Details of the Target

General Information of Target

Target ID LDTP04200
Target Name Glutathione synthetase (GSS)
Gene Name GSS
Gene ID 2937
Synonyms
Glutathione synthetase; GSH synthetase; GSH-S; EC 6.3.2.3; Glutathione synthase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSA
LLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVF
LGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL
SNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFE
DISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQ
LAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSR
FVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVV
QCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Eukaryotic GSH synthase family
Function
Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.
TTD ID
T69420
Uniprot ID
P48637
DrugMap ID
TTVEWR4
Ensemble ID
ENST00000451957.2
HGNC ID
HGNC:4624

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SNU449 SNV: p.V263M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		2.34  LDD0066  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
ONAyne
 Probe Info  		K364(5.48)  LDD0274  [3]
Probe 1
 Probe Info  		Y375(12.14); Y395(18.32)  LDD3495  [4]
DBIA
 Probe Info  		C294(1.49); C409(1.23)  LDD3312  [5]
BTD
 Probe Info  		C294(0.87)  LDD1700  [6]
HHS-482
 Probe Info  		Y375(1.00)  LDD0285  [7]
HHS-475
 Probe Info  		Y375(0.68); Y395(1.66)  LDD0264  [8]
HHS-465
 Probe Info  		Y375(10.00)  LDD2237  [9]
Acrolein
 Probe Info  		N.A.  LDD0221  [10]
ATP probe
 Probe Info  		K186(0.00); K306(0.00)  LDD0199  [11]
N1
 Probe Info  		C294(0.00); D296(0.00)  LDD0245  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C294(0.00); C409(0.00); C422(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C294(0.00); C409(0.00); C422(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
IPM
 Probe Info  		N.A.  LDD0147  [17]
NHS
 Probe Info  		K178(0.00); K186(0.00)  LDD0010  [18]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
1c-yne
 Probe Info  		K400(0.00); K141(0.00)  LDD0228  [19]
NAIA_5
 Probe Info  		C294(0.00); C409(0.00); C422(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		9.32  LDD0477  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C294(0.24)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C294(0.57); C409(0.57)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C294(0.58); C409(0.37)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C409(0.99)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C294(0.51)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C294(1.29); C409(1.14)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C409(1.73)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C294(0.45); C409(0.39)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C409(0.82)  LDD2131  [6]
 LDCM0214  AC1 HEK-293T C409(0.86)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C422(1.02)  LDD1508  [22]
 LDCM0276  AC17 HEK-293T C409(1.07)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C422(0.93)  LDD1516  [22]
 LDCM0279  AC2 HEK-293T C422(1.05)  LDD1518  [22]
 LDCM0281  AC21 HEK-293T C409(1.07)  LDD1520  [22]
 LDCM0284  AC24 HEK-293T C294(0.97)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C409(1.02)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C422(1.06)  LDD1525  [22]
 LDCM0289  AC29 HEK-293T C409(0.95)  LDD1528  [22]
 LDCM0293  AC32 HEK-293T C294(0.96)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C409(1.17)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C422(1.10)  LDD1534  [22]
 LDCM0298  AC37 HEK-293T C409(1.09)  LDD1537  [22]
 LDCM0302  AC40 HEK-293T C294(1.06)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C409(1.08)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C422(0.96)  LDD1543  [22]
 LDCM0307  AC45 HEK-293T C409(0.97)  LDD1546  [22]
 LDCM0310  AC48 HEK-293T C294(0.96)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C409(0.95)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C409(0.88)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C422(1.03)  LDD1552  [22]
 LDCM0316  AC53 HEK-293T C409(0.85)  LDD1555  [22]
 LDCM0319  AC56 HEK-293T C294(0.97)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C409(0.90)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C422(0.92)  LDD1560  [22]
 LDCM0325  AC61 HEK-293T C409(0.90)  LDD1564  [22]
 LDCM0328  AC64 HEK-293T C294(0.96)  LDD1567  [22]
 LDCM0345  AC8 HEK-293T C294(1.01)  LDD1569  [22]
 LDCM0545  Acetamide MDA-MB-231 C294(0.29)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C294(0.50); C409(0.53)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C409(0.90)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C409(0.96)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C294(1.04)  LDD1514  [22]
 LDCM0498  BS-3668 MDA-MB-231 C294(0.33); C409(0.90)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C409(0.00); H456(0.00)  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C409(1.01)  LDD1571  [22]
 LDCM0369  CL100 HEK-293T C409(0.94)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C409(1.00)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C409(0.88)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C409(1.07)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C409(1.11)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C409(1.18)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C409(0.99)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C409(1.15)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C409(1.15)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C409(0.95)  LDD1582  [22]
 LDCM0380  CL110 HEK-293T C409(1.01)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C409(0.90)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C409(0.99)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C409(0.95)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C409(0.87)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C409(0.99)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C409(0.93)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C409(1.09)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C409(0.91)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C409(1.11)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C294(0.89)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C409(1.17)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C409(0.92)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C409(1.06)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C409(0.98)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C409(1.23)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C409(0.77)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C409(0.92)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C409(1.04)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C409(0.96)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C409(0.70)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C409(0.90)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C409(1.09)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C409(1.32)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C409(1.27)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C422(0.97)  LDD1609  [22]
 LDCM0407  CL2 HEK-293T C409(1.10)  LDD1611  [22]
 LDCM0409  CL21 HEK-293T C409(1.43)  LDD1613  [22]
 LDCM0412  CL24 HEK-293T C294(1.07)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C409(0.97)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C409(0.83)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C409(1.12)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C409(1.15)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C409(1.10)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C409(0.99)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C422(0.96)  LDD1623  [22]
 LDCM0422  CL33 HEK-293T C409(1.41)  LDD1626  [22]
 LDCM0425  CL36 HEK-293T C294(0.92)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C409(1.07)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C409(0.98)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C409(1.22)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C409(1.12)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C409(1.11)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C422(0.84)  LDD1636  [22]
 LDCM0435  CL45 HEK-293T C409(1.60)  LDD1639  [22]
 LDCM0438  CL48 HEK-293T C294(0.99)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C409(0.88)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C409(0.93)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C409(1.01)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C409(1.13)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C409(1.06)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C422(0.91)  LDD1648  [22]
 LDCM0448  CL57 HEK-293T C409(1.81)  LDD1651  [22]
 LDCM0451  CL6 HEK-293T C422(1.10)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C294(1.00)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C409(0.96)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C409(1.00)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C409(1.20)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C409(1.23)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C409(0.98)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C422(1.08)  LDD1661  [22]
 LDCM0461  CL69 HEK-293T C409(1.32)  LDD1664  [22]
 LDCM0465  CL72 HEK-293T C294(1.01)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C409(0.91)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C409(1.04)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C409(1.14)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C409(1.03)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C422(0.98)  LDD1674  [22]
 LDCM0475  CL81 HEK-293T C409(1.62)  LDD1678  [22]
 LDCM0478  CL84 HEK-293T C294(0.95)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C409(0.93)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C409(0.83)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C409(0.94)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C409(1.13)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C409(0.95)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C409(1.41)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C422(0.85)  LDD1688  [22]
 LDCM0488  CL93 HEK-293T C409(1.17)  LDD1691  [22]
 LDCM0491  CL96 HEK-293T C294(0.94)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C409(0.84)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C409(0.72)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C409(0.81)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C409(1.23)  LDD1698  [22]
 LDCM0468  Fragment33 HEK-293T C409(1.06)  LDD1671  [22]
 LDCM0427  Fragment51 HEK-293T C409(0.95)  LDD1631  [22]
 LDCM0116  HHS-0101 DM93 Y375(0.68); Y395(1.66)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y375(0.95); Y395(1.11)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y375(0.82); Y395(1.77)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y375(0.42); Y395(1.98)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y375(0.52); Y395(0.94)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0123  JWB131 DM93 Y375(1.00)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y375(0.80)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y375(1.35); Y395(0.92)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y375(2.89)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y375(1.84); Y395(0.76)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y375(1.07)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y375(0.44); Y395(1.63)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y375(1.06); Y395(0.52)  LDD0292  [7]
 LDCM0022  KB02 HEK-293T C294(1.23); C409(1.15)  LDD1492  [22]
 LDCM0023  KB03 Jurkat C409(4.03)  LDD0315  [14]
 LDCM0024  KB05 HMCB C294(1.49); C409(1.23)  LDD3312  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C409(1.31)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C294(0.38)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C294(0.36); C409(0.96)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C294(1.28); C409(1.55)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C409(1.04)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C294(2.76); C409(2.90)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C294(0.32)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C294(0.63); C409(0.62)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C294(0.70); C409(0.72)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C294(0.39); C409(1.03)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C409(0.24)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C294(0.90); C409(0.84)  LDD2101  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C294(2.33)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C409(0.39)  LDD2106  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C409(0.54)  LDD2110  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C294(0.83); C409(0.53)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C294(0.51)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C294(0.57)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C409(2.05)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C294(0.72)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C294(0.39); C409(1.22)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C294(0.45)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C409(1.00)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C294(0.40); C409(0.41)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C294(0.80); C409(1.10)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C294(0.75)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C294(0.61); C409(1.22)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C409(0.59)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C294(0.91); C409(0.62)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C294(0.66); C409(1.13)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C409(1.00)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C294(0.75)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C294(0.87)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C294(0.37); C409(0.80)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C294(0.41)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C294(1.01); C409(0.74)  LDD2143  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C294(0.15)  LDD2145  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C294(1.67)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C409(0.57)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C294(0.46)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C294(0.24); C409(0.75)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C294(0.39); C409(0.42)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C409(2.91)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutathione synthetase (GSS) Eukaryotic GSH synthase family P48637
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetylcysteine Small molecular drug DB06151
Cysteine Small molecular drug DB00151
Glutathione Small molecular drug DB00143
Glycine Small molecular drug DB00145
Copper . DB09130
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gamma-glutamylcysteine . DB03408
Phosphoaminophosphonic Acid-adenylate Ester . DB04395

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402