Details of the Target

General Information of Target

Target ID LDTP00617
Target Name Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)
Gene Name INPPL1
Gene ID 3636
Synonyms
SHIP2; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; EC 3.1.3.86; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
Target Bioclass
Enzyme
Family
Inositol 1,4,5-trisphosphate 5-phosphatase family
Subcellular location
Cytoplasm, cytosol
Function
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly. Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2. Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification.
Uniprot ID
O15357
Ensemble ID
ENST00000298229.7
HGNC ID
HGNC:6080
ChEMBL ID
CHEMBL2331064

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.P977TfsTer7
SNV: p.A1093V		 .
AN3CA Deletion: p.R1156GfsTer46 .
CAMA1 SNV: p.R649Ter .
EFO27 Deletion: p.R1156GfsTer46 DBIA    Probe Info 
HCT15 SNV: p.M502T DBIA    Probe Info 
HEC1 SNV: p.L1205P DBIA    Probe Info 
HEC1B SNV: p.Q255Ter; p.L1205P .
HUPT3 SNV: p.G1191W DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.R1156GfsTer46 DBIA    Probe Info 
KMS12BM SNV: p.I500V DBIA    Probe Info 
LNCaP clone FGC Deletion: p.P976HfsTer155; p.R1156GfsTer46 .
LS180 SNV: p.L34M; p.S651R DBIA    Probe Info 
MCC13 SNV: p.L207F DBIA    Probe Info 
MFE296 Deletion: p.P976HfsTer155
SNV: p.R691Q		 DBIA    Probe Info 
MFE319 Deletion: p.E654del
Insertion: p.S1068QfsTer17		 DBIA    Probe Info 
MM1S SNV: p.P169R .
MOLT4 SNV: p.G39V .
NCIH1155 SNV: p.Q349Ter DBIA    Probe Info 
NCIH1993 SNV: p.E990Ter .
NCIH716 Insertion: p.G146VfsTer20 .
RL952 Deletion: p.P999RfsTer132; p.R1156GfsTer46 DBIA    Probe Info 
SJSA1 SNV: p.A1106T .
SKES1 SNV: p.A902S DBIA    Probe Info 
SUPT1 SNV: p.R70H DBIA    Probe Info 
SW756 SNV: p.I1208M .
TOV21G Deletion: p.R1156GfsTer46
SNV: p.F548L		 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.93  LDD0402  [1]
STPyne
 Probe Info  		K272(4.99); K376(10.00); K383(8.39); K391(3.46)  LDD0277  [2]
Probe 1
 Probe Info  		Y190(16.48)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C926(2.56)  LDD0169  [4]
HHS-475
 Probe Info  		Y1135(0.49); Y986(0.56)  LDD0264  [5]
DBIA
 Probe Info  		C926(1.04); C1121(0.96)  LDD0078  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [7]
BTD
 Probe Info  		N.A.  LDD0004  [8]
JW-RF-010
 Probe Info  		C926(0.00); C5(0.00)  LDD0026  [9]
NAIA_4
 Probe Info  		C926(0.00); C1187(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C5(0.00); C837(0.00); C926(0.00)  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		C926(0.00); C1121(0.00)  LDD0005  [8]
VSF
 Probe Info  		C926(0.00); C5(0.00); C1187(0.00)  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		C1187(0.00); H524(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		10.20  LDD0443  [13]
NAIA_5
 Probe Info  		C405(0.00); C1121(0.00); C926(0.00); C5(0.00)  LDD2223  [10]
HHS-465
 Probe Info  		Y1135(0.00); Y986(0.00)  LDD2240  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C926(1.17)  LDD2112  [15]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1121(0.54)  LDD2130  [15]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C926(0.96)  LDD2117  [15]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C926(0.90)  LDD2103  [15]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C926(1.64)  LDD2132  [15]
 LDCM0026  4SU-RNA+native RNA HEK-293T C926(2.56)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C689(1.45); C926(0.47)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C689(1.14); C926(0.93)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C1121(0.84); C689(0.89); C926(1.07)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C1121(0.85); C689(0.79); C926(1.21)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C1121(0.86); C689(0.80); C926(0.94)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C1121(1.06); C689(0.87); C926(1.65)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C1121(0.90); C689(0.82); C926(1.57)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C1121(0.96); C689(0.90); C926(0.85)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C1121(1.05); C689(0.90); C926(1.13)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C1121(0.73); C689(0.91); C926(1.31)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C1121(0.66); C689(0.80); C926(1.19)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C1121(0.71); C689(0.81); C926(1.02)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C689(1.27); C926(0.93)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C1121(0.69); C689(0.82); C926(0.78)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C1121(0.79); C689(0.99); C926(1.14)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C1121(0.70); C689(0.86); C926(1.20)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C689(1.10)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C689(1.08)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C689(0.87)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C689(0.96)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C689(0.91)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C689(1.00)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C689(1.00)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C689(1.16); C926(0.92)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C689(0.89)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C689(1.05)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C689(1.14)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C689(1.18)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C689(1.02)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C689(1.16)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C689(1.10)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C689(1.10)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C689(1.07)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C689(1.41)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C689(1.10)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C689(0.95)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C689(1.11)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C689(1.13)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C689(1.00)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C689(1.10)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C689(1.00)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C689(0.96)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C689(0.96)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C689(1.04)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C689(1.13); C926(0.73)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C689(1.08)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C689(1.00)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C689(1.17)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C689(1.06); C926(1.03)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C689(1.23); C926(1.77)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C926(0.73); C689(1.24)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C689(0.93); C926(0.95)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C926(0.83); C689(1.03)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C926(1.03); C689(1.15)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C926(0.90); C689(1.07)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C926(0.69); C689(1.89)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C689(0.97); C926(1.26)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C689(0.94); C926(1.12)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C689(0.88); C926(1.04)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C689(1.26); C926(1.47)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C689(0.98); C926(1.81)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C689(0.92); C926(0.89)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C689(1.01); C926(0.77)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C689(1.07); C926(1.07)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C926(0.49); C689(1.01)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C926(0.58); C689(0.75)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C926(0.42); C689(0.88)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C926(0.44); C689(1.13)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C926(0.48); C689(0.99)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C926(0.45); C689(0.91)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C926(0.50); C689(1.04)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C926(0.42); C689(0.86)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C926(0.36); C689(0.99)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C1121(1.11)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C1121(1.14)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C1121(1.33)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C1121(1.34)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C1121(1.36)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C926(0.39); C689(1.56)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C1121(1.21)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C1121(1.25)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C1121(1.53)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C1121(1.45)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C1121(1.44)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C689(1.75)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C689(1.36)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C689(1.90)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C689(1.15)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C689(1.19)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C926(0.34); C689(1.42)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C689(1.52)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C689(1.43)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C689(1.22)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C689(1.29)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C689(1.94)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C689(2.66)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C689(0.88)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C689(1.02)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C689(0.91)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C689(0.76)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C926(0.31); C689(1.62)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C689(1.03)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C689(0.75)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C689(0.82)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C689(1.09)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C689(0.91)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C689(1.68)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C689(1.40)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C689(1.51)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C689(1.06)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C689(1.36)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C689(0.88); C926(0.95)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C689(1.46)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C689(1.57)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C689(1.47)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C689(2.06)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C689(1.78)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C689(1.43)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C689(1.34)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C689(2.06)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C689(0.82)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C689(0.76)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C689(1.00); C926(1.02)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C689(0.73)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C689(0.81)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C689(1.13)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C689(0.90)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C689(0.61)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C689(1.13)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C689(0.91)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C689(0.82)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C689(0.72)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C689(0.85)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C689(0.77); C926(0.77)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C689(0.75)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C689(0.63)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C689(0.54)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C689(1.03); C926(1.63); C1121(1.76)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C926(0.99); C689(1.02); C1121(1.11)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C689(0.74); C926(0.99); C1121(1.20)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C689(0.72); C926(0.81); C1121(1.31)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C926(0.73); C689(0.75); C1121(1.40)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C689(0.71); C926(1.09); C1121(1.15)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C689(0.95); C926(0.96); C1121(1.27)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C926(1.21); C689(1.26); C1121(1.54)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C689(0.92); C1121(1.01); C926(1.20)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C689(0.77); C926(0.91); C1121(1.23)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C689(0.65); C926(0.92); C1121(1.21)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C689(0.66); C926(0.78); C1121(0.93)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C926(0.94); C689(1.24); C1121(1.48)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C926(0.62); C689(0.97); C1121(0.99)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C689(0.81); C926(1.10); C1121(1.30)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C689(0.81); C1121(0.90); C926(2.38)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C1121(0.83); C926(0.88); C689(0.93)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C689(1.29); C926(0.80)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C689(1.17); C926(1.36)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C926(0.78); C689(0.98)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C926(1.04); C1121(0.96)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa H524(0.00); C1187(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C1121(2.62); C405(1.15); C926(1.03); C5(0.83)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C689(1.16)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C689(0.87)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C926(0.44); C689(1.32)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C926(0.81); C689(1.18)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C689(1.16); C926(1.19)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C926(0.70); C689(1.21)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C926(0.64); C689(1.07)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C926(0.67); C689(0.80)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C926(0.57); C689(0.92)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C926(0.55); C689(0.91)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C926(0.49); C689(0.86)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C926(0.56); C689(0.94)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C689(1.00)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C926(0.37); C689(0.98)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C926(0.44); C689(0.94)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C1121(1.06)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C1121(1.24)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C1121(1.27)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C1121(1.36)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C1121(1.22)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C689(1.18)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C689(1.42)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C689(1.44)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C689(0.81)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C689(1.25)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C689(1.01)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C689(0.85)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C689(0.74)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C689(1.00)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C689(1.24)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C689(1.53)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C689(1.88)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C689(1.63)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C689(0.95)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C689(1.04)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C689(1.23)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C926(0.88); C689(0.91)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C689(0.95)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C689(1.28)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C689(1.03)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C689(1.31)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C689(1.16)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C689(0.93)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C689(1.07)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C689(0.89)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C689(0.91)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C689(0.95)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C689(0.89)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C689(0.96)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C689(0.96)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C689(0.95)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C689(1.06)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C689(0.92)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C689(1.00)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C689(1.82); C926(0.79)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C689(1.38); C926(0.75)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C689(1.03); C926(1.01)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C689(1.01); C926(0.78)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C689(1.36); C926(0.58)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C689(1.37); C926(0.62)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C689(0.94); C926(0.55)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C689(1.29)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C689(1.36); C926(0.69)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C689(1.50); C926(0.57)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C689(1.21); C926(0.45)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C689(1.09); C926(0.53)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C689(0.86); C926(0.65)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C689(1.03); C926(0.58)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C689(0.86); C926(2.17)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C689(0.89); C926(1.24)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C689(1.25); C926(1.09)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C689(0.96); C926(0.88)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C689(1.30)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C689(1.10); C926(0.80)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C689(1.17); C926(0.91)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C689(1.11); C926(1.37)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C689(1.09); C926(1.03)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C689(1.08); C926(1.15)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C689(1.08); C926(1.71)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C689(0.87); C926(0.94)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C689(1.01); C926(0.92)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C689(0.95); C926(1.45)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C689(0.98); C926(0.78)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C689(1.19)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C689(1.02); C926(0.87)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C1121(0.98); C689(1.07)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C1121(0.99); C689(1.02)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C1121(1.06); C689(1.07)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C1121(1.00); C689(1.15)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C1121(0.84); C689(0.98)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C1121(0.94); C689(0.88)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C1121(0.88); C689(0.90)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C1121(0.95); C689(0.89)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C1121(0.99); C689(1.66)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C689(1.11)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C1121(1.00); C689(1.20)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C1121(0.97); C689(1.10)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C1121(0.99); C689(0.98)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C1121(0.96); C689(1.08)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C1121(1.13); C689(1.12)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C926(1.01)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C926(0.76)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C926(1.45)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C926(0.82)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C689(1.07)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C926(0.85)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C926(0.85)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C926(0.79)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C926(0.98)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C926(1.17)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C926(1.24)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C926(1.09)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C926(0.97)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C926(0.92)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C926(0.82)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C689(1.02)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C926(1.53)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C689(1.17); C926(0.73)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C689(0.96); C926(1.73)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C689(1.13); C926(0.94)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C689(1.07); C926(0.72)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C689(1.00); C926(1.65)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C689(0.97); C926(0.53)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C689(1.12); C926(0.48)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C689(1.27); C926(0.84)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C689(1.33); C926(0.63)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C215(0.95); C1121(1.11); C926(1.52); C405(1.02)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C926(3.08)  LDD1702  [15]
 LDCM0625  F8 Ramos C1187(0.93); C215(1.30)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C1187(0.91); C215(4.23)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C1187(0.55)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C1187(0.91)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C1187(0.82); C215(0.91); C926(1.71)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C1187(1.14)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C1187(0.77)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C1187(0.86); C215(1.19)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C1187(0.88); C215(1.43); C926(1.44)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C1187(0.71); C215(0.82); C926(0.97)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C1187(0.90); C215(1.11); C926(1.44)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C1187(1.00); C215(1.54)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C1187(0.88); C215(1.68); C926(1.17)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C1187(1.55); C215(2.91)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C1121(0.83); C689(1.07)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C1187(0.83); C215(1.64); C926(0.40)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C1187(1.01); C215(3.74)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C689(1.00); C926(0.55)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C1187(0.94); C215(1.67)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C1187(0.91); C215(1.24)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C1187(0.90); C215(4.75)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C1187(0.96)  LDD2188  [17]
 LDCM0116  HHS-0101 DM93 Y1135(0.49); Y986(0.56)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y1135(0.60)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y1135(0.46)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y986(0.33); Y1135(0.48)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y986(0.72); Y1135(1.16)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C1121(1.87)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C1121(1.59)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C1121(1.42)  LDD0082  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C926(0.79)  LDD2102  [15]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C926(0.95)  LDD2121  [15]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C926(1.24)  LDD2090  [15]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C926(0.73)  LDD2092  [15]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C926(1.38)  LDD2093  [15]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C926(1.01)  LDD2094  [15]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C926(0.86)  LDD2096  [15]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C926(1.10)  LDD2098  [15]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C926(0.83)  LDD2099  [15]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C926(0.93)  LDD2104  [15]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C926(1.67)  LDD2105  [15]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C926(1.20)  LDD2107  [15]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C926(1.03)  LDD2116  [15]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C926(0.87)  LDD2118  [15]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C926(1.22)  LDD2122  [15]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C926(1.01)  LDD2123  [15]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C926(0.90)  LDD2124  [15]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C926(1.20)  LDD2125  [15]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C926(1.29)  LDD2128  [15]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C926(1.08)  LDD2135  [15]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C926(1.22)  LDD2136  [15]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C926(1.00)  LDD2137  [15]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C926(1.11)  LDD2143  [15]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C926(1.33)  LDD2146  [15]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C926(2.51)  LDD2147  [15]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C926(0.98)  LDD2149  [15]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C926(0.94)  LDD2150  [15]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C926(1.50)  LDD2151  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C926(1.50)  LDD2207  [18]
 LDCM0021  THZ1 HCT 116 C926(0.92)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Ephrin type-A receptor 2 (EPHA2) Tyr protein kinase family P29317
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945
Adapter molecule crk (CRK) CRK family P46108
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Protein HID1 (HID1) Hid-1 family Q8IV36
Sorbin and SH3 domain-containing protein 1 (SORBS1) . Q9BX66

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
15 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.