(1.12); C86(1.19)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C224(0.83); C406(0.86); C86(1.27)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C224(0.73); C406(1.06); C86(1.31)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C224(1.11); C406(0.99); C86(1.24)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C224(0.99); C406(1.05); C86(1.29)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C224(0.86); C406(1.46); C86(1.05)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C224(0.99); C406(0.99); C86(1.12)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C224(0.83); C406(1.19); C86(0.77)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C224(1.10); C406(1.11); C86(1.12)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C224(0.82); C406(1.17); C86(1.39)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C224(1.15); C406(1.40); C86(1.26)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C224(0.91); C406(1.15); C86(1.14)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C224(0.77); C406(1.12); C86(1.24)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C224(0.77); C406(1.06); C86(1.37)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C224(0.86); C406(1.11); C86(1.31)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C224(1.57); C232(2.18); C237(2.18); C406(1.06)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C224(1.67); C232(1.78); C237(1.78); C406(1.18)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C224(1.44); C232(1.64); C237(1.64); C406(1.13)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C224(1.38); C232(1.64); C237(1.64); C406(1.11)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C224(0.97); C232(0.65); C237(0.65); C406(0.92)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C224(1.26); C232(1.27); C237(1.27); C406(1.22)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C224(1.14); C232(0.76); C237(0.76); C406(0.81)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C224(0.95); C232(0.66); C237(0.66); C406(0.83)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C224(0.98); C232(0.63); C237(0.63); C406(0.80)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C224(1.06); C232(0.72); C237(0.72); C406(0.81)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C224(0.97); C232(0.56); C237(0.56); C406(0.52)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C224(0.76); C232(0.35); C237(0.35); C406(0.61)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C224(1.06); C406(0.98); C86(1.38)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C224(0.83); C232(0.37); C237(0.37); C406(0.57)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C224(0.84); C232(0.42); C237(0.42); C406(0.56)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C224(1.08); C232(0.65); C237(0.65); C406(0.90)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C224(1.25); C86(1.00)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C224(0.98); C86(1.30)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C224(1.00); C86(1.07)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C224(0.98); C86(1.12)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C224(0.95); C86(1.16)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C224(0.85); C86(1.35)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C224(0.96); C86(1.37)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C406(1.04); C224(1.04); C86(1.40)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C224(1.00); C86(1.07)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C224(1.08); C86(1.16)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C224(1.02); C86(1.05)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C224(0.73); C86(1.35)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C224(1.05); C86(1.28)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C224(0.87); C86(1.07)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C224(0.93); C86(0.95)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C224(1.02); C86(1.08)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C406(0.93); C86(1.02); C224(1.05)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C224(0.99); C86(1.00); C406(1.16)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C86(1.00); C406(1.03); C224(1.07)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C224(0.99); C86(1.14); C406(1.20)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C406(0.94); C86(0.95); C224(1.35)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C86(0.86); C406(0.91); C224(1.13)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C406(0.91); C86(0.92); C224(1.05)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C406(0.93); C224(1.05); C86(1.06)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C86(0.88); C406(0.93); C224(1.27)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C86(1.14); C224(1.28)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C224(0.79); C86(1.43)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C224(0.75); C86(1.35)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C224(0.59); C86(1.17)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C224(0.48); C86(1.63)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C224(1.10); C86(1.24); C406(1.34)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C224(0.45); C86(1.44)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C224(0.68); C86(1.35)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C224(0.42); C86(1.75)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C224(1.40); C86(1.44)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C86(1.41); C224(1.42)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C86(0.71); C224(0.93); C406(0.98)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C224(0.91); C86(1.00); C406(1.00)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C224(0.85); C406(1.09); C86(1.62)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C224(0.88); C406(0.98); C86(1.21)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C224(0.79); C86(1.02); C406(1.03)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C224(1.09); C86(1.28); C406(1.46)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C224(0.94); C406(0.96); C86(1.29)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C224(0.96); C406(1.02); C86(1.26)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C224(0.96); C406(0.99); C86(1.13)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C224(0.96); C406(0.99); C86(1.12)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C224(0.98); C406(1.07); C86(1.09)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C224(0.81); C406(0.93); C86(1.18)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C224(0.34); C86(0.99); C406(1.06)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C224(0.50); C406(1.20); C86(1.21)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C224(0.44); C406(1.15); C86(1.24)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C224(0.59); C86(0.92); C406(0.99)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C224(1.08); C86(1.18); C406(1.43)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C224(0.34); C406(1.01); C86(1.07)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C224(0.51); C86(1.06); C406(1.06)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C224(0.47); C86(0.93); C406(1.03)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C224(0.70); C86(0.92); C406(1.01)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C224(0.61); C86(0.99); C406(1.05)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C406(1.00); C224(1.00); C86(1.19)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C224(0.56); C86(0.93); C406(1.35)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C224(1.00); C406(1.19); C86(1.34); C232(1.98)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C232(0.81); C237(0.81); C406(1.07); C224(1.15)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C224(0.95); C406(1.27); C86(1.39); C232(2.08)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C224(0.95); C406(1.01); C86(1.38)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C224(1.06); C406(1.36); C86(1.45); C232(2.03)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C224(0.94); C406(1.23); C232(1.30); C237(1.30)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C224(0.96); C406(1.04); C232(1.57); C237(1.57)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C224(0.98); C406(1.12); C86(1.41); C232(1.85)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C224(0.95); C406(1.35); C86(1.49); C232(1.82)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C232(0.72); C237(0.72); C224(1.16); C406(1.59)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C232(0.70); C237(0.70); C224(1.16); C406(1.51)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C224(0.65); C406(1.06); C232(1.56); C237(1.56)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C224(0.96); C406(1.03); C86(1.05); C232(1.34)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C224(0.97); C406(1.02); C86(1.12); C232(1.53)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C224(0.96); C406(1.03); C86(1.23)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C232(0.77); C237(0.77); C224(0.81); C406(1.03)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C224(1.04); C86(1.04); C406(1.11); C232(1.82)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C232(0.86); C237(0.86); C224(0.95); C86(1.02)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C232(0.73); C237(0.73); C224(0.85); C406(1.02)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C224(0.94); C86(1.04); C406(1.07); C232(1.60)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C224(0.73); C232(0.86); C237(0.86); C86(1.01)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C406(0.95); C224(1.02); C86(1.21); C232(1.24)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C406(0.93); C224(0.96); C86(1.23); C232(1.36)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C224(0.97); C86(1.04); C406(1.12); C232(1.23)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C224(0.96); C232(1.01); C237(1.01); C406(1.15)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C224(0.92); C406(1.02); C86(1.07)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C224(0.90); C86(0.97); C406(1.24); C232(1.31)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C224(0.65); C86(0.84); C406(1.13); C232(1.27)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C224(0.74); C86(0.88); C406(1.15); C232(1.40)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C224(0.76); C406(0.88); C232(1.18); C237(1.18)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C224(0.75); C406(0.88); C86(1.01); C232(1.05)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C224(0.46); C232(0.55); C237(0.55); C86(0.91)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C224(0.62); C406(0.84); C232(0.95); C237(0.95)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C224(0.59); C406(0.81); C86(0.95); C232(1.21)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C224(0.62); C406(0.75); C86(1.16); C232(1.36)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C224(0.49); C406(0.88); C232(1.02); C237(1.02)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C224(0.49); C406(0.85); C232(0.86); C237(0.86)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C224(0.59); C232(0.75); C237(0.75); C406(0.86)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C224(0.55); C232(0.63); C237(0.63); C406(0.94)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C224(0.64); C406(0.88); C232(0.94); C237(0.94)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C224(0.59); C232(0.79); C237(0.79); C86(0.90)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C224(0.54); C406(0.76); C232(1.12); C237(1.12)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C224(0.65); C232(0.69); C237(0.69); C406(0.92)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C224(0.46); C232(0.71); C237(0.71); C406(0.76)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C232(0.26); C237(0.26); C224(0.50); C406(0.53)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C232(0.39); C237(0.39); C224(0.74); C86(0.83)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C224(0.93); C406(0.94); C86(1.12)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C224(1.01); C406(1.01); C86(1.21)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C224(0.84); C406(0.99); C86(1.57)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C86(1.15); C224(1.02); C406(0.86)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa C86(0.00); C12(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C12(1.58); C224(1.24); C406(1.01); C268(0.18)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C86(0.80); C224(0.86); C406(0.95)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C406(0.81); C224(0.89); C86(1.13)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C86(1.10); C224(1.17); C406(1.21)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C224(0.92); C406(1.05); C86(1.39)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C406(0.94); C224(0.99); C86(1.33)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C406(0.87); C224(0.93); C86(1.53)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C406(0.89); C224(0.99); C86(1.35)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C224(0.92); C406(0.98); C86(1.04)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C406(0.81); C224(0.89); C86(1.00)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C224(0.93); C406(1.10); C86(1.26)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C224(0.95); C406(1.04); C86(1.11)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C224(0.88); C406(0.97); C86(1.03)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C406(0.72); C224(0.87); C86(1.02)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C224(0.87); C406(0.90); C86(1.13)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C224(0.87); C406(0.89); C86(0.90)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C224(0.93); C86(1.02)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C224(0.68); C86(1.28)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C224(0.75); C86(1.29)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C224(0.95); C86(1.19)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C224(1.14); C86(1.58)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C224(0.62); C406(0.72); C86(1.10)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C224(0.87); C86(0.98); C406(1.00)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C224(0.94); C86(1.04); C406(1.05)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C224(0.89); C406(0.89); C86(1.35)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C224(0.91); C406(1.14); C86(1.15)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C224(0.74); C406(0.97); C86(1.15)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C86(0.84); C224(0.91); C406(1.05)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C224(0.73); C86(0.98); C406(1.10)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C224(0.46); C86(1.05); C406(1.15)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C232(0.72); C237(0.72); C86(1.25); C406(1.41)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C232(0.73); C237(0.73); C406(0.98); C224(1.06)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C232(1.11); C237(1.11); C224(1.15); C406(1.20)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C224(0.99); C232(1.18); C237(1.18); C406(1.47)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C406(0.81); C86(1.02); C224(1.27)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C406(0.92); C86(1.07); C224(1.21)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C406(0.73); C224(0.96); C86(1.06)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C406(0.95); C232(1.00); C237(1.00); C224(1.15)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C232(0.78); C237(0.78); C406(0.86); C86(0.94)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C232(0.88); C237(0.88); C224(0.94); C406(1.07)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C232(0.84); C237(0.84); C406(0.88); C224(1.08)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C406(0.81); C86(0.89); C224(0.94)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C232(0.77); C237(0.77); C406(0.97); C224(1.08)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C232(0.72); C237(0.72); C224(0.77); C406(0.91)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C224(0.61); C232(0.85); C237(0.85); C406(1.03)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C224(0.78); C232(0.95); C237(0.95); C406(1.19)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C224(0.87); C232(0.90); C237(0.90); C406(1.14)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C224(0.70); C232(0.71); C237(0.71); C406(1.20)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C224(0.99); C232(0.95); C237(0.95); C406(0.94)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C224(0.88); C232(0.99); C237(0.99); C406(1.09)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C224(0.78); C232(0.80); C237(0.80); C406(0.95)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C224(0.95); C232(0.85); C237(0.85); C406(1.21)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C224(0.89); C406(0.86); C86(0.90)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C224(1.07); C232(1.14); C237(1.14); C406(1.15)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C224(1.10); C232(1.11); C237(1.11); C406(0.77)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C224(1.01); C406(0.74); C86(1.05)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C224(0.81); C406(0.75); C86(1.27)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C224(0.87); C406(0.75); C86(1.08)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C224(1.37); C406(0.85); C86(1.18)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C224(0.88); C406(0.91); C86(1.10)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C224(1.35); C406(1.13); C86(1.32)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C224(1.04); C406(0.87); C86(1.29)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C224(1.04); C406(0.85); C86(0.91)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C224(1.14); C406(0.82); C86(1.74)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C224(1.13); C406(0.98); C86(1.19)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C224(1.46); C406(0.69); C86(1.24)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C224(1.04); C406(0.77); C86(1.22)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C224(1.11); C406(0.81); C86(0.98)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C224(0.40); C406(0.74); C86(1.09)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C224(0.74); C406(1.07); C86(1.01)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C224(0.90); C406(1.03); C86(0.83)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C224(0.93); C406(0.89); C86(1.05)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C224(1.02); C406(0.96); C86(1.01)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C224(0.96); C406(0.88); C86(1.02)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C224(0.83); C406(0.95); C86(1.02)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C224(0.83); C406(0.87); C86(1.05)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C224(0.74); C406(0.91); C86(1.22)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C224(1.05); C406(0.89); C86(1.02)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C224(0.73); C406(0.92); C86(1.02)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C224(0.99); C406(0.86); C86(1.06)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C224(0.87); C406(1.04); C86(0.97)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C224(0.82); C406(0.87); C86(1.20)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C224(0.93); C406(0.82); C86(0.99)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C224(0.93); C406(0.93); C86(0.97)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C224(0.95); C406(0.91); C86(1.02)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C224(0.97); C406(0.82); C86(0.98)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C224(1.07); C86(1.12)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C224(0.96); C86(1.07)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C224(0.96); C86(1.24)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C224(0.92); C86(1.20)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C224(1.14); C86(1.12)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C224(0.94); C86(1.26)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C224(1.33); C86(1.03)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C224(1.22); C86(1.20)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C224(0.97); C86(1.10)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C224(1.01); C406(1.01); C86(1.27)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C224(0.92); C86(1.14)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C224(0.97); C86(1.00)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C224(1.01); C86(0.96)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C224(0.86); C86(1.06)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C224(1.07); C86(1.17)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C224(1.33); C406(1.01); C86(1.14)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C224(0.87); C406(0.89); C86(0.97)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C224(1.06); C406(0.93); C86(1.50)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C224(1.18); C406(1.10); C86(1.49)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C224(0.94); C406(0.91); C86(1.15)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C224(1.10); C406(0.99); C86(1.08)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C224(1.18); C406(0.98); C86(1.24)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C224(0.99); C406(0.96); C86(1.31)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C224(0.70); C406(1.00); C86(1.41)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C224(0.66); C406(0.92); C86(1.56)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C224(1.01); C406(0.98); C86(1.23)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C224(0.96); C406(1.06); C86(1.14)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C224(0.74); C406(1.03); C86(1.27)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C224(1.15); C406(0.97); C86(1.48)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C224(0.73); C406(0.88); C86(1.29)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C224(0.94); C406(1.38); C86(1.02)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C224(1.20); C406(0.97); C86(0.81)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C224(0.93); C406(0.93); C86(1.22)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C224(0.89); C406(0.89); C86(0.92)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C224(1.30); C406(1.03); C86(1.09)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C224(1.29); C406(1.17); C86(1.22)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C224(0.98); C406(0.93); C86(1.19)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C224(0.87); C406(1.08); C86(1.17)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C224(0.96); C406(1.03); C86(1.09)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C224(0.94); C406(1.23); C86(1.15)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C224(0.99); C406(1.45); C86(1.15)  LDD0811  [9]
 LDCM0634  CY-0357 Hep-G2 C12(0.31)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C406(0.99); C224(1.12); C268(0.98); C86(1.45)  LDD1698  [27]
 LDCM0625  F8 Ramos C224(0.46); C12(0.95); C86(0.40); C406(0.61)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C224(1.01); C12(0.75); C86(0.43); C406(0.35)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C224(5.66); C12(0.09); C86(12.77); C268(5.23)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C224(1.11); C12(0.82); C86(0.31); C406(0.40)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C224(1.19); C12(1.16); C86(1.66); C406(0.87)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C224(0.65); C12(0.87); C406(0.64); C268(7.30)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C224(1.14); C12(0.73); C86(0.29); C406(0.51)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C224(0.94); C12(1.04); C86(0.94); C406(0.67)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C224(1.02); C12(0.92); C86(0.59); C406(0.58)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C224(1.41); C12(1.31); C86(1.79); C406(0.85)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C224(0.87); C12(0.61); C406(0.42)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C224(0.88); C12(1.16); C86(0.57); C406(0.96)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C224(1.22); C12(0.92); C86(0.77); C406(1.00)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C224(0.85); C12(0.63); C86(0.24); C406(0.43)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C224(1.04); C86(1.22)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C224(0.58); C12(0.92); C86(1.20); C406(0.93)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C224(0.65); C12(0.93); C86(1.96); C406(0.62)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C224(0.82); C406(0.70); C86(1.19)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C224(1.01); C12(1.33); C406(0.80)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C224(0.79); C12(1.18); C86(0.58); C406(0.85)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C224(0.60); C12(0.31); C86(1.24); C406(0.13)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C224(1.06); C12(0.85); C86(0.49); C406(0.42)  LDD2188  [28]
 LDCM0107  IAA HeLa C406(0.00); C86(0.00)  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C406(1.19); C86(1.38)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C406(1.14); C86(1.01)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C406(1.37); C86(1.12)  LDD0082  [9]
 LDCM0138  KDT501 HEK-293T 3.78  LDD0335  [25]
 LDCM0109  NEM HeLa N.A.  LDD0225  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C406(0.77)  LDD2089  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C406(0.99)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C86(1.03); C406(0.96)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C86(0.68); C406(0.74)  LDD2109  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C86(1.29)  LDD2119  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C86(0.86); C406(1.15)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C86(1.02); C406(0.96)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C86(1.22); C406(1.04)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C86(1.36)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C406(1.16)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C86(1.53); C406(1.30)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C86(0.95)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C86(1.33); C406(1.01)  LDD2140  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C86(2.45); C406(2.04)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C86(0.91)  LDD2146  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C224(0.07)  LDD2207  [29]
 LDCM0021  THZ1 HCT 116 C86(1.02)  LDD2173  [9]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(S)-3-hydroxy-3-methylglutaryl-coa Small molecular drug D06XQX
L-659,699 Small molecular drug D07SEU
(7r12r13r)-13-formyl-1214-dihydroxy-357-trimethyltetradeca-24-dienoic Acid . DB07740

References

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Mass spectrometry data entry: PXD037665
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD007570
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