Details of the Target

General Information of Target

Target ID LDTP04960
Target Name Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)
Gene Name PPP1CB
Gene ID 5500
Synonyms
Serine/threonine-protein phosphatase PP1-beta catalytic subunit; PP-1B; PPP1CD; EC 3.1.3.16; EC 3.1.3.53
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKI
CGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
RGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQ
SMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDL
DLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
KAKYQYGGLNSGRPVTPPRTANPPKKR
Target Bioclass
Enzyme
Family
PPP phosphatase family, PP-1 subfamily
Subcellular location
Cytoplasm
Function
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.
Uniprot ID
P62140
Ensemble ID
ENST00000296122.10
HGNC ID
HGNC:9282
ChEMBL ID
CHEMBL4546

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.76  LDD0402  [1]
TH211
 Probe Info  		Y304(8.94)  LDD0257  [2]
STPyne
 Probe Info  		K146(10.00); K303(5.98); K325(7.14)  LDD0277  [3]
ONAyne
 Probe Info  		K25(8.33)  LDD0275  [3]
Probe 1
 Probe Info  		Y68(21.49); Y304(26.53); Y306(20.58)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C21(2.26); C126(2.29)  LDD0169  [5]
DBIA
 Probe Info  		C244(4.43)  LDD0204  [6]
HHS-482
 Probe Info  		Y133(0.66); Y136(0.92)  LDD0285  [7]
HHS-475
 Probe Info  		Y136(0.68); Y306(0.85); Y254(0.89); Y304(0.93)  LDD0264  [8]
HHS-465
 Probe Info  		Y133(10.00); Y136(10.00); Y304(10.00); Y306(10.00)  LDD2237  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C61(0.00); C201(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C126(0.00); C154(0.00); C201(0.00); C139(0.00)  LDD0032  [12]
IPIAA_H
 Probe Info  		C244(0.00); C126(0.00); C104(0.00); C170(0.00)  LDD0030  [13]
IPIAA_L
 Probe Info  		C244(0.00); C201(0.00); C126(0.00); C139(0.00)  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C244(0.00); C61(0.00); C201(0.00)  LDD0037  [11]
BTD
 Probe Info  		N.A.  LDD0004  [14]
NAIA_4
 Probe Info  		C126(0.00); C139(0.00)  LDD2226  [15]
WYneO
 Probe Info  		C61(0.00); C244(0.00)  LDD0022  [14]
IPM
 Probe Info  		N.A.  LDD0147  [16]
SF
 Probe Info  		Y306(0.00); Y133(0.00); Y136(0.00); Y254(0.00)  LDD0028  [17]
TFBX
 Probe Info  		C139(0.00); C244(0.00); C170(0.00); C126(0.00)  LDD0148  [16]
Phosphinate-6
 Probe Info  		C139(0.00); C126(0.00); C21(0.00)  LDD0018  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [19]
Acrolein
 Probe Info  		C61(0.00); C244(0.00)  LDD0217  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
AOyne
 Probe Info  		6.70  LDD0443  [22]
NAIA_5
 Probe Info  		C61(0.00); C244(0.00); C21(0.00); C201(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [23]
FFF probe14
 Probe Info  		6.71  LDD0477  [23]
FFF probe2
 Probe Info  		5.89  LDD0463  [23]
STS-1
 Probe Info  		N.A.  LDD0137  [24]
STS-2
 Probe Info  		N.A.  LDD0139  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C126(0.69); C61(1.08); C171(0.44)  LDD2142  [26]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C21(0.62); C126(0.48); C61(1.27)  LDD2112  [26]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C21(0.53)  LDD2095  [26]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C21(0.85); C126(1.05)  LDD2130  [26]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C21(1.04); C126(0.94); C170(1.06); C171(1.28)  LDD2117  [26]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C21(0.90)  LDD2152  [26]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C21(1.45); C126(1.20)  LDD2103  [26]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C21(0.52)  LDD2132  [26]
 LDCM0025  4SU-RNA DM93 C170(10.47)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C21(2.26); C126(2.29)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C61(1.25)  LDD0531  [27]
 LDCM0215  AC10 HEK-293T C201(1.19); C61(1.00)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C201(1.01); C61(1.02)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C201(1.01); C61(0.95)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C201(0.99); C61(1.02)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C201(0.97); C61(0.98)  LDD1513  [28]
 LDCM0276  AC17 HCT 116 C61(0.98)  LDD0593  [27]
 LDCM0277  AC18 HCT 116 C61(0.78)  LDD0594  [27]
 LDCM0278  AC19 HCT 116 C61(1.10)  LDD0595  [27]
 LDCM0279  AC2 HCT 116 C61(0.98)  LDD0596  [27]
 LDCM0280  AC20 HCT 116 C61(0.98)  LDD0597  [27]
 LDCM0281  AC21 HCT 116 C61(0.97)  LDD0598  [27]
 LDCM0282  AC22 HCT 116 C61(0.98)  LDD0599  [27]
 LDCM0283  AC23 HCT 116 C61(0.94)  LDD0600  [27]
 LDCM0284  AC24 HCT 116 C61(1.01)  LDD0601  [27]
 LDCM0285  AC25 HEK-293T C201(0.91); C61(1.01)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C201(1.13); C61(0.99)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C201(0.96); C61(0.96)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C201(1.13); C61(0.99)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C201(1.04)  LDD1528  [28]
 LDCM0290  AC3 HCT 116 C61(1.28)  LDD0607  [27]
 LDCM0291  AC30 HEK-293T C201(1.10); C61(1.13)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C201(1.08); C61(1.10)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C201(1.01); C61(0.94)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C201(0.91); C61(1.00)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C201(0.87); C61(0.95)  LDD1534  [28]
 LDCM0296  AC35 HCT 116 C61(1.36)  LDD0613  [27]
 LDCM0297  AC36 HCT 116 C61(0.90)  LDD0614  [27]
 LDCM0298  AC37 HCT 116 C61(1.83)  LDD0615  [27]
 LDCM0299  AC38 HCT 116 C61(0.90)  LDD0616  [27]
 LDCM0300  AC39 HCT 116 C61(0.91)  LDD0617  [27]
 LDCM0301  AC4 HCT 116 C61(1.24)  LDD0618  [27]
 LDCM0302  AC40 HCT 116 C61(1.09)  LDD0619  [27]
 LDCM0303  AC41 HCT 116 C61(0.89)  LDD0620  [27]
 LDCM0304  AC42 HCT 116 C61(0.84)  LDD0621  [27]
 LDCM0305  AC43 HCT 116 C61(0.75)  LDD0622  [27]
 LDCM0306  AC44 HCT 116 C61(1.50)  LDD0623  [27]
 LDCM0307  AC45 HCT 116 C61(1.49)  LDD0624  [27]
 LDCM0308  AC46 HCT 116 C61(0.42)  LDD0625  [27]
 LDCM0309  AC47 HCT 116 C61(0.56)  LDD0626  [27]
 LDCM0310  AC48 HCT 116 C61(0.54)  LDD0627  [27]
 LDCM0311  AC49 HCT 116 C61(0.48)  LDD0628  [27]
 LDCM0312  AC5 HCT 116 C61(1.56)  LDD0629  [27]
 LDCM0313  AC50 HCT 116 C61(0.40)  LDD0630  [27]
 LDCM0314  AC51 HCT 116 C61(0.44)  LDD0631  [27]
 LDCM0315  AC52 HCT 116 C61(0.41)  LDD0632  [27]
 LDCM0316  AC53 HCT 116 C61(0.59)  LDD0633  [27]
 LDCM0317  AC54 HCT 116 C61(0.53)  LDD0634  [27]
 LDCM0318  AC55 HCT 116 C61(0.79)  LDD0635  [27]
 LDCM0319  AC56 HCT 116 C61(0.44)  LDD0636  [27]
 LDCM0320  AC57 HEK-293T C201(0.90); C61(1.06)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C201(0.82); C61(1.02)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C201(0.91); C61(1.00)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C201(0.98); C61(1.06)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C201(0.91); C61(1.02)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C201(1.02)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C201(1.10); C61(1.06)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C201(1.02); C61(1.10)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C201(1.15); C61(0.85)  LDD1567  [28]
 LDCM0332  AC68 HCT 116 C61(1.37)  LDD0649  [27]
 LDCM0333  AC69 HCT 116 C61(0.97)  LDD0650  [27]
 LDCM0334  AC7 HEK-293T C201(0.95); C61(1.01)  LDD1568  [28]
 LDCM0335  AC70 HCT 116 C61(0.84)  LDD0652  [27]
 LDCM0336  AC71 HCT 116 C61(1.24)  LDD0653  [27]
 LDCM0337  AC72 HCT 116 C61(1.22)  LDD0654  [27]
 LDCM0338  AC73 HCT 116 C61(0.87)  LDD0655  [27]
 LDCM0339  AC74 HCT 116 C61(0.89)  LDD0656  [27]
 LDCM0340  AC75 HCT 116 C61(0.82)  LDD0657  [27]
 LDCM0341  AC76 HCT 116 C61(1.35)  LDD0658  [27]
 LDCM0342  AC77 HCT 116 C61(1.18)  LDD0659  [27]
 LDCM0343  AC78 HCT 116 C61(1.25)  LDD0660  [27]
 LDCM0344  AC79 HCT 116 C61(1.30)  LDD0661  [27]
 LDCM0345  AC8 HEK-293T C201(1.23); C61(0.97)  LDD1569  [28]
 LDCM0346  AC80 HCT 116 C61(1.11)  LDD0663  [27]
 LDCM0347  AC81 HCT 116 C61(1.22)  LDD0664  [27]
 LDCM0348  AC82 HCT 116 C61(0.43)  LDD0665  [27]
 LDCM0545  Acetamide MDA-MB-231 C21(1.02); C126(0.36); C244(0.92)  LDD2138  [26]
 LDCM0520  AKOS000195272 MDA-MB-231 C21(1.38); C126(0.85); C244(0.79); C61(1.01)  LDD2113  [26]
 LDCM0248  AKOS034007472 HEK-293T C201(0.99)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C201(0.98); C61(0.98)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C201(1.11); C61(0.93)  LDD1514  [28]
 LDCM0156  Aniline NCI-H1299 12.19  LDD0403  [1]
 LDCM0102  BDHI 8 Jurkat C244(4.43)  LDD0204  [6]
 LDCM0498  BS-3668 MDA-MB-231 C21(0.48)  LDD2091  [26]
 LDCM0630  CCW28-3 231MFP C126(1.27)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa C244(0.00); C61(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C244(20.00)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C201(1.08)  LDD1571  [28]
 LDCM0368  CL10 HEK-293T C201(1.21); C61(1.09)  LDD1572  [28]
 LDCM0369  CL100 HCT 116 C61(1.24)  LDD0686  [27]
 LDCM0370  CL101 HEK-293T C201(1.11)  LDD1574  [28]
 LDCM0371  CL102 HEK-293T C201(0.97); C61(0.99)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C201(1.04); C61(1.01)  LDD1576  [28]
 LDCM0373  CL104 HEK-293T C201(0.84); C61(1.04)  LDD1577  [28]
 LDCM0374  CL105 HCT 116 C61(0.97)  LDD0691  [27]
 LDCM0375  CL106 HCT 116 C61(0.78)  LDD0692  [27]
 LDCM0376  CL107 HCT 116 C61(1.07)  LDD0693  [27]
 LDCM0377  CL108 HCT 116 C61(1.01)  LDD0694  [27]
 LDCM0378  CL109 HCT 116 C61(0.84)  LDD0695  [27]
 LDCM0379  CL11 HEK-293T C201(0.79); C61(1.11)  LDD1583  [28]
 LDCM0380  CL110 HCT 116 C61(0.76)  LDD0697  [27]
 LDCM0381  CL111 HCT 116 C61(0.79)  LDD0698  [27]
 LDCM0382  CL112 HEK-293T C201(0.91); C61(1.02)  LDD1586  [28]
 LDCM0383  CL113 HEK-293T C201(1.16)  LDD1587  [28]
 LDCM0384  CL114 HEK-293T C201(0.95); C61(0.97)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C201(1.13); C61(1.03)  LDD1589  [28]
 LDCM0386  CL116 HEK-293T C201(0.93); C61(1.07)  LDD1590  [28]
 LDCM0387  CL117 HCT 116 C61(0.77)  LDD0704  [27]
 LDCM0388  CL118 HCT 116 C61(0.79)  LDD0705  [27]
 LDCM0389  CL119 HCT 116 C61(0.75)  LDD0706  [27]
 LDCM0390  CL12 HEK-293T C201(1.04); C61(0.98)  LDD1594  [28]
 LDCM0391  CL120 HCT 116 C61(0.73)  LDD0708  [27]
 LDCM0392  CL121 HCT 116 C61(0.85)  LDD0709  [27]
 LDCM0393  CL122 HCT 116 C61(0.57)  LDD0710  [27]
 LDCM0394  CL123 HCT 116 C61(0.61)  LDD0711  [27]
 LDCM0395  CL124 HCT 116 C61(0.47)  LDD0712  [27]
 LDCM0396  CL125 HEK-293T C201(1.18)  LDD1600  [28]
 LDCM0397  CL126 HEK-293T C201(0.98); C61(0.90)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C201(1.00); C61(0.98)  LDD1602  [28]
 LDCM0399  CL128 HEK-293T C201(0.90); C61(1.00)  LDD1603  [28]
 LDCM0400  CL13 HEK-293T C201(1.15)  LDD1604  [28]
 LDCM0401  CL14 HEK-293T C201(0.99); C61(1.00)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C201(1.22); C61(0.97)  LDD1606  [28]
 LDCM0403  CL16 HEK-293T C201(1.00); C61(1.10)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C201(0.98); C61(1.02)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C201(1.13); C61(1.02)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C201(1.07); C61(1.06)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C201(0.96); C61(1.09)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C201(1.30); C61(1.05)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C201(1.07)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C201(1.13); C61(1.18)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C201(0.82); C61(1.15)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C201(1.31); C61(0.91)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C201(1.13)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C201(1.05); C61(1.02)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C201(1.13); C61(1.04)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C201(0.88); C61(0.96)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C201(0.98); C61(1.07)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C201(1.21); C61(1.05)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C201(1.11); C61(1.04)  LDD1623  [28]
 LDCM0420  CL31 HCT 116 C61(0.68)  LDD0737  [27]
 LDCM0421  CL32 HCT 116 C61(0.69)  LDD0738  [27]
 LDCM0422  CL33 HCT 116 C61(0.55)  LDD0739  [27]
 LDCM0423  CL34 HCT 116 C61(0.67)  LDD0740  [27]
 LDCM0424  CL35 HCT 116 C61(0.90)  LDD0741  [27]
 LDCM0425  CL36 HCT 116 C61(0.59)  LDD0742  [27]
 LDCM0426  CL37 HCT 116 C61(0.81)  LDD0743  [27]
 LDCM0428  CL39 HCT 116 C61(0.72)  LDD0745  [27]
 LDCM0429  CL4 HEK-293T C201(0.90); C61(1.07)  LDD1633  [28]
 LDCM0430  CL40 HCT 116 C61(0.55)  LDD0747  [27]
 LDCM0431  CL41 HCT 116 C61(0.71)  LDD0748  [27]
 LDCM0432  CL42 HCT 116 C61(0.68)  LDD0749  [27]
 LDCM0433  CL43 HCT 116 C61(0.68)  LDD0750  [27]
 LDCM0434  CL44 HCT 116 C61(0.61)  LDD0751  [27]
 LDCM0435  CL45 HCT 116 C61(0.50)  LDD0752  [27]
 LDCM0436  CL46 HEK-293T C201(1.11); C61(1.05)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C201(0.79); C61(1.08)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C201(1.26); C61(1.02)  LDD1642  [28]
 LDCM0439  CL49 HEK-293T C201(1.24)  LDD1643  [28]
 LDCM0440  CL5 HEK-293T C201(1.01); C61(1.03)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C201(0.97); C61(0.96)  LDD1645  [28]
 LDCM0443  CL52 HEK-293T C201(0.98); C61(1.02)  LDD1646  [28]
 LDCM0444  CL53 HEK-293T C201(0.99); C61(0.99)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C201(1.26); C61(0.98)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C201(1.06); C61(0.96)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C201(1.03); C61(1.12)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C201(1.04)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C201(1.22); C61(0.88)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C201(0.82); C61(1.10)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C201(1.10); C61(0.92)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C201(1.16); C61(1.01)  LDD1655  [28]
 LDCM0453  CL61 HCT 116 C61(1.34)  LDD0770  [27]
 LDCM0454  CL62 HCT 116 C61(1.19)  LDD0771  [27]
 LDCM0455  CL63 HCT 116 C61(1.32)  LDD0772  [27]
 LDCM0456  CL64 HCT 116 C61(1.32)  LDD0773  [27]
 LDCM0457  CL65 HCT 116 C61(1.36)  LDD0774  [27]
 LDCM0458  CL66 HCT 116 C61(1.32)  LDD0775  [27]
 LDCM0459  CL67 HCT 116 C61(1.41)  LDD0776  [27]
 LDCM0460  CL68 HCT 116 C61(1.23)  LDD0777  [27]
 LDCM0461  CL69 HCT 116 C61(0.84)  LDD0778  [27]
 LDCM0462  CL7 HEK-293T C201(1.01); C61(1.09)  LDD1665  [28]
 LDCM0463  CL70 HCT 116 C61(0.99)  LDD0780  [27]
 LDCM0464  CL71 HCT 116 C61(1.16)  LDD0781  [27]
 LDCM0465  CL72 HCT 116 C61(1.02)  LDD0782  [27]
 LDCM0466  CL73 HCT 116 C61(1.04)  LDD0783  [27]
 LDCM0467  CL74 HCT 116 C61(1.08)  LDD0784  [27]
 LDCM0469  CL76 HEK-293T C201(1.09); C61(1.06)  LDD1672  [28]
 LDCM0470  CL77 HEK-293T C201(1.00); C61(1.04)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C201(0.95); C61(0.94)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C201(1.01); C61(0.98)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C201(1.16); C61(0.98)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C201(1.15); C61(1.03)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C201(1.05)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C201(0.99); C61(1.11)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C201(0.90); C61(1.07)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C201(1.14); C61(0.92)  LDD1681  [28]
 LDCM0479  CL85 HEK-293T C201(1.28)  LDD1682  [28]
 LDCM0480  CL86 HEK-293T C201(0.96); C61(1.08)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C201(1.22); C61(1.03)  LDD1684  [28]
 LDCM0482  CL88 HEK-293T C201(0.88); C61(1.09)  LDD1685  [28]
 LDCM0483  CL89 HEK-293T C201(1.01); C61(1.01)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C201(1.21)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C201(1.01); C61(1.04)  LDD1688  [28]
 LDCM0486  CL91 HCT 116 C61(0.70)  LDD0803  [27]
 LDCM0487  CL92 HCT 116 C61(0.91)  LDD0804  [27]
 LDCM0488  CL93 HCT 116 C61(1.25)  LDD0805  [27]
 LDCM0489  CL94 HCT 116 C61(1.41)  LDD0806  [27]
 LDCM0490  CL95 HCT 116 C61(0.79)  LDD0807  [27]
 LDCM0491  CL96 HCT 116 C61(0.84)  LDD0808  [27]
 LDCM0492  CL97 HCT 116 C61(0.72)  LDD0809  [27]
 LDCM0493  CL98 HCT 116 C61(1.12)  LDD0810  [27]
 LDCM0494  CL99 HCT 116 C61(1.28)  LDD0811  [27]
 LDCM0495  E2913 HEK-293T C201(1.03); C61(1.12)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C61(2.94); C21(1.05)  LDD1702  [26]
 LDCM0468  Fragment33 HCT 116 C61(1.32)  LDD0785  [27]
 LDCM0427  Fragment51 HCT 116 C61(0.49)  LDD0744  [27]
 LDCM0116  HHS-0101 DM93 Y136(0.68); Y306(0.85); Y254(0.89); Y304(0.93)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y136(0.53); Y304(0.72); Y133(0.75); Y306(0.80)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y136(0.61); Y306(0.74); Y304(0.84); Y133(0.92)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y304(0.85); Y136(0.85); Y306(0.89); Y133(1.28)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y304(0.80); Y136(0.89); Y133(1.54); Y306(1.83)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y133(0.66); Y136(0.92)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y133(0.54); Y136(0.77)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y133(1.06); Y136(1.11)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y133(3.34); Y136(3.33)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y133(2.02); Y136(2.35)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y133(0.09); Y136(1.19)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y133(0.38); Y136(0.43)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y133(0.89); Y136(0.99)  LDD0292  [7]
 LDCM0022  KB02 HEK-293T C61(1.00); C201(1.00)  LDD1492  [28]
 LDCM0023  KB03 Jurkat C201(4.30); C244(61.18)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C83(1.48); C256(1.84); C61(1.25); C96(1.52)  LDD3310  [30]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C21(1.27)  LDD2102  [26]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C21(0.54); C126(1.21)  LDD2121  [26]
 LDCM0109  NEM HeLa C61(0.00); H65(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C21(1.06); C126(0.53); C244(0.91)  LDD2089  [26]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C21(1.23)  LDD2092  [26]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C21(1.96); C126(0.91); C244(0.98)  LDD2093  [26]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C126(1.40); C244(1.84)  LDD2094  [26]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C21(0.36); C126(0.53); C244(0.22); C170(0.21)  LDD2096  [26]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C21(1.23); C61(1.36)  LDD2098  [26]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C21(1.06); C126(0.90); C244(1.55)  LDD2099  [26]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C21(0.71); C61(1.14)  LDD2100  [26]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C126(1.00); C244(0.72); C61(1.03)  LDD2101  [26]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C21(0.48); C61(0.76)  LDD2104  [26]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C21(2.10); C61(1.03)  LDD2105  [26]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C21(0.27); C126(0.38); C61(0.67)  LDD2106  [26]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C21(1.12); C61(1.19)  LDD2107  [26]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C21(0.60); C126(0.30); C244(0.52); C61(1.75)  LDD2108  [26]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C21(0.93)  LDD2109  [26]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C61(0.81)  LDD2110  [26]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C21(0.95); C126(0.94)  LDD2111  [26]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C21(0.62)  LDD2114  [26]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C61(1.11)  LDD2115  [26]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C21(0.62); C126(0.84)  LDD2116  [26]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C21(0.56); C126(0.96); C244(0.43)  LDD2118  [26]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C21(3.59); C126(2.01); C61(1.10)  LDD2119  [26]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C21(0.76); C126(0.93); C244(0.75); C61(0.71)  LDD2120  [26]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C21(0.58); C126(0.79); C244(0.27)  LDD2122  [26]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C61(1.29)  LDD2123  [26]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C21(0.52); C126(0.78); C244(0.35); C171(0.22)  LDD2124  [26]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C21(0.86)  LDD2125  [26]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C21(0.55); C126(0.76); C61(1.68)  LDD2126  [26]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C21(0.88); C126(0.98); C244(0.90); C61(1.19)  LDD2127  [26]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C21(0.62); C126(0.98)  LDD2128  [26]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C21(1.35)  LDD2129  [26]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C61(0.97)  LDD2133  [26]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C61(0.90)  LDD2134  [26]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C21(0.99); C126(1.12); C61(1.05)  LDD2135  [26]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C21(1.40); C126(1.03); C244(1.24); C61(1.53)  LDD2136  [26]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C21(1.16); C126(0.96); C244(1.31); C170(0.73)  LDD2137  [26]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C126(1.55)  LDD1700  [26]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C21(0.83); C126(0.64); C244(1.09); C61(1.13)  LDD2140  [26]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C61(1.16)  LDD2141  [26]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C21(0.81); C126(1.04); C244(0.94); C61(0.72)  LDD2143  [26]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C21(3.33); C126(2.46); C244(1.76); C61(1.78)  LDD2144  [26]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C21(0.93); C61(1.78)  LDD2146  [26]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C21(2.17); C126(3.68); C61(1.09); C170(0.83)  LDD2147  [26]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C61(0.77)  LDD2148  [26]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C21(0.61); C126(0.86); C170(0.25)  LDD2149  [26]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C126(0.36)  LDD2150  [26]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C21(0.64)  LDD2151  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatase and actin regulator 3 (PHACTR3) Phosphatase and actin regulator family Q96KR7
Protein phosphatase inhibitor 2 family member B (PPP1R2B) Protein phosphatase inhibitor 2 family Q6NXS1
Protein phosphatase inhibitor 2 family member C (PPP1R2C) Protein phosphatase inhibitor 2 family O14990
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
E3 ubiquitin-protein ligase PPP1R11 (PPP1R11) . O60927
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine/serine-rich nuclear protein 1 (CSRNP1) AXUD1 family Q96S65
Cysteine/serine-rich nuclear protein 2 (CSRNP2) AXUD1 family Q9H175
RelA-associated inhibitor (PPP1R13L) IASPP family Q8WUF5
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Ribosomal RNA processing protein 1 homolog B (RRP1B) RRP1 family Q14684
Protein phosphatase 1 regulatory subunit 7 (PPP1R7) SDS22 family Q15435
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Neurabin-2 (PPP1R9B) . Q96SB3
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Protein phosphatase 1 regulatory subunit 27 (PPP1R27) . Q86WC6
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) . Q9UQK1
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
27 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840