Details of the Target

General Information of Target

Target ID LDTP05183
Target Name Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB)
Gene Name LACTB
Gene ID 114294
Synonyms
MRPL56; Serine beta-lactamase-like protein LACTB, mitochondrial; EC 3.4.-.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYRLMSAVTARAAAPGGLASSCGRRGVHQRAGLPPLGHGWVGGLGLGLGLALGVKLAGGL
RGAAPAQSPAAPDPEASPLAEPPQEQSLAPWSPQTPAPPCSRCFARAIESSRDLLHRIKD
EVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALAKLWEA
GKLDLDIPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALK
MMKENVAFEQEKEGKSNEKNDFTKFKTEQENEAKCRNSKPGKKKNDFEQGELYLREKFEN
SIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERASGCKYLDYMQKIFHDLDMLTTV
QEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQV
GLFKNSNENLLPGYLKPETMVMMWTPVPNTEMSWDKEGKYAMAWGVVERKQTYGSCRKQR
HYASHTGGAVGASSVLLVLPEELDTETINNKVPPRGIIVSIICNMQSVGLNSTALKIALE
FDKDRSD
Target Bioclass
Enzyme
Family
Peptidase S12 family
Subcellular location
Mitochondrion
Function
Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism.
Uniprot ID
P83111
Ensemble ID
ENST00000261893.9
HGNC ID
HGNC:16468

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 Deletion: p.T507RfsTer25 .
CCFSTTG1 SNV: p.F410S .
MCC13 SNV: p.E303K DBIA    Probe Info 
NCIH1650 SNV: p.N277S DBIA    Probe Info 
PEO1 SNV: p.T170N DBIA    Probe Info 
SNU423 SNV: p.V41G DBIA    Probe Info 
T24 SNV: p.K511R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K225(0.45); K297(1.28)  LDD0277  [2]
Probe 1
 Probe Info  		Y201(45.45); Y346(9.56)  LDD3495  [3]
BTD
 Probe Info  		C154(1.36); C476(1.12)  LDD1700  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
DBIA
 Probe Info  		C476(1.06)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C523(0.00); C476(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
NAIA_5
 Probe Info  		C275(0.00); C476(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		54.57  LDD1948  [11]
STS-2
 Probe Info  		N.A.  LDD0138  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C154(0.48); C275(0.69)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C154(0.72)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C154(0.67)  LDD2095  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C154(0.72); C476(0.66); C275(0.78)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C154(1.42); C476(1.00)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C154(0.74)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C154(0.61)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C154(0.95)  LDD2131  [4]
 LDCM0214  AC1 PaTu 8988t C476(0.60)  LDD1093  [6]
 LDCM0215  AC10 PaTu 8988t C476(0.70)  LDD1094  [6]
 LDCM0216  AC100 HCT 116 C476(0.93)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C476(0.92)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C476(0.71)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C476(0.64)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C476(0.68)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C476(0.72)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C476(1.05)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C476(0.69)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C476(1.00)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C476(1.11)  LDD0542  [6]
 LDCM0226  AC11 PaTu 8988t C476(0.67)  LDD1105  [6]
 LDCM0227  AC110 HCT 116 C476(1.26)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C476(1.03)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C476(0.79)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C476(1.12)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C476(1.01)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C476(0.85)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C476(0.77)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C476(1.11)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C476(1.19)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C476(0.98)  LDD0553  [6]
 LDCM0237  AC12 PaTu 8988t C476(0.80)  LDD1116  [6]
 LDCM0238  AC120 HCT 116 C476(1.69)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C476(0.90)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C476(1.14)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C476(0.83)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C476(0.98)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C476(1.07)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C476(0.98)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C476(1.01)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C476(1.05)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C476(0.99)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C476(1.10)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C476(1.36)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C476(1.56)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C476(0.79)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C476(1.01)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C476(0.97)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C476(1.27)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C476(1.28)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C476(1.04)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C476(1.28)  LDD0575  [6]
 LDCM0259  AC14 PaTu 8988t C476(0.71)  LDD1138  [6]
 LDCM0260  AC140 HCT 116 C476(1.32)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C476(1.06)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C476(2.05)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C476(1.49)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C476(1.00)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C476(1.10)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C476(1.11)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C476(1.01)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C476(1.00)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C476(0.94)  LDD0586  [6]
 LDCM0270  AC15 PaTu 8988t C476(0.64)  LDD1149  [6]
 LDCM0271  AC150 HCT 116 C476(1.67)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C476(1.48)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C476(0.82)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C476(0.91)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C476(0.83)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C476(0.91)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C476(1.28)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C476(1.06)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C476(0.57)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C476(0.61)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C476(0.63)  LDD0595  [6]
 LDCM0279  AC2 PaTu 8988t C476(0.74)  LDD1158  [6]
 LDCM0280  AC20 HCT 116 C476(0.72)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C476(0.78)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C476(0.60)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C476(0.69)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C476(0.84)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C476(1.28)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C476(1.24)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C476(0.81)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C476(1.10)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C476(1.05)  LDD0606  [6]
 LDCM0290  AC3 PaTu 8988t C476(0.65)  LDD1169  [6]
 LDCM0291  AC30 HCT 116 C476(0.72)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C476(0.95)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C476(0.91)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C476(1.06)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C476(0.89)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C476(1.24)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C476(1.56)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C476(1.14)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C476(1.29)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C476(1.66)  LDD0617  [6]
 LDCM0301  AC4 PaTu 8988t C476(0.75)  LDD1180  [6]
 LDCM0302  AC40 HCT 116 C476(1.14)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C476(1.37)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C476(1.63)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C476(1.19)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C476(0.97)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C476(1.52)  LDD0624  [6]
 LDCM0312  AC5 PaTu 8988t C476(0.57)  LDD1191  [6]
 LDCM0320  AC57 HCT 116 C476(0.90)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C476(1.08)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C476(0.87)  LDD0639  [6]
 LDCM0323  AC6 PaTu 8988t C476(0.82)  LDD1202  [6]
 LDCM0324  AC60 HCT 116 C476(0.99)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C476(1.12)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C476(0.79)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C476(0.80)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C476(0.75)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C476(0.97)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C476(0.96)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C476(0.81)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C476(1.48)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C476(0.92)  LDD0650  [6]
 LDCM0334  AC7 PaTu 8988t C476(0.93)  LDD1213  [6]
 LDCM0335  AC70 HCT 116 C476(0.90)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C476(1.28)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C476(1.23)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C476(1.25)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C476(1.26)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C476(1.16)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C476(1.17)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C476(0.95)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C476(1.15)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C476(1.13)  LDD0661  [6]
 LDCM0345  AC8 PaTu 8988t C476(0.97)  LDD1224  [6]
 LDCM0346  AC80 HCT 116 C476(1.09)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C476(1.27)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C476(1.03)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C476(0.85)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C476(0.93)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C476(2.07)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C476(1.02)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C476(1.42)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C476(1.59)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C476(0.77)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C476(1.79)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C476(0.90)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C476(0.99)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C476(0.92)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C476(1.34)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C476(1.46)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C476(1.17)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C476(1.34)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C476(0.70)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C476(0.97)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C154(0.29)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C154(0.66)  LDD2113  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C476(0.67)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C476(0.71)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C476(0.81)  LDD1154  [6]
 LDCM0156  Aniline NCI-H1299 12.73  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C476(1.06)  LDD0078  [6]
 LDCM0632  CL-Sc Hep-G2 C476(0.45)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C476(1.01)  LDD1571  [13]
 LDCM0369  CL100 PaTu 8988t C476(0.80)  LDD1248  [6]
 LDCM0370  CL101 PaTu 8988t C476(0.83)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C476(0.76)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C476(0.85)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C476(0.70)  LDD1252  [6]
 LDCM0374  CL105 HCT 116 C476(0.64)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C476(0.53)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C476(0.62)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C476(0.64)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C476(0.82)  LDD0695  [6]
 LDCM0380  CL110 HCT 116 C476(0.85)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C476(0.64)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C476(1.20)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C476(0.79)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C476(1.02)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C476(1.25)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C476(0.84)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C476(1.62)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C476(1.18)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C476(1.22)  LDD0706  [6]
 LDCM0391  CL120 HCT 116 C476(1.18)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C476(1.13)  LDD1596  [13]
 LDCM0395  CL124 HEK-293T C476(1.06)  LDD1599  [13]
 LDCM0396  CL125 HCT 116 C476(1.07)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C476(1.17)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C476(1.23)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C476(0.99)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C476(1.10)  LDD1604  [13]
 LDCM0403  CL16 PaTu 8988t C476(1.31)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C476(1.24)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C476(1.10)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C476(1.26)  LDD1285  [6]
 LDCM0408  CL20 PaTu 8988t C476(1.30)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C476(1.16)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C476(1.28)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C476(1.04)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C476(1.29)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C476(1.15)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C476(1.24)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C476(1.05)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C476(1.20)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C476(1.18)  LDD1296  [6]
 LDCM0419  CL30 PaTu 8988t C476(1.13)  LDD1298  [6]
 LDCM0420  CL31 HCT 116 C476(1.19)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C476(1.36)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C476(0.90)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C476(0.93)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C476(0.91)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C476(1.04)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C476(1.07)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C476(0.94)  LDD0745  [6]
 LDCM0429  CL4 HEK-293T C476(0.98)  LDD1633  [13]
 LDCM0430  CL40 HCT 116 C476(0.99)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C476(0.98)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C476(1.17)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C476(1.06)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C476(0.96)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C476(1.09)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C476(1.30)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C476(0.76)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C476(1.06)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C476(0.75)  LDD0756  [6]
 LDCM0441  CL50 HCT 116 C476(0.98)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C476(1.14)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C476(0.85)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C476(0.50)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C476(0.76)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C476(0.55)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C476(0.64)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C476(0.66)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C476(1.02)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C476(0.88)  LDD0767  [6]
 LDCM0452  CL60 HCT 116 C476(1.12)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C476(1.10)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C476(1.00)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C476(1.25)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C476(0.73)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C476(1.00)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C476(0.81)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C476(0.77)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C476(1.36)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C476(0.97)  LDD0778  [6]
 LDCM0463  CL70 HCT 116 C476(1.01)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C476(0.98)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C476(1.28)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C476(1.10)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C476(0.88)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C476(1.05)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C476(1.72)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C476(0.98)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C476(0.87)  LDD0789  [6]
 LDCM0474  CL80 HCT 116 C476(1.17)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C476(0.77)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C476(0.81)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C476(0.86)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C476(0.85)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C476(1.02)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C476(1.06)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C476(0.87)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C476(0.73)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C476(0.92)  LDD0800  [6]
 LDCM0485  CL90 HCT 116 C476(1.33)  LDD0802  [6]
 LDCM0486  CL91 PaTu 8988t C476(0.86)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C476(0.77)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C476(0.75)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C476(0.79)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C476(0.72)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C476(0.74)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C476(0.79)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C476(0.68)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C476(0.80)  LDD1373  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C476(1.45)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C476(1.05)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C476(1.07)  LDD0744  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C476(0.98)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C476(0.96)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C523(1.51); C476(4.92); C154(3.85)  LDD3310  [14]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C154(0.77)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C154(0.44); C476(0.75)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C154(0.46); C476(0.71)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C154(0.94); C476(1.35); C275(1.15)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C154(1.14); C275(0.83)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C154(1.01)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C154(0.94); C275(1.14)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C154(1.03); C275(1.77)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C154(0.90)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C154(0.69); C275(0.95)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C154(0.94); C476(0.66); C275(0.87)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C154(0.48); C275(0.79)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C154(1.07)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C154(0.45); C275(0.80)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C154(1.34); C275(1.01)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C154(0.34)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C154(0.88); C476(0.72); C275(0.99)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C154(0.52); C275(0.68)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C154(0.57); C476(0.66)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C154(0.51); C275(1.70)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C154(0.82); C476(0.56)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C154(0.55)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C154(0.62)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C154(1.62)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C154(1.57); C476(0.75)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C476(1.93)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C154(0.88); C275(0.95)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C476(0.73); C275(0.68)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C154(0.78); C476(0.88); C275(1.04)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C154(1.07); C275(0.53)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C154(0.65); C476(0.60)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C154(1.05); C476(0.61)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C154(0.86); C476(0.74); C275(0.75)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C154(0.93)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C154(1.09); C476(1.00)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C154(0.62)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C154(0.38)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C154(1.42); C476(0.84)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C154(1.02); C476(1.01)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C154(1.10); C476(0.97); C275(0.92)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C154(1.36); C476(1.12)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C154(0.64); C476(0.64)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C154(0.58); C275(0.85)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C154(1.02)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C154(2.88)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C154(0.30)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C154(0.97); C476(0.84)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C154(2.74)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C154(0.54)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C154(0.37); C476(0.47)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C154(1.11)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C154(1.71); C275(1.64)  LDD2153  [4]

References

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Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
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Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840