Details of the Target

General Information of Target

Target ID LDTP02145
Target Name Gelsolin (GSN)
Gene Name GSN
Gene ID 2934
Synonyms
Gelsolin; AGEL; Actin-depolymerizing factor; ADF; Brevin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEARPNSMVVEHPEFL
KAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNEC
SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV
PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA
TQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKL
YKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALK
TASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVERV
PFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY
RHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFG
GKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPS
AAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDK
KMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEK
TEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAEL
AA
Target Type
Literature-reported
Target Bioclass
Other
Family
Villin/gelsolin family
Subcellular location
Secreted; Cytoplasm, cytoskeleton
Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
TTD ID
T23000
Uniprot ID
P06396
DrugMap ID
TTUH7OM
Ensemble ID
ENST00000373808.8
HGNC ID
HGNC:4620
ChEMBL ID
CHEMBL4295700

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
ONAyne
 Probe Info  		K193(8.33); K239(1.19); K368(1.28)  LDD0274  [2]
STPyne
 Probe Info  		K169(10.00); K177(8.33); K193(3.50); K239(8.32)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K193(2.07); K245(4.09); K239(4.09)  LDD3494  [3]
Probe 1
 Probe Info  		Y409(9.56); Y730(33.22)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C215(2.44)  LDD0170  [5]
HHS-482
 Probe Info  		Y371(0.92); Y409(0.94); Y465(1.07); Y469(1.02)  LDD0285  [6]
HHS-475
 Probe Info  		Y371(0.55); Y409(0.62); Y547(0.87); Y603(1.24)  LDD0264  [7]
DBIA
 Probe Info  		C331(0.94); C672(1.18)  LDD0531  [8]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C672(0.00); C331(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C672(0.00); C331(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C672(0.00); C331(0.00)  LDD0037  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
NAIA_5
 Probe Info  		C215(0.00); C672(0.00); C331(0.00)  LDD2223  [14]
TPP-AC
 Probe Info  		N.A.  LDD0427  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C215(2.44)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C215(2.14)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C331(0.94); C672(1.18)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C672(1.25)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C331(1.02)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C331(0.86)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C331(0.91)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C331(0.90)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C331(1.02)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C331(1.07)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C331(0.69)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C331(0.81)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C331(0.88)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C331(0.87)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C672(1.51)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C331(0.75)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C331(0.74)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C331(0.80)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C331(1.36); C672(0.74)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C331(0.74); C672(0.78)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C331(0.85); C672(1.18)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C331(0.98); C672(1.48)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C331(1.47); C672(0.86)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C331(1.17); C672(0.92)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C331(0.94); C672(0.94)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C672(0.93)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C331(0.67); C672(0.82)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C331(1.41); C672(0.88)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C331(0.82); C672(0.75)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C331(1.53); C672(0.83)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C331(1.33); C672(1.02)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C331(0.78); C672(1.00)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C331(0.79); C672(0.87)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C331(0.98); C672(0.83)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C331(0.80)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C331(0.97)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C331(1.18)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C331(1.01)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C331(0.96)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C331(1.04)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C331(0.99)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C331(1.15)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C331(1.38)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C331(1.02)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C331(1.11)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C331(1.29)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C672(1.01)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C331(1.10)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C331(1.05)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C331(1.29)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C331(1.01); C672(1.22)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C672(0.96); C331(1.08)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C672(1.09); C331(1.11)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C331(0.99); C672(1.13)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C331(0.81); C672(1.05)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C672(0.44); C331(0.91)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C672(0.58); C331(0.92)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C672(1.05)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C331(0.93); C672(1.13)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C331(0.99); C672(1.26)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C331(0.83); C672(1.58)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C672(0.52); C331(1.22)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C331(1.01); C672(0.98)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C331(1.13); C672(0.85)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C331(0.98); C672(0.79)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C331(0.92); C672(1.07)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C331(0.72); C672(1.01)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C331(0.78); C672(0.80)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C331(0.96); C672(1.58)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C672(1.40); C331(1.42)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C331(0.28); C672(0.36)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C331(0.50); C672(0.67)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C331(0.36); C672(0.67)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C331(0.42); C672(0.97)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C331(0.72); C672(1.15)  LDD0601  [8]
 LDCM0285  AC25 HEK-293T C672(0.82)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C672(1.07)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C672(1.05)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C672(0.85)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C672(0.84)  LDD0887  [8]
 LDCM0290  AC3 HCT 116 C672(1.70); C331(1.72)  LDD0607  [8]
 LDCM0291  AC30 HEK-293T C672(0.97)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C672(0.78)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C672(0.79)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C672(0.88)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C672(0.83)  LDD0893  [8]
 LDCM0296  AC35 HCT 116 C331(1.10)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C331(1.11)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C331(1.05)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C331(1.17)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C331(1.07)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C331(1.27); C672(1.60)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C331(0.90)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C331(1.00)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C331(1.02)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C331(0.98)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C331(1.03)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C331(0.95)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C672(0.85); C331(0.92)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C331(1.07); C672(1.16)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C672(1.12); C331(1.23)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C672(0.82); C331(1.04)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C331(1.50); C672(1.68)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C331(1.04); C672(1.26)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C672(0.97); C331(1.09)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C331(1.04); C672(1.26)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C331(0.93); C672(1.08)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C331(1.14); C672(1.27)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C331(0.72); C672(1.09)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C672(0.67); C331(0.90)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C672(1.01); C331(1.20)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C672(0.96); C331(1.15)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C672(0.89); C331(1.16)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C672(0.95)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C672(0.84); C331(1.05)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C672(0.93); C331(1.10)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C672(0.85); C331(0.97)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C672(0.88); C331(0.92)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C672(0.88); C331(0.91)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C672(1.08); C331(1.21)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C672(0.82); C331(1.12)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C672(0.69); C331(1.20)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C672(1.08); C331(1.09)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C331(1.06); C672(1.29)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C672(1.29)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C331(0.88); C672(1.61)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C331(1.00); C672(1.53)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C331(1.08); C672(1.85)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C331(0.90); C672(1.38)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C331(1.05); C672(1.57)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C331(0.63); C672(1.10)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C331(0.89); C672(1.34)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C331(0.76); C672(1.17)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C331(0.74); C672(1.24)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C331(0.83); C672(1.26)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C672(0.98)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C331(0.85); C672(1.51)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C331(0.83); C672(1.73)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C331(0.93); C672(1.44)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C331(1.02); C672(1.04)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C672(1.04); C331(1.07)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C331(1.06); C672(1.19)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C331(1.08); C672(1.41)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C331(1.14); C672(1.59)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C331(1.12); C672(1.46)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C331(1.01); C672(1.39)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C331(1.35); C672(1.39)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C672(0.92); C331(1.16)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C672(1.05); C331(1.14)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C331(1.07); C672(1.23)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C672(1.12); C331(1.19)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C331(1.21); C672(1.33)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C331(1.11); C672(1.17)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C672(1.05); C331(1.09)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C331(1.01)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C331(1.00)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C672(1.23)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C672(1.41)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C672(1.01)  LDD0592  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C331(1.03); C672(1.19)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C331(0.97); C672(1.50)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C672(1.12); C331(1.12)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C672(1.06)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C672(1.64)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C672(1.14)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C672(1.21)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C331(0.64); C672(0.85)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C331(0.78); C672(1.10)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C331(0.64); C672(0.72)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C331(0.97); C672(1.24)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C331(0.50); C672(0.93)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C331(0.91); C672(2.01)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C331(0.45); C672(0.87)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C331(0.77); C672(1.67)  LDD0698  [8]
 LDCM0382  CL112 HEK-293T C672(1.02)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C672(0.97)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C672(1.30)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C672(0.81)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C672(0.94)  LDD0984  [8]
 LDCM0387  CL117 HCT 116 C331(0.96)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C331(1.18)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C331(1.09)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C331(0.80); C672(1.23)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C331(1.08)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C672(0.83); C331(1.04)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C331(0.86); C672(1.16)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C672(0.90); C331(1.12)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C672(0.61); C331(1.07)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C331(0.88); C672(0.97)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C672(0.71); C331(1.15)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C672(0.79); C331(1.18)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C672(0.83); C331(1.25)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C331(1.15); C672(2.61)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C331(1.13); C672(1.78)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C331(0.94); C672(1.66)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C331(0.78); C672(0.84)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C331(1.22)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C331(1.20)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C331(1.16)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C672(0.87); C331(1.02)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C331(1.33)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C331(1.32)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C331(1.10)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C331(0.89)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C331(0.95)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C331(0.89)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C331(0.76)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C331(1.19)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C331(1.16)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C331(1.35)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C331(0.99); C672(1.10)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C331(1.37)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C331(1.02); C672(1.24)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C331(0.94); C672(0.95)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C331(0.69); C672(0.80)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C331(1.15); C672(1.12)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C331(0.96); C672(1.19)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C331(1.02); C672(1.28)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C331(0.76); C672(0.96)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C331(0.74); C672(0.87)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C331(1.04); C672(1.46)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C331(0.87); C672(1.01)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C331(1.11); C672(1.15)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C331(1.05); C672(1.47)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C331(1.10); C672(1.12)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C331(1.28); C672(1.50)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C331(1.29); C672(1.64)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C331(1.38); C672(1.17)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C331(2.10); C672(1.23)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C331(1.96); C672(1.09)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C331(1.49); C672(1.01)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C331(1.07); C672(1.82)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C331(2.06); C672(1.55)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C331(1.66); C672(1.16)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C331(1.98); C672(1.12)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C331(1.40); C672(1.71)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C331(1.34); C672(1.01)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C331(1.36); C672(0.87)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C331(1.53); C672(1.20)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C331(1.80); C672(1.39)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C331(1.71); C672(1.08)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C331(1.73); C672(1.45)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C331(1.14); C672(1.68)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C331(2.06); C672(1.33)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C331(1.14)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C331(1.14)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C331(1.09)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C331(0.86)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C331(1.13)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C331(0.96)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C331(0.95)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C331(1.66)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C331(0.94)  LDD1059  [8]
 LDCM0462  CL7 HCT 116 C331(1.23); C672(2.07)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C331(1.03)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C331(1.22)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C331(0.75)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C331(1.23)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C331(0.86)  LDD1065  [8]
 LDCM0469  CL76 HCT 116 C331(0.89)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C331(0.56)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C331(0.60)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C331(0.80)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C331(0.88); C672(0.91)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C331(0.74)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C331(0.78)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C331(0.85)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C331(0.72)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C331(0.85)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C331(1.14)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C331(1.12)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C331(0.68)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C331(0.71)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C331(0.74)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C331(0.93); C672(1.43)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C331(0.53)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C331(0.82); C672(0.80)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C331(1.11); C672(0.80)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C331(1.50); C672(1.21)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C331(1.40); C672(1.33)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C331(1.24); C672(1.22)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C331(1.60); C672(1.37)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C331(1.69); C672(1.40)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C331(1.18); C672(1.13)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C331(0.90); C672(0.93)  LDD0811  [8]
 LDCM0468  Fragment33 HEK-293T C331(0.65)  LDD1066  [8]
 LDCM0427  Fragment51 HCT 116 C331(0.87); C672(0.91)  LDD0744  [8]
 LDCM0116  HHS-0101 DM93 Y371(0.55); Y409(0.62); Y547(0.87); Y603(1.24)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y371(0.62); Y603(0.75); Y547(0.79); Y469(1.21)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y371(0.59); Y603(0.61); Y547(0.96); Y469(1.72)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y371(0.66); Y547(0.85); Y409(0.97); Y603(1.12)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y603(0.52); Y547(0.59); Y371(0.61); Y409(1.27)  LDD0268  [7]
 LDCM0107  IAA HeLa C331(0.00); C672(0.00)  LDD0221  [13]
 LDCM0123  JWB131 DM93 Y371(0.92); Y409(0.94); Y465(1.07); Y469(1.02)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y160(0.34); Y409(0.57); Y465(0.27); Y469(0.33)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y409(1.03); Y465(0.79); Y469(1.05); Y480(1.05)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y160(19.24); Y409(2.93); Y465(2.86); Y469(5.25)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y160(5.96); Y409(1.99); Y465(2.74); Y469(2.44)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y160(6.71); Y409(1.23); Y465(1.11); Y469(1.22)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y160(1.60); Y409(0.53); Y465(0.53); Y469(0.31)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y160(0.90); Y409(0.93); Y465(0.61); Y469(0.93)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C331(0.98)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C331(0.93)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C331(1.05)  LDD3310  [18]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) 3-beta-HSD family P14060
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) Archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family P0DPB6
DNA-directed RNA polymerase I subunit RPA12 (POLR1H) Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family Q9P1U0
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
Peptidyl-prolyl cis-trans isomerase E (PPIE) Cyclophilin-type PPIase family Q9UNP9
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Putative inactive beta-glucuronidase-like protein SMA3 (GUSBP1) Glycosyl hydrolase 2 family Q15486
Cytochrome c oxidase assembly factor 7 (COA7) Hcp beta-lactamase family Q96BR5
Lysyl oxidase homolog 4 (LOXL4) Lysyl oxidase family Q96JB6
Dihydropyrimidinase (DPYS) Hydantoinase/dihydropyrimidinase family Q14117
Dihydropyrimidinase-related protein 5 (DPYSL5) Hydantoinase/dihydropyrimidinase family Q9BPU6
Thiol S-methyltransferase TMT1A (TMT1A) Methyltransferase superfamily Q9H8H3
E3 SUMO-protein ligase NSE2 (NSMCE2) NSE2 family Q96MF7
Cyclin-dependent kinase 2 (CDK2) CMGC Ser/Thr protein kinase family P24941
Dual specificity protein phosphatase 10 (DUSP10) Protein-tyrosine phosphatase family Q9Y6W6
N-acetylaspartylglutamate synthase A (RIMKLA) RimK family Q8IXN7
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) Short-chain dehydrogenases/reductases (SDR) family Q53GQ0
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Carbohydrate sulfotransferase 8 (CHST8) Sulfotransferase 2 family Q9H2A9
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Methylcytosine dioxygenase TET2 (TET2) TET family Q6N021
Ubiquitin-conjugating enzyme E2 A (UBE2A) Ubiquitin-conjugating enzyme family P49459
Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) Ubiquitin-conjugating enzyme family Q13404
ATPase PAAT (PAAT) . Q9H8K7
E3 ubiquitin-protein ligase RNF138 (RNF138) . Q8WVD3
Inactive phospholipase C-like protein 2 (PLCL2) . Q9UPR0
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) . Q1L5Z9
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Beta-arrestin-1 (ARRB1) Arrestin family P49407
Beta-arrestin-2 (ARRB2) Arrestin family P32121
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
Peroxisome proliferator-activated receptor alpha (PPARA) Nuclear hormone receptor family Q07869
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) Tim17/Tim22/Tim23 family O60830
Kelch-like protein 3 (KLHL3) . Q9UH77
Transcription factor
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Transcription factor NF-E2 45 kDa subunit (NFE2) BZIP family Q16621
Fos-related antigen 1 (FOSL1) BZIP family P15407
Fos-related antigen 2 (FOSL2) BZIP family P15408
Transcription factor Jun (JUN) BZIP family P05412
Transcription factor E2F8 (E2F8) E2F/DP family A0AVK6
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 436 (ZNF436) Krueppel C2H2-type zinc-finger protein family Q9C0F3
Myb/SANT-like DNA-binding domain-containing protein 3 (MSANTD3) MSANTD3 family Q96H12
Nuclear receptor subfamily 1 group D member 2 (NR1D2) Nuclear hormone receptor family Q14995
Androgen receptor (AR) Nuclear hormone receptor family P10275
DNA-binding protein inhibitor ID-1 (ID1) . P41134
Golgin-45 (BLZF1) . Q9H2G9
LIM/homeobox protein Lhx5 (LHX5) . Q9H2C1
Myc proto-oncogene protein (MYC) . P01106
Transcription factor p65 (RELA) . Q04206
Zinc finger protein 581 (ZNF581) . Q9P0T4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 141 (CCDC141) . Q6ZP82
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-37 (IL37) IL-1 family Q9NZH6
Other
Click To Hide/Show 73 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Drebrin-like protein (DBNL) ABP1 family Q9UJU6
ADP-ribosylation factor-like protein 2-binding protein (ARL2BP) ARL2BP family Q9Y2Y0
Aurora kinase A- and ninein-interacting protein (AUNIP) AUNIP family Q9H7T9
Protein BEX5 (BEX5) BEX family Q5H9J7
Protein Tob1 (TOB1) BTG family P50616
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
RNA polymerase II elongation factor ELL2 (ELL2) ELL/occludin family O00472
Large ribosomal subunit protein eL31 (RPL31) Eukaryotic ribosomal protein eL31 family P62899
Small ribosomal subunit protein eS4, X isoform (RPS4X) Eukaryotic ribosomal protein eS4 family P62701
Protein FAM163A (FAM163A) FAM163 family Q96GL9
Protein FAM184A (FAM184A) FAM184 family Q8NB25
Protein FAM83A (FAM83A) FAM83 family Q86UY5
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Iron-sulfur cluster assembly 2 homolog, mitochondrial (ISCA2) HesB/IscA family Q86U28
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Ragulator complex protein LAMTOR1 (LAMTOR1) LAMTOR1 family Q6IAA8
55 kDa erythrocyte membrane protein (MPP1) MAGUK family Q00013
Protein PALS1 (PALS1) MAGUK family Q8N3R9
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
Myozenin-2 (MYOZ2) Myozenin family Q9NPC6
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Proteasome activator complex subunit 1 (PSME1) PA28 family Q06323
PHD finger protein 23 (PHF23) PHF23 family Q9BUL5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) SNF5 family Q12824
Charged multivesicular body protein 7 (CHMP7) SNF7 family Q8WUX9
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
Tubulin-specific chaperone C (TBCC) TBCC family Q15814
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Translin-associated protein X (TSNAX) Translin family Q99598
NEDD8 (NEDD8) Ubiquitin family Q15843
Small ribosomal subunit protein uS14m (MRPS14) Universal ribosomal protein uS14 family O60783
Small ribosomal subunit protein uS8 (RPS15A) Universal ribosomal protein uS8 family P62244
Vacuolar protein sorting-associated protein 11 homolog (VPS11) VPS11 family Q9H270
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
Protein Wnt-7a (WNT7A) Wnt family O00755
A-kinase-interacting protein 1 (AKIP1) . Q9NQ31
Allograft inflammatory factor 1 (AIF1) . P55008
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Developmental pluripotency-associated protein 2 (DPPA2) . Q7Z7J5
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Ephexin-1 (NGEF) . Q8N5V2
HCLS1-binding protein 3 (HS1BP3) . Q53T59
Insulin-like growth factor-binding protein 4 (IGFBP4) . P22692
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Leucine rich adaptor protein 1 (LURAP1) . Q96LR2
Microspherule protein 1 (MCRS1) . Q96EZ8
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Neutrophil cytosol factor 1 (NCF1) . P14598
Outer dynein arm-docking complex subunit 3 (ODAD3) . A5D8V7
Period circadian protein homolog 1 (PER1) . O15534
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) . Q6ZR37
Probable RNA-binding protein 46 (RBM46) . Q8TBY0
Proheparin-binding EGF-like growth factor (HBEGF) . Q99075
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Putative protein CLUHP3 (CLUHP3) . Q96NS8
Putative uncharacterized protein encoded by LINC00518 (LINC00518) . Q8N0U6
Putative uncharacterized protein RUSC1-AS1 (RUSC1-AS1) . Q66K80
Ras GTPase-activating-like protein IQGAP3 (IQGAP3) . Q86VI3
Sperm microtubule associated protein 2 (SPMAP2) . Q9P2T0
Spermatogenesis-associated protein 12 (SPATA12) . Q7Z6I5
Spermatogenesis-associated serine-rich protein 1 (SPATS1) . Q496A3
Suppressor of cytokine signaling 6 (SOCS6) . O14544
Telethonin (TCAP) . O15273
Torsin-1A-interacting protein 2, isoform IFRG15 (TOR1AIP2) . Q9H496
Transmembrane protein 61 (TMEM61) . Q8N0U2
Uncharacterized protein C3orf36 (C3orf36) . Q3SXR2
WW domain binding protein 1-like (WBP1L) . Q9NX94
Zinc finger CCHC domain-containing protein 17 (ZCCHC17) . Q9NP64

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Zinc . DB01593
Zinc Acetate . DB14487
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Latrunculin A . DB02621

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840