Details of the Target

General Information of Target

Target ID LDTP11649
Target Name Egl nine homolog 1 (EGLN1)
Gene Name EGLN1
Gene ID 54583
Synonyms
C1orf12; Egl nine homolog 1; EC 1.14.11.29; Hypoxia-inducible factor prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2; SM-20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSSCVRPVPTTVRFVDSLICNSSRSFMDLKALLSSLNDFASLSFAESWDNVGLLVEPSP
PHTVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWNTWKERLVIRALENR
VGIYSPHTAYDAAPQGVNNWLAKGLGACTSRPIHPSKAPNYPTEGNHRVEFNVNYTQDLD
KVMSAVKGIDGVSVTSFSARTGNEEQTRINLNCTQKALMQVVDFLSRNKQLYQKTEILSL
EKPLLLHTGMGRLCTLDESVSLATMIDRIKRHLKLSHIRLALGVGRTLESQVKVVALCAG
SGSSVLQGVEADLYLTGEMSHHDTLDAASQGINVILCEHSNTERGFLSDLRDMLDSHLEN
KINIILSETDRDPLQVV
Target Type
Patented-recorded
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
TTD ID
T32880
Uniprot ID
Q9GZT9
DrugMap ID
TT9ISBX
Ensemble ID
ENST00000366641.4
HGNC ID
HGNC:1232
ChEMBL ID
CHEMBL5697

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ICC10 SNV: p.T296A DBIA    Probe Info 
ICC106 SNV: p.T296A DBIA    Probe Info 
ICC108 SNV: p.T296A DBIA    Probe Info 
MOLT4 SNV: p.R281L IA-alkyne    Probe Info 
OVK18 Deletion: p.D106TfsTer7 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.96  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K255(0.99); K408(5.00)  LDD0277  [3]
BTD
 Probe Info  		C127(1.17)  LDD1699  [4]
AHL-Pu-1
 Probe Info  		C127(2.09)  LDD0169  [5]
DBIA
 Probe Info  		C42(1.06); C43(0.96); C201(0.95); C21(0.93)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C127(0.00); C302(0.00); C266(0.00); C208(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C127(0.00); C302(0.00); C266(0.00); C208(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C127(0.00); C302(0.00); C266(0.00); C208(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		C127(0.00); C302(0.00)  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		12.70  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C127(1.01)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C127(1.05)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C127(0.70)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C127(0.80)  LDD2131  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C127(2.09)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C201(1.04); C302(0.60); C42(1.14); C43(1.14)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C201(1.09); C208(0.81); C42(0.73); C43(0.73)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C323(0.42); C326(0.42); C42(1.17); C43(1.17)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C323(0.39); C326(0.39); C42(1.29); C43(1.29)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C323(0.45); C326(0.45); C42(1.11); C43(1.11)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C323(0.40); C326(0.40); C42(1.24); C43(1.24)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C323(0.40); C326(0.40); C42(1.08); C43(1.08)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C323(0.31); C326(0.31); C42(1.30); C43(1.30)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C323(0.29); C326(0.29); C42(1.59); C43(1.59)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C323(0.26); C326(0.26); C42(1.39); C43(1.39)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C323(0.44); C326(0.44); C42(1.45); C43(1.45)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C323(0.74); C326(0.74); C42(0.93); C43(0.93)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C201(1.03); C208(0.72); C42(1.07); C43(1.07)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C323(0.63); C326(0.63); C42(1.61); C43(1.61)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C323(0.58); C326(0.58); C42(1.68); C43(1.68)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C323(0.36); C326(0.36); C42(1.69); C43(1.69)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C201(0.83); C208(0.97); C302(1.10); C42(1.05)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C201(0.73); C208(0.98); C302(1.22); C42(1.05)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C201(0.74); C208(0.93); C302(1.13); C42(0.99)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C201(0.79); C208(0.98); C302(1.41); C42(1.12)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C201(0.79); C208(1.08); C302(1.09); C42(1.10)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C201(0.73); C208(1.01); C302(1.18); C42(0.96)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C201(0.89); C208(0.95); C302(1.07); C42(1.10)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C201(1.04); C208(0.83); C42(0.82); C43(0.82)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C201(0.71); C208(0.89); C302(1.47); C42(1.04)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C201(1.00); C208(1.09); C302(0.93); C42(0.90)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C201(0.81); C208(0.99); C302(1.26); C42(1.07)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C201(0.79); C208(1.05); C302(0.82); C42(1.05)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C201(0.67); C208(1.06); C302(1.04); C42(1.14)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C201(0.86); C208(0.92); C302(1.21); C42(1.06)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C201(0.81); C208(0.98); C302(1.18); C42(0.99)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C201(0.70); C208(1.01); C302(1.29); C42(1.08)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C208(1.09); C302(1.66); C323(0.76); C326(0.76)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C208(1.19); C302(0.93); C323(1.14); C326(1.14)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C208(0.99); C302(1.00); C323(0.84); C326(0.84)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C208(1.02); C302(1.50); C323(1.88); C326(1.88)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C208(1.01); C302(1.00); C323(0.76); C326(0.76)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C208(0.97); C302(0.91); C323(0.69); C326(0.69)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C208(0.89); C302(1.08); C323(0.67); C326(0.67)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C208(0.96); C302(0.95); C323(0.69); C326(0.69)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C208(0.91); C302(0.85); C323(0.71); C326(0.71)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C208(0.96); C302(0.97); C323(0.69); C326(0.69)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C208(0.86); C302(0.90); C323(0.62); C326(0.62)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C208(0.90); C302(0.78); C323(0.69); C326(0.69)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C201(1.14); C208(0.78); C42(1.09); C43(1.09)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C208(0.85); C302(1.07); C323(0.62); C326(0.62)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C208(0.88); C302(0.81); C323(0.69); C326(0.69)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C208(1.02); C302(0.88); C323(0.74); C326(0.74)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C201(1.07); C208(0.76); C323(0.69); C326(0.72)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C201(0.62); C326(0.63); C208(0.75); C323(0.82)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C326(0.70); C42(0.71); C43(0.71); C323(0.77)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C326(0.47); C323(0.54); C208(0.60); C42(0.93)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C323(0.57); C326(0.61); C201(0.70); C208(0.73)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C326(0.53); C323(0.54); C208(0.63); C201(0.82)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C326(0.43); C323(0.45); C208(0.60); C201(0.74)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C208(0.76); C42(0.84); C43(0.84); C201(1.07)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C326(0.58); C323(0.63); C42(0.76); C43(0.76)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C326(0.75); C208(0.78); C323(0.87); C42(0.90)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C323(0.53); C208(0.56); C326(0.59); C201(0.66)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C208(0.55); C323(0.65); C326(0.69); C42(0.79)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C201(0.70); C208(0.70); C323(0.68); C326(0.64)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C201(0.86); C208(0.60); C323(0.72); C326(0.62)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C201(0.88); C208(0.90); C323(0.91); C326(0.95)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C201(0.73); C208(0.77); C323(1.23); C326(1.41)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C42(0.44); C43(0.44); C302(0.82); C326(0.82)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C42(0.59); C43(0.59); C208(0.60); C326(0.96)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C42(0.50); C43(0.50); C208(0.86); C326(0.89)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C302(0.67); C42(0.99); C43(0.99); C201(1.10)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C42(0.52); C43(0.52); C208(0.80); C326(0.96)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C42(0.52); C43(0.52); C208(0.83); C326(0.89)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C42(0.47); C43(0.47); C326(0.67); C302(0.97)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C42(0.43); C43(0.43); C208(0.89); C201(0.90)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C42(0.50); C43(0.50); C201(0.96); C302(1.01)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C201(0.91)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C201(1.05)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C201(0.76)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C201(0.77)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C201(0.85)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C302(0.68); C42(0.92); C43(0.92); C201(1.08)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C201(0.90)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C201(0.95)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C201(0.80)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C201(0.76)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C201(0.72)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C302(2.05)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C302(1.06)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C302(1.01)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C302(0.97)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C302(0.83)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C302(0.58); C42(1.11); C43(1.11); C201(1.13)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C302(0.83)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C302(0.87)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C302(0.87)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C302(0.78)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C302(0.94)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C302(1.04)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C208(0.95); C201(0.97); C302(0.98); C43(1.00)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C208(0.98); C201(1.02); C43(1.05); C302(1.06)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C302(0.80); C208(1.04); C43(1.04); C201(1.31)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C302(0.92); C201(1.00); C208(1.02); C43(1.56)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C302(0.57); C42(1.03); C43(1.03); C201(1.13)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C208(0.93); C302(1.01); C201(1.05); C43(1.50)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C43(0.80); C201(1.09); C208(1.13); C302(1.14)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C201(0.90); C208(0.97); C43(0.98); C302(0.99)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C208(0.85); C201(0.91); C302(0.92); C43(1.18)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C208(0.95); C201(0.96); C302(1.10); C43(1.29)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C208(0.89); C201(0.99); C302(1.06); C43(1.44)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C302(0.94); C208(1.03); C201(1.26); C43(2.30)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C42(0.82); C43(0.82)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C42(0.92); C43(0.92)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C42(0.99); C43(0.99)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C208(0.79); C42(0.99); C43(0.99); C201(1.05)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C42(1.18); C43(1.18)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C42(1.17); C43(1.17)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C42(1.07); C43(1.07)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C42(1.00); C43(1.00)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C42(1.12); C43(1.12)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C42(1.24); C43(1.24)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C42(0.97); C43(0.97)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C42(1.52); C43(1.52)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C323(0.57); C326(0.63); C42(0.95); C43(1.06)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C326(0.72); C323(0.74); C42(0.79); C43(1.07)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C42(0.88); C43(0.88); C208(0.90); C201(1.00)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C323(0.43); C326(0.67); C42(0.70); C43(0.91)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C323(0.69); C42(0.70); C43(0.80); C326(0.81)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C326(0.72); C42(0.73); C323(0.75); C43(1.06)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C323(0.68); C326(0.77); C42(0.89); C43(1.03)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C323(0.67); C42(0.70); C326(0.89); C43(1.08)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C326(0.70); C323(0.71); C42(0.74); C43(0.93)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C323(0.63); C42(0.63); C326(0.79); C43(0.86)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C323(0.54); C326(0.62); C42(0.91); C43(0.98)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C323(0.70); C326(0.83); C42(0.84); C43(1.05)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C323(0.60); C326(0.68); C42(0.74); C43(1.02)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C208(0.81); C42(0.88); C43(0.88); C201(1.14)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C323(0.57); C42(0.87); C326(0.87); C43(0.93)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C42(0.71); C323(0.73); C326(0.82); C43(1.06)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C323(0.59); C326(0.78); C42(0.79); C43(0.92)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C323(0.52); C326(0.52); C302(0.64); C43(1.39)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C323(0.53); C326(0.53); C302(0.88); C42(1.19)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C323(0.54); C326(0.54); C302(0.79); C42(1.05)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C323(0.60); C326(0.60); C302(0.63); C42(0.97)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C302(0.74); C42(0.91); C43(0.94); C323(0.99)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C323(0.86); C326(0.86); C43(1.04); C42(1.07)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C323(0.79); C326(0.79); C302(0.81); C43(1.14)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C43(0.84); C42(0.85); C302(1.08); C323(1.63)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C323(0.60); C326(0.60); C302(0.71); C43(1.27)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C323(0.61); C326(0.61); C302(0.90); C43(1.29)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C323(0.86); C326(0.86); C42(1.04); C43(1.04)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C323(0.93); C326(0.93); C43(1.06); C42(1.10)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C323(0.83); C326(0.83); C42(0.96); C43(0.96)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C323(0.72); C326(0.72); C43(1.03); C42(1.03)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C302(0.64); C323(0.70); C326(0.70); C42(1.14)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C323(0.20); C326(0.20); C42(1.48); C43(1.48)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C323(0.52); C326(0.52); C42(1.25); C43(1.25)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C127(0.62)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C201(1.05); C208(0.98); C42(0.92); C43(0.92)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C208(0.86); C42(0.93); C43(0.93); C201(1.07)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C208(0.65); C42(0.85); C43(0.85); C201(1.19)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 13.09  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C42(1.06); C43(0.96); C201(0.95); C21(0.93)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C127(0.52)  LDD2091  [4]
 LDCM0632  CL-Sc Hep-G2 C201(20.00); C127(20.00)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C326(0.78); C42(0.98); C43(0.98); C323(1.00)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C323(0.80); C326(0.82); C302(0.85); C42(1.21)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C302(0.60); C201(1.10); C42(1.10); C43(1.10)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C208(0.75); C201(1.10); C42(1.26); C43(1.26)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C42(0.77); C43(0.77); C208(0.90); C201(1.04)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C208(0.88); C201(0.98); C42(0.99); C43(0.99)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C42(0.83); C43(0.83); C208(0.98); C201(1.09)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C42(0.53); C43(0.53); C326(0.58); C208(0.74)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C42(0.51); C43(0.51); C326(0.60); C208(0.61)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C326(0.47); C42(0.56); C43(0.56); C208(0.57)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C42(0.41); C43(0.41); C208(0.60); C326(0.66)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C326(0.43); C42(0.59); C43(0.59); C208(0.77)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C326(0.66); C42(0.70); C43(0.70); C323(0.76)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C42(0.43); C43(0.43); C208(0.71); C326(0.72)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C42(0.53); C43(0.53); C326(0.62); C208(0.70)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C201(1.03)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C201(0.64)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C201(0.92)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C201(0.89)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C201(1.13)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C302(0.84)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C302(1.06)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C302(0.96)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C326(0.63); C302(0.83); C323(0.86); C42(1.02)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C302(0.74)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C208(0.79); C201(0.92); C43(0.98); C302(1.32)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C208(0.83); C302(0.85); C43(1.12); C201(1.16)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C302(0.77); C208(0.79); C201(0.99); C43(1.27)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C208(0.83); C302(0.86); C201(1.15); C43(1.28)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C42(0.89); C43(0.89)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C42(0.79); C43(0.79)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C42(1.00); C43(1.00)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C42(0.92); C43(0.92)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C326(0.63); C302(0.75); C42(0.95); C43(0.95)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C326(0.77); C302(0.81); C323(0.90); C42(0.98)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C326(0.53); C302(0.64); C323(0.70); C42(0.85)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C326(0.42); C302(0.93); C42(1.14); C43(1.14)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C326(0.43); C42(0.89); C43(0.95); C302(1.11)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C326(0.74); C302(0.91); C43(1.02); C42(1.03)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C326(0.43); C302(0.95); C43(1.16); C201(1.21)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C323(0.87); C326(0.87); C302(0.95); C42(1.17)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C326(0.57); C302(0.92); C42(1.27); C43(1.32)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C326(0.35); C42(0.99); C43(1.01); C302(1.07)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C326(0.51); C302(1.05); C42(1.08); C43(1.09)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C326(0.66); C43(0.89); C42(0.97); C302(1.13)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C326(0.49); C42(0.92); C302(0.95); C43(0.97)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C201(1.43); C302(0.76); C326(0.31); C42(0.81)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C201(1.16); C302(0.99); C326(0.34); C42(0.83)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C201(1.41); C302(0.68); C326(0.36); C42(0.87)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C201(1.22); C302(0.82); C326(0.40); C42(0.92)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C201(1.25); C302(0.80); C326(0.40); C42(1.12)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C302(0.80); C323(0.94); C326(0.63); C42(1.25)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C201(1.21); C302(0.83); C326(0.54); C42(0.93)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C208(0.72); C302(0.59); C323(1.43); C42(1.03)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C208(0.62); C302(0.58); C323(1.85); C42(1.04)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C208(0.64); C302(0.64); C323(3.00); C42(0.79)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C208(0.70); C302(0.69); C323(1.29); C42(0.97)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C208(0.67); C302(0.66); C323(3.56); C42(1.15)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C208(0.62); C302(0.61); C323(1.61); C42(0.89)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C208(0.69); C302(0.66); C323(1.80); C42(0.83)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C208(0.61); C302(0.54); C323(1.19); C42(1.00)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C302(0.84); C323(0.99); C326(0.61); C42(1.15)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C208(0.60); C302(0.65); C323(1.76); C42(0.96)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C208(0.70); C302(0.58); C323(1.09); C42(1.13)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C208(0.78); C302(0.82); C323(1.25); C42(0.71)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C208(0.71); C302(0.77); C323(2.09); C42(0.94)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C208(0.69); C302(0.68); C323(1.74); C42(0.88)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C208(0.64); C302(0.46); C323(1.12); C42(0.87)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C201(0.59); C42(0.93); C43(0.93)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C201(0.92); C42(0.97); C43(0.97)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C201(0.92); C42(0.98); C43(0.98)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C201(1.00); C42(0.76); C43(0.76)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C302(1.09); C323(0.93); C326(0.83); C42(1.06)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C201(0.97); C42(0.91); C43(0.91)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C201(0.91); C42(0.86); C43(0.86)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C201(0.95); C42(0.99); C43(0.99)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C201(0.85); C42(0.92); C43(0.92)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C201(0.84); C42(0.96); C43(0.96)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C201(0.84); C42(0.86); C43(0.86)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C201(0.97); C42(1.00); C43(1.00)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C201(0.89); C42(0.82); C43(0.82)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C201(0.95); C42(0.96); C43(0.96)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C201(0.97); C42(0.90); C43(0.90)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C302(1.19); C323(0.63); C326(0.47); C42(1.08)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C201(0.94); C42(0.99); C43(0.99)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C208(0.96); C302(0.85); C42(0.98); C43(0.98)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C208(0.88); C302(0.74); C42(1.12); C43(1.12)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C208(0.78); C302(0.77); C42(0.97); C43(0.97)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C208(0.83); C302(1.00); C42(0.84); C43(0.84)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C208(0.90); C302(0.97); C42(0.71); C43(0.71)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C208(0.80); C302(0.84); C42(0.83); C43(0.83)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C208(0.93); C302(0.90); C42(0.76); C43(0.76)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C208(0.71); C302(0.68); C42(0.84); C43(0.84)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C208(0.69); C302(0.74); C42(0.92); C43(0.92)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C302(0.85); C323(0.65); C326(0.58); C42(0.92)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C208(0.82); C302(0.78); C42(0.82); C43(0.82)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C208(0.80); C302(0.85); C42(0.89); C43(0.89)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C208(0.85); C302(0.84); C42(0.77); C43(0.77)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C208(0.71); C302(0.76); C42(0.99); C43(0.99)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C208(0.83); C302(0.78); C42(0.86); C43(0.86)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C201(1.04); C42(0.75); C43(0.75)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C201(0.94); C42(0.61); C43(0.61)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C201(1.06); C42(0.74); C43(0.74)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C201(1.03); C42(0.71); C43(0.71)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C302(0.82); C323(0.83); C326(1.06); C42(1.27)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C201(0.94); C42(0.74); C43(0.74)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C201(1.12); C42(0.68); C43(0.68)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C201(1.08); C42(0.58); C43(0.58)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C201(1.06); C42(0.69); C43(0.69)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C201(1.09); C42(0.87); C43(0.87)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C201(1.14); C42(0.72); C43(0.72)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C201(1.12); C42(0.70); C43(0.70)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C201(1.07); C42(0.58); C43(0.58)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C201(1.09); C42(0.57); C43(0.57)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C201(1.29); C42(0.68); C43(0.68)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C302(0.85); C323(0.94); C326(0.86); C42(1.11)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C201(0.99); C42(0.55); C43(0.55)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C201(1.06); C302(0.79); C42(1.06); C43(1.06)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C201(1.10); C302(0.98); C42(0.94); C43(0.94)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C201(1.07); C302(0.84); C42(0.77); C43(0.77)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C201(1.13); C302(0.76); C42(1.14); C43(1.14)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C201(1.13); C302(0.70); C42(0.80); C43(0.80)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C201(1.16); C302(0.75); C42(0.94); C43(0.94)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C201(1.00); C302(0.63); C42(1.11); C43(1.11)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C201(0.98); C302(0.64); C42(0.95); C43(0.95)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C201(1.10); C302(0.69); C42(1.11); C43(1.11)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C127(1.00); C58(1.00); C201(1.03); C266(0.77)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C127(1.30)  LDD1702  [4]
 LDCM0625  F8 Ramos C127(1.47); C201(0.92)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C127(1.32)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C127(0.56); C201(1.65)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C127(0.73); C201(0.99)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C127(1.11); C201(0.99)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C127(0.73); C201(0.76)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C127(0.64); C201(1.98)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C127(1.09); C201(0.77)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C127(0.87); C201(1.09)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C127(1.03); C201(0.99)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C127(0.99); C201(0.53)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C127(1.34); C201(0.96)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C127(1.02); C201(1.09)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C127(2.56); C201(1.14)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C208(0.76); C302(0.73); C42(0.80); C43(0.80)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C127(0.97); C201(0.68)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C127(0.88); C201(0.80)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C208(0.74); C302(0.73); C323(1.23); C42(0.89)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C127(1.31); C201(0.90)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C127(1.51); C201(0.78)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C127(0.85); C201(0.69)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C127(0.88); C201(0.78)  LDD2188  [16]
 LDCM0022  KB02 HCT 116 C127(2.25); C21(1.10); C24(1.10)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C127(1.20); C21(1.09); C24(1.09)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C127(1.70); C21(0.97); C24(0.97)  LDD0082  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C127(0.56)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C127(0.96)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C127(1.10)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C127(1.29)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C127(0.81)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C127(0.73)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C127(0.78)  LDD2099  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C127(0.82)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C127(1.69)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C127(1.07)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C127(0.90)  LDD2109  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C127(1.09)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C127(1.04)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C127(0.86)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C127(1.04)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C127(1.05)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C127(1.07)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C127(0.92)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C127(1.09)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C127(0.91)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C127(0.95)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C127(0.94)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C127(0.85)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C127(1.19)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C127(1.08)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C127(0.98)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C127(0.72)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C127(0.82)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C127(1.06)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C127(3.10)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C127(1.06)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C127(2.72)  LDD2147  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C127(1.14)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C127(0.43)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C127(2.15)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C127(1.80)  LDD2153  [4]
 LDCM0131  RA190 MM1.R C127(1.30)  LDD0304  [17]
 LDCM0021  THZ1 HCT 116 C42(1.72); C43(1.72); C21(1.56); C24(1.56)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein OS-9 (OS9) OS-9 family Q13438
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endothelial PAS domain-containing protein 1 (EPAS1) . Q99814
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665

The Drug(s) Related To This Target

Approved
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126
Iron Small molecular drug DB01592
Roxadustat Small molecular drug DB04847
Ferrous Ascorbate . DB14490
Ferrous Fumarate . DB14491
Ferrous Gluconate . DB14488
Ferrous Glycine Sulfate . DB14501
Ferrous Succinate . DB14489
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fg-4592 Small molecular drug D03YKE
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Daprodustat Small molecular drug DB11682
Iox1 Small molecular drug D0X5US
Iox2 Small molecular drug D0WA3E
Fg-2216 . DB08687
Krh-102053 . D09SXR
N-[(4-hydroxy-8-iodoisoquinolin-3-yl)Carbonyl]Glycine . DB07112
Vadadustat . DB12255
Patented
Click To Hide/Show 33 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us10100051, Compound 1 Small molecular drug D05FDR
Us10100051, Compound 10 Small molecular drug D05TTX
Us10100051, Compound 11 Small molecular drug D0VI2M
Us10100051, Compound 2 Small molecular drug D04BTN
Us10149841, Compound 1 Small molecular drug D0JR2Q
Us10149841, Compound 19 Small molecular drug D0F0DX
Us10149841, Compound 5 Small molecular drug D0OR4X
Us10149841, Compound 9 Small molecular drug D0QI0J
Us8536181, A41 Small molecular drug D00IKR
Us8536181, C14 Small molecular drug D0HN5O
Us8536181, C17 Small molecular drug D01PPR
Us8536181, C35 Small molecular drug D03PGC
Us8598210, Table Xv, 1 Small molecular drug D0Q9AF
Us8598210, Table Xv, 2 Small molecular drug D00ECX
Us8598210, Table Xv, 4 Small molecular drug D01XZT
Us8598210, Table Xv, 5 Small molecular drug D00XHH
Us8921389, 1 Small molecular drug D0YY5J
Us8921389, 123 Small molecular drug D0Y3NI
Us8921389, 2 Small molecular drug D04YMG
Us8921389, 210 Small molecular drug D02IRO
Us8921389, 22 Small molecular drug D0I4PX
Us9340511, 2 Small molecular drug D0D8AV
Us9340511, 5 Small molecular drug D0LO2C
Us9340511, 6 Small molecular drug D0MS5W
Us9340511, 7 Small molecular drug D0V6AZ
Us9409892, 136 Small molecular drug D0VK5C
Us9409892, 148 Small molecular drug D0SM8Z
Us9409892, 19 Small molecular drug D0V9WU
Us9409892, 59 Small molecular drug D0R4CX
Us9422240, 1-282 Small molecular drug D05EHX
Us9422240, 1-286 Small molecular drug D0L9XU
Us9422240, 1-297 Small molecular drug D0K5UR
Us9422240, 1-298 Small molecular drug D00CAO

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.