Details of the Target

General Information of Target

Target ID LDTP01575
Target Name E3 ubiquitin-protein ligase ARIH2 (ARIH2)
Gene Name ARIH2
Gene ID 10425
Synonyms
ARI2; TRIAD1; E3 ubiquitin-protein ligase ARIH2; ARI-2; Protein ariadne-2 homolog; EC 2.3.2.31; RING-type E3 ubiquitin transferase ARIH2; Triad1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQ
FTCLTYKESEGALNEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYKSNSAQLLVEA
RVQPNPSKHVPTSHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVG
VSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQ
EPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKC
NICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQARE
ALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKC
RYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAE
QRRRTLLKDFHDT
Target Bioclass
Enzyme
Family
RBR family, Ariadne subfamily
Subcellular location
Nucleus
Function
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis.
Uniprot ID
O95376
Ensemble ID
ENST00000356401.9
HGNC ID
HGNC:690

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y337(20.00); Y343(20.00); Y467(20.00); Y289(5.41)  LDD0257  [1]
STPyne
 Probe Info  		K148(5.56); K392(10.00)  LDD0277  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
IPM
 Probe Info  		C280(0.00); C340(0.00); C252(0.00); C257(0.00)  LDD0241  [3]
HHS-482
 Probe Info  		Y467(0.73)  LDD0285  [4]
HHS-475
 Probe Info  		Y467(1.47)  LDD0264  [5]
HHS-465
 Probe Info  		Y337(10.00); Y467(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C156(1.10); C161(1.10)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C280(0.00); C340(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C270(0.00); C340(0.00); C280(0.00); C161(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		9.80  LDD0443  [13]
NAIA_5
 Probe Info  		C280(0.00); C270(0.00); C340(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C340(2.02)  LDD0371  [14]
 LDCM0026  4SU-RNA+native RNA HEK-293T C340(7.70)  LDD0372  [14]
 LDCM0214  AC1 HCT 116 C323(1.10); C156(0.95); C161(0.99); C183(1.21)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C156(0.70); C161(0.70); C183(0.86); C188(0.86)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C323(0.70); C156(0.49); C161(0.69); C183(1.04)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C323(0.82); C156(0.55); C161(0.76); C183(0.85)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C323(1.22); C156(0.56); C161(0.97); C183(0.97)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C323(1.14); C156(0.44); C161(0.89); C183(0.78)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C323(1.01); C156(0.58); C161(0.82); C183(0.98)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C323(0.92); C156(0.45); C161(0.64); C183(0.88)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C323(0.66); C156(0.35); C161(0.77); C183(0.80)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C323(0.65); C156(0.35); C161(0.61); C183(0.88)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C323(0.51); C156(0.46); C161(0.76); C183(0.96)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C323(0.74); C156(0.55); C161(0.63); C183(1.04)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C156(0.90); C161(0.90); C183(0.90); C188(0.90)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C323(0.80); C156(0.63); C161(0.93); C183(0.88)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C323(0.92); C156(0.48); C161(0.73); C183(0.80)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C323(0.95); C156(0.37); C161(0.64); C183(0.82)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C323(0.97); C156(1.11); C161(1.06); C183(1.07)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C323(0.91); C156(0.96); C161(0.96); C183(1.09)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C323(0.89); C156(1.05); C161(1.00); C183(0.92)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C323(0.75); C156(1.03); C161(0.95); C183(0.92)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C323(0.69); C156(1.18); C161(0.97); C183(1.05)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C323(0.67); C156(1.21); C161(1.06); C183(1.15)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C323(0.61); C156(0.98); C161(0.93); C183(1.04)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C156(1.11); C161(1.11); C183(1.05); C188(1.05)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C323(2.17); C156(1.08); C161(0.89); C183(0.99)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C323(1.14); C156(0.84); C161(0.78); C183(1.07)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C323(0.72); C156(0.78); C161(0.75); C183(1.11)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C323(1.00); C156(1.01); C161(0.84); C183(0.91)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C323(0.89); C156(1.05); C161(1.01); C183(1.27)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C323(0.99); C156(0.83); C161(0.77); C183(1.10)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C323(0.95); C156(0.81); C161(0.73); C183(1.06)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C323(0.72); C156(0.85); C161(0.71); C183(1.08)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C156(1.21); C161(1.21); C183(1.83); C188(1.83)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C156(1.07); C161(1.07); C183(1.53); C188(1.53)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C156(1.03); C161(1.03); C183(1.21); C188(1.21)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C156(1.60); C161(1.60); C183(1.42); C188(1.42)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C156(1.08); C161(1.08); C183(1.41); C188(1.41)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C156(0.96); C161(0.96); C183(1.37); C188(1.37)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C156(1.10); C161(1.10); C183(1.18); C188(1.18)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C156(1.14); C161(1.14); C183(1.23); C188(1.23)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C156(0.97); C161(0.97); C183(1.25); C188(1.25)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C156(0.92); C161(0.92); C183(1.32); C188(1.32)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C156(1.09); C161(1.09); C183(1.08); C188(1.08)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C156(0.89); C161(0.89); C183(1.24); C188(1.24)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C156(1.12); C161(1.12); C183(0.89); C188(0.89)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C156(0.98); C161(0.98); C183(1.19); C188(1.19)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C156(0.98); C161(0.98); C183(1.14); C188(1.14)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C156(0.92); C161(0.92); C183(1.25); C188(1.25)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C156(0.88); C161(0.83); C183(0.96); C188(0.96)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C161(0.77); C257(0.78); C156(0.79); C252(0.81)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C161(0.79); C156(0.81); C326(0.88); C252(0.96)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C257(0.75); C252(0.77); C161(0.79); C310(0.79)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C161(0.74); C257(0.79); C156(0.82); C252(0.83)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C310(0.60); C315(0.60); C257(0.67); C252(0.73)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C257(0.61); C310(0.66); C252(0.69); C315(0.73)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C257(0.82); C183(0.83); C188(0.83); C156(0.94)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C156(0.74); C326(0.78); C161(0.79); C257(0.81)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C257(0.84); C252(0.84); C161(0.91); C156(0.92)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C310(0.65); C315(0.74); C257(0.77); C252(0.78)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C310(0.50); C315(0.51); C257(0.63); C156(0.66)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C156(0.96); C161(0.92); C183(1.16); C188(1.15)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C156(0.78); C161(0.82); C183(1.35); C188(1.42)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C156(0.84); C161(0.81); C183(1.03); C188(0.99)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C156(1.20); C161(1.21); C183(0.98); C188(0.99)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C310(0.75); C315(0.75); C156(0.86); C252(0.91)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C252(0.72); C257(0.72); C310(0.74); C315(0.74)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C310(0.65); C315(0.65); C161(0.91); C156(0.93)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C252(0.63); C257(0.63); C326(0.71); C323(0.76)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C310(0.77); C315(0.77); C252(0.92); C257(0.92)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C310(0.62); C315(0.62); C252(0.95); C257(0.95)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C310(0.72); C315(0.72); C252(1.08); C257(1.08)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C310(0.58); C315(0.58); C252(0.85); C257(0.85)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C310(0.60); C315(0.60); C156(0.90); C161(0.96)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C161(0.93); C183(0.99); C188(0.99); C156(0.99)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C300(0.70); C303(0.70); C183(0.97); C188(0.97)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C300(0.82); C303(0.82); C183(0.90); C188(0.90)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C315(0.75); C300(0.77); C303(0.77); C310(0.85)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C300(0.50); C303(0.50); C156(0.79); C257(0.91)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C252(0.68); C257(0.68); C323(0.69); C326(0.70)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C300(0.51); C303(0.51); C156(0.54); C315(0.57)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C300(0.72); C303(0.72); C315(0.88); C252(0.95)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C300(0.53); C303(0.53); C315(0.67); C257(0.83)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C183(0.79); C188(0.79); C315(0.84); C300(0.89)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C300(0.83); C303(0.83); C315(0.84); C183(0.92)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C300(0.75); C303(0.75); C161(0.94); C156(1.12)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C300(0.87); C303(0.87); C161(0.95); C252(1.10)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C156(0.84); C183(0.86); C161(0.92); C188(0.97)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C300(0.79); C303(0.79); C156(0.92); C161(0.93)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C300(0.79); C303(0.79); C315(0.84); C161(0.89)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C252(0.55); C257(0.55); C326(0.77); C323(0.79)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C300(0.82); C303(0.82); C156(0.93); C161(0.99)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C183(0.78); C300(0.81); C303(0.81); C257(0.89)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C300(0.72); C303(0.72); C183(0.79); C161(0.96)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C300(0.56); C303(0.56); C183(0.78); C315(0.81)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C183(0.80); C161(0.91); C156(0.94); C300(0.95)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C300(0.78); C303(0.78); C161(0.82); C156(0.83)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C156(0.49); C161(0.81); C257(0.86); C300(0.86)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C156(0.58); C161(0.79); C300(0.87); C303(0.87)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C156(0.63); C161(0.72); C300(0.75); C303(0.75)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C156(0.59); C300(0.71); C303(0.71); C257(0.78)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C252(0.50); C257(0.50); C326(0.77); C323(0.84)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C156(0.62); C300(0.74); C303(0.74); C183(0.82)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C156(0.59); C183(0.82); C188(0.82); C257(0.91)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C156(0.74); C183(0.88); C188(0.88); C310(0.92)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C300(0.74); C303(0.74); C183(0.79); C188(0.79)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C156(0.56); C161(0.71); C300(0.85); C303(0.85)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C300(0.69); C303(0.69); C257(0.73); C156(0.76)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C156(0.61); C300(0.61); C303(0.61); C183(0.73)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C252(0.74); C257(0.74); C323(0.77); C326(0.77)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C252(0.62); C257(0.62); C183(0.65); C188(0.65)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C252(0.71); C257(0.71); C161(0.85); C156(0.86)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C156(0.78); C161(0.78); C183(0.78); C188(0.78)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C252(0.64); C257(0.64); C156(0.74); C161(0.74)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C252(0.65); C257(0.65); C161(0.67); C156(0.77)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C252(0.69); C257(0.69); C323(0.73); C326(0.73)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C252(0.71); C257(0.71); C323(0.72); C326(0.72)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C252(0.69); C257(0.69); C161(0.91); C323(0.95)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C252(0.55); C257(0.55); C156(0.70); C161(0.73)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C252(0.61); C257(0.61); C161(0.72); C183(0.73)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C252(0.48); C257(0.48); C161(0.64); C156(0.73)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C300(0.76); C303(0.76); C161(0.90); C310(0.91)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C300(0.65); C303(0.65); C310(0.78); C315(0.78)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C156(0.70); C161(0.70); C183(0.79); C188(0.79)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C300(0.64); C303(0.64); C326(0.67); C161(0.71)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C300(0.81); C303(0.81); C326(0.85); C161(0.89)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C300(0.66); C303(0.66); C156(0.71); C161(0.73)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C300(0.44); C303(0.44); C310(0.53); C315(0.53)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C300(0.44); C303(0.44); C310(0.67); C315(0.67)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C300(0.48); C303(0.48); C310(0.64); C315(0.64)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C300(0.67); C303(0.67); C156(0.82); C161(0.82)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C300(0.70); C303(0.70); C310(0.80); C315(0.80)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C300(0.65); C303(0.65); C156(0.77); C161(0.78)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C300(0.69); C303(0.69); C310(0.74); C315(0.74)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C257(0.79); C183(0.80); C188(0.80); C156(0.81)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C300(0.70); C303(0.70); C183(0.88); C188(0.88)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C300(0.69); C303(0.69); C310(0.74); C315(0.74)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C300(0.44); C303(0.44); C310(0.73); C315(0.73)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C257(0.56); C252(0.64); C300(0.69); C303(0.69)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C257(0.60); C252(0.64); C300(0.64); C303(0.64)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C257(0.62); C252(0.66); C156(0.77); C310(0.78)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C257(0.78); C252(0.79); C156(0.84); C300(0.92)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C310(0.77); C315(0.77); C252(0.79); C257(0.80)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C257(0.77); C252(0.78); C310(0.84); C315(0.84)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C257(0.67); C252(0.69); C300(0.73); C303(0.73)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C156(0.79); C161(0.81); C310(0.83); C315(0.83)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C257(0.74); C252(0.82); C300(0.86); C303(0.86)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C257(0.74); C252(0.78); C300(0.86); C303(0.86)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C252(0.85); C310(0.85); C315(0.85); C257(0.85)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C156(0.90); C310(0.91); C315(0.91); C257(0.93)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C257(0.56); C252(0.57); C300(0.73); C303(0.73)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C257(0.76); C300(0.80); C303(0.80); C252(0.80)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C257(0.68); C300(0.70); C303(0.70); C252(0.72)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C310(0.28); C315(0.28); C156(0.29); C257(0.33)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C156(0.51); C257(0.59); C252(0.63); C310(0.63)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C156(0.77); C161(0.77); C183(1.05); C188(1.05)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C257(0.71); C156(0.76); C161(0.76); C252(0.80)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C257(0.73); C156(0.75); C161(0.75); C183(0.83)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C156(1.10); C161(1.10)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C300(0.95); C303(0.95); C252(0.96); C183(0.99)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C257(0.70); C252(0.77); C310(0.85); C315(0.85)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C252(0.54); C257(0.54); C323(0.82); C326(0.84)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C156(0.70); C161(0.70); C183(0.79); C188(0.79)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C156(0.78); C161(0.78); C183(0.89); C188(0.89)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C156(0.85); C161(0.85); C257(0.86); C183(0.89)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C183(0.81); C188(0.81); C257(0.83); C252(0.92)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C310(0.53); C315(0.53); C252(0.72); C257(0.72)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C310(0.56); C315(0.56); C252(0.61); C257(0.61)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C310(0.47); C315(0.47); C252(0.64); C257(0.64)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C310(0.57); C315(0.57); C252(0.62); C257(0.62)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C310(0.49); C315(0.49); C252(0.80); C257(0.80)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C257(0.74); C252(0.80); C300(0.88); C303(0.88)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C310(0.55); C315(0.55); C252(0.68); C257(0.68)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C310(0.56); C315(0.56); C252(0.75); C257(0.75)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C300(0.79); C303(0.79); C315(0.89); C161(0.89)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C300(0.56); C303(0.56); C315(0.82); C257(0.83)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C300(0.47); C303(0.47); C315(0.64); C310(0.82)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C300(0.55); C303(0.55); C183(0.82); C188(0.82)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C300(0.75); C303(0.75); C315(0.81); C183(0.90)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C300(0.71); C303(0.71); C315(0.80); C310(1.00)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C300(0.63); C303(0.63); C156(0.86); C315(0.92)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C300(0.65); C303(0.65); C161(0.88); C315(0.88)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C257(0.83); C252(0.92); C310(0.94); C315(0.94)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C300(0.64); C303(0.64); C315(0.78); C161(0.81)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C183(0.76); C188(0.76); C156(0.93); C310(0.95)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C300(0.70); C303(0.70); C183(0.72); C188(0.72)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C300(0.68); C303(0.68); C310(0.73); C315(0.73)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C156(0.54); C300(0.69); C303(0.69); C161(0.77)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C323(0.61); C326(0.61); C156(0.85); C183(0.86)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C183(0.56); C188(0.56); C252(0.87); C257(0.87)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C183(0.74); C188(0.74); C252(0.83); C257(0.83)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C323(0.72); C326(0.72); C161(0.79); C252(0.82)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C257(0.76); C310(0.78); C315(0.78); C183(0.81)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C300(0.88); C303(0.88); C156(0.92); C252(0.96)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C300(0.78); C303(0.78); C183(0.87); C188(0.87)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C183(0.78); C188(0.78); C156(0.85); C310(0.95)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C323(0.60); C252(0.74); C257(0.74); C326(0.81)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C252(0.52); C257(0.52); C323(0.74); C326(0.79)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C252(0.72); C257(0.72); C323(0.88); C326(0.89)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C183(0.96); C188(0.96); C300(1.03); C303(1.03)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C252(0.87); C257(0.87); C323(0.94); C183(0.94)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C252(0.65); C257(0.65); C323(0.68); C326(0.77)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C252(0.67); C257(0.67); C183(0.92); C188(0.92)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C161(0.90); C156(0.93); C310(0.94); C315(0.94)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C252(0.74); C257(0.74); C161(0.89); C310(0.95)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C323(0.70); C156(1.08); C161(1.05); C183(1.26)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C323(0.78); C156(0.95); C161(0.91); C183(0.99)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C323(0.97); C156(0.99); C161(1.01); C183(0.98)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C323(0.66); C156(1.08); C161(1.05); C183(1.03)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C323(2.06); C156(1.14); C161(1.12); C183(1.00)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C156(0.97); C161(1.07); C183(1.11); C188(1.11)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C323(1.45); C156(1.07); C161(0.95); C183(1.34)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C323(0.71); C156(0.98); C161(1.00); C183(1.14)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C156(0.85); C161(0.94); C183(0.69); C188(0.69)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C156(0.80); C161(0.96); C183(0.87); C188(0.87)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C156(1.15); C161(1.28); C183(0.83); C188(0.83)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C156(1.12); C161(1.08); C183(0.96); C188(0.96)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C156(1.19); C161(1.32); C183(0.97); C188(0.97)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C156(1.14); C161(1.13); C183(0.93); C188(0.93)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C156(1.22); C161(1.13); C183(0.92); C188(0.92)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C156(0.97); C161(0.99); C183(0.99); C188(0.99)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C156(1.00); C161(1.01); C183(0.82); C188(0.82)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C156(1.14); C161(1.22); C183(0.78); C188(0.78)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C156(1.20); C161(1.19); C183(0.98); C188(0.98)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C156(1.40); C161(1.34); C183(0.83); C188(0.83)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C156(1.03); C161(1.04); C183(1.01); C188(1.01)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C156(0.91); C161(0.92); C183(1.03); C188(1.03)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C156(0.84); C161(0.79); C183(1.24); C188(1.24)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C156(0.78); C161(0.79); C183(1.07); C188(1.07)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C156(0.96); C161(0.93); C183(1.15); C188(1.15)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C156(0.94); C161(0.88); C183(1.19); C188(1.19)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C156(1.26); C161(1.02); C183(1.00); C188(1.00)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C156(1.01); C161(0.96); C183(1.19); C188(1.19)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C156(0.88); C161(0.80); C183(1.17); C188(1.17)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C156(0.99); C161(0.94); C183(1.14); C188(1.14)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C156(1.15); C161(1.21); C183(1.11); C188(1.11)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C156(0.85); C161(0.74); C183(1.07); C188(1.07)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C156(1.02); C161(0.91); C183(1.22); C188(1.22)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C156(0.99); C161(0.85); C183(0.99); C188(0.99)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C156(1.14); C161(1.01); C183(1.16); C188(1.16)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C156(0.88); C161(0.82); C183(1.17); C188(1.17)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C156(1.13); C161(0.98); C183(1.12); C188(1.12)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C156(1.08); C161(0.98); C183(0.97); C188(0.97)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C156(0.91); C161(0.81); C183(1.09); C188(1.09)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C156(0.86); C161(0.84); C183(0.88); C188(0.88)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C156(0.91); C161(0.73); C183(0.70); C188(0.70)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C156(1.13); C161(0.84); C183(0.66); C188(0.66)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C156(0.95); C161(0.89); C183(0.72); C188(0.72)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C156(1.11); C161(0.94); C183(0.90); C188(0.90)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C156(1.09); C161(0.94); C183(0.80); C188(0.80)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C156(1.26); C161(0.99); C183(0.76); C188(0.76)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C156(1.98); C161(1.36); C183(0.57); C188(0.57)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C156(0.99); C161(0.99); C183(0.60); C188(0.60)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C156(0.92); C161(0.84); C183(1.38); C188(1.38)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C156(0.99); C161(1.03); C183(0.73); C188(0.73)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C156(1.03); C161(0.89); C183(0.73); C188(0.73)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C156(0.97); C161(0.83); C183(0.77); C188(0.77)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C156(1.29); C161(0.92); C183(0.74); C188(0.74)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C156(1.11); C161(0.95); C183(0.74); C188(0.74)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C156(0.90); C161(0.93); C183(0.77); C188(0.77)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C156(0.94); C161(0.92); C183(0.83); C188(0.83)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C156(0.80); C161(0.81); C183(0.93); C188(0.93)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C156(0.95); C161(0.97); C183(1.18); C188(1.18)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C156(0.93); C161(1.09); C183(1.00); C188(1.00)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C156(0.83); C161(0.85); C183(0.97); C188(0.97)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C156(1.01); C161(1.03); C183(0.94); C188(0.94)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C156(1.04); C161(1.05); C183(0.97); C188(0.97)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C156(0.80); C161(0.82); C183(0.96); C188(0.96)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C156(0.77); C161(0.78); C183(0.94); C188(0.94)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C156(0.89); C161(0.91); C183(0.78); C188(0.78)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C156(0.92); C161(0.94); C183(0.85); C188(0.85)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C156(0.85); C161(0.87); C183(0.76); C188(0.76)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C156(0.84); C161(0.85); C183(0.72); C188(0.72)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C156(0.98); C161(1.00); C183(0.96); C188(0.96)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C156(0.72); C161(0.96); C183(0.93); C188(0.93)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C156(1.16); C161(1.18); C183(0.84); C188(0.84)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C323(1.43); C156(1.05); C161(1.08); C183(0.93)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C323(1.51); C156(1.26); C161(1.18); C183(0.90)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C323(0.69); C156(1.20); C161(1.14); C183(1.11)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C323(1.03); C156(1.35); C161(1.14); C183(1.02)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C323(0.96); C156(1.15); C161(1.15); C183(1.09)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C323(1.21); C156(1.11); C161(1.16); C183(1.09)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C323(1.13); C156(1.11); C161(1.14); C183(0.96)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C323(0.93); C156(0.92); C161(0.97); C183(1.06)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C323(0.95); C156(0.94); C161(1.01); C183(1.05)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C340(1.11); C270(1.01); C310(0.95); C252(0.87)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C340(1.27)  LDD1702  [16]
 LDCM0625  F8 Ramos C340(1.07); 0.54  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C340(0.44); 0.62  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C340(17.22)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C340(0.55); 1.10  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C340(1.00)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C340(0.60)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C340(0.45); 0.75  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C340(0.54); 0.76  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C340(0.65)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C340(1.03)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C340(0.21); 0.75  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C340(0.88); 0.77  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C340(1.26)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C340(0.67)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C156(0.85); C161(0.91); C183(0.69); C188(0.69)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C340(0.94); 1.16  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C340(0.53); 0.31  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C156(0.99); C161(0.99); C183(0.90); C188(0.90)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C340(1.27)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C340(1.63)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C340(0.39); 0.21  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C340(0.30); 0.48  LDD2188  [17]
 LDCM0116  HHS-0101 DM93 Y467(1.47)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y467(0.97)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y467(1.15)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y467(1.57)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y467(0.91)  LDD0268  [5]
 LDCM0107  IAA HeLa H477(0.00); C340(0.00)  LDD0221  [12]
 LDCM0123  JWB131 DM93 Y467(0.73)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y467(0.85)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y467(0.91)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y467(4.33)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y467(2.45)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y467(1.26)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y467(0.59)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y467(1.07)  LDD0292  [4]
 LDCM0022  KB02 HCT 116 C156(1.45); C161(1.16); C252(1.35); C257(1.35)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C156(1.57); C161(1.35); C252(1.34); C257(1.34)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C156(1.67); C161(1.47); C252(1.42); C257(1.42)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [12]
 LDCM0021  THZ1 HCT 116 C156(1.34); C161(1.34); C139(1.23); C142(1.23)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-5 (CUL5) Cullin family Q93034
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) Ser/Thr protein kinase family O43683
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) Ubiquitin-conjugating enzyme family P68036
Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) Ubiquitin-conjugating enzyme family O14933
UTP--glucose-1-phosphate uridylyltransferase (UGP2) UDPGP type 1 family Q16851
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Proto-oncogene c-Rel (REL) . Q04864

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578