Details of the Target

General Information of Target

Target ID LDTP15429
Target Name Large ribosomal subunit protein mL50 (MRPL50)
Gene Name MRPL50
Gene ID 54534
Synonyms
Large ribosomal subunit protein mL50; 39S ribosomal protein L50, mitochondrial; L50mt; MRP-L50
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKRLQEAQLYKEEGNQRYREGKYRDAVSRYHRALLQLRGLDPSLPSPLPNLGPQGPALT
PEQENILHTTQTDCYNNLAACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFH
LQDYDQARHYLLAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG
Target Bioclass
Other
Family
Mitochondrion-specific ribosomal protein mL50 family
Subcellular location
Mitochondrion
Uniprot ID
Q8N5N7
Ensemble ID
ENST00000374865.5
HGNC ID
HGNC:16654

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.D125V .
NCIH1155 SNV: p.A59P DBIA    Probe Info 
PF382 SNV: p.P133R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C52(2.91)  LDD0169  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C52(1.07)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
BTD
 Probe Info  		N.A.  LDD0004  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
WYneO
 Probe Info  		N.A.  LDD0022  [6]
IPM
 Probe Info  		N.A.  LDD0005  [6]
PPMS
 Probe Info  		N.A.  LDD0008  [6]
Phosphinate-6
 Probe Info  		C52(0.00); C121(0.00)  LDD0018  [9]
Crotonaldehyde
 Probe Info  		C52(0.00); C121(0.00)  LDD0219  [3]
Methacrolein
 Probe Info  		C52(0.00); C121(0.00)  LDD0218  [3]
W1
 Probe Info  		N.A.  LDD0236  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C52(0.56)  LDD2142  [12]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C52(0.75)  LDD2112  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C52(0.90); C121(0.76)  LDD2117  [12]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C52(1.02)  LDD2152  [12]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C52(0.88)  LDD2103  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C52(2.91)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C52(1.15)  LDD1507  [13]
 LDCM0215  AC10 HCT 116 C52(1.28)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C52(1.03)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C52(1.03)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C52(1.00)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C52(1.02)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C52(0.90)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C52(0.89)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C52(1.06)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C52(1.09)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C52(0.87)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C52(0.83)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C52(1.42)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C52(1.13)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C52(1.04)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C52(1.08)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C52(0.82)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C52(0.88)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C52(0.78)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C52(1.18)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C52(0.73)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C52(1.04)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C52(0.92)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C52(1.22)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C52(0.91)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C52(0.74)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C52(0.87)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C52(0.83)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C52(0.93)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C52(1.06)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C52(0.95)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C52(0.88)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C52(1.29)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C52(1.02)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C52(0.97)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C52(0.90)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C52(1.00)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C52(0.81)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C52(1.19)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C52(1.05)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C52(1.41)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C52(0.95)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C52(0.95)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C52(0.75)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C52(1.02)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C52(1.00)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C52(1.04)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C52(1.05)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C52(0.98)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C52(1.24)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C52(1.11)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C52(1.13)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C52(1.16)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C52(1.23)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C52(1.00)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C52(0.99)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C52(1.57)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C52(1.23)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C52(1.06)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C52(0.86)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C52(1.03)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C52(1.11)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C52(0.90)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C52(0.94)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C52(0.84)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C52(1.07)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C52(1.08)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C52(1.41)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C52(1.15)  LDD1534  [13]
 LDCM0296  AC35 HCT 116 C52(1.12)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C52(1.15)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C52(0.89)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C52(1.19)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C52(1.19)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C52(0.91)  LDD1540  [13]
 LDCM0302  AC40 HCT 116 C52(1.06)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C52(1.06)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C52(1.28)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C52(1.23)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C52(1.00)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C52(1.01)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C52(1.08)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C52(1.30)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C52(1.21)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C52(1.22)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C52(0.88)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C52(1.04)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C52(1.09)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C52(1.28)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C52(1.08)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C52(1.17)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C52(1.39)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C52(1.20)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C52(1.09)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C52(1.02)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C52(1.20)  LDD1561  [13]
 LDCM0323  AC6 HCT 116 C52(1.32)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C52(1.27)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C52(0.88)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C52(1.02)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C52(1.30)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C52(1.09)  LDD1567  [13]
 LDCM0334  AC7 HCT 116 C52(1.21)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C52(1.26)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C52(1.02)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C52(1.11)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C52(1.07)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C52(1.12)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C52(1.07)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C52(0.98)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C52(1.00)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C52(1.40)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C52(1.07)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C52(1.26)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C52(1.17)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C52(1.22)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C52(1.20)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C52(1.47)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C52(1.15)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C52(1.01)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C52(0.95)  LDD0683  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C52(0.72); C121(0.75)  LDD2113  [12]
 LDCM0248  AKOS034007472 HCT 116 C52(1.18)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C52(1.42)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C52(1.55)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 14.79  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C52(1.07)  LDD0078  [4]
 LDCM0630  CCW28-3 231MFP C52(1.37)  LDD2214  [14]
 LDCM0108  Chloroacetamide HeLa C52(0.00); C121(0.00)  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C52(20.00)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C52(0.88)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C52(0.68)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C52(1.10)  LDD1573  [13]
 LDCM0370  CL101 HCT 116 C52(1.49)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C52(1.12)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C52(1.17)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C52(1.33)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C52(1.02)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C52(0.99)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C52(1.16)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C52(0.98)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C52(0.98)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C52(1.04)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C52(0.90)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C52(0.90)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C52(0.90)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C52(1.10)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C52(0.94)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C52(1.03)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C52(1.19)  LDD1590  [13]
 LDCM0387  CL117 HCT 116 C52(1.57)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C52(1.32)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C52(1.28)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C52(1.02)  LDD1594  [13]
 LDCM0391  CL120 HCT 116 C52(1.17)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C52(1.03)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C52(1.07)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C52(0.99)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C52(1.00)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C52(0.92)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C52(1.07)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C52(1.02)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C52(1.08)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C52(1.06)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C52(1.04)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C52(1.11)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C52(1.11)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C52(1.12)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C52(0.94)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C52(1.02)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C52(1.09)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C52(1.26)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C52(0.92)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C52(0.91)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C52(1.32)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C52(1.01)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C52(1.06)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C52(1.25)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C52(1.12)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C52(1.07)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C52(1.14)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C52(1.00)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C52(1.03)  LDD1623  [13]
 LDCM0420  CL31 HCT 116 C52(0.82)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C52(0.90)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C52(1.03)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C52(1.01)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C52(1.00)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C52(0.96)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C52(0.99)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C52(0.79)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C52(0.99)  LDD1633  [13]
 LDCM0430  CL40 HCT 116 C52(0.84)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C52(0.91)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C52(0.85)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C52(0.93)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C52(0.84)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C52(0.99)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C52(1.00)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C52(0.92)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C52(1.01)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C52(0.97)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C52(1.21)  LDD1644  [13]
 LDCM0441  CL50 HCT 116 C52(0.98)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C52(0.94)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C52(0.73)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C52(0.79)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C52(0.80)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C52(0.79)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C52(0.99)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C52(0.74)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C52(0.83)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C52(0.87)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C52(0.90)  LDD1654  [13]
 LDCM0452  CL60 HCT 116 C52(1.30)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C52(0.94)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C52(1.06)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C52(1.14)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C52(1.12)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C52(1.00)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C52(1.21)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C52(1.33)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C52(1.30)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C52(1.20)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C52(1.07)  LDD1665  [13]
 LDCM0463  CL70 HCT 116 C52(1.25)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C52(1.10)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C52(1.18)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C52(1.35)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C52(1.26)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C52(1.05)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C52(1.08)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C52(1.28)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C52(1.24)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C52(0.73)  LDD1676  [13]
 LDCM0474  CL80 HCT 116 C52(1.06)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C52(1.19)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C52(1.29)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C52(1.12)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C52(1.53)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C52(1.21)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C52(0.95)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C52(1.21)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C52(1.33)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C52(1.82)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C52(0.72)  LDD1687  [13]
 LDCM0485  CL90 HCT 116 C52(0.86)  LDD0802  [4]
 LDCM0486  CL91 HEK-293T C52(1.14)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C52(1.25)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C52(0.94)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C52(1.09)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C52(0.99)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C52(1.03)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C52(0.96)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C52(0.91)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C52(0.86)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C52(1.09)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C52(1.01); C121(0.82)  LDD1702  [12]
 LDCM0625  F8 Ramos C52(0.89)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C52(0.75)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C52(1.32)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C52(0.70)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C52(1.08)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C52(0.30)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C52(0.65)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C52(1.02)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C52(2.22)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C52(1.60)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C52(0.59)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C52(1.22)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C52(1.24)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C52(0.86)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C52(1.30)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C52(0.95)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C52(0.83)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C52(0.92)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C52(1.25)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C52(1.07)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C52(0.64)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C52(0.70)  LDD2188  [15]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HEK-293T C52(1.18)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C52(1.26)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C52(0.97)  LDD3310  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C52(0.80)  LDD2102  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C52(1.21)  LDD2090  [12]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C52(0.93)  LDD2092  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C52(1.15)  LDD2093  [12]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C52(1.07)  LDD2094  [12]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C52(0.83); C121(0.71)  LDD2097  [12]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C52(0.97)  LDD2098  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C52(1.49); C121(1.00)  LDD2099  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C52(0.47)  LDD2100  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C52(1.02); C121(0.77)  LDD2101  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C52(0.41)  LDD2104  [12]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C52(1.20)  LDD2105  [12]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C52(1.39)  LDD2106  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C52(0.95); C121(0.98)  LDD2107  [12]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C52(0.53)  LDD2108  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C52(1.20); C121(0.92)  LDD2109  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C52(0.70)  LDD2110  [12]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C52(1.59); C121(1.03)  LDD2111  [12]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C52(0.45)  LDD2114  [12]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C121(0.67)  LDD2115  [12]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C52(0.77)  LDD2118  [12]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C52(0.82)  LDD2120  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C52(0.89); C121(1.21)  LDD2123  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C52(0.74); C121(0.94)  LDD2125  [12]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C52(1.06)  LDD2126  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C52(0.85); C121(0.87)  LDD2127  [12]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C52(0.91)  LDD2128  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C52(1.55)  LDD2129  [12]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C52(1.09)  LDD2133  [12]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C52(0.53); C121(0.51)  LDD2134  [12]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C52(1.48); C121(2.07)  LDD2135  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C52(1.00); C121(1.18)  LDD2136  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C52(1.25); C121(0.91)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C121(1.36)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C52(0.74); C121(0.82)  LDD2140  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C52(0.69)  LDD2141  [12]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C52(0.81)  LDD2143  [12]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C52(0.93); C121(1.30)  LDD2146  [12]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C52(1.67)  LDD2147  [12]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C52(0.56)  LDD2148  [12]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C52(0.89)  LDD2151  [12]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C52(1.63)  LDD2153  [12]
 LDCM0021  THZ1 HCT 116 C52(1.09)  LDD2173  [4]

References

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2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840