Details of the Target

General Information of Target

Target ID LDTP00490
Target Name Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)
Gene Name HGS
Gene ID 9146
Synonyms
HRS; Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Uniprot ID
O14964
Ensemble ID
ENST00000329138.9
HGNC ID
HGNC:4897

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.M738I DBIA    Probe Info 
HEC1 SNV: p.R488H DBIA    Probe Info 
HEC1B SNV: p.R488H .
HEP3B217 SNV: p.V527M DBIA    Probe Info 
HT SNV: p.V439M DBIA    Probe Info 
HT115 SNV: p.S270Ter DBIA    Probe Info 
JHH7 SNV: p.S703Y .
JURKAT SNV: p.R422H .
K562 SNV: p.P351R .
KMS11 SNV: p.K51Q DBIA    Probe Info 
LS180 SNV: p.R546Q DBIA    Probe Info 
MFE296 Deletion: p.S272RfsTer8 DBIA    Probe Info 
MOLT4 SNV: p.P719Q IA-alkyne    Probe Info 
RL952 SNV: p.A150V; p.D479N DBIA    Probe Info 
SKOV3 SNV: p.E278G DBIA    Probe Info 
SNGM SNV: p.R120Q DBIA    Probe Info 
T98G SNV: p.A511S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K202(3.43); K207(7.44); K424(5.31); K473(3.77)  LDD0277  [2]
ONAyne
 Probe Info  		K207(10.00)  LDD0275  [2]
OPA-S-S-alkyne
 Probe Info  		K551(0.82)  LDD3494  [3]
Probe 1
 Probe Info  		Y132(9.67); Y286(68.13); Y289(153.33); Y524(12.45)  LDD3495  [4]
BTD
 Probe Info  		C75(2.68)  LDD1700  [5]
HHS-475
 Probe Info  		Y289(1.07); Y308(1.84)  LDD0264  [6]
HHS-465
 Probe Info  		Y286(6.78); Y289(10.00)  LDD2237  [7]
DBIA
 Probe Info  		C185(1.02); C190(1.02)  LDD0078  [8]
5E-2FA
 Probe Info  		H80(0.00); H140(0.00); H59(0.00)  LDD2235  [9]
m-APA
 Probe Info  		H140(0.00); H59(0.00)  LDD2231  [9]
N1
 Probe Info  		N.A.  LDD0245  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C166(0.00); C75(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C166(0.00); C185(0.00); C190(0.00); C75(0.00)  LDD0037  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
IPM
 Probe Info  		N.A.  LDD0005  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
TFBX
 Probe Info  		C190(0.00); C215(0.00)  LDD0148  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		C190(0.00); C75(0.00)  LDD0217  [17]
Methacrolein
 Probe Info  		C75(0.00); C215(0.00)  LDD0218  [17]
W1
 Probe Info  		C215(0.00); C212(0.00); C166(0.00)  LDD0236  [18]
NAIA_5
 Probe Info  		C166(0.00); C32(0.00); C193(0.00); C75(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C75(0.85)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C75(1.57)  LDD2112  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C75(1.03)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C75(1.14); C190(0.94); C185(1.17)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C75(1.16); C190(0.98)  LDD2152  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C75(0.52)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C75(0.66)  LDD2131  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C212(3.61)  LDD0372  [21]
 LDCM0214  AC1 HCT 116 C185(1.02); C166(1.15); C190(0.95); C212(0.82)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C185(0.96); C166(1.16); C190(0.98); C212(1.12)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C185(0.87); C166(0.90); C190(0.94); C212(0.77)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C185(0.84); C166(0.94); C190(0.92); C212(0.80)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C185(0.97); C166(0.90); C190(1.01); C212(0.96)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C185(1.01); C166(1.07); C190(1.09); C212(1.00)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C185(0.96); C166(1.02); C190(0.99); C212(0.81)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C185(0.97); C166(1.10); C190(1.07); C212(1.09)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C185(0.99); C166(1.11); C190(1.20); C212(1.05)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C185(0.87); C166(1.03); C190(1.08); C212(0.94)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C185(0.84); C166(0.90); C190(0.95); C212(0.83)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C185(0.86); C166(0.91); C190(0.89); C212(0.85)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C185(1.15); C166(1.16); C190(1.06); C212(1.26)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C185(0.88); C166(1.11); C190(0.93); C212(0.93)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C185(0.94); C166(1.00); C190(0.92); C212(1.06)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C185(0.92); C166(1.03); C190(1.04); C212(0.95)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C185(0.86); C166(1.02); C190(0.99); C212(1.40)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C185(0.97); C166(1.01); C190(1.14); C212(1.17)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C185(0.55); C166(1.27); C190(1.16); C212(1.27)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C185(1.15); C166(1.27); C190(0.85); C212(1.37)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C185(0.61); C166(1.16); C190(0.97); C212(1.22)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C185(0.81); C166(1.06); C190(1.07); C212(1.28)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C185(0.79); C166(1.13); C190(1.10); C212(1.20)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C185(0.93); C166(1.08); C190(0.94); C212(1.16)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C185(1.15); C166(1.20); C190(1.20); C212(1.04)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C185(0.85); C166(1.02); C190(0.93); C212(1.35)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C185(0.77); C166(1.17); C190(1.12); C212(1.17)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C185(0.55); C166(0.99); C190(0.90); C212(0.98)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C185(1.25); C166(0.98); C190(0.90); C212(1.19)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C185(0.79); C166(1.07); C190(1.04); C212(1.22)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C185(1.04); C166(1.25); C190(0.97); C212(1.10)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C185(0.69); C166(1.19); C190(0.85); C212(1.27)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C185(0.33); C166(1.15); C190(0.80); C212(1.04)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C185(0.24); C166(0.83); C190(0.54); C212(0.49)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C185(0.27); C166(1.00); C190(1.02); C212(0.61)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C185(0.27); C166(0.79); C190(0.60); C212(0.51)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C185(0.27); C166(0.98); C190(0.56); C212(0.51)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C185(0.30); C166(1.07); C190(0.71); C212(0.79)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C185(0.29); C166(1.12); C190(0.79); C212(0.69)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C185(0.32); C166(1.04); C190(0.69); C212(0.68)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C185(0.35); C166(1.02); C190(0.66); C212(0.65)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C185(0.36); C166(1.07); C190(0.58); C212(0.61)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C185(0.35); C166(1.09); C190(0.77); C212(0.65)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C185(0.31); C166(1.16); C190(0.69); C212(0.73)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C185(1.04); C166(1.13); C190(0.99); C212(1.07)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C185(0.31); C166(1.12); C190(0.81); C212(0.64)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C185(0.31); C166(1.12); C190(0.71); C212(0.75)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C185(0.36); C166(1.03); C190(0.54); C212(0.60)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C185(1.01); C166(0.92); C190(1.06); C212(0.91)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C75(0.50); C185(1.06); C166(1.14); C215(1.23)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C75(0.60); C215(0.98); C212(0.98); C185(1.00)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C75(0.49); C185(0.95); C212(1.08); C190(1.11)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C75(0.48); C185(0.96); C166(1.18); C212(1.24)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C75(0.42); C185(1.07); C212(1.28); C215(1.38)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C75(0.47); C185(1.00); C212(1.21); C190(1.27)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C190(0.99); C75(0.99); C185(1.04); C166(1.07)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C75(0.67); C185(0.85); C190(0.96); C215(1.03)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C75(0.67); C185(0.99); C215(1.01); C212(1.10)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C75(0.49); C185(0.99); C190(1.29); C212(1.31)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C75(0.41); C185(1.10); C212(1.55); C166(1.64)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C185(0.97); C166(1.21); C190(1.31); C212(1.19)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C185(0.94); C166(1.36); C190(1.37); C212(1.21)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C185(0.93); C166(1.02); C190(1.10); C212(1.19)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C185(1.04); C166(1.04); C190(1.14); C212(1.08)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C190(0.76); C75(0.78); C212(0.90); C215(0.96)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C75(0.60); C212(0.84); C190(1.06); C215(1.18)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C75(0.71); C190(0.81); C212(1.09); C215(1.13)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C190(0.88); C215(0.90); C212(0.95); C185(1.00)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C190(0.79); C75(0.84); C166(1.10); C215(1.11)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C75(0.66); C190(0.86); C166(1.08); C212(1.23)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C75(0.91); C190(0.93); C166(1.05); C215(1.11)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C75(0.77); C212(0.86); C190(0.87); C166(1.01)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C75(0.81); C212(0.97); C190(0.99); C166(1.00)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C166(1.03); C75(1.09); C215(1.28); C212(1.45)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C75(0.85); C166(0.99); C215(1.26); C212(1.47)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C75(0.75); C166(1.00); C215(1.26); C212(1.44)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C75(0.72); C166(1.04); C215(1.39); C212(1.62)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C75(0.59); C166(1.03); C215(1.32); C212(1.47)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C215(0.84); C190(0.87); C185(0.91); C212(0.92)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C75(0.60); C166(1.17); C215(1.25); C212(1.40)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C75(0.69); C166(1.05); C215(1.25); C212(1.49)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C75(0.57); C166(1.15); C215(1.38); C212(1.62)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C75(0.71); C166(1.07); C215(1.62); C212(1.63)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C75(0.73); C166(1.07); C215(1.33); C212(1.60)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C212(0.83); C215(0.83); C166(1.01); C190(1.13)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C166(1.03); C190(1.12); C212(1.13); C215(1.13)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C166(0.99); C190(1.11); C212(1.12); C215(1.12)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C75(0.94); C185(1.03); C166(1.07); C190(1.10)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C190(1.06); C75(1.06); C166(1.08); C212(1.18)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C185(0.78); C215(0.83); C212(0.84); C190(0.84)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C166(1.08); C212(1.08); C215(1.08); C75(1.10)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C212(1.14); C215(1.14); C75(1.20); C190(1.21)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C166(1.02); C75(1.09); C212(1.13); C215(1.13)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C75(0.96); C212(1.13); C215(1.13); C185(1.19)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C75(1.02); C166(1.03); C190(1.21); C212(1.23)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C166(1.01); C212(1.32); C215(1.32); C75(1.37)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C185(0.67); C166(0.94); C212(0.95); C215(0.95)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C185(0.77); C190(0.92); C212(0.93); C215(0.93)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C185(0.75); C75(0.93); C190(1.00); C212(1.05)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C185(0.74); C75(0.75); C212(1.16); C215(1.16)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C212(0.71); C215(0.82); C190(0.84); C185(0.86)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C185(0.65); C75(0.72); C166(1.11); C190(1.12)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C166(0.86); C185(0.95); C190(1.01); C212(1.05)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C185(0.95); C166(0.96); C75(0.99); C212(1.04)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C185(0.89); C75(0.89); C166(1.00); C190(1.00)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C185(0.77); C75(0.92); C190(1.08); C166(1.11)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C75(0.77); C185(0.93); C190(1.15); C212(1.17)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C75(0.79); C185(0.83); C190(1.37); C166(1.44)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C75(0.72); C215(0.85); C212(0.86); C185(0.96)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C75(0.63); C215(0.78); C212(0.80); C185(0.94)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C75(0.58); C215(0.75); C212(0.77); C185(0.98)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C75(0.74); C185(0.98); C190(1.00); C215(1.15)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C75(0.58); C215(1.00); C185(1.01); C190(1.01)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C75(0.58); C215(0.89); C212(0.95); C185(1.00)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C75(0.57); C215(0.93); C185(0.93); C212(0.93)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C75(0.60); C212(0.92); C215(0.94); C185(0.98)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C75(0.74); C215(0.96); C212(0.98); C185(0.99)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C75(0.59); C215(0.71); C190(0.72); C212(0.73)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C75(0.65); C215(0.66); C212(0.68); C190(0.71)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C75(0.49); C190(0.74); C185(0.76); C215(0.79)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C75(0.95); C166(0.96); C212(1.39); C190(1.39)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C75(0.81); C166(0.98); C190(1.28); C212(1.38)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C75(0.88); C190(0.90); C185(0.90); C166(1.12)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C166(0.91); C75(0.91); C212(1.12); C190(1.19)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C166(0.85); C75(1.23); C212(1.25); C190(1.26)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C166(0.90); C75(0.94); C190(1.38); C212(1.39)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C75(0.89); C166(1.06); C190(1.34); C212(1.37)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C75(0.83); C166(1.08); C212(1.25); C190(1.28)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C75(0.71); C166(1.13); C190(1.37); C185(1.77)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C166(0.92); C75(1.07); C212(1.32); C190(1.38)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C75(0.93); C166(1.01); C190(1.35); C212(1.48)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C166(0.83); C75(0.96); C190(1.22); C212(1.46)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C166(0.82); C75(1.12); C190(1.20); C212(1.29)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C75(0.79); C185(0.87); C190(0.90); C212(1.15)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C75(0.90); C166(0.93); C190(1.40); C212(1.62)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C166(0.86); C75(0.91); C190(1.29); C212(1.46)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C75(0.76); C166(1.16); C212(1.42); C190(1.42)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C185(0.54); C75(0.62); C190(1.05); C212(1.12)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C185(0.49); C75(0.66); C212(1.06); C190(1.10)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C185(0.41); C75(0.71); C212(0.88); C215(1.03)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C185(0.53); C75(0.77); C212(0.95); C190(1.00)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C185(0.57); C190(0.78); C75(0.86); C212(0.91)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C185(0.43); C190(0.84); C75(0.84); C212(1.19)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C185(0.51); C75(0.64); C190(0.91); C166(1.18)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C190(0.76); C185(0.85); C212(0.94); C215(0.96)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C185(0.70); C75(0.74); C190(1.07); C212(1.30)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C185(0.54); C75(0.72); C190(1.01); C212(1.27)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C185(0.58); C75(0.68); C190(0.93); C212(1.10)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C185(0.44); C75(0.84); C190(0.92); C212(1.07)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C185(0.57); C75(0.69); C190(0.85); C212(1.02)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C185(0.48); C75(0.80); C190(0.95); C212(1.02)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C185(0.57); C75(0.62); C190(1.03); C212(1.26)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C75(0.73); C185(1.01); C212(1.16); C166(1.31)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C75(0.73); C190(0.86); C215(0.88); C185(0.90)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C75(0.49)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C75(1.14)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C185(1.00); C166(1.10); C190(0.99); C212(1.19)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C75(0.90); C185(1.00); C190(1.01); C212(1.17)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C75(0.77); C185(0.91); C190(0.98); C166(1.45)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C185(1.02); C190(1.02)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C75(0.68)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C75(1.72)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C212(0.84); C185(0.87); C166(0.90); C190(0.90)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C75(0.77); C185(0.96); C190(1.00); C166(1.02)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C212(0.94); C190(0.95); C185(1.06); C215(1.10)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C75(0.85); C166(1.12); C190(1.14); C212(1.18)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C190(0.87); C185(0.89); C75(0.94); C166(0.96)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C190(0.92); C212(0.93); C166(0.95); C185(1.01)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C185(0.82); C190(0.82); C212(0.91); C166(0.98)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C75(0.64); C190(0.74); C212(0.80); C215(0.91)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C75(0.48); C190(0.95); C212(0.96); C215(1.03)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C75(0.61); C190(0.90); C212(0.95); C215(1.01)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C75(0.54); C190(0.78); C212(0.94); C215(0.98)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C75(0.65); C190(0.73); C215(0.99); C212(1.02)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C185(0.63); C190(0.67); C75(0.95); C215(1.05)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C75(0.52); C190(0.68); C212(0.80); C215(0.83)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C75(0.68); C190(0.75); C212(0.81); C215(0.90)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C166(0.82); C75(0.91); C215(1.06); C212(1.18)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C75(0.58); C166(1.02); C215(1.26); C212(1.45)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C75(0.67); C166(0.82); C215(1.26); C212(1.48)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C75(0.67); C166(0.95); C215(1.47); C190(1.58)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C75(0.77); C166(1.07); C215(1.52); C190(1.61)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C75(0.76); C185(0.88); C166(1.00); C190(1.30)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C166(1.05); C75(1.06); C190(1.10); C185(1.15)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C75(1.07); C212(1.15); C215(1.15); C190(1.17)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C75(0.81); C190(0.89); C185(0.89); C215(1.26)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C75(0.98); C190(1.10); C166(1.12); C212(1.14)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C185(0.73); C75(0.74); C190(1.05); C166(1.52)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C75(0.84); C185(0.85); C212(0.93); C215(0.93)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C185(0.55); C75(0.71); C190(0.86); C212(0.86)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C185(0.64); C75(0.85); C190(1.01); C166(1.19)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C75(0.74); C212(0.76); C215(0.77); C190(0.90)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C75(0.68); C190(0.98); C185(1.01); C166(1.12)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C75(0.63); C215(0.77); C212(0.80); C190(0.96)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C75(0.68); C215(0.80); C212(0.84); C185(0.91)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C75(0.77); C185(0.82); C190(0.82); C215(1.00)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C215(0.88); C190(0.90); C75(0.91); C212(0.93)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C185(0.78); C190(0.79); C75(0.80); C215(1.11)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C75(0.74); C215(0.94); C166(1.05); C190(1.15)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C75(0.68); C185(0.89); C215(0.92); C212(0.93)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C75(0.68); C215(1.17); C185(1.20); C212(1.24)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C75(0.69); C215(0.83); C212(0.95); C185(1.01)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C215(1.03); C185(1.03); C75(1.05); C166(1.07)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C75(0.67); C215(1.03); C185(1.05); C212(1.21)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C75(0.63); C215(0.79); C212(0.88); C185(0.97)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C75(0.67); C215(0.92); C212(1.05); C185(1.23)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C75(0.72); C215(0.99); C212(1.07); C190(1.21)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C75(0.74); C215(0.93); C212(1.02); C185(1.29)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C185(1.18); C166(1.32); C190(1.33); C212(1.06)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C185(1.22); C166(1.23); C190(1.28); C212(1.27)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C185(1.02); C166(1.16); C190(1.18); C212(1.23)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C185(1.14); C166(1.21); C190(1.34); C212(1.07)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C185(1.16); C166(1.39); C190(1.35); C212(1.14)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C185(0.95); C166(1.08); C190(1.02); C212(1.05)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C185(1.24); C166(1.26); C190(1.23); C212(1.03)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C185(0.78); C166(0.91); C190(0.95); C212(1.02)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C185(1.00); C166(1.14); C190(1.07); C212(0.89)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C185(0.92); C166(0.79); C190(0.95); C212(0.84)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C185(0.94); C166(1.18); C190(1.19); C212(1.06)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C185(0.92); C166(1.14); C190(1.08); C212(1.21)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C185(0.83); C166(1.24); C190(1.03); C212(0.92)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C185(0.90); C166(1.01); C190(1.09); C212(1.23)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C185(1.06); C166(0.90); C190(1.15); C212(1.10)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C185(1.05); C166(0.94); C190(0.99); C212(1.23)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C185(0.78); C166(0.94); C190(1.01); C212(1.16)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C185(1.02); C166(0.94); C190(1.15); C212(0.96)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C185(0.90); C166(1.30); C190(1.20); C212(1.25)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C185(1.06); C166(1.07); C190(1.23); C212(1.21)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C185(0.95); C166(1.08); C190(1.16); C212(0.94)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C185(0.84); C166(1.31); C190(1.15); C212(1.10)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C185(1.02); C166(0.85); C190(0.96); C215(0.90)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C185(1.07); C166(0.84); C190(0.98); C215(0.85)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C185(1.17); C166(0.84); C190(1.06); C215(0.94)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C185(0.99); C166(0.85); C190(1.00); C215(0.97)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C185(1.06); C166(1.09); C190(1.05); C212(1.12)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C185(0.96); C166(0.76); C190(0.94); C215(0.87)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C185(1.01); C166(0.91); C190(0.97); C215(1.03)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C185(1.19); C166(0.91); C190(1.07); C215(1.02)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C185(1.07); C166(0.88); C190(1.01); C215(0.90)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C185(1.11); C166(0.94); C190(1.06); C215(0.90)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C185(1.15); C166(0.87); C190(1.05); C215(0.84)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C185(1.13); C166(0.99); C190(1.02); C215(0.97)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C185(1.08); C166(0.80); C190(1.00); C215(0.85)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C185(1.15); C166(0.88); C190(1.13); C215(0.99)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C185(1.01); C166(0.92); C190(1.02); C215(0.95)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C185(0.94); C166(1.10); C190(0.93); C212(0.99)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C185(1.18); C166(0.83); C190(1.02); C215(0.98)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C185(0.77); C166(1.17); C190(0.87); C212(1.13)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C185(0.75); C166(1.24); C190(0.84); C212(1.16)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C185(0.92); C166(1.12); C190(0.95); C212(1.26)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C185(1.66); C166(1.38); C190(1.30); C212(1.34)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C185(0.95); C166(1.19); C190(0.95); C212(0.81)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C185(1.26); C166(1.36); C190(1.15); C212(1.44)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C185(1.39); C166(1.24); C190(1.26); C212(1.05)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C185(1.07); C166(1.24); C190(1.08); C212(1.19)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C185(0.99); C166(1.26); C190(1.05); C212(1.40)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C185(0.78); C166(1.29); C190(0.79); C212(1.10)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C185(0.97); C166(1.35); C190(1.05); C212(1.21)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C185(1.35); C166(1.29); C190(1.24); C212(0.93)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C185(0.96); C166(1.29); C190(0.96); C212(1.06)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C185(0.92); C166(1.19); C190(1.03); C212(1.01)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C185(1.10); C166(1.25); C190(1.08); C212(1.17)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C185(0.92); C166(0.90); C190(0.98); C212(0.79)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C185(0.79); C166(0.93); C190(0.87); C212(0.72)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C185(0.92); C166(1.08); C190(0.91); C212(0.86)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C185(0.86); C166(1.10); C190(1.01); C212(0.88)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C185(1.05); C166(1.17); C190(1.01); C212(0.92)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C185(0.94); C166(0.91); C190(1.00); C212(0.80)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C185(0.71); C166(0.93); C190(0.91); C212(0.65)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C185(0.68); C166(1.25); C190(0.80); C212(0.66)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C185(0.86); C166(1.14); C190(0.95); C212(0.83)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C185(1.01); C166(1.22); C190(1.09); C212(0.93)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C185(1.01); C166(0.99); C190(1.03); C212(0.85)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C185(0.94); C166(1.02); C190(1.06); C212(0.81)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C185(0.66); C166(1.01); C190(1.12); C212(0.65)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C185(0.69); C166(1.14); C190(1.02); C212(0.69)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C185(0.82); C166(1.41); C190(0.97); C212(0.74)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C185(1.06); C166(1.20); C190(1.02); C212(1.20)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C185(0.60); C166(0.74); C190(0.76); C212(0.57)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C185(1.03); C166(1.00); C190(0.97); C212(1.01)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C185(1.11); C166(0.97); C190(0.91); C212(0.99)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C185(0.96); C166(1.10); C190(0.89); C212(0.90)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C185(1.18); C166(1.07); C190(0.99); C212(0.81)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C185(0.90); C166(0.96); C190(0.86); C212(0.92)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C185(0.94); C166(1.10); C190(0.91); C212(1.02)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C185(0.92); C166(1.06); C190(0.81); C212(0.83)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C185(1.06); C166(1.08); C190(0.92); C212(0.91)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C185(1.12); C166(1.29); C190(0.93); C212(1.17)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C166(1.07); C32(1.04); C190(0.84); C185(0.99)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C75(2.52); C185(0.89); C190(0.84)  LDD1702  [5]
 LDCM0625  F8 Ramos 1.31  LDD2187  [23]
 LDCM0572  Fragment10 Ramos 1.20  LDD2189  [23]
 LDCM0573  Fragment11 Ramos 1.17  LDD2190  [23]
 LDCM0574  Fragment12 Ramos 0.76  LDD2191  [23]
 LDCM0575  Fragment13 Ramos 2.95  LDD2192  [23]
 LDCM0576  Fragment14 Ramos 0.89  LDD2193  [23]
 LDCM0579  Fragment20 Ramos 0.56  LDD2194  [23]
 LDCM0580  Fragment21 Ramos 1.26  LDD2195  [23]
 LDCM0582  Fragment23 Ramos 0.88  LDD2196  [23]
 LDCM0578  Fragment27 Ramos 0.47  LDD2197  [23]
 LDCM0586  Fragment28 Ramos 0.55  LDD2198  [23]
 LDCM0588  Fragment30 Ramos 1.10  LDD2199  [23]
 LDCM0589  Fragment31 Ramos 2.56  LDD2200  [23]
 LDCM0590  Fragment32 Ramos 0.55  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C185(0.94); C166(1.29); C190(1.02); C212(1.07)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos 0.65  LDD2203  [23]
 LDCM0566  Fragment4 Ramos 0.86  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C185(0.71); C166(1.13); C190(1.26); C212(1.74)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos 1.19  LDD2204  [23]
 LDCM0614  Fragment56 Ramos 1.51  LDD2205  [23]
 LDCM0569  Fragment7 Ramos 0.63  LDD2186  [23]
 LDCM0571  Fragment9 Ramos 0.74  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y289(1.07); Y308(1.84)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y308(1.09)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y289(0.75)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y289(1.01); Y308(3.24)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y289(1.41); Y308(1.94)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C190(1.45); C215(1.50); C212(1.91)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C190(1.14); C215(1.16); C212(1.54)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C190(1.50); C215(1.37); C212(0.93)  LDD0082  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C75(0.90)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C75(0.73)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0224  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C75(0.81)  LDD2089  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C75(1.16)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C75(1.20)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C75(0.76)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C75(1.28)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C75(1.26); C190(1.13)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C75(0.75)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C75(1.02)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C75(1.00)  LDD2104  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C75(1.05)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C75(1.02); C190(0.91); C185(0.96)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C75(1.22)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C75(0.69); C190(0.96)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C75(1.61); C190(0.93); C185(1.05)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C75(0.80)  LDD2115  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C75(1.06)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C75(1.75)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C75(0.75)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C75(0.92)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C75(1.07); C190(0.83)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C75(0.79)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C75(0.90); C190(0.99); C185(1.02)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C75(1.12)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C75(1.03); C190(0.75); C185(0.93)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C75(0.83)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C75(1.08); C190(0.93)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C75(0.73)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C75(0.71)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C75(0.88); C190(0.96); C185(1.18)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C75(1.48); C190(1.35); C185(0.99)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C75(1.01); C190(0.98)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C75(2.68)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C75(1.00); C190(0.96)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C75(0.98)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C75(1.22)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C75(2.53); C185(0.99)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C75(0.92); C190(1.07)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C75(0.74)  LDD2148  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C75(0.44)  LDD2150  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C75(1.11)  LDD2151  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C185(1.45)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C185(0.18)  LDD2207  [24]
 LDCM0021  THZ1 HCT 116 C212(1.40); C215(1.40); C185(1.33); C190(1.33)  LDD2173  [8]
 LDCM0112  W16 Hep-G2 C215(0.50); C190(0.58)  LDD0239  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fidgetin (FIGN) AAA ATPase family Q5HY92
Adenine nucleotide translocase lysine N-methyltransferase (ANTKMT) ANT/ATPSC lysine N-methyltransferase family Q9BQD7
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) Complex I NDUFB10 subunit family O96000
Formimidoyltransferase-cyclodeaminase (FTCD) Cyclodeaminase/cyclohydrolase family; Formiminotransferase family O95954
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (GATC) GatC family O43716
Phospholipase A and acyltransferase 1 (PLAAT1) H-rev107 family Q9HDD0
Mediator of RNA polymerase II transcription subunit 21 (MED21) Mediator complex subunit 21 family Q13503
Glutamine-dependent NAD(+) synthetase (NADSYN1) NAD synthetase family Q6IA69
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Proteasome subunit beta type-11 (PSMB11) Peptidase T1B family A5LHX3
Proteasome subunit beta type-4 (PSMB4) Peptidase T1B family P28070
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Serine/threonine-protein kinase 32C (STK32C) Ser/Thr protein kinase family Q86UX6
L-serine dehydratase/L-threonine deaminase (SDS) Serine/threonine dehydratase family P20132
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
E3 ubiquitin-protein ligase TRIM17 (TRIM17) TRIM/RBCC family Q9Y577
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1) . P51178
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Secretion-regulating guanine nucleotide exchange factor (SERGEF) . Q9UGK8
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PPP2R3B) . Q9Y5P8
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Uncharacterized protein C20orf173 (C20orf173) . Q96LM9
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 7 (EXOC7) EXO70 family Q9UPT5
Importin-4 (IPO4) Importin beta family Q8TEX9
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Sorting nexin-7 (SNX7) Sorting nexin family Q9UNH6
Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock transcription factor, Y-linked (HSFY1; HSFY2) HSF family Q96LI6
Krueppel-like factor 4 (KLF4) Krueppel C2H2-type zinc-finger protein family O43474
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
POU domain class 2-associating factor 1 (POU2AF1) POU2AF family Q16633
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Forkhead box protein D4-like 1 (FOXD4L1) . Q9NU39
Paired box protein Pax-5 (PAX5) . Q02548
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
T-box transcription factor TBX19 (TBX19) . O60806
Transcriptional adapter 2-alpha (TADA2A) . O75478
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2C adrenergic receptor (ADRA2C) G-protein coupled receptor 1 family P18825
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) CEA family P40199
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon alpha-16 (IFNA16) Alpha/beta interferon family P05015
Other
Click To Hide/Show 120 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Alpha-actinin-3 (ACTN3) Alpha-actinin family Q08043
Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1) BLOC1S1 family P78537
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Coiled-coil domain-containing protein 103 (CCDC103) CCDC103/PR46b family Q8IW40
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cilia- and flagella-associated protein 68 (CFAP68) CFAP68 family Q9H5F2
Conserved oligomeric Golgi complex subunit 8 (COG8) COG8 family Q96MW5
G1/S-specific cyclin-D3 (CCND3) Cyclin family P30281
DPY30 domain-containing protein 1 (DYDC1) Dpy-30 family Q8WWB3
Golgin subfamily A member 7B (GOLGA7B) ERF4 family Q2TAP0
Fibrillin-1 (FBN1) Fibrillin family P35555
Secretin (SCT) Glucagon family P09683
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Inhibitor of growth protein 5 (ING5) ING family Q8WYH8
Integrator complex subunit 4 (INTS4) Integrator subunit 4 family Q96HW7
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 13 (KRT13) Intermediate filament family P13646
Keratin, type I cytoskeletal 14 (KRT14) Intermediate filament family P02533
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type I cytoskeletal 18 (KRT18) Intermediate filament family P05783
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 24 (KRT24) Intermediate filament family Q2M2I5
Keratin, type I cytoskeletal 25 (KRT25) Intermediate filament family Q7Z3Z0
Keratin, type I cytoskeletal 26 (KRT26) Intermediate filament family Q7Z3Y9
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 39 (KRT39) Intermediate filament family Q6A163
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cuticular Hb2 (KRT82) Intermediate filament family Q9NSB4
Keratin, type II cuticular Hb6 (KRT86) Intermediate filament family O43790
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Keratin, type II cytoskeletal 3 (KRT3) Intermediate filament family P12035
Keratin, type II cytoskeletal 6A (KRT6A) Intermediate filament family P02538
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Phakinin (BFSP2) Intermediate filament family Q13515
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) JAKMIP family Q96AA8
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Protein LDOC1 (LDOC1) LDOC1 family O95751
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
Mediator of RNA polymerase II transcription subunit 30 (MED30) Mediator complex subunit 30 family Q96HR3
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Mediator of RNA polymerase II transcription subunit 7 (MED7) Mediator complex subunit 7 family O43513
MIF4G domain-containing protein (MIF4GD) MIF4GD family A9UHW6
Protein Mis18-beta (OIP5) Mis18 family O43482
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) MISS family Q8NDC0
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
N-myc-interactor (NMI) NMI family Q13287
Outer dynein arm-docking complex subunit 1 (ODAD1) ODA1/DCC2 family Q96M63
Odontogenic ameloblast-associated protein (ODAM) ODAM family A1E959
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
R-spondin-4 (RSPO4) R-spondin family Q2I0M5
Exocyst complex component 3-like protein (EXOC3L1) SEC6 family Q86VI1
Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B) Small Tim family Q9Y5J6
Sperm microtubule inner protein 6 (SPMIP6) SMRP1 family Q8NCR6
Kinetochore protein Spc25 (SPC25) SPC25 family Q9HBM1
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
Signal transducing adapter molecule 1 (STAM) STAM family Q92783
Stathmin-3 (STMN3) Stathmin family Q9NZ72
Syntaxin-11 (STX11) Syntaxin family O75558
T-complex protein 11-like protein 2 (TCP11L2) TCP11 family Q8N4U5
Tektin-1 (TEKT1) Tektin family Q969V4
Tektin-5 (TEKT5) Tektin family Q96M29
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Ciliary microtubule inner protein 2A (CIMIP2A) UPF0605 family Q6J272
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
Arfaptin-2 (ARFIP2) . P53365
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4
Bcl-2-binding component 3, isoforms 3/4 (BBC3) . Q96PG8
BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL) . Q6AI39
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Cleavage stimulation factor subunit 2 tau variant (CSTF2T) . Q9H0L4
CTTNBP2 N-terminal-like protein (CTTNBP2NL) . Q9P2B4
DAZ-associated protein 2 (DAZAP2) . Q15038
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Epidermal growth factor-like protein 7 (EGFL7) . Q9UHF1
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
Guanylyl cyclase-activating protein 3 (GUCA1C) . O95843
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) . P52272
Huntingtin-associated protein 1 (HAP1) . P54257
Kinetochore-associated protein DSN1 homolog (DSN1) . Q9H410
Leucine rich adaptor protein 1 (LURAP1) . Q96LR2
Leucine-rich repeat-containing protein 61 (LRRC61) . Q9BV99
LIM domain transcription factor LMO4 (LMO4) . P61968
Melanoma-associated antigen B4 (MAGEB4) . O15481
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Peflin (PEF1) . Q9UBV8
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
Protein FAM185A (FAM185A) . Q8N0U4
Protein moonraker (KIAA0753) . Q2KHM9
Protein TFG (TFG) . Q92734
Ras association domain-containing protein 4 (RASSF4) . Q9H2L5
Rhombotin-1 (LMO1) . P25800
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
Spermatogenesis-associated protein 12 (SPATA12) . Q7Z6I5
TNF receptor-associated factor 1 (TRAF1) . Q13077
TP53-binding protein 1 (TP53BP1) . Q12888
Ubiquilin-2 (UBQLN2) . Q9UHD9
Ubiquilin-like protein (UBQLNL) . Q8IYU4
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Uncharacterized protein C3orf36 (C3orf36) . Q3SXR2
Uncharacterized protein KIAA0825 (KIAA0825) . Q8IV33
Vinexin (SORBS3) . O60504

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Citric Acid Small molecular drug DB04272

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.