Details of the Target

General Information of Target

Target ID LDTP04113
Target Name Glucosamine-6-phosphate isomerase 1 (GNPDA1)
Gene Name GNPDA1
Gene ID 10007
Synonyms
GNPI; HLN; KIAA0060; Glucosamine-6-phosphate isomerase 1; EC 3.5.99.6; Glucosamine-6-phosphate deaminase 1; GNPDA 1; GlcN6P deaminase 1; Oscillin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGD
LSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDA
FEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD
EDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD
Target Bioclass
Enzyme
Family
Glucosamine/galactosamine-6-phosphate isomerase family
Subcellular location
Cytoplasm
Function
Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo.
Uniprot ID
P46926
Ensemble ID
ENST00000311337.11
HGNC ID
HGNC:4417

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.A163V .
MOLT4 SNV: p.L260F IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K264(10.00); K273(8.57)  LDD0277  [2]
Probe 1
 Probe Info  		Y56(18.15); Y270(19.30)  LDD3495  [3]
BTD
 Probe Info  		C239(0.25)  LDD2106  [4]
AHL-Pu-1
 Probe Info  		C48(2.01)  LDD0171  [5]
HHS-482
 Probe Info  		Y34(1.07)  LDD0285  [6]
HHS-475
 Probe Info  		Y34(0.81); Y56(1.17); Y270(1.37)  LDD0264  [7]
HHS-465
 Probe Info  		Y34(10.00)  LDD2237  [8]
Acrolein
 Probe Info  		N.A.  LDD0222  [9]
DBIA
 Probe Info  		C48(1.66)  LDD0080  [10]
ATP probe
 Probe Info  		K50(0.00); K51(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C118(0.00); C239(0.00); C48(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C239(0.00); C48(0.00)  LDD0037  [12]
SF
 Probe Info  		N.A.  LDD0028  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
AOyne
 Probe Info  		7.80  LDD0443  [16]
NAIA_5
 Probe Info  		C48(0.00); C239(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C48(2.01)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C48(1.00)  LDD0812  [10]
 LDCM0215  AC10 HEK-293T C48(1.05)  LDD0813  [10]
 LDCM0216  AC100 HCT 116 C48(0.70)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C48(0.58)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C48(0.65)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C48(0.68)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C48(0.65)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C48(0.50)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C48(0.66)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C48(0.82)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C48(0.40)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C48(0.43)  LDD0542  [10]
 LDCM0226  AC11 HEK-293T C48(0.99)  LDD0824  [10]
 LDCM0227  AC110 HCT 116 C48(0.44)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C48(0.56)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C48(0.78)  LDD0546  [10]
 LDCM0230  AC113 HEK-293T C48(0.60)  LDD0828  [10]
 LDCM0231  AC114 HEK-293T C48(0.86)  LDD0829  [10]
 LDCM0232  AC115 HEK-293T C48(0.68)  LDD0830  [10]
 LDCM0233  AC116 HEK-293T C48(0.91)  LDD0831  [10]
 LDCM0234  AC117 HEK-293T C48(0.96)  LDD0832  [10]
 LDCM0235  AC118 HEK-293T C48(0.86)  LDD0833  [10]
 LDCM0236  AC119 HEK-293T C48(1.42)  LDD0834  [10]
 LDCM0237  AC12 HEK-293T C48(0.97)  LDD0835  [10]
 LDCM0238  AC120 HEK-293T C48(0.82)  LDD0836  [10]
 LDCM0239  AC121 HEK-293T C48(0.83)  LDD0837  [10]
 LDCM0240  AC122 HEK-293T C48(0.80)  LDD0838  [10]
 LDCM0241  AC123 HEK-293T C48(0.86)  LDD0839  [10]
 LDCM0242  AC124 HEK-293T C48(0.99)  LDD0840  [10]
 LDCM0243  AC125 HEK-293T C48(1.11)  LDD0841  [10]
 LDCM0244  AC126 HEK-293T C48(0.91)  LDD0842  [10]
 LDCM0245  AC127 HEK-293T C48(1.16)  LDD0843  [10]
 LDCM0246  AC128 HEK-293T C48(0.36)  LDD0844  [10]
 LDCM0247  AC129 HEK-293T C48(0.70)  LDD0845  [10]
 LDCM0249  AC130 HEK-293T C48(0.94)  LDD0847  [10]
 LDCM0250  AC131 HEK-293T C48(0.62)  LDD0848  [10]
 LDCM0251  AC132 HEK-293T C48(0.63)  LDD0849  [10]
 LDCM0252  AC133 HEK-293T C48(0.66)  LDD0850  [10]
 LDCM0253  AC134 HEK-293T C48(0.90)  LDD0851  [10]
 LDCM0254  AC135 HEK-293T C48(0.55)  LDD0852  [10]
 LDCM0255  AC136 HEK-293T C48(0.84)  LDD0853  [10]
 LDCM0256  AC137 HEK-293T C48(0.77)  LDD0854  [10]
 LDCM0257  AC138 HEK-293T C48(0.60)  LDD0855  [10]
 LDCM0258  AC139 HEK-293T C48(0.66)  LDD0856  [10]
 LDCM0259  AC14 HEK-293T C48(1.08)  LDD0857  [10]
 LDCM0260  AC140 HEK-293T C48(0.92)  LDD0858  [10]
 LDCM0261  AC141 HEK-293T C48(1.28)  LDD0859  [10]
 LDCM0262  AC142 HEK-293T C48(0.81)  LDD0860  [10]
 LDCM0263  AC143 HEK-293T C48(0.63)  LDD0861  [10]
 LDCM0264  AC144 HEK-293T C48(1.13)  LDD0862  [10]
 LDCM0265  AC145 HEK-293T C48(0.89)  LDD0863  [10]
 LDCM0266  AC146 HEK-293T C48(0.87)  LDD0864  [10]
 LDCM0267  AC147 HEK-293T C48(0.77)  LDD0865  [10]
 LDCM0268  AC148 HEK-293T C48(0.53)  LDD0866  [10]
 LDCM0269  AC149 HEK-293T C48(0.69)  LDD0867  [10]
 LDCM0270  AC15 HEK-293T C48(1.15)  LDD0868  [10]
 LDCM0271  AC150 HEK-293T C48(1.00)  LDD0869  [10]
 LDCM0272  AC151 HEK-293T C48(1.27)  LDD0870  [10]
 LDCM0273  AC152 HEK-293T C48(0.95)  LDD0871  [10]
 LDCM0274  AC153 HEK-293T C48(0.99)  LDD0872  [10]
 LDCM0621  AC154 HEK-293T C48(0.96)  LDD2162  [10]
 LDCM0622  AC155 HEK-293T C48(0.94)  LDD2163  [10]
 LDCM0623  AC156 HEK-293T C48(0.87)  LDD2164  [10]
 LDCM0624  AC157 HEK-293T C48(1.02)  LDD2165  [10]
 LDCM0276  AC17 HEK-293T C48(1.14)  LDD0874  [10]
 LDCM0277  AC18 HEK-293T C48(0.89)  LDD0875  [10]
 LDCM0278  AC19 HEK-293T C48(1.21)  LDD0876  [10]
 LDCM0279  AC2 HEK-293T C48(0.97)  LDD0877  [10]
 LDCM0280  AC20 HEK-293T C48(0.94)  LDD0878  [10]
 LDCM0281  AC21 HEK-293T C48(1.15)  LDD0879  [10]
 LDCM0282  AC22 HEK-293T C48(1.22)  LDD0880  [10]
 LDCM0283  AC23 HEK-293T C48(1.42)  LDD0881  [10]
 LDCM0284  AC24 HEK-293T C48(1.16)  LDD0882  [10]
 LDCM0285  AC25 PaTu 8988t C48(1.05)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C48(0.88)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C48(0.86)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C48(0.83)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C48(0.84)  LDD1168  [10]
 LDCM0290  AC3 HEK-293T C48(0.71)  LDD0888  [10]
 LDCM0291  AC30 PaTu 8988t C48(0.95)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C48(0.95)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C48(0.84)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C48(0.80)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C48(0.85)  LDD1174  [10]
 LDCM0296  AC35 HEK-293T C48(0.56)  LDD0894  [10]
 LDCM0297  AC36 HEK-293T C48(0.72)  LDD0895  [10]
 LDCM0298  AC37 HEK-293T C48(0.70)  LDD0896  [10]
 LDCM0299  AC38 HEK-293T C48(0.71)  LDD0897  [10]
 LDCM0300  AC39 HEK-293T C48(0.68)  LDD0898  [10]
 LDCM0301  AC4 HEK-293T C48(0.77)  LDD0899  [10]
 LDCM0302  AC40 HEK-293T C48(0.86)  LDD0900  [10]
 LDCM0303  AC41 HEK-293T C48(0.95)  LDD0901  [10]
 LDCM0304  AC42 HEK-293T C48(0.87)  LDD0902  [10]
 LDCM0305  AC43 HEK-293T C48(0.80)  LDD0903  [10]
 LDCM0306  AC44 HEK-293T C48(0.89)  LDD0904  [10]
 LDCM0307  AC45 HEK-293T C48(0.68)  LDD0905  [10]
 LDCM0308  AC46 HEK-293T C48(1.29)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C48(1.15)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C48(0.98)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C48(1.01)  LDD0909  [10]
 LDCM0312  AC5 HEK-293T C48(1.65)  LDD0910  [10]
 LDCM0313  AC50 HEK-293T C48(0.87)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C48(0.87)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C48(0.95)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C48(1.20)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C48(0.97)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C48(1.57)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C48(1.39)  LDD0917  [10]
 LDCM0320  AC57 HCT 116 C48(0.98)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C48(0.97)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C48(0.90)  LDD0639  [10]
 LDCM0323  AC6 HEK-293T C48(1.32)  LDD0921  [10]
 LDCM0324  AC60 HCT 116 C48(1.01)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C48(0.81)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C48(0.87)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C48(0.80)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C48(0.87)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C48(0.86)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C48(0.98)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C48(0.60)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C48(1.02)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C48(1.04)  LDD0650  [10]
 LDCM0334  AC7 HEK-293T C48(1.15)  LDD0932  [10]
 LDCM0335  AC70 HCT 116 C48(0.55)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C48(0.96)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C48(1.00)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C48(0.73)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C48(0.88)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C48(1.12)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C48(1.19)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C48(1.10)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C48(1.27)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C48(1.50)  LDD0661  [10]
 LDCM0345  AC8 HEK-293T C48(1.65)  LDD0943  [10]
 LDCM0346  AC80 HCT 116 C48(1.19)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C48(0.62)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C48(0.15)  LDD0665  [10]
 LDCM0349  AC83 HEK-293T C48(0.89)  LDD0947  [10]
 LDCM0350  AC84 HEK-293T C48(1.43)  LDD0948  [10]
 LDCM0351  AC85 HEK-293T C48(1.51)  LDD0949  [10]
 LDCM0352  AC86 HEK-293T C48(1.27)  LDD0950  [10]
 LDCM0353  AC87 HEK-293T C48(1.59)  LDD0951  [10]
 LDCM0354  AC88 HEK-293T C48(1.33)  LDD0952  [10]
 LDCM0355  AC89 HEK-293T C48(1.69)  LDD0953  [10]
 LDCM0357  AC90 HEK-293T C48(1.80)  LDD0955  [10]
 LDCM0358  AC91 HEK-293T C48(0.91)  LDD0956  [10]
 LDCM0359  AC92 HEK-293T C48(1.10)  LDD0957  [10]
 LDCM0360  AC93 HEK-293T C48(1.09)  LDD0958  [10]
 LDCM0361  AC94 HEK-293T C48(1.42)  LDD0959  [10]
 LDCM0362  AC95 HEK-293T C48(1.72)  LDD0960  [10]
 LDCM0363  AC96 HEK-293T C48(1.10)  LDD0961  [10]
 LDCM0364  AC97 HEK-293T C48(2.22)  LDD0962  [10]
 LDCM0365  AC98 HCT 116 C48(0.22)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C48(0.58)  LDD0683  [10]
 LDCM0248  AKOS034007472 HEK-293T C48(1.31)  LDD0846  [10]
 LDCM0356  AKOS034007680 HEK-293T C48(1.30)  LDD0954  [10]
 LDCM0275  AKOS034007705 HEK-293T C48(1.59)  LDD0873  [10]
 LDCM0020  ARS-1620 HCC44 C48(1.10)  LDD2171  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C48(1.17)  LDD0965  [10]
 LDCM0368  CL10 HEK-293T C48(1.05)  LDD0966  [10]
 LDCM0369  CL100 HEK-293T C48(1.22)  LDD0967  [10]
 LDCM0370  CL101 HEK-293T C48(1.41)  LDD0968  [10]
 LDCM0371  CL102 HEK-293T C48(1.20)  LDD0969  [10]
 LDCM0372  CL103 HEK-293T C48(1.36)  LDD0970  [10]
 LDCM0373  CL104 HEK-293T C48(1.34)  LDD0971  [10]
 LDCM0374  CL105 HEK-293T C48(0.83)  LDD0972  [10]
 LDCM0375  CL106 HEK-293T C48(0.76)  LDD0973  [10]
 LDCM0376  CL107 HEK-293T C48(1.00)  LDD0974  [10]
 LDCM0377  CL108 HEK-293T C48(1.21)  LDD0975  [10]
 LDCM0378  CL109 HEK-293T C48(1.27)  LDD0976  [10]
 LDCM0379  CL11 HEK-293T C48(1.00)  LDD0977  [10]
 LDCM0380  CL110 HEK-293T C48(1.19)  LDD0978  [10]
 LDCM0381  CL111 HEK-293T C48(1.59)  LDD0979  [10]
 LDCM0382  CL112 PaTu 8988t C48(0.99)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C48(0.92)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C48(0.90)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C48(0.72)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C48(0.67)  LDD1265  [10]
 LDCM0387  CL117 HEK-293T C48(0.76)  LDD0985  [10]
 LDCM0388  CL118 HEK-293T C48(0.46)  LDD0986  [10]
 LDCM0389  CL119 HEK-293T C48(1.01)  LDD0987  [10]
 LDCM0390  CL12 HEK-293T C48(0.92)  LDD0988  [10]
 LDCM0391  CL120 HEK-293T C48(0.90)  LDD0989  [10]
 LDCM0392  CL121 HEK-293T C48(1.53)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C48(1.59)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C48(1.29)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C48(1.56)  LDD0993  [10]
 LDCM0396  CL125 HCT 116 C48(1.45)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C48(0.94)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C48(1.60)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C48(0.99)  LDD0716  [10]
 LDCM0400  CL13 HEK-293T C48(0.97)  LDD0998  [10]
 LDCM0401  CL14 HEK-293T C48(1.21)  LDD0999  [10]
 LDCM0402  CL15 HEK-293T C48(1.09)  LDD1000  [10]
 LDCM0403  CL16 HEK-293T C48(2.29)  LDD1001  [10]
 LDCM0404  CL17 HEK-293T C48(0.87)  LDD1002  [10]
 LDCM0405  CL18 HEK-293T C48(1.38)  LDD1003  [10]
 LDCM0406  CL19 HEK-293T C48(1.08)  LDD1004  [10]
 LDCM0407  CL2 HEK-293T C48(1.10)  LDD1005  [10]
 LDCM0408  CL20 HEK-293T C48(1.36)  LDD1006  [10]
 LDCM0409  CL21 HEK-293T C48(0.80)  LDD1007  [10]
 LDCM0410  CL22 HEK-293T C48(0.87)  LDD1008  [10]
 LDCM0411  CL23 HEK-293T C48(0.67)  LDD1009  [10]
 LDCM0412  CL24 HEK-293T C48(0.92)  LDD1010  [10]
 LDCM0413  CL25 HEK-293T C48(0.95)  LDD1011  [10]
 LDCM0414  CL26 HEK-293T C48(0.74)  LDD1012  [10]
 LDCM0415  CL27 HEK-293T C48(1.24)  LDD1013  [10]
 LDCM0416  CL28 HEK-293T C48(0.80)  LDD1014  [10]
 LDCM0417  CL29 HEK-293T C48(0.82)  LDD1015  [10]
 LDCM0418  CL3 HEK-293T C48(1.18)  LDD1016  [10]
 LDCM0419  CL30 HEK-293T C48(0.73)  LDD1017  [10]
 LDCM0420  CL31 HEK-293T C48(1.41)  LDD1018  [10]
 LDCM0421  CL32 HEK-293T C48(1.26)  LDD1019  [10]
 LDCM0422  CL33 HEK-293T C48(1.17)  LDD1020  [10]
 LDCM0423  CL34 HEK-293T C48(1.11)  LDD1021  [10]
 LDCM0424  CL35 HEK-293T C48(1.49)  LDD1022  [10]
 LDCM0425  CL36 HEK-293T C48(1.16)  LDD1023  [10]
 LDCM0426  CL37 HEK-293T C48(1.19)  LDD1024  [10]
 LDCM0428  CL39 HEK-293T C48(1.27)  LDD1026  [10]
 LDCM0429  CL4 HEK-293T C48(1.06)  LDD1027  [10]
 LDCM0430  CL40 HEK-293T C48(1.03)  LDD1028  [10]
 LDCM0431  CL41 HEK-293T C48(1.26)  LDD1029  [10]
 LDCM0432  CL42 HEK-293T C48(1.44)  LDD1030  [10]
 LDCM0433  CL43 HEK-293T C48(0.98)  LDD1031  [10]
 LDCM0434  CL44 HEK-293T C48(1.58)  LDD1032  [10]
 LDCM0435  CL45 HEK-293T C48(1.53)  LDD1033  [10]
 LDCM0436  CL46 HCT 116 C48(1.26)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C48(1.18)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C48(1.37)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C48(1.39)  LDD0756  [10]
 LDCM0440  CL5 HEK-293T C48(1.11)  LDD1038  [10]
 LDCM0441  CL50 HCT 116 C48(1.33)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C48(1.25)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C48(1.17)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C48(1.39)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C48(1.93)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C48(1.56)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C48(1.12)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C48(1.14)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C48(1.66)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C48(1.15)  LDD0767  [10]
 LDCM0451  CL6 HEK-293T C48(0.79)  LDD1049  [10]
 LDCM0452  CL60 HCT 116 C48(1.17)  LDD0769  [10]
 LDCM0453  CL61 HEK-293T C48(1.11)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C48(1.01)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C48(1.00)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C48(0.96)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C48(1.08)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C48(0.78)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C48(0.91)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C48(0.86)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C48(0.91)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C48(1.13)  LDD1060  [10]
 LDCM0463  CL70 HEK-293T C48(0.77)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C48(0.78)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C48(1.14)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C48(0.82)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C48(1.23)  LDD1065  [10]
 LDCM0469  CL76 HCT 116 C48(0.60)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C48(0.84)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C48(0.93)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C48(0.63)  LDD0789  [10]
 LDCM0473  CL8 HEK-293T C48(1.47)  LDD1071  [10]
 LDCM0474  CL80 HCT 116 C48(0.69)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C48(0.73)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C48(0.45)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C48(0.52)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C48(0.45)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C48(0.85)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C48(0.98)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C48(0.77)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C48(0.57)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C48(0.42)  LDD0800  [10]
 LDCM0484  CL9 HEK-293T C48(0.87)  LDD1082  [10]
 LDCM0485  CL90 HCT 116 C48(0.90)  LDD0802  [10]
 LDCM0486  CL91 HEK-293T C48(1.21)  LDD1084  [10]
 LDCM0487  CL92 HEK-293T C48(0.96)  LDD1085  [10]
 LDCM0488  CL93 HEK-293T C48(0.85)  LDD1086  [10]
 LDCM0489  CL94 HEK-293T C48(1.41)  LDD1087  [10]
 LDCM0490  CL95 HEK-293T C48(1.66)  LDD1088  [10]
 LDCM0491  CL96 HEK-293T C48(1.89)  LDD1089  [10]
 LDCM0492  CL97 HEK-293T C48(1.26)  LDD1090  [10]
 LDCM0493  CL98 HEK-293T C48(1.09)  LDD1091  [10]
 LDCM0494  CL99 HEK-293T C48(0.59)  LDD1092  [10]
 LDCM0495  E2913 HEK-293T C118(1.04)  LDD1698  [19]
 LDCM0625  F8 Ramos C48(0.97)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C48(0.48)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C48(0.05)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C48(0.51)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C48(0.82)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C48(0.98)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C48(0.42)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C48(0.73)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C48(0.91)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C48(0.85)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C48(1.35)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C48(0.80)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C48(1.03)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C48(0.47)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C48(0.83)  LDD1066  [10]
 LDCM0596  Fragment38 Ramos C48(0.70)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C48(0.70)  LDD2184  [20]
 LDCM0427  Fragment51 HEK-293T C48(1.01)  LDD1025  [10]
 LDCM0610  Fragment52 Ramos C48(0.90)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C48(0.89)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C48(0.51)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C48(0.40)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y34(0.81); Y56(1.17); Y270(1.37)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y34(0.74); Y270(1.21); Y56(2.24)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y34(0.84); Y56(0.87); Y270(1.39)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y34(0.85); Y270(1.47); Y56(1.70)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y34(0.85); Y270(1.23); Y56(1.84)  LDD0268  [7]
 LDCM0123  JWB131 DM93 Y34(1.07)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y34(1.28)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y34(1.28)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y34(10.29)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y34(3.12)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y34(0.34)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y34(1.14)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y34(1.92)  LDD0292  [6]
 LDCM0022  KB02 HCT 116 C48(1.66)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C48(1.85)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C48(1.62)  LDD0082  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C239(0.25)  LDD2106  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C48(0.40)  LDD2145  [4]
 LDCM0021  THZ1 HCT 116 C48(1.10)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphoribosyltransferase domain-containing protein 1 (PRTFDC1) Purine/pyrimidine phosphoribosyltransferase family Q9NRG1

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-deoxy-2-amino Glucitol-6-phosphate Small molecular drug DB02445
Beta-d-glucose Small molecular drug DB02379
N-acetyl-d-glucosamine-6-phosphate . DB03951

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578