Details of the Target

General Information of Target

Target ID LDTP19320
Target Name Ankyrin repeat domain-containing protein 39 (ANKRD39)
Gene Name ANKRD39
Gene ID 51239
Synonyms
Ankyrin repeat domain-containing protein 39
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEGPAEWGPEAALGPEAVLRFLAERGGRALHAELVQHFRGALGGEPEQRARARAHFKELV
NAVATVRVDPADGAKYVHLKKRFCEGPSEPSGDPPRIQVTAEPEAPDGPAGPEARDRLPD
AAAPESLPGQGRELGEGEPPAPAHWPPLSAGARRKNSRRDVQPLPRTPAPGPSEDLELPP
HGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGG
DSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFI
TGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLL
VGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLSKVLP
SHLITYKLSHALEDGGDHHHHHHSAEGWVGGKAKDPGRKASGSSSGRIKPRLNKIRFRTQ
IVHTTPSFRDPEQPLEGRGEEGVGEERPVKGHSPFTLRPKSNVFG
Target Bioclass
Other
Family
ANKRD39 family
Uniprot ID
Q53RE8
Ensemble ID
ENST00000393537.5
HGNC ID
HGNC:28640

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.96  LDD0402  [1]
IPM
 Probe Info  		C107(0.00); C90(0.00); C146(0.00)  LDD0241  [2]
HHS-482
 Probe Info  		Y65(1.00)  LDD0285  [3]
HHS-475
 Probe Info  		Y65(1.05)  LDD0264  [4]
HHS-465
 Probe Info  		Y65(1.79)  LDD2237  [5]
DBIA
 Probe Info  		C173(1.01)  LDD0531  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
Phosphinate-6
 Probe Info  		C107(0.00); C173(0.00)  LDD0018  [10]
NAIA_5
 Probe Info  		C146(0.00); C107(0.00); C90(0.00); C80(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C173(1.01)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C168(1.20); C173(1.20)  LDD0532  [6]
 LDCM0216  AC100 HEK-293T C168(1.22); C173(1.22)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C168(1.35); C173(1.35)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C168(1.08); C173(1.08)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C168(1.21); C173(1.21)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C168(1.07); C173(1.07)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C168(1.21); C173(1.21)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C168(1.15); C173(1.15)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C168(1.33); C173(1.33)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C168(1.06); C173(1.06)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C168(1.09); C173(1.09)  LDD0823  [6]
 LDCM0226  AC11 HCT 116 C168(1.25); C173(1.25)  LDD0543  [6]
 LDCM0227  AC110 HEK-293T C168(1.16); C173(1.16)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C168(1.15); C173(1.15)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C168(1.05); C173(1.05)  LDD0827  [6]
 LDCM0230  AC113 HCT 116 C168(1.13); C173(1.13)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C168(1.20); C173(1.23)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C168(1.05); C173(1.11)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C168(1.20); C173(1.28)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C168(1.41); C173(1.37)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C168(1.18); C173(1.19)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C168(1.47); C173(1.41)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C168(0.98); C173(0.98)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C168(1.23); C173(1.21)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C168(1.11); C173(1.16)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C168(1.26); C173(1.16)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C168(1.42); C173(1.43)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C168(1.33); C173(1.23)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C168(1.20); C173(1.07)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C168(1.07); C173(1.08)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C168(1.34); C173(1.31)  LDD0562  [6]
 LDCM0246  AC128 HEK-293T C168(1.11); C173(1.11)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C168(1.02); C173(1.02)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C168(1.29); C173(1.29)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C168(1.10); C173(1.10)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C168(1.30); C173(1.30)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C168(1.23); C173(1.23)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C168(1.09); C173(1.09)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C168(1.09); C173(1.09)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C168(1.38); C173(1.38)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C168(1.31); C173(1.31)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C168(1.09); C173(1.09)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C168(1.17); C173(1.17)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C168(1.01); C173(1.01)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C168(1.20); C173(1.20)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C168(1.05); C173(1.05)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C168(1.14); C173(1.14)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C168(0.91); C173(0.91)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C168(0.89); C173(0.89)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C168(0.86); C173(0.86)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C168(0.98); C173(0.98)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C168(0.89); C173(0.89)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C168(0.89); C173(0.89)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C168(0.89); C173(0.89)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C168(0.96); C173(0.96)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C168(1.01); C173(1.01)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C168(1.69); C173(1.69)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C168(0.96); C173(0.96)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C168(1.05); C173(1.05)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C168(1.04); C173(1.04)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C168(1.33); C173(1.33)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C168(1.02); C173(1.02)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C168(1.04); C173(1.04)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C173(0.98); C168(1.08)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C173(0.93); C168(0.96)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C173(1.10); C168(1.18)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C173(1.43)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C173(0.93); C168(0.96)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C173(0.98); C168(1.01)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C173(0.98); C168(1.02)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C173(1.13); C168(1.14)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C173(0.99); C168(1.03)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C168(0.72); C173(0.72)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C168(1.04); C173(1.04)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C168(0.86); C173(0.86)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C168(1.27); C173(1.27)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C168(1.05); C173(1.05)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C173(1.02)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C168(1.17); C173(1.17)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C168(1.09); C173(1.09)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C168(1.28); C173(1.28)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C168(1.15); C173(1.15)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C168(0.89); C173(0.89)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C168(1.03); C173(1.03)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C168(0.95); C173(0.95)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C168(1.05); C173(1.05)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C168(0.96); C173(0.96)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C168(0.99); C173(0.99)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C173(0.79)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C168(1.04); C173(1.04)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C168(0.90); C173(0.90)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C168(0.85); C173(0.85)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C168(0.95); C173(0.95)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C168(1.10); C173(1.10)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C168(1.27); C173(1.27)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C168(0.75); C173(0.75)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C168(0.78); C173(0.78)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C168(0.76); C173(0.76)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C168(1.29); C173(1.29)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C173(0.96)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C168(1.43); C173(1.43)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C168(0.77); C173(0.77)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C168(0.97); C173(0.97)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C168(1.31); C173(1.31)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C168(1.14); C173(1.14)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C168(1.34); C173(1.34)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C168(1.87); C173(1.87)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C168(1.03); C173(1.03)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C168(1.22); C173(1.22)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C168(1.08); C173(1.08)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C168(1.13); C173(1.13)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C168(0.87); C173(0.87)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C168(1.14); C173(1.14)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C168(1.03); C173(1.03)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C168(0.98); C173(0.98)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C168(1.03); C173(1.03)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C168(1.51); C173(1.51)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C168(1.32); C173(1.32)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C168(1.26); C173(1.26)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C168(0.88); C173(0.88)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C168(0.85); C173(0.85)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C168(0.99); C173(0.99)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C168(0.91); C173(0.91)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C168(0.85); C173(0.85)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C168(0.88); C173(0.88)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C168(0.82); C173(0.82)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C168(0.76); C173(0.76)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C168(0.97); C173(0.97)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C168(0.79); C173(0.79)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C168(0.91); C173(0.91)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C168(0.94); C173(0.94)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C168(0.91); C173(0.91)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C168(1.10); C173(1.10)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C168(0.92); C173(0.92)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C168(0.94); C173(0.94)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C168(1.00); C173(1.00)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C168(0.98); C173(0.98)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C168(1.00); C173(1.00)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C168(1.19); C173(1.19)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C168(1.22); C173(1.22)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C168(1.06); C173(1.06)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C168(1.19); C173(1.19)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C168(1.05); C173(1.05)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C168(1.15); C173(1.15)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C168(1.02); C173(1.02)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C168(1.03); C173(1.03)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C168(1.18); C173(1.18)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C168(1.09); C173(1.09)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C168(0.99); C173(0.99)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C168(1.02); C173(1.02)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C168(1.23); C173(1.23)  LDD0681  [6]
 LDCM0365  AC98 HEK-293T C168(1.11); C173(1.11)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C168(1.11); C173(1.11)  LDD0964  [6]
 LDCM0248  AKOS034007472 HCT 116 C168(1.02); C173(1.02)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C168(1.21); C173(1.21)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C168(1.04); C173(1.04)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C168(1.09); C173(1.09)  LDD2171  [6]
 LDCM0632  CL-Sc Hep-G2 C146(20.00); C146(1.03); C90(0.77)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C168(1.18); C173(1.18)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C168(1.33); C173(1.33)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C173(1.07)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C168(1.20); C173(1.20)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C168(1.21); C173(1.21)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C168(1.23); C173(1.23)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C168(1.04); C173(1.04)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C173(1.03); C168(1.13)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C173(1.01); C168(1.08)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C173(0.92); C168(0.99)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C173(1.16); C168(1.28)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C173(1.02); C168(1.04)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C168(1.07); C173(1.07)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C173(1.27); C168(1.28)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C173(1.16); C168(1.17)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C168(0.93); C173(0.93)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C168(1.32); C173(1.32)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C168(1.22); C173(1.22)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C168(0.96); C173(0.96)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C168(0.96); C173(0.96)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C168(1.17); C173(1.17)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C168(0.99); C173(0.99)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C168(1.00); C173(1.00)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C168(1.42); C173(1.42)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C168(1.13); C173(1.13)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C168(2.12); C173(2.12)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C168(0.81); C173(0.81)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C168(1.41); C173(1.41)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C168(1.12); C173(1.12)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C168(1.09); C173(1.09)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C168(1.02); C173(1.02)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C168(0.92); C173(0.92)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C168(1.04); C173(1.04)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C168(1.13); C173(1.13)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C168(1.03); C173(1.03)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C168(0.92); C173(0.92)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C168(1.46); C173(1.46)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C168(1.14); C173(1.14)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C168(1.25); C173(1.25)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C168(1.24); C173(1.24)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C168(0.95); C173(0.95)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C168(1.39); C173(1.39)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C168(1.84); C173(1.84)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C168(2.35); C173(2.35)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C168(1.40); C173(1.40)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C168(1.91); C173(1.91)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C168(1.90); C173(1.90)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C168(1.21); C173(1.21)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C168(1.33); C173(1.33)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C168(1.61); C173(1.61)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C168(1.53); C173(1.53)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C168(1.07); C173(1.07)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C168(1.24); C173(1.24)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C168(0.95); C173(0.95)  LDD0737  [6]
 LDCM0421  CL32 HEK-293T C168(0.86); C173(0.86)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C168(1.03); C173(1.03)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C168(0.95); C173(0.95)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C168(0.96); C173(0.96)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C168(1.06); C173(1.06)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C168(1.19); C173(1.19)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C168(1.00); C173(1.00)  LDD1026  [6]
 LDCM0429  CL4 HCT 116 C168(1.16); C173(1.16)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C168(0.85); C173(0.85)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C168(1.00); C173(1.00)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C168(0.85); C173(0.85)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C168(0.83); C173(0.83)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C168(1.00); C173(1.00)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C168(1.40); C173(1.40)  LDD1033  [6]
 LDCM0436  CL46 HCT 116 C168(1.29); C173(1.29)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C168(1.27); C173(1.27)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C168(1.27); C173(1.27)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C168(1.16); C173(1.16)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C168(0.95); C173(0.95)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C168(0.99); C173(0.99)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C168(1.23); C173(1.23)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C168(1.25); C173(1.25)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C168(1.17); C173(1.17)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C168(1.26); C173(1.26)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C168(1.24); C173(1.24)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C168(1.23); C173(1.23)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C168(1.48); C173(1.48)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C168(1.28); C173(1.28)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C168(1.22); C173(1.22)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C168(0.99); C173(0.99)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C168(1.24); C173(1.24)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C168(1.07); C173(1.07)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C168(1.13); C173(1.07)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C168(1.40); C173(1.41)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C168(1.76); C173(1.80)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C168(1.12); C173(1.17)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C168(2.12); C173(2.27)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C168(1.65); C173(1.81)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C168(1.45); C173(1.44)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C168(1.07); C173(1.09)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C168(0.99); C173(0.99)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C168(1.28); C173(1.28)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C168(1.57); C173(1.60)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C168(1.19); C173(1.24)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C168(1.38); C173(1.37)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C168(1.50); C173(1.52)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C168(0.90); C173(0.90)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C168(1.00); C173(1.00)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C168(0.78); C173(0.78)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C168(0.95); C173(0.95)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C168(1.26); C173(1.26)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C168(0.90); C173(0.90)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C168(0.86); C173(0.86)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C168(0.90); C173(0.90)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C168(1.10); C173(1.10)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C168(1.04); C173(1.04)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C168(1.28); C173(1.28)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C168(1.08); C173(1.08)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C168(1.00); C173(1.00)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C168(1.11); C173(1.11)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C168(0.98); C173(0.98)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C168(1.22); C173(1.22)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C168(1.01); C173(1.01)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C173(1.06)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C173(1.11)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C173(0.94)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C173(0.99)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C173(0.90)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C173(1.04)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C173(1.14)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C173(1.07)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C173(0.96)  LDD0811  [6]
 LDCM0625  F8 Ramos C107(1.00); C90(1.42)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C90(0.26)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C107(2.04)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C90(0.44)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C90(0.64)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C107(0.98)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C90(0.57)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C90(0.70)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C90(0.36)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C90(0.82)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C107(0.68); C90(0.46)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C90(0.63)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C90(0.83)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C90(0.28)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C168(1.43); C173(1.80)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C90(1.59)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C107(0.44); C90(0.70)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C168(1.16); C173(1.16)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C90(0.98)  LDD2204  [12]
 LDCM0569  Fragment7 Ramos C107(0.65); C90(0.46)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C90(0.28)  LDD2188  [12]
 LDCM0116  HHS-0101 DM93 Y65(1.05)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y65(1.75)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y65(2.06)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y65(3.00)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y65(1.79)  LDD0268  [4]
 LDCM0123  JWB131 DM93 Y65(1.00)  LDD0285  [3]
 LDCM0124  JWB142 DM93 Y65(0.60)  LDD0286  [3]
 LDCM0125  JWB146 DM93 Y65(1.47)  LDD0287  [3]
 LDCM0126  JWB150 DM93 Y65(2.14)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y65(10.90)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y65(1.35)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y65(0.34)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y65(1.01)  LDD0292  [3]
 LDCM0022  KB02 Ramos C107(0.33); C90(0.41)  LDD2182  [12]
 LDCM0023  KB03 Ramos C107(0.35); C90(0.53)  LDD2183  [12]
 LDCM0024  KB05 G361 C90(1.35)  LDD3311  [13]
 LDCM0131  RA190 MM1.R C173(4.03)  LDD0304  [14]
 LDCM0021  THZ1 HCT 116 C168(1.09); C173(1.09)  LDD2173  [6]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.