Details of the Target

General Information of Target

Target ID LDTP01781
Target Name Purine nucleoside phosphorylase (PNP)
Gene Name PNP
Gene ID 4860
Synonyms
NP; Purine nucleoside phosphorylase; PNP; EC 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
PNP/MTAP phosphorylase family
Subcellular location
Cytoplasm
Function
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine.
TTD ID
T78198
Uniprot ID
P00491
DrugMap ID
TTMCF1Y
Ensemble ID
ENST00000361505.10
HGNC ID
HGNC:7892
ChEMBL ID
CHEMBL4338

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		6.56  LDD0215  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
BTD
 Probe Info  		C78(2.29)  LDD1699  [3]
AZ-9
 Probe Info  		E250(10.00)  LDD2208  [4]
HHS-465
 Probe Info  		Y50(1.28); Y91(10.00)  LDD2237  [5]
DBIA
 Probe Info  		C31(1.05)  LDD0078  [6]
5E-2FA
 Probe Info  		H23(0.00); H20(0.00); H64(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		K265(0.00); K95(0.00)  LDD0199  [8]
m-APA
 Probe Info  		H23(0.00); H64(0.00)  LDD2231  [7]
CY-1
 Probe Info  		N.A.  LDD0246  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C78(0.00); C206(0.00); C31(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C78(0.00); C31(0.00); C206(0.00)  LDD0036  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C78(0.00); C31(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
IPM
 Probe Info  		N.A.  LDD0005  [13]
NHS
 Probe Info  		K211(0.00); K265(0.00)  LDD0010  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
STPyne
 Probe Info  		K265(0.00); K270(0.00)  LDD0009  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
Acrolein
 Probe Info  		H257(0.00); H104(0.00)  LDD0217  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		5.00  LDD0443  [18]
NAIA_5
 Probe Info  		C78(0.00); C31(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]
DA-2
 Probe Info  		N.A.  LDD0070  [22]
STS-1
 Probe Info  		N.A.  LDD0068  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C78(0.53); C31(0.79)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C78(0.84); C31(0.90)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C78(0.40)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C78(0.65)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C78(1.23); C31(1.00)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C78(1.36)  LDD2152  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C78(0.45)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C78(0.50)  LDD2131  [3]
 LDCM0214  AC1 HCT 116 C31(0.81)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C31(0.98)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C31(0.97)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C31(1.02)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C31(0.95)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C31(1.09)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C31(1.13)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C31(1.09)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C31(0.99)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C31(1.13)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C31(0.93)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C31(0.86)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C31(1.07)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C31(0.92)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C31(1.01)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C31(1.05)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C31(0.97)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C31(1.14)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C31(1.30)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C31(1.21)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C31(1.09)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C31(1.05)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C31(1.09)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C31(0.93)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C31(1.15)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C31(0.93)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C31(1.06)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C31(0.96)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C31(0.94)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C31(1.04)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C31(1.15)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C31(1.07)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C31(0.84)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C31(0.90)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C31(1.02)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C31(0.85)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C31(0.92)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C31(0.89)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C31(1.06)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C31(0.90)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C31(0.88)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C31(0.91)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C31(1.02)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C31(0.95)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C31(0.99)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C31(1.14)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C31(1.11)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C31(0.92)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C31(0.99)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C31(1.17)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C31(1.08)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C31(1.27)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C31(1.24)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C31(1.26)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C31(1.33)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C31(1.03)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C31(1.07)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C31(1.16)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C31(1.39)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C31(1.53)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C31(1.25)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C31(1.12)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C31(1.07)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C31(1.19)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C31(0.99)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C31(1.07)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C31(1.07)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C31(0.88)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C31(1.01)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C31(1.02)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C31(1.01)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C31(0.89)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C31(1.00)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C31(0.91)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C31(1.02)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C31(1.05)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C31(1.02)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C31(1.14)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C31(0.90)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C31(1.18)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C31(1.10)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C31(1.25)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C31(1.11)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C31(1.22)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C31(0.85)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C31(0.88)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C31(0.92)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C31(0.92)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C31(0.94)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C31(0.83)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C31(0.99)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C31(1.03)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C31(0.99)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C31(1.05)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C31(1.07)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C31(1.17)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C31(1.16)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C31(1.02)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C31(1.15)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C31(1.35)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C31(0.87)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C31(1.33)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C31(1.02)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C31(1.15)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C31(1.02)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C31(1.21)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C31(1.09)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C31(1.26)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C31(1.21)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C31(1.25)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C31(1.32)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C31(1.12)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C31(1.22)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C31(1.31)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C31(1.44)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C31(1.18)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C31(1.34)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C31(1.36)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C31(1.40)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C31(1.51)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C31(0.96)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C31(0.84)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C31(0.99)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C31(0.92)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C31(0.74)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C31(1.01)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C31(0.93)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C31(0.74)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C31(0.99)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C31(0.77)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C31(0.84)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C31(0.91)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C31(1.01)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C31(1.07)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C31(0.70)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C31(0.96)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C31(0.86)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C31(1.30)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C31(1.18)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C31(1.00)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C31(1.11)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C31(1.13)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C31(1.16)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C31(1.23)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C31(0.89)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C31(1.23)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C31(1.30)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C31(1.09)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C31(1.07)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C31(1.10)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C31(1.14)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C31(1.21)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C31(1.15)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C31(0.84)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C78(0.87)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C78(0.75)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C31(0.92)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C31(0.96)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C31(1.21)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C31(1.05)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C78(0.86)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa H257(0.00); C31(0.00); H64(0.00); H104(0.00)  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C31(0.88)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C31(1.26)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C31(0.84)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C31(1.04)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C31(0.90)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C31(0.85)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C31(0.94)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C31(1.08)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C31(1.20)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C31(1.19)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C31(1.28)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C31(1.06)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C31(1.00)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C31(1.06)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C31(1.07)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C31(0.87)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C31(1.14)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C31(1.02)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C31(1.03)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C31(1.05)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C31(2.05)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C31(0.99)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C31(1.09)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C31(1.19)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C31(1.00)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C31(1.39)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C31(1.12)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C31(1.12)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C31(1.19)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C31(1.13)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C31(1.04)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C31(1.05)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C31(1.27)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C31(0.95)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C31(1.10)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C31(0.76)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C31(1.20)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C31(1.04)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C31(1.14)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C31(1.04)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C31(1.09)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C31(1.18)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C31(1.18)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C31(1.51)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C31(1.51)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C31(1.48)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C31(1.33)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C31(1.25)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C31(1.07)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C31(1.21)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C31(1.20)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C31(0.94)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C31(1.12)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C31(0.88)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C31(1.08)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C31(1.01)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C31(1.07)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C31(1.06)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C31(1.01)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C31(0.97)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C31(1.04)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C31(0.84)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C31(0.93)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C31(1.02)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C31(1.00)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C31(0.95)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C31(0.94)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C31(0.88)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C31(0.95)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C31(0.96)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C31(0.95)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C31(0.96)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C31(0.84)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C31(0.81)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C31(0.85)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C31(0.98)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C31(1.05)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C31(0.98)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C31(1.01)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C31(1.10)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C31(0.97)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C31(0.96)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C31(0.98)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C31(0.92)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C31(0.94)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C31(0.97)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C31(1.23)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C31(0.90)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C31(0.86)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C31(0.92)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C31(0.93)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C31(0.82)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C31(1.10)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C31(1.04)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C31(1.03)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C31(1.05)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C31(0.87)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C31(1.30)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C31(0.80)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C31(0.82)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C31(0.97)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C31(0.93)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C31(1.05)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C31(1.13)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C31(1.03)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C31(0.94)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C31(1.08)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C31(1.40)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C31(1.33)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C31(1.43)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C31(1.10)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C31(1.16)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C31(1.10)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C31(1.27)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C31(1.63)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C31(1.06)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C31(0.95)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C31(1.07)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C31(0.88)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C31(0.73)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C31(0.84)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C31(0.81)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C31(0.96)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C31(0.99)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C31(0.91)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C31(0.85)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C31(1.02); C206(1.01); C78(0.92)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C78(2.00); C31(1.29)  LDD1702  [3]
 LDCM0625  F8 Ramos C31(4.99)  LDD2187  [25]
 LDCM0573  Fragment11 Ramos C31(0.05)  LDD2190  [25]
 LDCM0576  Fragment14 Ramos C31(0.76)  LDD2193  [25]
 LDCM0586  Fragment28 Ramos C31(1.24)  LDD2198  [25]
 LDCM0468  Fragment33 HCT 116 C31(1.37)  LDD0785  [6]
 LDCM0566  Fragment4 Ramos C31(0.78)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C31(0.97)  LDD0744  [6]
 LDCM0569  Fragment7 Ramos C31(0.73)  LDD2186  [25]
 LDCM0107  IAA HeLa H257(0.00); H104(0.00); H64(0.00); H135(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C31(1.09)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C31(1.06)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C31(0.89)  LDD0082  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C78(1.11)  LDD2102  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C78(0.93)  LDD2121  [3]
 LDCM0109  NEM HeLa H257(0.00); H64(0.00); H104(0.00)  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C78(0.96)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C78(1.23)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C78(1.14); C31(1.10)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C78(1.42)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C31(1.67)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C78(0.25)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C78(0.85)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C78(1.17); C31(0.64)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C78(1.28); C31(0.82)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C78(0.44)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C78(0.77)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C78(0.54); C31(0.38)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C78(2.18)  LDD2105  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C78(0.54); C31(0.27)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C78(1.09); C31(0.92)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C78(0.76)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C78(0.65); C31(0.62)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C78(0.63); C31(0.26)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C78(1.11)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C78(0.59); C31(0.32)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C78(0.48)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C78(0.55)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C78(0.51)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C78(1.56)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C78(0.58)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C78(0.42)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C78(1.03); C31(0.88)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C78(0.31)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C78(0.99); C31(0.80)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C78(0.37)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C78(1.13); C31(1.53)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C78(0.88)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C78(1.54)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C78(0.70)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C78(0.48)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C78(1.50); C31(0.53)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C78(1.19); C31(1.30)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C78(1.00); C31(1.31)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C78(2.34)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C78(0.98)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C78(0.57)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C78(0.77)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C78(1.97)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C78(0.27)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C78(1.03)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C78(1.23)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C78(0.49)  LDD2148  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C78(0.44)  LDD2149  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C78(0.92)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C78(0.34)  LDD2151  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C78(2.47)  LDD2153  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C31(1.29); C31(0.40)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C31(0.67)  LDD2207  [26]
 LDCM0021  THZ1 HCT 116 C31(0.97)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Purine nucleoside phosphorylase (PNP) PNP/MTAP phosphorylase family P00491
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) Ser/Thr protein kinase family Q9BXM7
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Sortilin-related receptor (SORL1) VPS10-related sortilin family Q92673
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein TGIF1 (TGIF1) TALE/TGIF homeobox family Q15583
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine Small molecular drug DB00640
Cladribine Small molecular drug DB00242
Didanosine Small molecular drug DB00900
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2'3'-dideoxyinosine Small molecular drug D04XYL
Bcx-3408 Small molecular drug D02ZKR
Forodesine Small molecular drug D02ZUO
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine Small molecular drug D0H1OL
Peldesine Small molecular drug D08OBT
Investigative
Click To Hide/Show 40 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(+/-)-5'-deoxy-4'-fluoro-5'-methylthio-dadme-immh Small molecular drug D07BGQ
2-hydroxymethyl-pyrrolidine-3,4-diol Small molecular drug D06KVV
3-((2-pyrrolidine-1-yl)-ethyl)Uracil Small molecular drug D0D7PF
3-deoxyguanosine Small molecular drug D0J0HK
5'-deoxy-4'-hydroxy-5'-methylthio-dadme-immh Small molecular drug D0T7LB
5'-methylthio-immh Small molecular drug D0E6BI
5'-phenylthio-immh Small molecular drug D0R5RF
7-tert-butyl-2, 3-dihydro-3, 3-dimethyl Substituted Dihydrofuran 30 (Dhdmbf30) Small molecular drug D02COM
8-amino-9-benzylguanine Small molecular drug D0Z3OD
8-aminoguanine Small molecular drug D0R6UA
8-aminoguanosine Small molecular drug D0FI2L
8-aza-dadme-immh Small molecular drug D0N2AA
8-azaguanine Small molecular drug D01OHV
8-azaguanine Small molecular drug DB01667
8-iodo-guanine Small molecular drug D01NTY
9-(5,5-difluoro-5-phosphonopentyl)Guanine Small molecular drug D07BNM
9-(55-difluoro-5-phosphonopentyl)Guanine Small molecular drug DB04260
9-deazahypoxanthine Small molecular drug D0N5BA
9-deazainosine Small molecular drug D0I8JJ
9-deazainosine Small molecular drug DB02796
9-deazainosine-2',3'-o-ethylidenephosphonate Small molecular drug D0F7DM
9-deazainosine-2'3'-o-ethylidenephosphonate Small molecular drug DB04753
Aza-c-nucleosides Small molecular drug D0BP5T
Guanine Small molecular drug DB02377
Guanosine-2',3'-o-ethylidenephosphonate Small molecular drug D08TGC
Guanosine-2',3'-o-methylidenephosphonate Small molecular drug D0N2LE
Guanosine-2'3'-o-ethylidenephosphonate Small molecular drug DB04754
Guanosine-2'3'-o-methylidenephosphonate Small molecular drug DB04757
Hypoxanthine Small molecular drug D03HVE
Immucillin-g Small molecular drug D0A9WP
Mt-immucillin-h Small molecular drug D04JOV
Ribose-1-phosphate Small molecular drug D04LUI
(2s3r4s5s)-34-dihydroxy-2-[(Methylsulfanyl)Methyl]-5-(4-oxo-45-dihydro-1h-pyrrolo[32-d]Pyrimidin-7-yl)Pyrrolidinium . DB03881
(3r4r)-3-hydroxy-4-(Hydroxymethyl)-1-[(4-oxo-44a57a-tetrahydro-3h-pyrrolo[32-d]Pyrimidin-7-yl)Methyl]Pyrrolidinium . DB03551
2-amino-7-[2-(2-hydroxy-1-hydroxymethyl-ethylamino)-ethyl]-17-dihydro-purin-6-one . DB02391
26-diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine . DB02222
3'-deoxyguanosine . DB03609
5'-methylthio-immucillin-h . D0SO9G
Dadme-immg . D07VEW
Inosine . DB04335
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ci-972 Small molecular drug D05UPB

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
23 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
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Mass spectrometry data entry: PXD044402
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