Details of the Target

General Information of Target

Target ID LDTP04334
Target Name DNA ligase 3 (LIG3)
Gene Name LIG3
Gene ID 3980
Synonyms
DNA ligase 3; EC 6.5.1.1; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQ
GSHLRSRATYLVFLPGLHVGLCSGPCEMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIG
KVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAP
SSPTPKRSLSSSKCDPRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGSAGDGFH
GDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDL
KMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNAQEVEKEPGQRRALSVQASLMTP
VQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVAH
FKDYIPQAFPGGHSMILDSEVLLIDNKTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYF
NDVSLMDRPLCERRKFLHDNMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLK
DVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGS
QKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAA
VWEITGAEFSKSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTV
VAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLSNSNSKDGNMQTAKPS
AMKVGEKLATKSSPVKVGEKRKAADETLCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFV
AFDGDLVQEFDMTSATHVLGSRDKNPAAQQVSPEWIWACIRKRRLVAPC
Target Bioclass
Enzyme
Family
ATP-dependent DNA ligase family
Subcellular location
Nucleus; Mitochondrion
Function
Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair.
Uniprot ID
P49916
Ensemble ID
ENST00000262327.9
HGNC ID
HGNC:6600
ChEMBL ID
CHEMBL4295773

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P55H DBIA    Probe Info 
CAL27 SNV: p.K984N DBIA    Probe Info 
COLO792 SNV: p.D543G DBIA    Probe Info 
HCC1143 SNV: p.K6E DBIA    Probe Info 
HCT15 SNV: p.A196S DBIA    Probe Info 
HEC1B SNV: p.S242R .
HT1080 SNV: p.T219S DBIA    Probe Info 
HT115 SNV: p.S818Y DBIA    Probe Info 
IGROV1 Deletion: p.I157SfsTer21 DBIA    Probe Info 
KNS42 Deletion: p.A685PfsTer23 DBIA    Probe Info 
LS180 SNV: p.T204A DBIA    Probe Info 
MCC13 SNV: p.S832F DBIA    Probe Info 
MFE319 Insertion: p.C108MfsTer26 DBIA    Probe Info 
MOLT4 SNV: p.S885N IA-alkyne    Probe Info 
NCIH1048 Deletion: p.I157SfsTer21 DBIA    Probe Info 
SUPT1 SNV: p.T877S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y666(13.80); Y97(10.57); Y767(7.88); Y525(5.20)  LDD0257  [1]
BTD
 Probe Info  		C270(0.33)  LDD2099  [2]
MCL-4
 Probe Info  		1.60  LDD0049  [3]
AHL-Pu-1
 Probe Info  		C929(2.69); C729(2.10)  LDD0168  [4]
HHS-475
 Probe Info  		Y438(0.55)  LDD0264  [5]
DBIA
 Probe Info  		C929(1.06)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C729(0.00); C999(0.00); C94(0.00); C404(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C729(0.00); C404(0.00); C999(0.00); C94(0.00)  LDD0036  [7]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [8]
Lodoacetamide azide
 Probe Info  		C929(0.00); C404(0.00); C999(0.00); C336(0.00)  LDD0037  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
NPM
 Probe Info  		N.A.  LDD0016  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
TFBX
 Probe Info  		C336(0.00); C729(0.00); C94(0.00)  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		C336(0.00); C929(0.00)  LDD0236  [12]
NAIA_5
 Probe Info  		C729(0.00); C94(0.00); C105(0.00)  LDD2223  [13]
HHS-482
 Probe Info  		Y438(1.01)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C201
 Probe Info  		45.25  LDD1877  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C929(2.69); C729(2.10)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C929(3.62)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C336(1.37); C999(0.83); C729(1.21); C929(1.14)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C336(0.85); C999(0.66); C729(1.50); C929(1.38)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C336(0.72); C999(0.72); C729(0.97); C929(0.93)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C336(0.71); C999(0.68); C729(1.07); C929(0.97)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C336(0.83); C999(0.70); C729(1.29); C929(1.04)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C336(0.90); C999(0.68); C729(1.17); C929(1.15)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C336(0.76); C999(0.71); C729(1.02); C929(1.07)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C336(0.66); C999(0.70); C729(0.81); C929(1.37)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C336(0.88); C999(0.73); C729(1.21); C929(1.42)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C336(0.64); C999(0.76); C729(0.97); C929(1.10)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C336(0.78); C999(0.63); C729(0.94); C929(0.93)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C336(0.91); C999(0.76); C729(1.08); C929(0.93)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C336(0.54); C999(0.54); C729(1.42); C929(1.13)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C336(0.77); C999(0.80); C729(1.20); C929(1.03)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C336(0.74); C999(0.76); C729(0.89); C929(1.09)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C336(0.78); C999(0.62); C729(0.96); C929(1.02)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C336(0.87); C999(0.96); C729(1.15); C929(1.15)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C336(1.14); C999(1.05); C729(1.02); C929(1.02)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C336(1.26); C999(0.94); C729(0.97); C929(0.94)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C336(1.13); C999(0.82); C729(1.02); C929(1.32)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C336(1.19); C999(0.93); C729(0.96); C929(1.19)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C336(1.23); C999(0.74); C729(1.16); C929(1.02)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C336(0.95); C999(0.71); C729(1.12); C929(1.09)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C336(0.69); C999(0.72); C729(1.29); C929(1.20)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C336(1.49); C999(0.49); C729(1.00); C929(0.79)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C336(1.14); C999(0.70); C729(0.94); C929(1.14)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C336(1.22); C999(0.67); C729(0.97); C929(0.88)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C336(1.12); C999(0.88); C729(0.72); C929(0.75)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C336(1.01); C999(0.87); C729(0.79); C929(1.01)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C336(1.55); C999(0.86); C729(0.90); C929(1.13)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C336(1.37); C999(0.92); C729(0.93); C929(0.99)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C336(1.67); C999(0.92); C729(0.90); C929(0.97)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C999(1.22); C929(1.14)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C999(1.52); C929(1.15)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C999(1.30); C929(0.94)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C999(1.55); C929(0.91)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C999(1.01); C929(1.11)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C999(1.11); C929(1.03)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C999(1.28); C929(1.15)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C999(1.20); C929(1.17)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C999(0.89); C929(1.50)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C999(0.89); C929(1.18)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C999(0.99); C929(1.19)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C999(0.99); C929(1.28)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C336(0.82); C999(0.71); C729(1.50); C929(1.05)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C999(1.06); C929(1.23)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C999(0.93); C929(1.27)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C999(1.08); C929(1.16)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C999(1.00); C929(0.84); C729(0.84)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C929(0.98); C999(1.01); C729(1.02)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C999(0.94); C729(0.96); C929(0.98)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C999(0.91); C729(0.91); C929(1.13)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C729(0.75); C999(0.94); C929(1.12)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C729(0.83); C999(1.21); C929(1.48)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C729(0.83); C999(0.96); C929(1.22)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C336(0.46); C999(0.60); C929(1.28); C729(1.34)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C729(0.70); C999(0.72); C929(0.85)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C729(0.62); C999(0.80); C929(1.00)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C729(0.76); C999(0.98); C929(1.05)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C729(1.13); C999(1.27); C929(1.88)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C999(1.04); C729(0.82); C929(0.96)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C999(0.94); C729(0.88); C929(1.04)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C999(1.04); C729(0.86); C929(0.78)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C999(1.39); C729(0.85); C929(0.71)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C999(0.81); C499(0.88); C929(1.03); C336(1.05)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C499(0.70); C999(0.75); C336(1.08); C729(1.27)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C499(0.86); C999(0.89); C336(0.98); C729(1.04)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C999(0.72); C336(0.98); C729(1.08); C929(1.26)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C999(0.73); C499(0.93); C729(0.98); C929(1.09)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C999(0.70); C499(0.88); C929(1.18); C729(1.21)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C499(0.90); C999(0.91); C929(0.96); C729(0.98)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C999(0.78); C499(0.95); C929(1.05); C729(1.19)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C999(0.92); C499(0.92); C336(0.93); C929(1.00)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C336(0.62); C999(0.84); C929(1.18)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C336(0.42); C999(0.82); C929(1.43)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C336(0.50); C999(0.86); C929(1.44)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C336(0.33); C999(0.74); C929(1.41)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C336(0.41); C999(0.90); C929(1.48)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C999(0.74); C336(1.12); C929(1.14); C729(1.19)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C336(0.54); C999(0.80); C929(1.70)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C336(0.45); C999(0.81); C929(1.52)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C336(0.27); C999(0.84); C929(1.81)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C336(0.27); C999(0.82); C929(1.45)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C336(0.26); C999(0.84); C929(1.65)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C999(0.83); C929(0.92); C729(1.04); C499(1.27)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C729(0.73); C999(0.84); C929(0.88); C499(1.07)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C929(0.89); C999(1.04); C729(1.12); C336(1.31)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C729(0.85); C929(0.94); C499(1.00); C999(1.04)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C999(0.81); C729(0.84); C499(1.00); C929(1.09)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C999(0.72); C336(0.81); C729(1.18); C929(1.38)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C729(0.91); C999(0.99); C499(1.09); C336(1.12)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C999(0.81); C729(0.83); C929(1.06); C336(1.08)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C729(0.77); C999(0.92); C336(1.02); C499(1.07)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C729(0.83); C999(0.92); C929(1.06); C499(1.08)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C999(0.84); C729(1.08); C336(1.08); C929(1.18)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C999(0.99); C729(0.99); C336(1.10); C929(1.28)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C729(0.80); C929(1.16)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C729(0.78); C929(1.14)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C729(0.71); C929(1.17)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C729(0.69); C929(1.40)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C999(0.60); C336(0.76); C929(1.35); C729(1.36)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C729(0.71); C929(1.41)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C729(0.67); C929(1.11)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C729(0.69); C929(1.16)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C729(0.93); C929(1.29)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C729(0.82); C929(1.19)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C729(1.06); C929(1.38)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C729(0.74); C929(1.66)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C336(0.60); C999(0.74); C729(1.11); C499(1.17)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C336(0.77); C999(0.84); C729(1.04); C499(1.12)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C336(0.64); C999(0.72); C499(0.97); C729(1.11)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C336(0.48); C999(0.78); C729(1.05); C929(1.34)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C999(0.64); C336(0.86); C729(1.15); C499(1.35)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C999(0.76); C336(0.88); C929(1.22); C729(1.30)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C336(0.68); C999(0.82); C729(1.13); C499(1.17)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C336(0.59); C999(0.65); C729(1.00); C929(1.31)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C999(0.69); C336(0.78); C499(1.07); C729(1.10)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C999(0.67); C336(0.74); C729(1.09); C499(1.38)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C336(0.76); C999(0.81); C729(1.05); C929(1.37)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C999(0.62); C336(0.71); C499(0.90); C729(1.10)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C729(0.87); C929(1.03); C999(1.06)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C729(0.97); C929(1.08); C999(1.08)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C999(0.65); C336(0.80); C729(1.11); C929(1.17)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C999(1.00); C729(1.02); C929(1.15)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C729(1.06); C929(1.11); C999(1.13)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C729(1.06); C929(1.15); C999(1.28)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C729(1.03); C929(1.52); C999(1.53)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C729(1.04); C999(1.40); C929(1.50)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C729(1.02); C929(1.72); C999(1.76)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C729(1.11); C929(1.27); C999(1.43)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C729(0.83); C929(1.18); C999(1.54)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C729(0.93); C929(1.04); C999(1.22)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C729(0.98); C999(1.14); C929(1.15)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C999(0.55); C336(0.81); C729(1.09); C929(1.34)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C999(0.99); C729(1.00); C929(1.25)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C729(1.03); C929(1.05); C999(1.16)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C729(0.99); C999(1.61); C929(1.75)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C336(0.87); C999(1.05); C929(1.64)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C336(0.77); C999(0.89); C929(1.57)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C999(0.90); C336(1.16); C929(1.39)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C336(0.77); C999(0.93); C929(1.29)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C999(1.01); C929(1.09); C336(1.23)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C999(0.85); C336(0.99); C929(1.22)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C336(0.69); C999(1.11); C929(1.33)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C336(0.96); C929(0.98); C999(1.16)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C336(0.84); C999(1.05); C929(1.63)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C336(0.79); C999(1.01); C929(1.57)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C336(0.76); C999(0.83); C929(1.21)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C336(0.93); C999(1.02); C929(1.18)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C929(1.14); C999(1.31); C336(1.32)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C336(0.96); C999(1.07); C929(1.24)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C336(0.84); C999(1.06); C929(1.45)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C999(0.61); C336(0.80); C729(1.01); C929(1.53)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C336(0.64); C999(0.70); C929(0.83); C729(1.01)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C336(1.47); C999(0.83); C729(1.33); C929(1.13)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C999(0.63); C336(0.77); C929(1.08); C729(1.40)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C336(0.54); C999(0.79); C729(1.03); C929(1.87)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C929(1.06)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa H456(0.00); C270(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C929(1.84); C929(0.57)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C999(0.86); C929(0.93); C499(0.98); C729(1.15)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C336(0.79); C999(0.98); C929(1.01); C729(1.16)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C999(0.70); C336(0.86); C729(1.08); C929(1.26)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C999(0.61); C336(0.63); C729(1.27); C929(1.39)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C336(0.70); C999(0.75); C929(1.05); C729(1.19)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C999(0.77); C336(0.81); C929(1.08); C729(1.27)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C336(0.80); C999(0.96); C929(1.10); C729(1.41)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C999(0.65); C499(0.76); C336(1.05); C729(1.27)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C999(0.71); C499(0.74); C336(0.92); C929(1.33)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C999(0.76); C336(0.77); C499(0.77); C729(1.18)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C336(0.59); C499(0.69); C999(0.78); C729(1.29)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C499(0.81); C336(0.81); C999(0.82); C729(1.16)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C336(0.82); C929(1.01); C999(1.14); C729(1.15)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C499(0.67); C999(0.81); C336(0.87); C729(1.03)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C499(0.73); C999(0.87); C336(0.97); C929(1.19)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C999(0.81); C336(1.12); C929(1.21)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C336(0.25); C999(0.75); C929(1.65)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C336(0.43); C999(0.78); C929(1.47)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C336(0.43); C999(0.79); C929(1.45)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C336(0.47); C999(0.81); C929(1.34)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C729(0.81); C499(1.01); C999(1.16); C929(1.39)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C999(0.86); C336(0.91); C729(0.93); C929(1.01)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C729(0.84); C999(0.94); C336(0.96); C929(1.01)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C336(0.63); C929(1.02); C999(1.11); C729(1.19)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C729(0.83); C999(0.91); C929(1.00); C499(1.24)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C729(0.89); C929(1.04)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C729(0.90); C929(1.22)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C729(0.75); C929(1.32)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C729(0.82); C929(1.34)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C999(0.76); C729(1.04); C929(1.13); C336(1.18)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C999(0.66); C336(0.87); C729(1.07); C929(1.10)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C999(0.65); C729(1.14); C929(1.18); C336(1.24)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C336(0.53); C999(0.81); C729(1.04); C499(1.19)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C336(0.83); C929(1.02); C999(1.17); C729(1.19)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C929(0.96); C999(1.03); C729(1.10); C499(1.18)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C336(0.94); C499(0.99); C999(0.99); C929(1.00)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C336(0.79); C999(0.90); C929(1.02); C729(1.05)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C336(0.54); C729(0.85); C999(0.89); C929(1.49)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C929(1.14); C729(1.15); C999(1.31); C336(20.00)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C729(0.87); C336(1.07); C999(1.08); C929(1.29)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C999(0.81); C929(0.99); C499(1.07); C729(1.17)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C336(0.47); C729(0.86); C999(1.04); C929(2.38)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C336(0.75); C729(0.80); C999(1.01); C929(1.47)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C336(0.70); C729(1.05); C999(1.32); C929(2.78)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C336(0.47); C729(0.82); C999(1.06); C929(1.28)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C336(0.80); C729(0.99); C999(1.14); C929(1.56)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C336(0.64); C999(1.05); C729(0.82); C929(1.48)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C336(0.57); C999(1.04); C729(0.98); C929(1.43)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C336(0.76); C999(1.05); C729(0.85); C929(1.30)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C336(0.66); C999(1.11); C729(0.87); C929(1.36)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C336(0.54); C999(1.13); C729(0.92); C929(1.31)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C336(1.07); C999(0.93); C499(1.11); C729(1.05)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C336(1.51); C999(1.09); C729(0.88); C929(1.05)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C336(1.05); C999(0.93); C729(0.93); C929(1.18)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C336(1.05); C999(0.89); C729(0.95); C929(1.37)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C336(0.58); C999(0.78); C729(1.00); C929(1.21)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C336(0.56); C999(0.95); C729(1.13); C929(1.13)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C336(0.58); C999(1.06); C729(1.01); C929(1.04)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C336(0.54); C999(0.96); C729(1.09); C929(1.49)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C336(0.56); C999(1.33); C729(1.09); C929(1.22)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C336(0.55); C999(0.85); C729(1.17); C929(1.28)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C336(1.08); C999(0.92); C499(1.08); C729(1.09)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C336(0.45); C999(0.91); C729(0.97); C929(1.22)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C336(0.32); C999(0.87); C729(1.10); C929(0.95)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C336(0.53); C999(1.03); C729(1.04); C929(1.35)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C336(0.69); C999(1.03); C729(1.18); C929(1.24)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C336(0.63); C999(1.05); C729(1.06); C929(1.19)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C336(0.43); C999(1.17); C729(1.24); C929(1.45)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C336(0.93); C999(2.09); C729(1.13); C929(0.91)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C336(0.99); C999(2.43); C729(0.97); C929(0.94)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C336(0.60); C999(2.80); C729(1.09); C929(1.04)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C336(0.56); C999(2.15); C729(1.08); C929(0.94)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C336(0.83); C999(1.12); C499(1.03); C729(1.13)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C336(0.75); C999(2.25); C729(1.08); C929(0.96)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C336(1.00); C999(2.30); C729(1.15); C929(0.95)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C336(0.94); C999(1.42); C729(1.12); C929(1.06)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C336(0.52); C999(1.77); C729(1.06); C929(0.87)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C336(0.71); C999(4.04); C729(0.93); C929(1.02)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C336(0.95); C999(2.61); C729(1.08); C929(0.90)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C336(0.63); C999(1.46); C729(1.07); C929(1.13)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C336(0.89); C999(1.62); C729(1.02); C929(0.90)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C336(1.02); C999(1.83); C729(1.13); C929(0.91)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C336(0.84); C999(1.41); C729(1.00); C929(0.92)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C336(0.77); C999(0.93); C499(1.10); C729(1.21)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C336(0.59); C999(1.40); C729(1.09); C929(1.00)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C336(1.37); C999(0.70); C729(0.69); C929(1.10)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C336(3.48); C999(1.01); C729(0.70); C929(1.13)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C336(2.27); C999(0.80); C729(0.64); C929(1.28)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C336(1.78); C999(1.03); C729(1.02); C929(1.39)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C336(1.62); C999(1.03); C729(0.79); C929(1.11)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C336(1.60); C999(1.11); C729(0.66); C929(1.72)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C336(1.31); C999(0.96); C729(0.51); C929(1.35)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C336(2.04); C999(0.60); C729(1.33); C929(1.23)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C336(2.31); C999(0.85); C729(0.99); C929(1.03)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C336(0.69); C999(1.04); C499(1.39); C729(1.17)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C336(1.97); C999(0.65); C729(0.75); C929(1.25)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C336(2.17); C999(0.70); C729(0.61); C929(1.60)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C336(1.38); C999(0.95); C729(1.36); C929(1.22)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C336(1.61); C999(0.77); C729(0.62); C929(1.28)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C336(1.66); C999(0.80); C729(0.76); C929(1.30)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C336(0.81); C999(1.13); C729(1.29); C929(1.02)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C336(0.60); C999(1.00); C729(1.04); C929(1.04)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C336(0.60); C999(0.85); C729(0.97); C929(1.10)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C336(0.84); C999(1.03); C729(1.09); C929(1.23)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C336(1.19); C999(0.99); C499(1.00); C729(1.17)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C336(1.76); C999(1.24); C729(0.83); C929(0.99)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C336(0.56); C999(0.95); C729(0.99); C929(1.15)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C336(0.62); C999(1.24); C729(0.55); C929(1.38)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C336(0.42); C999(0.95); C729(0.88); C929(1.37)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C336(0.73); C999(1.16); C729(1.18); C929(1.53)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C336(0.61); C999(1.14); C729(0.81); C929(1.16)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C336(0.57); C999(0.91); C729(0.96); C929(1.04)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C336(0.48); C999(0.91); C729(1.03); C929(1.25)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C336(0.72); C999(1.06); C729(0.84); C929(1.25)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C336(0.81); C999(1.34); C729(0.72); C929(1.66)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C336(0.89); C999(0.99); C499(1.17); C729(1.18)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C336(20.00); C999(0.97); C729(0.75); C929(1.31)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C336(0.98); C999(0.78); C729(1.13); C929(1.11)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C336(1.30); C999(0.63); C729(0.91); C929(1.29)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C336(0.87); C999(0.79); C729(1.03); C929(1.04)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C336(0.70); C999(0.60); C729(1.07); C929(1.32)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C336(1.02); C999(0.63); C729(0.89); C929(1.24)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C336(2.14); C999(0.72); C729(1.12); C929(1.08)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C336(0.76); C999(0.72); C729(1.03); C929(1.10)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C336(0.71); C999(0.72); C729(1.01); C929(1.38)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C336(0.75); C999(0.67); C729(1.09); C929(1.45)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C929(1.05); C999(2.66)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C499(1.38); C729(1.13)  LDD1702  [2]
 LDCM0575  Fragment13 Ramos C929(1.30)  LDD2192  [18]
 LDCM0580  Fragment21 Ramos C929(0.86)  LDD2195  [18]
 LDCM0578  Fragment27 Ramos C929(0.81)  LDD2197  [18]
 LDCM0589  Fragment31 Ramos C929(0.80)  LDD2200  [18]
 LDCM0468  Fragment33 HCT 116 C336(1.55); C999(0.87); C729(0.68); C929(1.26)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C929(0.58)  LDD2203  [18]
 LDCM0427  Fragment51 HCT 116 C336(0.58); C999(0.96); C729(1.30); C929(1.58)  LDD0744  [6]
 LDCM0116  HHS-0101 DM93 Y438(0.55)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y438(0.30)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y438(0.83)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y438(0.05)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y438(0.06)  LDD0268  [5]
 LDCM0107  IAA HeLa H456(0.00); H428(0.00)  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C929(2.00)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C929(1.63)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C929(1.83)  LDD0082  [6]
 LDCM0006  Micheliolide M9-ENL1 1.60  LDD0049  [3]
 LDCM0109  NEM HeLa N.A.  LDD0224  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C270(0.33)  LDD2099  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C270(0.94)  LDD2109  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C261(2.43)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C261(0.91)  LDD2123  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C261(0.93)  LDD2127  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C261(1.57)  LDD2135  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C261(1.37)  LDD2137  [2]
 LDCM0131  RA190 MM1.R C929(1.12)  LDD0304  [19]
 LDCM0021  THZ1 HCT 116 C929(1.28)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein max (MAX) MAX family P61244

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bleomycin Small molecular drug DB00290

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.