Details of the Target

General Information of Target

Target ID LDTP06286
Target Name 116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2)
Gene Name EFTUD2
Gene ID 9343
Synonyms
KIAA0031; SNRP116; 116 kDa U5 small nuclear ribonucleoprotein component; Elongation factor Tu GTP-binding domain-containing protein 2; SNU114 homolog; hSNU114; U5 snRNP-specific protein, 116 kDa; U5-116 kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Target Bioclass
Enzyme
Family
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
Subcellular location
Nucleus
Function
Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Uniprot ID
Q15029
Ensemble ID
ENST00000402521.7
HGNC ID
HGNC:30858

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 Insertion: p.A246VfsTer19 .
CCK81 SNV: p.A445T; p.E626K DBIA    Probe Info 
FTC133 SNV: p.R888Q DBIA    Probe Info 
G402 SNV: p.T452I DBIA    Probe Info 
HCT15 SNV: p.D657G DBIA    Probe Info 
HEC1 SNV: p.G715Ter; p.R730H DBIA    Probe Info 
HEC1B SNV: p.R730H IA-alkyne    Probe Info 
HSC4 Insertion: p.T937NfsTer12 .
JHH7 SNV: p.I326F .
JURKAT SNV: p.D49N Compound 10    Probe Info 
JURLMK1 SNV: p.I935N DBIA    Probe Info 
NCIH1155 SNV: p.A503V DBIA    Probe Info 
NCIH1944 SNV: p.W549C DBIA    Probe Info 
NCIH2291 SNV: p.R813W DBIA    Probe Info 
NCIH446 SNV: p.D748H DBIA    Probe Info 
OE33 SNV: p.S944I DBIA    Probe Info 
OVTOKO SNV: p.R730H DBIA    Probe Info 
RL952 SNV: p.T749S DBIA    Probe Info 
TKKK SNV: p.V186M DBIA    Probe Info 
TOV21G SNV: p.S522Y; p.Q523K DBIA    Probe Info 
U87MG SNV: p.D273Y DBIA    Probe Info 
U937 SNV: p.T353A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.89  LDD0215  [1]
CHEMBL5175495
 Probe Info  		6.08  LDD0196  [2]
TH211
 Probe Info  		Y161(15.95); Y722(7.10)  LDD0260  [3]
C-Sul
 Probe Info  		2.40  LDD0066  [4]
STPyne
 Probe Info  		K646(0.79)  LDD0277  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
BTD
 Probe Info  		C256(2.29)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C663(2.82)  LDD0168  [7]
HHS-475
 Probe Info  		Y66(1.06)  LDD0264  [8]
DBIA
 Probe Info  		C144(1.08); C166(0.89)  LDD0078  [9]
ATP probe
 Probe Info  		K713(0.00); K646(0.00)  LDD0199  [10]
1d-yne
 Probe Info  		N.A.  LDD0358  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C674(0.00); C780(0.00); C434(0.00); C166(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C663(0.00); C166(0.00); C780(0.00)  LDD0032  [13]
IPIAA_H
 Probe Info  		C144(0.00); C639(0.00); C780(0.00)  LDD0030  [14]
IPIAA_L
 Probe Info  		C166(0.00); C434(0.00); C663(0.00); C639(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C674(0.00); C434(0.00); C166(0.00); C256(0.00)  LDD0037  [12]
IPM
 Probe Info  		N.A.  LDD0025  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
SF
 Probe Info  		K446(0.00); K359(0.00); Y276(0.00); Y869(0.00)  LDD0028  [18]
TFBX
 Probe Info  		C674(0.00); C780(0.00)  LDD0148  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
Ox-W18
 Probe Info  		W549(0.00); W724(0.00)  LDD2175  [20]
1c-yne
 Probe Info  		K684(0.00); K64(0.00); K763(0.00); K951(0.00)  LDD0228  [11]
Acrolein
 Probe Info  		C166(0.00); C144(0.00); H856(0.00); H502(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
Methacrolein
 Probe Info  		C166(0.00); C780(0.00); C525(0.00); C135(0.00)  LDD0218  [21]
NAIA_5
 Probe Info  		C674(0.00); C780(0.00); C166(0.00); C256(0.00)  LDD2223  [22]
HHS-465
 Probe Info  		N.A.  LDD2240  [23]
HHS-482
 Probe Info  		Y161(1.05); Y869(1.23)  LDD2239  [24]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.23  LDD0475  [25]
FFF probe3
 Probe Info  		5.56  LDD0464  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
DA-2
 Probe Info  		N.A.  LDD0072  [27]
STS-1
 Probe Info  		N.A.  LDD0068  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C780(0.52); C674(0.53)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C780(0.94); C674(1.13)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C780(0.59); C674(0.56)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C674(0.81)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C780(1.38); C135(1.57)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C256(1.58)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C780(0.57); C674(0.51)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C674(0.87)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C663(2.82)  LDD0168  [7]
 LDCM0214  AC1 HCT 116 C144(1.01); C148(1.27); C166(1.16); C674(1.10)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C144(1.10); C148(1.01); C166(1.01); C674(1.04)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C144(1.05); C148(0.89); C166(0.80); C674(0.85)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C144(0.86); C148(0.65); C166(0.79); C674(0.78)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C144(0.78); C148(0.55); C166(0.80); C674(0.87)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C144(0.80); C148(0.50); C166(0.80); C674(0.82)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C144(0.85); C148(0.58); C166(0.63); C674(0.98)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C144(0.81); C148(0.57); C166(0.71); C674(0.90)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C144(0.79); C148(0.57); C166(0.78); C674(0.94)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C144(0.76); C148(0.67); C166(0.64); C674(0.95)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C144(0.69); C148(0.47); C166(0.81); C674(0.70)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C144(0.78); C148(0.62); C166(0.76); C674(0.84)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C144(0.99); C148(0.98); C166(0.97); C674(1.20)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C144(0.81); C148(0.45); C166(0.81); C674(0.74)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C144(0.79); C148(0.59); C166(0.86); C674(0.68)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C144(0.63); C148(0.56); C166(0.79); C674(0.76)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C144(1.17); C148(1.17); C166(0.98); C780(0.79)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C144(1.03); C148(1.11); C166(0.79); C780(0.97)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C144(1.16); C148(1.18); C166(0.94); C780(1.21)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C144(1.02); C148(1.02); C166(0.91); C780(1.18)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C144(1.06); C148(1.01); C166(0.99); C780(0.87)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C144(1.13); C148(1.11); C166(1.02); C780(0.90)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C144(1.10); C148(1.08); C166(0.99); C780(0.68)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C144(1.08); C148(1.02); C166(1.15); C674(1.26)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C144(1.09); C148(1.12); C166(0.95); C780(0.84)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C144(1.12); C148(1.02); C166(0.88); C780(1.03)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C144(1.04); C148(1.02); C166(0.97); C780(0.82)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C144(1.21); C148(1.02); C166(0.93); C780(0.90)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C144(1.16); C148(1.10); C166(0.89); C780(0.79)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C144(1.12); C148(1.12); C166(0.94); C780(0.75)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C144(1.07); C148(1.05); C166(0.94); C780(0.84)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C144(1.17); C148(1.15); C166(0.92); C780(0.89)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C144(1.59); C148(1.37); C166(0.71); C674(1.19)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C144(1.38); C148(1.18); C166(0.86); C674(1.17)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C144(1.37); C148(1.15); C166(1.06); C674(1.25)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C144(1.42); C148(1.24); C166(0.87); C674(1.10)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C144(1.29); C148(0.99); C166(1.01); C674(0.81)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C144(1.68); C148(1.17); C166(0.97); C674(1.05)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C144(1.09); C148(0.73); C166(0.83); C674(0.84)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C144(1.49); C148(0.95); C166(0.93); C674(0.82)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C144(1.20); C148(0.87); C166(1.07); C674(0.86)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C144(1.31); C148(0.87); C166(0.92); C674(0.87)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C144(0.85); C148(0.52); C166(0.80); C674(0.59)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C144(0.93); C148(0.66); C166(1.06); C674(0.63)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C144(1.27); C148(1.18); C166(1.17); C674(1.19)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C144(0.78); C148(0.48); C166(0.81); C674(0.51)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C144(0.86); C148(0.49); C166(0.80); C674(0.48)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C144(1.31); C148(1.00); C166(1.01); C674(0.81)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C144(1.07); C148(1.07); C166(0.92); C674(1.00)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C674(0.83); C148(0.90); C144(0.94); C166(0.96)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C674(0.86); C148(0.92); C166(0.93); C144(0.95)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C674(0.86); C148(0.93); C166(1.01); C144(1.10)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C144(0.88); C148(0.89); C166(0.90); C674(0.94)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C674(0.68); C148(0.85); C166(0.86); C144(0.90)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C148(0.70); C144(0.85); C674(0.86); C166(0.93)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C148(0.98); C166(1.04); C144(1.05); C674(1.09)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C148(0.92); C144(1.02); C674(1.03); C166(1.13)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C148(0.95); C674(0.97); C166(0.99); C144(1.05)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C166(0.80); C148(0.81); C674(0.82); C144(0.91)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C674(0.59); C148(0.61); C144(0.72); C166(0.97)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C144(1.01); C148(0.91); C166(0.89); C674(0.87)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C144(1.00); C148(0.88); C166(1.10); C674(0.86)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C144(1.00); C148(0.90); C166(1.01); C674(1.08)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C144(1.11); C148(0.96); C166(1.05); C674(0.85)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C144(0.87); C148(0.88); C166(1.03); C674(1.19)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C148(0.66); C144(0.68); C166(0.91); C674(1.37)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C148(0.92); C674(0.93); C144(0.93); C166(1.02)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C144(0.79); C148(0.92); C674(1.04); C166(1.11)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C166(0.95); C148(1.10); C144(1.12); C674(1.16)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C166(1.00); C148(1.10); C144(1.11); C674(1.13)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C144(0.94); C148(0.95); C166(1.03); C674(1.17)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C148(0.91); C144(0.94); C166(0.98); C674(1.11)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C166(0.96); C148(0.96); C144(0.98); C674(1.16)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C148(0.90); C166(0.95); C674(0.99); C144(1.06)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C148(0.70); C144(0.85); C674(0.90); C166(0.94)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C148(0.75); C144(0.85); C166(0.87); C674(0.87)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C148(0.64); C144(0.79); C674(0.85); C166(0.97)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C148(0.78); C674(0.79); C144(0.82); C780(0.94)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C144(0.98); C674(1.09); C166(1.12); C148(1.23)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C148(0.64); C144(0.75); C674(0.77); C166(0.81)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C148(0.77); C674(0.92); C144(0.97); C166(1.01)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C148(0.58); C674(0.67); C144(0.73); C166(0.82)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C148(0.69); C144(0.82); C166(0.82); C674(0.85)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C148(0.67); C144(0.79); C674(0.81); C166(0.87)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C148(0.96); C144(1.07); C674(1.10); C166(1.20)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C148(0.86); C166(0.90); C144(0.95); C674(1.06)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C144(0.92); C674(1.06); C148(1.10); C780(1.31)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C144(0.94); C674(1.00); C148(1.02); C166(1.04)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C144(0.97); C148(1.01); C674(1.03); C166(1.04)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C166(1.00); C144(1.05); C674(1.16); C148(1.33)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C166(0.77); C674(0.88); C144(0.94); C148(0.95)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C144(1.02); C148(1.03); C674(1.10); C166(1.10)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C148(0.94); C674(0.94); C144(0.96); C166(1.05)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C148(0.82); C674(0.86); C144(0.87); C166(1.11)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C148(0.92); C144(0.95); C674(0.98); C780(1.07)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C148(0.69); C144(0.81); C674(0.93); C166(1.11)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C148(0.77); C144(0.81); C674(0.96); C166(1.06)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C148(0.85); C144(0.87); C166(0.97); C674(0.99)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C148(0.80); C144(0.83); C674(0.86); C166(1.05)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C148(0.69); C144(0.74); C674(0.76); C166(0.98)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C144(0.95); C166(1.01); C674(1.16); C148(1.17)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C674(0.74); C148(0.82); C144(0.86); C166(0.95)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C674(0.94); C166(0.94); C148(0.98); C144(0.99)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C148(0.88); C166(0.93); C144(0.93); C674(0.93)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C166(0.93); C674(0.94); C144(1.37); C148(1.39)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C166(0.88); C674(0.94); C144(1.10); C148(1.12)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C674(0.82); C148(0.87); C144(0.90); C166(1.00)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C148(0.53); C144(0.55); C674(0.63); C166(0.92)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C674(0.93); C780(1.06); C166(1.08); C144(1.20)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C148(0.81); C144(0.84); C166(0.95); C674(0.98)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C674(0.83); C166(1.09); C780(1.10); C144(1.20)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C148(0.89); C674(0.90); C166(0.91); C144(0.95)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C148(0.79); C144(0.83); C674(0.91); C780(1.02)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C674(0.80); C780(0.86); C144(0.93); C148(0.96)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C674(0.73); C780(0.83); C148(0.84); C144(0.85)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C780(0.82); C674(0.94); C148(0.95); C144(0.96)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C674(0.73); C780(0.79); C148(1.02); C166(1.03)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C674(0.80); C780(1.08); C148(1.08); C144(1.11)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C674(0.81); C780(0.98); C166(1.17); C148(1.34)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C674(0.49); C144(0.64); C148(0.65); C780(0.96)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C144(0.93); C148(0.94); C166(1.15); C674(1.27)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C674(0.79); C144(0.80); C148(0.83); C166(0.92)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C148(0.95); C674(0.98); C166(1.04); C144(1.07)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C148(0.61); C144(0.66); C674(0.77); C166(0.83)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C144(0.89); C148(0.90); C674(1.04); C166(1.07)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C148(0.75); C144(0.78); C166(0.86); C674(0.96)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C674(0.50); C148(0.63); C144(0.64); C166(0.84)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C674(0.50); C144(0.66); C148(0.70); C166(0.97)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C674(0.43); C148(0.58); C144(0.61); C166(0.89)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C144(0.83); C148(0.86); C674(0.89); C166(0.96)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C148(0.84); C144(0.87); C166(0.90); C674(0.94)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C144(0.82); C148(0.83); C674(0.93); C166(1.00)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C148(0.86); C144(0.90); C166(0.96); C674(1.20)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C148(0.85); C144(0.93); C166(0.94); C674(0.97)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C166(0.91); C144(0.92); C674(0.96); C148(0.96)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C148(0.95); C144(0.97); C674(1.08); C166(1.10)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C674(0.36); C148(0.59); C144(0.60); C166(0.82)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C674(0.65); C148(0.77); C144(0.80); C166(1.06)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C674(0.64); C148(0.71); C144(0.77); C166(0.91)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C674(0.71); C148(0.78); C144(0.83); C166(0.96)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C674(0.84); C148(0.90); C144(0.91); C166(0.91)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C674(0.80); C148(0.97); C144(1.04); C166(1.14)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C674(0.70); C148(0.88); C144(0.93); C166(1.02)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C674(0.67); C148(0.82); C144(0.88); C166(1.08)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C674(0.80); C148(0.89); C144(0.96); C166(1.02)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C674(0.72); C144(0.84); C148(0.85); C166(1.09)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C674(0.68); C148(0.84); C144(0.87); C166(1.00)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C674(0.70); C144(0.91); C166(0.91); C148(0.94)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C674(0.74); C166(0.85); C144(0.89); C148(0.94)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C674(0.84); C148(0.98); C144(1.00); C166(1.25)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C674(0.70); C144(0.91); C148(0.96); C166(0.98)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C674(0.67); C148(0.70); C144(0.78); C166(0.91)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C148(0.26); C166(0.55); C144(0.58); C674(0.65)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C148(0.60); C166(0.77); C144(0.79); C674(0.81)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C674(0.52)  LDD2138  [6]
 LDCM0248  AKOS034007472 HCT 116 C144(1.15); C148(1.16); C166(1.16); C674(1.30)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C166(1.03); C674(1.05); C148(1.08); C144(1.12)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C674(0.86); C166(0.87); C148(0.87); C780(0.94)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C144(1.08); C166(0.89)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C674(0.70)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C166(0.00); C525(0.00); C135(0.00); C780(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C144(0.54)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C144(0.80); C148(0.84); C674(0.96); C166(1.01)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C166(0.71); C674(0.73); C144(0.80); C148(0.84)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C144(0.94); C166(0.96); C674(1.00); C148(1.21)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C166(0.93); C148(0.95); C780(0.96); C144(1.00)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C148(1.06); C166(1.08); C674(1.11); C144(1.11)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C166(0.99); C148(1.01); C674(1.07); C780(1.09)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C148(1.10); C780(1.12); C166(1.14); C674(1.14)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C148(0.74); C144(0.77); C166(0.96); C674(1.00)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C674(0.73); C144(0.74); C148(0.74); C166(0.93)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C166(0.97); C148(0.97); C144(0.98); C674(1.09)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C148(0.79); C144(0.81); C674(0.88); C166(0.99)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C674(0.94); C148(1.01); C166(1.02); C144(1.07)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C166(0.83); C144(0.89); C148(0.93); C674(0.94)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C674(0.82); C166(0.92); C148(0.96); C144(1.02)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C148(0.79); C674(0.85); C144(0.85); C166(0.96)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C148(0.72); C166(0.84); C674(0.85); C144(0.92)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C148(0.58); C144(0.69); C674(0.75); C166(0.82)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C148(0.65); C674(0.76); C144(0.80); C166(0.87)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C148(0.59); C674(0.74); C144(0.81); C166(0.88)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C148(0.75); C144(0.88); C166(0.88); C674(0.95)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C148(0.63); C674(0.65); C144(0.73); C166(0.90)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C144(0.91); C148(0.97); C674(1.00); C166(1.14)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C148(0.87); C144(0.88); C674(0.93); C166(1.03)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C674(0.86); C166(0.86); C148(0.96); C144(0.96)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C148(0.82); C144(0.89); C674(1.11); C780(1.30)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C148(0.86); C144(0.88); C674(0.89); C166(1.01)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C148(0.73); C144(0.74); C674(0.77); C166(0.88)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C148(0.81); C144(0.82); C166(0.83); C674(0.84)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C148(0.75); C674(0.76); C144(0.78); C166(1.02)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C780(0.97); C674(1.02); C148(1.05); C144(1.11)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C148(0.84); C144(0.87); C674(1.01); C166(1.04)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C674(0.93); C780(0.96); C148(1.05); C144(1.10)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C780(0.77); C674(0.95); C166(0.99); C148(1.08)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C144(0.90); C148(0.94); C166(0.95); C674(0.98)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C166(0.99); C148(1.03); C144(1.04); C674(1.06)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C148(0.89); C144(0.89); C674(0.90); C166(1.01)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C148(0.77); C780(0.79); C144(0.82); C674(0.93)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C674(0.74); C148(0.78); C144(0.81); C166(0.93)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C780(1.02); C144(1.03); C674(1.04); C148(1.05)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C144(0.94); C780(0.96); C148(0.99); C674(1.00)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C166(1.02); C144(1.04); C148(1.06); C780(1.07)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C148(0.84); C144(0.85); C674(0.87); C166(0.89)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C148(0.73); C674(0.74); C144(0.75); C166(0.78)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C148(0.67); C144(0.72); C166(0.97); C674(1.02)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C780(0.83); C144(0.88); C674(0.89); C148(0.94)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C674(0.82); C144(0.84); C148(0.86); C780(0.87)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C144(0.82); C148(0.83); C166(0.78); C674(0.73)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C144(0.82); C148(0.78); C166(1.01); C674(0.87)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C144(0.92); C148(0.90); C166(0.99); C674(0.85)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C144(0.76); C148(0.69); C166(0.84); C674(0.88)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C144(0.83); C148(0.85); C166(0.89); C674(0.93)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C144(1.01); C148(0.96); C166(0.92); C674(1.09)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C144(0.89); C148(0.90); C166(0.96); C674(1.04)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C144(0.82); C148(0.76); C166(0.99); C674(0.61)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C144(1.08); C148(0.79); C166(1.36); C674(0.70)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C144(0.82); C148(0.73); C166(0.94); C674(0.67)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C144(0.74); C148(0.59); C166(0.84); C674(0.61)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C144(0.79); C148(0.69); C166(0.94); C674(0.68)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C144(0.81); C148(0.73); C166(0.81); C674(0.65)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C144(0.83); C148(0.72); C166(0.84); C674(0.64)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C144(0.75); C148(0.66); C166(0.83); C674(0.76)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C144(1.04); C148(1.04); C166(0.91); C674(1.15)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C144(0.79); C148(0.69); C166(1.04); C674(0.62)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C144(0.95); C148(0.80); C166(0.87); C674(0.70)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C144(0.65); C148(0.54); C166(0.75); C674(0.52)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C144(0.82); C148(0.71); C166(0.87); C674(0.76)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C144(0.82); C148(0.73); C166(1.02); C674(0.61)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C144(0.71); C148(0.57); C166(0.86); C674(0.50)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C144(1.02); C148(0.95); C166(0.97); C674(1.02)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C144(1.06); C148(1.02); C166(0.87); C674(0.96)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C144(1.04); C148(1.01); C166(0.97); C674(1.13)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C144(1.23); C148(1.22); C166(1.06); C674(1.00)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C144(1.05); C148(1.10); C166(1.07); C674(1.11)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C144(0.89); C148(0.83); C166(0.96); C674(1.07)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C144(1.30); C148(1.21); C166(0.86); C674(1.09)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C144(1.14); C148(1.07); C166(1.00); C674(1.00)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C144(1.15); C148(1.10); C166(0.99); C674(1.12)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C144(0.98); C148(0.93); C166(1.14); C674(0.96)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C144(1.28); C148(1.27); C166(0.90); C674(1.09)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C144(1.13); C148(1.09); C166(0.93); C674(0.94)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C144(1.22); C148(1.16); C166(1.06); C674(1.00)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C144(1.30); C148(1.23); C166(0.85); C674(0.91)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C144(1.11); C148(1.08); C166(0.97); C674(1.09)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C144(0.87); C148(0.88); C166(1.05); C674(0.88)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C144(1.04); C148(1.00); C166(0.84); C674(0.90)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C144(0.95); C148(1.13); C166(0.88); C674(1.10)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C144(0.90); C148(0.99); C166(0.89); C674(1.02)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C144(0.91); C148(0.90); C166(0.91); C674(0.97)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C144(0.84); C148(0.89); C166(0.83); C674(1.03)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C144(0.90); C148(1.05); C166(1.03); C674(1.13)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C144(0.80); C148(0.88); C166(0.78); C674(0.85)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C144(0.92); C148(0.94); C166(0.80); C674(1.09)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C144(0.94); C148(0.90); C166(1.03); C674(0.96)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C144(1.13); C148(0.94); C166(1.35); C674(1.19)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C144(0.87); C148(0.91); C166(0.94); C674(0.92)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C144(0.99); C148(1.02); C166(0.92); C674(1.08)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C144(0.83); C148(0.80); C166(0.82); C674(0.96)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C144(0.98); C148(0.94); C166(0.93); C674(0.91)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C144(0.86); C148(0.77); C166(0.97); C674(0.93)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C144(0.90); C148(0.91); C166(0.91); C674(0.98)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C144(0.87); C148(0.86); C166(1.21); C674(0.83)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C144(0.81); C148(0.73); C166(1.14); C674(0.79)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C144(0.86); C148(0.84); C166(0.91); C674(0.80)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C144(0.87); C148(0.82); C166(0.87); C674(0.72)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C144(0.90); C148(0.91); C166(0.80); C674(0.92)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C144(1.01); C148(1.01); C166(1.34); C674(0.94)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C144(0.88); C148(0.90); C166(0.93); C674(0.69)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C144(0.81); C148(0.79); C166(0.89); C674(0.62)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C144(0.78); C148(0.72); C166(0.92); C674(0.67)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C144(0.68); C148(0.64); C166(0.82); C674(0.56)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C144(0.77); C148(0.76); C166(0.96); C674(0.90)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C144(0.85); C148(0.83); C166(1.09); C674(0.89)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C144(0.79); C148(0.81); C166(1.10); C674(0.70)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C144(0.80); C148(0.78); C166(0.86); C674(0.67)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C144(0.71); C148(0.72); C166(0.79); C674(0.41)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C144(0.84); C148(0.89); C166(0.95); C674(1.02)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C144(0.76); C148(0.78); C166(0.87); C674(1.04)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C144(0.69); C148(0.68); C166(1.03); C674(0.86)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C144(0.74); C148(0.74); C166(0.93); C674(0.77)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C144(0.75); C148(0.84); C166(1.01); C674(0.95)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C144(0.82); C148(0.93); C166(1.05); C674(0.98)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C144(0.70); C148(0.71); C166(0.95); C674(0.87)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C144(0.75); C148(0.79); C166(1.00); C674(0.91)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C144(0.80); C148(0.82); C166(0.95); C674(0.86)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C144(0.88); C148(0.96); C166(0.92); C674(0.97)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C144(0.96); C148(1.17); C166(0.94); C674(0.96)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C135(0.93); C674(1.20); C780(0.99); C166(0.96)  LDD1698  [29]
 LDCM0468  Fragment33 HCT 116 C144(0.92); C148(0.97); C166(0.86); C674(1.02)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C144(0.68); C148(0.61); C166(0.95); C674(0.62)  LDD0744  [9]
 LDCM0116  HHS-0101 DM93 Y66(1.06)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y66(4.38)  LDD0265  [8]
 LDCM0107  IAA HeLa C135(0.00); C166(0.00); H928(0.00); H502(0.00)  LDD0221  [21]
 LDCM0022  KB02 HCT 116 C144(6.16); C674(1.98); C166(1.53)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C144(10.05); C674(2.32); C166(1.50)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C144(9.71); C674(2.09); C166(1.32)  LDD0082  [9]
 LDCM0109  NEM HeLa H502(0.00); C135(0.00); H856(0.00); H802(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C780(0.86); C674(1.02)  LDD2089  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C256(0.87)  LDD2093  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C780(1.28)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C780(0.55); C674(0.45)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C256(0.28)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C780(0.58); C674(0.77)  LDD2104  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C780(0.49); C674(0.32)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C780(1.18); C674(1.05)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C780(0.61); C674(0.75)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C780(0.88); C674(0.96); C135(0.66)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C780(0.58)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C256(0.94)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C780(0.57); C674(0.34); C148(0.63)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C256(0.30)  LDD2115  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C256(1.77)  LDD2119  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C780(1.23); C256(0.85)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C780(1.02); C674(1.29); C256(0.56); C135(1.15)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C674(1.57)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C780(2.08); C256(1.05)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C256(0.41)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C780(2.21); C256(2.02)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C780(1.34)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C780(1.30); C674(0.91); C256(0.83); C135(0.79)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C256(2.29)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C674(1.18); C256(0.70)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C780(0.85); C674(0.41)  LDD2141  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C256(2.38)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C780(0.37); C674(0.77)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C135(0.78)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C256(0.24)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C780(0.74); C674(0.48)  LDD2150  [6]
 LDCM0131  RA190 MM1.R C780(1.32)  LDD0304  [30]
 LDCM0021  THZ1 HCT 116 C166(1.05)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myc proto-oncogene protein (MYC) . P01106
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Red (IK) RED family Q13123
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Pre-mRNA-processing-splicing factor 8 (PRPF8) . Q6P2Q9
U5 small nuclear ribonucleoprotein 40 kDa protein (SNRNP40) . Q96DI7

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
24 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
28 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.