Details of the Target

General Information of Target

Target ID LDTP02589
Target Name Cyclin-dependent kinase 4 (CDK4)
Gene Name CDK4
Gene ID 1019
Synonyms
Cyclin-dependent kinase 4; EC 2.7.11.22; Cell division protein kinase 4; PSK-J3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Subcellular location
Cytoplasm
Function
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
TTD ID
T85799
Uniprot ID
P11802
DrugMap ID
TT0PG8F
Ensemble ID
ENST00000257904.11
HGNC ID
HGNC:1773
ChEMBL ID
CHEMBL331

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 Substitution: p.R24C DBIA    Probe Info 
LNCaP clone FGC SNV: p.P110L DBIA    Probe Info 
LS123 SNV: p.H30Q DBIA    Probe Info 
MEWO SNV: p.E11G DBIA    Probe Info 
NUGC3 Deletion: p.R246VfsTer31 .
SKMEL28 SNV: p.R24C DBIA    Probe Info 
SUPT1 SNV: p.R283Q DBIA    Probe Info 
WM793 SNV: p.K22Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y17(11.18)  LDD0257  [1]
TH216
 Probe Info  		Y17(9.46)  LDD0259  [1]
BTD
 Probe Info  		C215(1.03)  LDD2090  [2]
AHL-Pu-1
 Probe Info  		C215(3.93)  LDD0168  [3]
HHS-465
 Probe Info  		Y17(5.65)  LDD2237  [4]
DBIA
 Probe Info  		C78(0.95); C135(0.91)  LDD0078  [5]
ATP probe
 Probe Info  		K142(0.00); K211(0.00)  LDD0199  [6]
IA-alkyne
 Probe Info  		C78(0.00); C215(0.00)  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C78(0.00); C135(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
PPMS
 Probe Info  		N.A.  LDD0008  [11]
SF
 Probe Info  		K22(0.00); Y21(0.00)  LDD0028  [12]
Phosphinate-6
 Probe Info  		C135(0.00); C215(0.00)  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
1d-yne
 Probe Info  		N.A.  LDD0357  [14]
Acrolein
 Probe Info  		C78(0.00); C135(0.00); C215(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		C78(0.00); C135(0.00)  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C202(0.00); C135(0.00); C215(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		13.18  LDD1752  [18]
FFF probe11
 Probe Info  		5.21  LDD0471  [19]
FFF probe13
 Probe Info  		13.71  LDD0475  [19]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]
FFF probe2
 Probe Info  		16.30  LDD0463  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
STS-1
 Probe Info  		N.A.  LDD0136  [20]
STS-2
 Probe Info  		N.A.  LDD0139  [20]
OEA-DA
 Probe Info  		8.17  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C215(1.12)  LDD2112  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C215(0.99)  LDD2152  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C215(0.76)  LDD2132  [2]
 LDCM0025  4SU-RNA HEK-293T C215(3.93)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C78(2.23); C215(2.12)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C135(0.74); C215(1.02); C78(1.11)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C135(0.90); C215(1.01); C78(0.88)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C135(0.81); C215(0.70); C78(1.13)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C135(1.05); C215(0.87); C78(0.84)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C135(0.85); C215(0.84); C78(0.73)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C135(0.89); C215(0.71); C78(0.83)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C135(1.04); C215(0.78); C78(1.18)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C135(0.86); C215(0.77); C78(0.88)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C135(0.76); C215(0.82); C78(0.86)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C135(0.98); C215(0.67); C78(1.05)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C135(0.70); C215(0.81); C78(0.82)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C135(0.83); C215(0.80); C78(0.82)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C135(0.91); C215(0.91); C78(0.96)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C135(0.78); C215(0.75); C78(0.61)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C135(1.04); C215(0.78); C78(0.77)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C135(0.90); C215(0.72); C78(0.89)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C135(1.00); C215(0.99); C78(1.13)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C135(1.14); C215(0.94); C78(1.15)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C135(1.29); C215(0.93); C78(1.29)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C135(1.19); C215(0.92); C78(1.15)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C135(1.06); C215(0.92); C78(1.54)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C135(0.89); C215(0.97); C78(1.38)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C135(0.82); C215(0.90); C78(1.40)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C135(0.91); C215(0.95); C78(0.94)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C135(1.45); C215(0.99); C78(1.18)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C135(0.84); C215(1.00); C78(1.10)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C135(0.75); C215(0.92); C78(1.07)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C135(1.06); C215(0.87); C78(1.02)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C135(1.05); C215(0.94); C78(1.01)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C135(0.84); C215(1.03); C78(1.31)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C135(0.77); C215(0.95); C78(1.14)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C135(0.65); C215(0.90); C78(1.13)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C135(0.96); C215(1.01); C78(1.50)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C135(1.01); C215(0.95); C78(1.12)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C135(1.16); C215(0.96); C78(1.11)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C135(1.18); C215(1.01); C78(0.83)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C135(1.13); C215(1.24); C78(0.87)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C135(1.16); C215(0.99); C78(1.31)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C135(1.41); C215(1.04); C78(1.31)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C135(0.95); C215(1.01); C78(1.29)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C135(1.24); C215(1.00); C78(1.28)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C135(1.10); C215(1.20); C78(1.14)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C135(1.43); C215(1.05); C78(1.15)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C135(1.31); C215(1.00); C78(0.99)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C135(1.21); C215(0.88); C78(0.98)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C135(1.51); C215(1.12); C78(1.48)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C135(1.36); C215(1.08); C78(1.45)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C135(1.14); C215(1.00); C78(1.07)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C135(1.11); C215(0.82)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C215(0.83); C135(1.24)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C215(0.84); C135(1.18)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C215(0.73); C135(1.14)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C215(1.04); C135(1.18)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C215(0.80); C135(1.65)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C215(0.71); C135(1.32)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C78(0.84); C215(1.00); C135(1.12)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C215(0.82); C135(1.21)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C215(0.84); C135(1.21)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C215(0.70); C135(1.79)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C215(0.70); C135(1.62)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C135(1.37); C215(0.79)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C135(1.05); C215(0.77)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C135(0.94); C215(0.78)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C135(1.17); C215(0.78)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C135(0.90); C215(0.96); C78(1.06)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C215(1.05); C78(1.19); C135(1.27)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C215(0.91); C135(1.06); C78(1.21)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C135(0.79); C78(0.92); C215(1.05)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C215(1.01); C135(1.06); C78(1.11)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C215(0.85); C78(1.06); C135(1.08)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C215(0.95); C135(0.98); C78(1.12)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C215(0.99); C135(1.06); C78(1.28)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C215(0.95); C135(1.02); C78(1.14)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C135(0.72); C215(0.95); C78(1.00)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C135(0.73); C215(1.01); C78(1.07)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C215(0.85); C135(0.86); C78(0.97)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C135(0.72); C215(0.92); C78(1.03)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C135(0.82); C215(0.88); C78(1.03)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C135(0.73); C78(0.90); C215(1.10)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C215(0.80); C135(0.96); C78(1.11)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C135(0.82); C215(0.84); C78(0.91)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C215(0.91); C135(0.97); C78(1.04)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C215(0.84); C135(1.01); C78(1.19)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C215(0.76); C135(1.04); C78(1.36)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C215(1.01)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C215(0.96)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C215(0.96)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C215(0.97)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C215(1.00)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C135(0.78); C78(0.85); C215(1.09)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C215(0.96)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C215(1.04)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C215(0.96)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C215(0.98)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C215(0.99)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C215(0.99)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C135(0.93); C215(0.96); C78(1.13)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C135(0.81); C215(1.04); C78(1.14)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C135(0.91); C215(1.08); C78(1.15)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C135(0.91); C215(0.94); C78(1.11)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C135(0.81); C78(0.87); C215(1.14)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C215(0.90); C135(1.01); C78(1.16)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C78(1.06); C135(1.10); C215(1.18)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C135(0.85); C215(1.08); C78(1.21)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C215(0.98); C135(1.13); C78(1.19)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C135(0.94); C215(0.99); C78(1.06)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C135(0.89); C215(0.91); C78(1.19)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C215(1.02); C78(1.06); C135(1.24)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C215(0.66); C78(0.95); C135(1.13)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C215(0.60); C78(1.08); C135(1.47)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C215(0.74); C78(0.97); C135(1.36)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C78(0.87); C215(0.91); C135(1.05)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C215(0.65); C78(1.00); C135(1.30)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C215(0.62); C78(0.94); C135(1.14)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C215(0.68); C78(1.03); C135(1.35)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C215(0.64); C78(1.07); C135(1.18)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C215(0.70); C78(0.94); C135(1.15)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C215(0.90); C78(0.97); C135(1.02)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C215(0.93); C78(0.93); C135(1.07)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C215(0.73); C78(1.09); C135(1.13)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C78(0.96); C215(1.09); C135(1.13)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C78(0.76); C215(1.20); C135(1.25)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C215(0.90); C78(0.93); C135(0.97)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C135(0.75); C215(0.92); C78(1.15)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C78(0.89); C215(0.90); C135(0.96)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C215(0.82); C135(0.90); C78(1.05)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C78(0.82); C215(0.89); C135(1.01)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C78(0.86); C215(1.07); C135(1.33)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C215(0.83); C135(0.98); C78(1.18)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C135(0.97); C215(1.03); C78(1.36)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C78(0.81); C215(0.84); C135(1.35)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C135(1.03); C215(1.09); C78(1.21)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C78(0.79); C215(0.86); C135(0.93)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C78(0.86); C215(0.92); C135(0.99)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C215(1.05); C78(1.10); C135(1.16)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C215(0.92); C78(1.15); C135(1.28)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C215(0.85); C135(0.86); C78(1.07)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C215(0.94); C78(1.22); C135(1.52)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C215(0.95); C78(1.03); C135(1.54)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C215(0.96); C78(1.05); C135(1.21)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C78(1.05); C215(1.08); C135(1.19)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C215(0.95); C135(0.96); C78(1.64)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C215(0.95); C135(1.01); C78(1.19)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C215(0.85); C78(1.04); C135(1.16)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C135(0.57); C215(1.14); C78(1.31)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C215(0.90); C78(1.07); C135(1.17)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C215(0.96); C135(1.05); C78(1.10)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C215(0.96); C135(0.97); C78(1.05)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C135(0.88); C215(0.91); C78(1.54)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C215(0.80); C135(0.83); C78(1.40)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C135(0.92); C215(0.93); C78(1.42)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C215(0.87); C135(1.01); C78(1.55)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C215(0.63); C135(1.04); C78(1.25)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C78(0.60); C135(0.69); C215(0.81)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C135(0.90); C215(1.00); C78(0.85)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C78(0.84); C215(0.95); C135(1.00)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C215(0.88); C78(0.99); C135(1.27)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C78(0.95); C135(0.91)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa C135(0.00); C78(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C135(1.12); C215(0.81)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C135(1.03); C215(1.05); C78(1.14)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C215(0.81); C135(0.83); C78(1.14)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C135(0.76); C215(1.06); C78(1.12)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C78(0.79); C215(0.91); C135(1.06)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C78(0.96); C135(1.04); C215(1.06)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C135(0.89); C78(0.92); C215(0.99)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C78(0.84); C215(0.92); C135(1.11)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C215(0.91); C135(1.00); C78(1.21)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C215(0.82); C135(1.09); C78(1.20)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C215(0.97); C135(1.03); C78(1.29)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C215(0.91); C135(0.95); C78(1.40)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C215(0.85); C135(1.07); C78(1.31)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C215(0.84); C135(0.87); C78(1.14)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C215(0.94); C135(1.15); C78(1.28)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C215(0.93); C135(1.25); C78(1.42)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C135(0.95); C78(1.00); C215(1.02)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C215(0.83); C78(0.97); C135(1.20)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C215(0.90); C78(1.13); C135(1.29)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C215(0.97); C135(1.02); C78(1.15)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C215(0.95); C135(0.97); C78(1.08)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C215(0.85)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C215(1.05)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C215(1.00)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C215(0.86); C78(0.91); C135(1.00)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C215(1.13)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C215(0.86); C78(1.04); C135(1.08)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C78(0.94); C215(0.95); C135(1.45)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C78(1.01); C135(1.10); C215(1.13)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C135(0.85); C215(1.04); C78(1.07)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C135(0.85); C215(0.86); C78(0.99)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C215(0.82); C78(1.01); C135(1.34)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C215(0.80); C78(1.03); C135(1.12)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C215(0.78); C135(0.99); C78(1.06)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C215(0.87); C78(0.98); C135(1.16)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C215(1.01); C135(1.02); C78(1.07)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C215(0.91); C78(0.96); C135(1.14)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C215(0.87); C135(0.98)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C215(0.79); C135(0.98); C78(1.39)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C215(0.67); C135(0.79); C78(1.13)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C215(0.76); C135(0.91); C78(1.11)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C135(0.93); C215(0.94); C78(1.03)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C215(0.78); C135(0.95); C78(1.20)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C215(0.87); C78(0.99); C135(1.04)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C78(0.75); C215(0.93); C135(1.85)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C215(0.88); C135(1.13); C78(1.50)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C135(0.83); C215(0.84); C78(0.92)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C135(0.85); C215(0.81); C78(1.20)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C135(0.99); C215(0.74); C78(0.93)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C135(0.91); C215(0.89); C78(0.98)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C135(0.74); C215(0.77); C78(1.05)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C135(1.04); C215(0.83); C78(0.75)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C135(0.84); C215(0.91); C78(1.07)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C135(0.89); C215(0.80); C78(1.23)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C135(0.93); C215(0.93); C78(1.05)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C135(0.98); C215(0.77); C78(0.97)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C135(0.92); C215(0.79); C78(1.10)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C135(1.10); C215(0.76); C78(1.13)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C135(0.92); C215(0.79); C78(0.98)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C135(1.39); C215(0.82); C78(1.33)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C135(1.08); C215(0.83); C78(1.01)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C135(0.74); C215(0.91); C78(1.01)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C135(0.96); C215(0.97); C78(0.88)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C135(0.90); C215(0.80); C78(1.19)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C135(1.28); C215(0.85); C78(0.99)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C135(1.37); C215(0.89); C78(1.12)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C135(0.85); C215(0.78); C78(1.11)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C135(0.74); C215(0.84); C78(1.21)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C135(0.78); C215(0.87); C78(1.30)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C135(0.62); C215(1.20)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C135(0.75); C215(1.08)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C135(0.75); C215(1.05)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C135(0.73); C215(1.08)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C135(0.90); C215(0.95); C78(0.82)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C135(0.78); C215(1.13)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C135(0.65); C215(1.22)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C135(0.80); C215(1.09)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C135(2.04); C215(1.09)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C135(0.66); C215(1.10)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C135(0.74); C215(1.01)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C135(0.95); C215(1.01)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C135(0.99); C215(1.11)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C135(0.75); C215(1.03)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C135(0.78); C215(1.07)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C135(0.79); C215(0.84); C78(0.88)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C135(0.76); C215(1.04)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C135(0.98); C215(0.93); C78(1.43)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C135(0.79); C215(0.91); C78(1.00)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C135(1.04); C215(0.90); C78(1.46)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C135(0.97); C215(0.94); C78(1.25)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C135(0.98); C215(0.91); C78(1.16)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C135(1.16); C215(0.85); C78(1.29)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C135(1.43); C215(0.80); C78(1.72)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C135(3.11); C215(0.73); C78(1.24)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C135(1.11); C215(0.73); C78(1.15)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C135(0.74); C215(0.90); C78(1.04)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C135(1.15); C215(0.79); C78(1.46)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C135(1.20); C215(0.96); C78(1.28)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C135(1.27); C215(0.95); C78(1.44)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C135(1.22); C215(0.83); C78(1.18)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C135(1.43); C215(0.88); C78(1.44)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C135(1.36); C215(0.87)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C135(1.89); C215(0.94)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C135(1.19); C215(0.94)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C135(1.20); C215(0.94)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C135(1.01); C215(1.02); C78(1.21)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C135(1.10); C215(0.78)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C135(0.97); C215(0.98)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C135(1.01); C215(0.90)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C135(1.11); C215(0.89)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C135(1.17); C215(0.95)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C135(1.59); C215(0.90)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C135(1.37); C215(0.94)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C135(1.31); C215(1.00)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C135(1.67); C215(0.92)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C135(1.16); C215(0.89)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C135(0.86); C215(0.87); C78(0.93)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C135(1.53); C215(1.06)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C135(0.95); C215(1.00); C78(1.08)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C135(1.03); C215(1.07); C78(1.01)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C135(0.74); C215(1.06); C78(0.93)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C135(0.87); C215(0.98); C78(1.02)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C135(1.02); C215(1.07); C78(1.07)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C135(0.93); C215(1.08); C78(0.95)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C135(0.92); C215(1.07); C78(1.10)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C135(0.82); C215(1.02); C78(1.06)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C135(0.76); C215(1.03); C78(0.95)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C78(0.91); C135(0.84); C215(0.94)  LDD1698  [22]
 LDCM0573  Fragment11 Ramos C78(0.27)  LDD2190  [23]
 LDCM0575  Fragment13 Ramos C78(0.99)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C78(0.77)  LDD2193  [23]
 LDCM0580  Fragment21 Ramos C78(1.22)  LDD2195  [23]
 LDCM0578  Fragment27 Ramos C78(0.91)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C78(0.75)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C78(0.97)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C78(1.07)  LDD2200  [23]
 LDCM0468  Fragment33 HCT 116 C135(1.40); C215(0.81); C78(1.26)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C78(0.97)  LDD2203  [23]
 LDCM0427  Fragment51 HCT 116 C135(0.96); C215(0.81); C78(1.51)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C78(1.00)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C78(0.97)  LDD2205  [23]
 LDCM0022  KB02 HCT 116 C135(1.06); C78(1.32)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C135(1.08); C78(1.25)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C135(2.30); C78(1.24)  LDD0082  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C215(0.80)  LDD2102  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C215(1.03)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C215(0.81)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C215(1.04)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C215(0.96)  LDD2094  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C215(0.87)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C215(1.01)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C215(1.00)  LDD2100  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C215(0.61)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C215(0.91)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C215(0.99)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C215(0.65)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C215(0.97)  LDD2108  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C215(0.91)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C215(0.67)  LDD2114  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C215(1.46)  LDD2119  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C215(0.77)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C215(1.40)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C215(0.96)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C215(0.79)  LDD2133  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C215(1.01)  LDD2135  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C215(1.03)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C215(1.84)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C215(1.01)  LDD2146  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C215(1.64)  LDD2153  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C78(3.06)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C78(0.87)  LDD2207  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2-oxoglutarate dehydrogenase-like, mitochondrial (OGDHL) Alpha-ketoglutarate dehydrogenase family Q9ULD0
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B) Cytidine and deoxycytidylate deaminase family Q9UH17
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
Cyclin-dependent kinase 7 (CDK7) CMGC Ser/Thr protein kinase family P50613
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
G1/S-specific cyclin-D1 (CCND1) Cyclin family P24385
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Myc proto-oncogene protein (MYC) . P01106
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) CDKN2 cyclin-dependent kinase inhibitor family P42772
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) CDKN2 cyclin-dependent kinase inhibitor family P42773
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Cyclin-dependent kinase inhibitor 2A (CDKN2A) CDKN2 cyclin-dependent kinase inhibitor family P42771
G1/S-specific cyclin-D2 (CCND2) Cyclin family P30279
G1/S-specific cyclin-D3 (CCND3) Cyclin family P30281
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Protein INCA1 (INCA1) INCA family Q0VD86
Retinoblastoma-like protein 1 (RBL1) Retinoblastoma protein (RB) family P28749

The Drug(s) Related To This Target

Approved
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abemaciclib Small molecular drug DB12001
Apremilast Small molecular drug D07ESC
Fostamatinib Small molecular drug DB12010
Ly2835219 Small molecular drug D05SBO
Palbociclib Small molecular drug D00UZR
Ribociclib Small molecular drug DB11730
Ribociclib Succinate Small molecular drug D01HVT
Trilaciclib . D0AP9E
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lee011 Small molecular drug D08MXP
Phase 2
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
P-276 Small molecular drug D0W8IY
P276-00 Small molecular drug D05IRT
Ro 31-7453 Small molecular drug D01UMT
Fcn-437 . D8ZV2Q
G1t38 . D0WU1O
Glr2007 . D4IS0G
Phase 1
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ag-024322 Small molecular drug D0IX4B
Fn-1501 Small molecular drug DKCU40
Pha-793887 Small molecular drug D0P1CV
Rgb-286638 Small molecular drug D03DKV
G1t28-1 . D01XZG
P1446a-05 . D0DX4J
Pf-07220060 . DZJ3D5
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Inoc-005 . D07ZJC
Investigative
Click To Hide/Show 23 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-(1h-indazol-6-yl)-3-pyridin-2-yl-urea Small molecular drug D0G4JS
1-(7-hydroxy-naphthalen-1-yl)-3-pyridin-2-yl-urea Small molecular drug D0M8CO
1-(9-oxo-9h-fluoren-4-yl)-3-pyridin-2-yl-urea Small molecular drug D0X1NW
1-pyridin-2-yl-3-quinolin-5-yl-urea Small molecular drug D0T2VG
10-hydroxy-18-methoxybetaenone Small molecular drug D0W6CE
3,4-di-(4-methoxyphenyl)-1h-pyrrole-2,5-dione Small molecular drug D00NYT
3,4-diphenyl-1h-pyrrole-2,5-dione Small molecular drug D0C3WY
3-(4-methoxyphenyl)-4-phenyl-1h-pyrrole-2,5-dione Small molecular drug D0EK0G
3-(Indole-3-yl)-4-phenyl-1h-pyrrole-2,5-dione Small molecular drug D06AOY
4-[(3,5-diamino-1h-pyrazol-4-yl)Diazenyl]Phenol Small molecular drug D0A5RM
Alvocidib Small molecular drug DB03496
Cdk4 Inhibitor Iii Small molecular drug D07HPE
Fascaplysin Small molecular drug D09OAH
K00024 Small molecular drug D0D5HQ
N-(2-(1h-indol-3-yl)Ethyl)Biphenyl-4-carboxamide Small molecular drug D03VDM
Nsc-625987 Small molecular drug D0VD8B
Nu-6102 Small molecular drug D0Y5RO
Nu6140 Small molecular drug D04WFN
Pmid18986805c9b Small molecular drug D0P6JS
Purvalanol Small molecular drug DB02733
Pyrazolopyridazine 1 Small molecular drug D02DLC
Pyrazolopyridazine 2 Small molecular drug D0O0VP
Ro-0505124 Small molecular drug D09RYV
Patented
Click To Hide/Show 14 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Imidazo Pyridine Derivative 3 Small molecular drug D0WT7D
Indole-based Analog 13 Small molecular drug D0LX6X
Oxazolyl Methylthiothiazole Derivative 1 Small molecular drug D0M5DX
Palbociclib/Ribociclib Analog 1 Small molecular drug D03HED
Pmid25726713-compound-47 Small molecular drug D0X5VI
Pmid25726713-compound-48 Small molecular drug D0WJ3W
Pmid25726713-compound-49 Small molecular drug D07TVO
Pmid25726713-compound-50 Small molecular drug D0Y8JF
Pmid25726713-compound-51 Small molecular drug D0KH7Q
Pmid25991433-compound-a1 Small molecular drug D0H4HD
Pmid26161698-compound-17 Small molecular drug D0FQ6V
Pyrrolo[2,3-d]Pyrimidine Derivative 10 Small molecular drug D04AKA
Pyrrolo[2,3-d]Pyrimidine Derivative 9 Small molecular drug D08KKC
Isoquinoline 1,3-dione Derivative 1 . D0W4MN
Discontinued
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bay 10-00394 Small molecular drug D0NV9O
Pd-0183812 Small molecular drug D0Z0KD
R547 Small molecular drug D04FHB
Zk 304709 Small molecular drug D00VBT
Cyc-103 . D0Y6HA

References

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2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.