Details of the Target

General Information of Target

Target ID LDTP04415
Target Name Dual specificity protein phosphatase 3 (DUSP3)
Gene Name DUSP3
Gene ID 1845
Synonyms
VHR; Dual specificity protein phosphatase 3; EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase VHR; Vaccinia H1-related phosphatase; VHR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVL
NAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRV
LVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKE
GKLKP
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Subcellular location
Nucleus
Function Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Uniprot ID
P51452
Ensemble ID
ENST00000226004.8
HGNC ID
HGNC:3069
ChEMBL ID
CHEMBL2635

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH23 SNV: p.M69K DBIA    Probe Info 
TOV21G SNV: p.C30Ter DBIA    Probe Info 
VCAP SNV: p.K79R; p.G127V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C124(1.88)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C171(6.86)  LDD0170  [3]
HHS-482
 Probe Info  		Y101(0.52)  LDD0285  [4]
HHS-475
 Probe Info  		Y101(0.91)  LDD0264  [5]
HHS-465
 Probe Info  		Y101(10.00)  LDD2237  [6]
Acrolein
 Probe Info  		C171(0.00); C124(0.00); C30(0.00)  LDD0222  [7]
DBIA
 Probe Info  		C171(0.93)  LDD0532  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
IPM
 Probe Info  		N.A.  LDD2156  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C124(1.00)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C124(1.15)  LDD2152  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C124(0.85)  LDD2132  [2]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C124(0.86)  LDD2131  [2]
 LDCM0025  4SU-RNA DM93 C171(6.86)  LDD0170  [3]
 LDCM0214  AC1 PaTu 8988t C171(1.90)  LDD1093  [8]
 LDCM0215  AC10 HCT 116 C171(0.93)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C171(1.23)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C171(1.87)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C171(1.56)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C171(1.71)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C171(1.82)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C171(1.85)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C171(1.84)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C171(2.22)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C171(1.52)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C171(1.90)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C171(0.97)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C171(1.67)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C171(1.70)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C171(1.79)  LDD0546  [8]
 LDCM0230  AC113 HEK-293T C171(1.52)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C171(1.09)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C171(1.11)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C171(1.15)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C171(0.72)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C171(0.78)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C171(0.55)  LDD0834  [8]
 LDCM0237  AC12 HCT 116 C171(0.96)  LDD0554  [8]
 LDCM0238  AC120 HEK-293T C171(0.80)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C171(0.58)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C171(0.37)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C171(0.40)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C171(0.55)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C171(0.41)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C171(0.28)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C171(0.29)  LDD0843  [8]
 LDCM0246  AC128 HEK-293T C171(1.26)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C171(0.92)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C171(0.99)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C171(1.11)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C171(1.03)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C171(0.57)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C171(0.84)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C171(0.66)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C171(0.83)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C171(0.44)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C171(0.43)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C171(0.44)  LDD0856  [8]
 LDCM0259  AC14 HCT 116 C171(0.79)  LDD0576  [8]
 LDCM0260  AC140 HEK-293T C171(0.65)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C171(0.46)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C171(0.69)  LDD0860  [8]
 LDCM0263  AC143 HCT 116 C171(0.97)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C171(1.37)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C171(0.98)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C171(1.15)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C171(1.00)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C171(0.76)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C171(1.16)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C171(0.96)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C171(1.23)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C171(0.94)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C171(1.06)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C171(1.54)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C171(0.87)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C171(1.13)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C171(1.09)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C171(1.06)  LDD2161  [8]
 LDCM0276  AC17 PaTu 8988t C171(0.84)  LDD1155  [8]
 LDCM0277  AC18 PaTu 8988t C171(0.81)  LDD1156  [8]
 LDCM0278  AC19 PaTu 8988t C171(1.17)  LDD1157  [8]
 LDCM0279  AC2 PaTu 8988t C171(1.97)  LDD1158  [8]
 LDCM0280  AC20 PaTu 8988t C171(0.92)  LDD1159  [8]
 LDCM0281  AC21 PaTu 8988t C171(1.02)  LDD1160  [8]
 LDCM0282  AC22 PaTu 8988t C171(0.87)  LDD1161  [8]
 LDCM0283  AC23 PaTu 8988t C171(0.90)  LDD1162  [8]
 LDCM0284  AC24 PaTu 8988t C171(0.86)  LDD1163  [8]
 LDCM0285  AC25 HEK-293T C171(0.73)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C171(0.67)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C171(0.62)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C171(0.59)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C171(0.54)  LDD0887  [8]
 LDCM0290  AC3 PaTu 8988t C171(1.83)  LDD1169  [8]
 LDCM0291  AC30 HEK-293T C171(0.69)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C171(0.83)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C171(0.73)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C171(0.71)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C171(0.82)  LDD0893  [8]
 LDCM0296  AC35 PaTu 8988t C171(0.81)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C171(0.70)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C171(0.72)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C171(0.53)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C171(0.68)  LDD1179  [8]
 LDCM0301  AC4 PaTu 8988t C171(2.23)  LDD1180  [8]
 LDCM0302  AC40 PaTu 8988t C171(0.63)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C171(0.61)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C171(0.65)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C171(0.54)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C171(0.60)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C171(0.78)  LDD1186  [8]
 LDCM0308  AC46 HEK-293T C171(0.97)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C171(1.09)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C171(0.99)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C171(0.89)  LDD1550  [19]
 LDCM0312  AC5 PaTu 8988t C171(1.58)  LDD1191  [8]
 LDCM0313  AC50 HEK-293T C171(0.98)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C171(0.98)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C171(0.90)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C171(1.05)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C171(0.98)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C171(0.94)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C171(1.24)  LDD1558  [19]
 LDCM0320  AC57 PaTu 8988t C171(1.43)  LDD1199  [8]
 LDCM0321  AC58 PaTu 8988t C171(1.66)  LDD1200  [8]
 LDCM0322  AC59 PaTu 8988t C171(1.38)  LDD1201  [8]
 LDCM0323  AC6 HCT 116 C171(0.86)  LDD0640  [8]
 LDCM0324  AC60 PaTu 8988t C171(1.66)  LDD1203  [8]
 LDCM0325  AC61 PaTu 8988t C171(1.55)  LDD1204  [8]
 LDCM0326  AC62 PaTu 8988t C171(1.39)  LDD1205  [8]
 LDCM0327  AC63 PaTu 8988t C171(1.48)  LDD1206  [8]
 LDCM0328  AC64 PaTu 8988t C171(1.81)  LDD1207  [8]
 LDCM0329  AC65 PaTu 8988t C171(1.22)  LDD1208  [8]
 LDCM0330  AC66 PaTu 8988t C171(1.82)  LDD1209  [8]
 LDCM0331  AC67 PaTu 8988t C171(1.73)  LDD1210  [8]
 LDCM0332  AC68 HCT 116 C171(0.76)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C171(0.85)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C171(0.86)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C171(0.67)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C171(0.78)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C171(0.89)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C171(0.72)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C171(0.71)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C171(0.56)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C171(0.87)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C171(0.74)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C171(1.03)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C171(1.04)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C171(0.86)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C171(0.86)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C171(0.77)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C171(0.52)  LDD0665  [8]
 LDCM0349  AC83 HEK-293T C171(0.93)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C171(0.70)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C171(0.76)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C171(0.89)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C171(0.90)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C171(0.68)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C171(0.74)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C171(0.77)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C171(0.76)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C171(0.85)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C171(0.87)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C171(0.75)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C171(0.82)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C171(0.64)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C171(0.57)  LDD0962  [8]
 LDCM0365  AC98 HCT 116 C171(1.11)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C171(1.90)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C124(0.43)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C171(0.93)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C171(0.99)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C171(0.89)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 13.15  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C124(0.41)  LDD2091  [2]
 LDCM0630  CCW28-3 231MFP C171(1.53)  LDD2214  [20]
 LDCM0108  Chloroacetamide HeLa C171(0.00); C124(0.00); C30(0.00)  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C171(2.47)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C171(0.73)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C171(0.99)  LDD0685  [8]
 LDCM0369  CL100 PaTu 8988t C171(1.62)  LDD1248  [8]
 LDCM0370  CL101 HCT 116 C171(1.09)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C171(0.99)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C171(0.99)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C171(1.16)  LDD0690  [8]
 LDCM0374  CL105 PaTu 8988t C171(0.85)  LDD1253  [8]
 LDCM0375  CL106 PaTu 8988t C171(0.88)  LDD1254  [8]
 LDCM0376  CL107 PaTu 8988t C171(0.85)  LDD1255  [8]
 LDCM0377  CL108 PaTu 8988t C171(0.69)  LDD1256  [8]
 LDCM0378  CL109 PaTu 8988t C171(0.95)  LDD1257  [8]
 LDCM0379  CL11 HCT 116 C171(1.15)  LDD0696  [8]
 LDCM0380  CL110 PaTu 8988t C171(0.78)  LDD1259  [8]
 LDCM0381  CL111 PaTu 8988t C171(0.88)  LDD1260  [8]
 LDCM0382  CL112 HEK-293T C171(0.52)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C171(0.69)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C171(0.32)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C171(0.67)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C171(0.57)  LDD0984  [8]
 LDCM0387  CL117 PaTu 8988t C171(0.66)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C171(1.17)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C171(0.69)  LDD1268  [8]
 LDCM0390  CL12 HCT 116 C171(1.40)  LDD0707  [8]
 LDCM0391  CL120 PaTu 8988t C171(0.74)  LDD1270  [8]
 LDCM0392  CL121 HEK-293T C171(0.97)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C171(1.09)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C171(0.88)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C171(0.86)  LDD1599  [19]
 LDCM0396  CL125 PaTu 8988t C171(1.11)  LDD1275  [8]
 LDCM0397  CL126 PaTu 8988t C171(1.17)  LDD1276  [8]
 LDCM0398  CL127 PaTu 8988t C171(1.32)  LDD1277  [8]
 LDCM0399  CL128 PaTu 8988t C171(1.20)  LDD1278  [8]
 LDCM0400  CL13 HCT 116 C171(1.19)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C171(1.12)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C171(1.27)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C171(1.24)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C171(1.14)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C171(1.39)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C171(1.42)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C171(0.78)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C171(1.17)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C171(1.02)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C171(1.20)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C171(1.46)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C171(0.95)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C171(0.93)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C171(1.60)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C171(1.20)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C171(1.03)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C171(1.04)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C171(0.90)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C171(1.18)  LDD0736  [8]
 LDCM0420  CL31 PaTu 8988t C171(1.15)  LDD1299  [8]
 LDCM0421  CL32 HCT 116 C171(0.86)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C171(0.70)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C171(1.03)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C171(1.10)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C171(0.92)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C171(0.99)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C171(0.91)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C171(0.86)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C171(0.94)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C171(0.87)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C171(0.97)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C171(1.09)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C171(1.18)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C171(1.03)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C171(0.98)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C171(0.99)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C171(0.97)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C171(1.07)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C171(0.96)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C171(1.07)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C171(1.29)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C171(1.03)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C171(0.92)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C171(1.02)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C171(1.05)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C171(1.03)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C171(0.95)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C171(1.28)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C171(1.25)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C171(0.94)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C171(1.24)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C171(1.87)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C171(1.49)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C171(1.27)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C171(0.97)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C171(1.02)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C171(1.40)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C171(1.76)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C171(1.60)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C171(1.16)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C171(1.19)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C171(1.48)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C171(1.30)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C171(1.85)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C171(1.29)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C171(1.24)  LDD0784  [8]
 LDCM0469  CL76 PaTu 8988t C171(1.26)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C171(1.00)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C171(1.02)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C171(1.08)  LDD1351  [8]
 LDCM0473  CL8 HCT 116 C171(1.42)  LDD0790  [8]
 LDCM0474  CL80 PaTu 8988t C171(1.34)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C171(1.08)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C171(1.02)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C171(1.10)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C171(1.06)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C171(1.03)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C171(1.10)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C171(1.08)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C171(1.10)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C171(1.09)  LDD1362  [8]
 LDCM0484  CL9 HCT 116 C171(1.25)  LDD0801  [8]
 LDCM0485  CL90 PaTu 8988t C171(1.05)  LDD1364  [8]
 LDCM0486  CL91 PaTu 8988t C171(1.26)  LDD1365  [8]
 LDCM0487  CL92 PaTu 8988t C171(1.56)  LDD1366  [8]
 LDCM0488  CL93 PaTu 8988t C171(1.47)  LDD1367  [8]
 LDCM0489  CL94 PaTu 8988t C171(1.47)  LDD1368  [8]
 LDCM0490  CL95 PaTu 8988t C171(1.65)  LDD1369  [8]
 LDCM0491  CL96 PaTu 8988t C171(1.78)  LDD1370  [8]
 LDCM0492  CL97 PaTu 8988t C171(1.66)  LDD1371  [8]
 LDCM0493  CL98 PaTu 8988t C171(1.77)  LDD1372  [8]
 LDCM0494  CL99 PaTu 8988t C171(1.98)  LDD1373  [8]
 LDCM0495  E2913 HEK-293T C171(0.94)  LDD1698  [19]
 LDCM0468  Fragment33 HCT 116 C171(1.00)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C171(0.88)  LDD0744  [8]
 LDCM0116  HHS-0101 DM93 Y101(0.91)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y101(0.66)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y101(0.73)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y101(0.71)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y101(0.83)  LDD0268  [5]
 LDCM0123  JWB131 DM93 Y101(0.52)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y101(0.88)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y101(0.86)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y101(3.63)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y101(2.40)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y101(1.93)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y101(0.88)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y101(1.18)  LDD0292  [4]
 LDCM0022  KB02 HEK-293T C171(1.18)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C171(1.10)  LDD1497  [19]
 LDCM0024  KB05 HMCB C171(8.95); C83(3.34)  LDD3312  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C124(0.63)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C124(1.19)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C124(1.06)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C124(1.00)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C124(0.84)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C124(1.34)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C124(2.27)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C124(1.13)  LDD2123  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C124(0.42)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C124(0.82)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C124(1.18)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C124(1.34)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C124(1.23)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C124(1.44)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C124(1.06)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C124(1.88)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C124(0.96)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C124(2.33)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C124(1.23)  LDD2146  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C124(0.50)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-1 (MEOX1) . P50221

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840