Details of the Target

General Information of Target

Target ID LDTP04715
Target Name Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1)
Gene Name OXCT1
Gene ID 5019
Synonyms
OXCT; SCOT; Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; SCOT; EC 2.8.3.5; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s; Succinyl-CoA:3-oxoacid CoA transferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVL
VGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENA
EFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSV
AIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAET
TVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDD
VRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNITVHLQSENGVLGLGPYPRQHEAD
ADLINAGKETVTILPGASFFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMV
KGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDK
KKGLTLIELWEGLTVDDVQKSTGCDFAVSPKLMPMQQIAN
Target Bioclass
Enzyme
Family
3-oxoacid CoA-transferase family
Subcellular location
Mitochondrion
Function
Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production. Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Uniprot ID
P55809
Ensemble ID
ENST00000196371.10
HGNC ID
HGNC:8527

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.P459S DBIA    Probe Info 
KMCH1 SNV: p.A57S DBIA    Probe Info 
MIAPACA2 SNV: p.D95N DBIA    Probe Info 
NCIH1792 SNV: p.K481Q DBIA    Probe Info 
NCIH23 SNV: p.T397S DBIA    Probe Info 
REC1 SNV: p.S33T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y174(20.00); Y407(18.57); Y161(6.54)  LDD0260  [1]
AZ-9
 Probe Info  		E123(10.00)  LDD2209  [2]
Probe 1
 Probe Info  		Y115(8.00)  LDD3495  [3]
BTD
 Probe Info  		C456(2.77)  LDD1700  [4]
DBIA
 Probe Info  		C504(6.05)  LDD0209  [5]
HHS-475
 Probe Info  		Y161(0.78)  LDD0264  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
m-APA
 Probe Info  		H196(0.00); H357(0.00)  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C456(0.00); C235(0.00); C504(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C456(0.00); C504(0.00)  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C456(0.00); C235(0.00); C504(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		C465(0.00); C456(0.00); C504(0.00)  LDD0027  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
PF-06672131
 Probe Info  		N.A.  LDD0152  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		C504(0.00); C235(0.00); C456(0.00)  LDD0217  [15]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [15]
Crotonaldehyde
 Probe Info  		C504(0.00); C235(0.00); H357(0.00); H443(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C504(0.00); C235(0.00); C456(0.00)  LDD0218  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
HHS-465
 Probe Info  		Y161(0.00); Y115(0.00); K173(0.00); K296(0.00)  LDD2240  [16]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [17]
STS-2
 Probe Info  		N.A.  LDD0138  [17]
DA-2
 Probe Info  		N.A.  LDD0072  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C456(0.73)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C456(1.15)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C235(1.15); C456(1.00); C504(1.19)  LDD2117  [4]
 LDCM0214  AC1 HEK-293T C504(0.95); C235(1.02); C456(0.94)  LDD1507  [19]
 LDCM0215  AC10 PaTu 8988t C504(0.50)  LDD1094  [20]
 LDCM0216  AC100 HCT 116 C235(1.05); C504(1.99)  LDD0533  [20]
 LDCM0217  AC101 HCT 116 C235(0.96); C504(0.73)  LDD0534  [20]
 LDCM0218  AC102 HCT 116 C235(0.77); C504(0.91)  LDD0535  [20]
 LDCM0219  AC103 HCT 116 C235(0.50); C504(0.26)  LDD0536  [20]
 LDCM0220  AC104 HCT 116 C235(0.61); C504(0.42)  LDD0537  [20]
 LDCM0221  AC105 HCT 116 C235(0.69); C504(0.46)  LDD0538  [20]
 LDCM0222  AC106 HCT 116 C235(0.67); C504(0.51)  LDD0539  [20]
 LDCM0223  AC107 HCT 116 C235(0.37); C504(0.33)  LDD0540  [20]
 LDCM0224  AC108 HCT 116 C235(0.65); C504(0.32)  LDD0541  [20]
 LDCM0225  AC109 HCT 116 C235(0.63); C504(0.24)  LDD0542  [20]
 LDCM0226  AC11 PaTu 8988t C504(0.28)  LDD1105  [20]
 LDCM0227  AC110 HCT 116 C235(0.56); C504(0.22)  LDD0544  [20]
 LDCM0228  AC111 HCT 116 C235(0.59); C504(0.21)  LDD0545  [20]
 LDCM0229  AC112 HCT 116 C235(0.51); C504(0.36)  LDD0546  [20]
 LDCM0237  AC12 PaTu 8988t C504(0.51)  LDD1116  [20]
 LDCM0246  AC128 PaTu 8988t C504(1.05)  LDD1125  [20]
 LDCM0247  AC129 PaTu 8988t C504(0.69)  LDD1126  [20]
 LDCM0249  AC130 PaTu 8988t C504(0.83)  LDD1128  [20]
 LDCM0250  AC131 PaTu 8988t C504(0.79)  LDD1129  [20]
 LDCM0251  AC132 PaTu 8988t C504(0.91)  LDD1130  [20]
 LDCM0252  AC133 PaTu 8988t C504(0.11)  LDD1131  [20]
 LDCM0253  AC134 PaTu 8988t C504(0.24)  LDD1132  [20]
 LDCM0254  AC135 PaTu 8988t C504(0.11)  LDD1133  [20]
 LDCM0255  AC136 PaTu 8988t C504(0.25)  LDD1134  [20]
 LDCM0256  AC137 PaTu 8988t C504(0.12)  LDD1135  [20]
 LDCM0257  AC138 PaTu 8988t C504(0.80)  LDD1136  [20]
 LDCM0258  AC139 PaTu 8988t C504(0.58)  LDD1137  [20]
 LDCM0259  AC14 PaTu 8988t C504(0.40)  LDD1138  [20]
 LDCM0260  AC140 PaTu 8988t C504(0.78)  LDD1139  [20]
 LDCM0261  AC141 PaTu 8988t C504(0.92)  LDD1140  [20]
 LDCM0262  AC142 PaTu 8988t C504(0.48)  LDD1141  [20]
 LDCM0263  AC143 HCT 116 C235(0.99)  LDD0580  [20]
 LDCM0264  AC144 HCT 116 C235(0.94)  LDD0581  [20]
 LDCM0265  AC145 HCT 116 C235(0.93)  LDD0582  [20]
 LDCM0266  AC146 HCT 116 C235(1.09)  LDD0583  [20]
 LDCM0267  AC147 HCT 116 C235(0.80)  LDD0584  [20]
 LDCM0268  AC148 HCT 116 C235(0.21)  LDD0585  [20]
 LDCM0269  AC149 HCT 116 C235(0.70)  LDD0586  [20]
 LDCM0270  AC15 PaTu 8988t C504(0.67)  LDD1149  [20]
 LDCM0271  AC150 HCT 116 C235(1.21)  LDD0588  [20]
 LDCM0272  AC151 HCT 116 C235(1.09)  LDD0589  [20]
 LDCM0273  AC152 HCT 116 C235(0.61)  LDD0590  [20]
 LDCM0274  AC153 HCT 116 C235(0.15)  LDD0591  [20]
 LDCM0621  AC154 HCT 116 C235(0.96)  LDD2158  [20]
 LDCM0622  AC155 HCT 116 C235(0.99)  LDD2159  [20]
 LDCM0623  AC156 HCT 116 C235(0.91)  LDD2160  [20]
 LDCM0624  AC157 HCT 116 C235(1.10)  LDD2161  [20]
 LDCM0276  AC17 PaTu 8988t C504(0.82)  LDD1155  [20]
 LDCM0277  AC18 PaTu 8988t C504(0.45)  LDD1156  [20]
 LDCM0278  AC19 PaTu 8988t C504(0.90)  LDD1157  [20]
 LDCM0279  AC2 HEK-293T C504(1.09); C235(1.02); C456(1.01); C67(1.03)  LDD1518  [19]
 LDCM0280  AC20 PaTu 8988t C504(0.97)  LDD1159  [20]
 LDCM0281  AC21 PaTu 8988t C504(0.86)  LDD1160  [20]
 LDCM0282  AC22 PaTu 8988t C504(0.89)  LDD1161  [20]
 LDCM0283  AC23 PaTu 8988t C504(0.31)  LDD1162  [20]
 LDCM0284  AC24 PaTu 8988t C504(0.27)  LDD1163  [20]
 LDCM0285  AC25 HCT 116 C504(1.07)  LDD0602  [20]
 LDCM0286  AC26 HCT 116 C504(0.75)  LDD0603  [20]
 LDCM0287  AC27 HCT 116 C504(1.21)  LDD0604  [20]
 LDCM0288  AC28 HCT 116 C504(0.98)  LDD0605  [20]
 LDCM0289  AC29 HCT 116 C504(1.06)  LDD0606  [20]
 LDCM0290  AC3 HEK-293T C504(0.97); C235(1.08); C67(0.93)  LDD1529  [19]
 LDCM0291  AC30 HCT 116 C504(0.80)  LDD0608  [20]
 LDCM0292  AC31 HCT 116 C504(0.76)  LDD0609  [20]
 LDCM0293  AC32 HCT 116 C504(0.55)  LDD0610  [20]
 LDCM0294  AC33 HCT 116 C504(0.76)  LDD0611  [20]
 LDCM0295  AC34 HCT 116 C504(0.65)  LDD0612  [20]
 LDCM0296  AC35 HCT 116 C235(0.84)  LDD0613  [20]
 LDCM0297  AC36 HCT 116 C235(1.15)  LDD0614  [20]
 LDCM0298  AC37 HCT 116 C235(1.19)  LDD0615  [20]
 LDCM0299  AC38 HCT 116 C235(1.14)  LDD0616  [20]
 LDCM0300  AC39 HCT 116 C235(0.97)  LDD0617  [20]
 LDCM0301  AC4 HEK-293T C504(1.00); C235(1.14); C456(1.07); C67(1.03)  LDD1540  [19]
 LDCM0302  AC40 HCT 116 C235(0.65)  LDD0619  [20]
 LDCM0303  AC41 HCT 116 C235(1.11)  LDD0620  [20]
 LDCM0304  AC42 HCT 116 C235(0.82)  LDD0621  [20]
 LDCM0305  AC43 HCT 116 C235(1.16)  LDD0622  [20]
 LDCM0306  AC44 HCT 116 C235(1.05)  LDD0623  [20]
 LDCM0307  AC45 HCT 116 C235(0.70)  LDD0624  [20]
 LDCM0308  AC46 HCT 116 C504(0.73); C235(1.17)  LDD0625  [20]
 LDCM0309  AC47 HCT 116 C504(0.59); C235(1.35)  LDD0626  [20]
 LDCM0310  AC48 HCT 116 C504(0.88); C235(1.55)  LDD0627  [20]
 LDCM0311  AC49 HCT 116 C504(0.09); C235(0.32)  LDD0628  [20]
 LDCM0312  AC5 HEK-293T C504(1.04); C235(1.00); C456(1.14)  LDD1551  [19]
 LDCM0313  AC50 HCT 116 C504(0.15); C235(0.48)  LDD0630  [20]
 LDCM0314  AC51 HCT 116 C235(1.73); C504(3.71)  LDD0631  [20]
 LDCM0315  AC52 HCT 116 C504(0.51); C235(1.16)  LDD0632  [20]
 LDCM0316  AC53 HCT 116 C504(0.31); C235(0.74)  LDD0633  [20]
 LDCM0317  AC54 HCT 116 C504(0.31); C235(0.68)  LDD0634  [20]
 LDCM0318  AC55 HCT 116 C504(0.11); C235(0.41)  LDD0635  [20]
 LDCM0319  AC56 HCT 116 C504(0.03); C235(0.16)  LDD0636  [20]
 LDCM0320  AC57 PaTu 8988t C504(1.66)  LDD1199  [20]
 LDCM0321  AC58 PaTu 8988t C504(0.50)  LDD1200  [20]
 LDCM0322  AC59 PaTu 8988t C504(1.25)  LDD1201  [20]
 LDCM0323  AC6 PaTu 8988t C504(0.82)  LDD1202  [20]
 LDCM0324  AC60 PaTu 8988t C504(1.08)  LDD1203  [20]
 LDCM0325  AC61 PaTu 8988t C504(0.68)  LDD1204  [20]
 LDCM0326  AC62 PaTu 8988t C504(1.59)  LDD1205  [20]
 LDCM0327  AC63 PaTu 8988t C504(1.64)  LDD1206  [20]
 LDCM0328  AC64 PaTu 8988t C504(0.69)  LDD1207  [20]
 LDCM0329  AC65 PaTu 8988t C504(0.48)  LDD1208  [20]
 LDCM0330  AC66 PaTu 8988t C504(0.41)  LDD1209  [20]
 LDCM0331  AC67 PaTu 8988t C504(1.11)  LDD1210  [20]
 LDCM0332  AC68 HCT 116 C235(0.79)  LDD0649  [20]
 LDCM0333  AC69 HCT 116 C235(0.97)  LDD0650  [20]
 LDCM0334  AC7 PaTu 8988t C504(0.97)  LDD1213  [20]
 LDCM0335  AC70 HCT 116 C235(0.33)  LDD0652  [20]
 LDCM0336  AC71 HCT 116 C235(1.08)  LDD0653  [20]
 LDCM0337  AC72 HCT 116 C235(0.77)  LDD0654  [20]
 LDCM0338  AC73 HCT 116 C235(0.14)  LDD0655  [20]
 LDCM0339  AC74 HCT 116 C235(0.18)  LDD0656  [20]
 LDCM0340  AC75 HCT 116 C235(0.09)  LDD0657  [20]
 LDCM0341  AC76 HCT 116 C235(0.54)  LDD0658  [20]
 LDCM0342  AC77 HCT 116 C235(0.59)  LDD0659  [20]
 LDCM0343  AC78 HCT 116 C235(1.07)  LDD0660  [20]
 LDCM0344  AC79 HCT 116 C235(1.00)  LDD0661  [20]
 LDCM0345  AC8 PaTu 8988t C504(0.77)  LDD1224  [20]
 LDCM0346  AC80 HCT 116 C235(0.62)  LDD0663  [20]
 LDCM0347  AC81 HCT 116 C235(0.74)  LDD0664  [20]
 LDCM0348  AC82 HCT 116 C235(0.09)  LDD0665  [20]
 LDCM0349  AC83 HCT 116 C235(0.30)  LDD0666  [20]
 LDCM0350  AC84 HCT 116 C235(0.47)  LDD0667  [20]
 LDCM0351  AC85 HCT 116 C235(1.05)  LDD0668  [20]
 LDCM0352  AC86 HCT 116 C235(0.98)  LDD0669  [20]
 LDCM0353  AC87 HCT 116 C235(1.05)  LDD0670  [20]
 LDCM0354  AC88 HCT 116 C235(0.97)  LDD0671  [20]
 LDCM0355  AC89 HCT 116 C235(0.69)  LDD0672  [20]
 LDCM0357  AC90 HCT 116 C235(1.64)  LDD0674  [20]
 LDCM0358  AC91 HCT 116 C235(0.25)  LDD0675  [20]
 LDCM0359  AC92 HCT 116 C235(0.37)  LDD0676  [20]
 LDCM0360  AC93 HCT 116 C235(1.01)  LDD0677  [20]
 LDCM0361  AC94 HCT 116 C235(1.05)  LDD0678  [20]
 LDCM0362  AC95 HCT 116 C235(1.08)  LDD0679  [20]
 LDCM0363  AC96 HCT 116 C235(0.93)  LDD0680  [20]
 LDCM0364  AC97 HCT 116 C235(0.54)  LDD0681  [20]
 LDCM0365  AC98 HCT 116 C504(0.02); C235(0.05)  LDD0682  [20]
 LDCM0366  AC99 HCT 116 C504(0.96); C235(1.12)  LDD0683  [20]
 LDCM0248  AKOS034007472 PaTu 8988t C504(0.26)  LDD1127  [20]
 LDCM0356  AKOS034007680 PaTu 8988t C504(0.72)  LDD1235  [20]
 LDCM0275  AKOS034007705 PaTu 8988t C504(0.88)  LDD1154  [20]
 LDCM0020  ARS-1620 HCC44 C504(1.03)  LDD2171  [20]
 LDCM0108  Chloroacetamide HeLa C504(0.00); C235(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C504(20.00)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C504(1.97)  LDD0684  [20]
 LDCM0368  CL10 HCT 116 C504(0.52)  LDD0685  [20]
 LDCM0369  CL100 HEK-293T C504(0.95); C235(0.91); C67(1.09)  LDD1573  [19]
 LDCM0370  CL101 PaTu 8988t C504(0.80)  LDD1249  [20]
 LDCM0371  CL102 PaTu 8988t C504(0.46)  LDD1250  [20]
 LDCM0372  CL103 PaTu 8988t C504(0.10)  LDD1251  [20]
 LDCM0373  CL104 PaTu 8988t C504(0.49)  LDD1252  [20]
 LDCM0374  CL105 PaTu 8988t C504(0.61)  LDD1253  [20]
 LDCM0375  CL106 PaTu 8988t C504(0.45)  LDD1254  [20]
 LDCM0376  CL107 PaTu 8988t C504(0.48)  LDD1255  [20]
 LDCM0377  CL108 PaTu 8988t C504(0.77)  LDD1256  [20]
 LDCM0378  CL109 PaTu 8988t C504(0.54)  LDD1257  [20]
 LDCM0379  CL11 HCT 116 C504(0.34)  LDD0696  [20]
 LDCM0380  CL110 PaTu 8988t C504(0.34)  LDD1259  [20]
 LDCM0381  CL111 PaTu 8988t C504(0.43)  LDD1260  [20]
 LDCM0382  CL112 HCT 116 C504(1.10)  LDD0699  [20]
 LDCM0383  CL113 HCT 116 C504(1.02)  LDD0700  [20]
 LDCM0384  CL114 HCT 116 C504(1.06)  LDD0701  [20]
 LDCM0385  CL115 HCT 116 C504(0.62)  LDD0702  [20]
 LDCM0386  CL116 HCT 116 C504(1.10)  LDD0703  [20]
 LDCM0387  CL117 HCT 116 C235(0.21)  LDD0704  [20]
 LDCM0388  CL118 HCT 116 C235(0.86)  LDD0705  [20]
 LDCM0389  CL119 HCT 116 C235(0.89)  LDD0706  [20]
 LDCM0390  CL12 HCT 116 C504(0.24)  LDD0707  [20]
 LDCM0391  CL120 HCT 116 C235(0.99)  LDD0708  [20]
 LDCM0392  CL121 HCT 116 C504(0.51); C235(0.84)  LDD0709  [20]
 LDCM0393  CL122 HCT 116 C504(0.48); C235(1.13)  LDD0710  [20]
 LDCM0394  CL123 HCT 116 C504(0.25); C235(0.66)  LDD0711  [20]
 LDCM0395  CL124 HCT 116 C504(0.15); C235(0.51)  LDD0712  [20]
 LDCM0396  CL125 PaTu 8988t C504(0.87)  LDD1275  [20]
 LDCM0397  CL126 PaTu 8988t C504(0.95)  LDD1276  [20]
 LDCM0398  CL127 PaTu 8988t C504(1.84)  LDD1277  [20]
 LDCM0399  CL128 PaTu 8988t C504(0.54)  LDD1278  [20]
 LDCM0400  CL13 HCT 116 C504(0.89)  LDD0717  [20]
 LDCM0401  CL14 HCT 116 C504(1.07)  LDD0718  [20]
 LDCM0402  CL15 HCT 116 C504(0.34)  LDD0719  [20]
 LDCM0403  CL16 HCT 116 C504(1.14)  LDD0720  [20]
 LDCM0404  CL17 HCT 116 C504(0.75)  LDD0721  [20]
 LDCM0405  CL18 HCT 116 C504(1.78)  LDD0722  [20]
 LDCM0406  CL19 HCT 116 C504(0.95)  LDD0723  [20]
 LDCM0407  CL2 HCT 116 C504(1.50)  LDD0724  [20]
 LDCM0408  CL20 HCT 116 C504(0.52)  LDD0725  [20]
 LDCM0409  CL21 HCT 116 C504(0.31)  LDD0726  [20]
 LDCM0410  CL22 HCT 116 C504(0.07)  LDD0727  [20]
 LDCM0411  CL23 HCT 116 C504(1.04)  LDD0728  [20]
 LDCM0412  CL24 HCT 116 C504(0.38)  LDD0729  [20]
 LDCM0413  CL25 HCT 116 C504(0.41)  LDD0730  [20]
 LDCM0414  CL26 HCT 116 C504(0.91)  LDD0731  [20]
 LDCM0415  CL27 HCT 116 C504(0.99)  LDD0732  [20]
 LDCM0416  CL28 HCT 116 C504(0.61)  LDD0733  [20]
 LDCM0417  CL29 HCT 116 C504(0.65)  LDD0734  [20]
 LDCM0418  CL3 HCT 116 C504(1.32)  LDD0735  [20]
 LDCM0419  CL30 HCT 116 C504(0.73)  LDD0736  [20]
 LDCM0420  CL31 HCT 116 C235(1.00)  LDD0737  [20]
 LDCM0421  CL32 HCT 116 C235(0.97)  LDD0738  [20]
 LDCM0422  CL33 HCT 116 C235(0.94)  LDD0739  [20]
 LDCM0423  CL34 HCT 116 C235(0.55)  LDD0740  [20]
 LDCM0424  CL35 HCT 116 C235(0.50)  LDD0741  [20]
 LDCM0425  CL36 HCT 116 C235(0.76)  LDD0742  [20]
 LDCM0426  CL37 HCT 116 C235(0.38)  LDD0743  [20]
 LDCM0428  CL39 HCT 116 C235(0.50)  LDD0745  [20]
 LDCM0429  CL4 HCT 116 C504(1.63)  LDD0746  [20]
 LDCM0430  CL40 HCT 116 C235(0.67)  LDD0747  [20]
 LDCM0431  CL41 HCT 116 C235(0.81)  LDD0748  [20]
 LDCM0432  CL42 HCT 116 C235(0.11)  LDD0749  [20]
 LDCM0433  CL43 HCT 116 C235(0.28)  LDD0750  [20]
 LDCM0434  CL44 HCT 116 C235(0.87)  LDD0751  [20]
 LDCM0435  CL45 HCT 116 C235(0.59)  LDD0752  [20]
 LDCM0436  CL46 PaTu 8988t C504(0.59)  LDD1315  [20]
 LDCM0437  CL47 PaTu 8988t C504(0.94)  LDD1316  [20]
 LDCM0438  CL48 PaTu 8988t C504(1.37)  LDD1317  [20]
 LDCM0439  CL49 PaTu 8988t C504(0.84)  LDD1318  [20]
 LDCM0440  CL5 HCT 116 C504(0.95)  LDD0757  [20]
 LDCM0441  CL50 PaTu 8988t C504(0.81)  LDD1320  [20]
 LDCM0442  CL51 PaTu 8988t C504(0.86)  LDD1321  [20]
 LDCM0443  CL52 PaTu 8988t C504(0.68)  LDD1322  [20]
 LDCM0444  CL53 PaTu 8988t C504(0.57)  LDD1323  [20]
 LDCM0445  CL54 PaTu 8988t C504(0.83)  LDD1324  [20]
 LDCM0446  CL55 PaTu 8988t C504(0.57)  LDD1325  [20]
 LDCM0447  CL56 PaTu 8988t C504(0.08)  LDD1326  [20]
 LDCM0448  CL57 PaTu 8988t C504(0.04)  LDD1327  [20]
 LDCM0449  CL58 PaTu 8988t C504(0.34)  LDD1328  [20]
 LDCM0450  CL59 PaTu 8988t C504(0.04)  LDD1329  [20]
 LDCM0451  CL6 HCT 116 C504(1.75)  LDD0768  [20]
 LDCM0452  CL60 PaTu 8988t C504(0.14)  LDD1331  [20]
 LDCM0453  CL61 PaTu 8988t C504(1.27)  LDD1332  [20]
 LDCM0454  CL62 PaTu 8988t C504(1.01)  LDD1333  [20]
 LDCM0455  CL63 PaTu 8988t C504(1.32)  LDD1334  [20]
 LDCM0456  CL64 PaTu 8988t C504(0.95)  LDD1335  [20]
 LDCM0457  CL65 PaTu 8988t C504(1.03)  LDD1336  [20]
 LDCM0458  CL66 PaTu 8988t C504(0.85)  LDD1337  [20]
 LDCM0459  CL67 PaTu 8988t C504(0.28)  LDD1338  [20]
 LDCM0460  CL68 PaTu 8988t C504(0.13)  LDD1339  [20]
 LDCM0461  CL69 PaTu 8988t C504(0.18)  LDD1340  [20]
 LDCM0462  CL7 HCT 116 C504(0.65)  LDD0779  [20]
 LDCM0463  CL70 PaTu 8988t C504(0.36)  LDD1342  [20]
 LDCM0464  CL71 PaTu 8988t C504(1.25)  LDD1343  [20]
 LDCM0465  CL72 PaTu 8988t C504(2.10)  LDD1344  [20]
 LDCM0466  CL73 PaTu 8988t C504(0.24)  LDD1345  [20]
 LDCM0467  CL74 PaTu 8988t C504(1.14)  LDD1346  [20]
 LDCM0469  CL76 HCT 116 C235(0.93); C504(0.96)  LDD0786  [20]
 LDCM0470  CL77 HCT 116 C235(0.78); C504(0.89)  LDD0787  [20]
 LDCM0471  CL78 HCT 116 C235(0.74); C504(1.12)  LDD0788  [20]
 LDCM0472  CL79 HCT 116 C235(0.62); C504(0.77)  LDD0789  [20]
 LDCM0473  CL8 HCT 116 C504(0.21)  LDD0790  [20]
 LDCM0474  CL80 HCT 116 C235(0.80); C504(0.81)  LDD0791  [20]
 LDCM0475  CL81 HCT 116 C235(0.73); C504(0.82)  LDD0792  [20]
 LDCM0476  CL82 HCT 116 C235(0.28); C504(0.44)  LDD0793  [20]
 LDCM0477  CL83 HCT 116 C235(0.42); C504(0.57)  LDD0794  [20]
 LDCM0478  CL84 HCT 116 C235(0.13); C504(0.21)  LDD0795  [20]
 LDCM0479  CL85 HCT 116 C235(0.83); C504(0.98)  LDD0796  [20]
 LDCM0480  CL86 HCT 116 C235(1.04); C504(1.51)  LDD0797  [20]
 LDCM0481  CL87 HCT 116 C235(1.01); C504(0.85)  LDD0798  [20]
 LDCM0482  CL88 HCT 116 C235(0.40); C504(0.66)  LDD0799  [20]
 LDCM0483  CL89 HCT 116 C235(0.09); C504(0.15)  LDD0800  [20]
 LDCM0484  CL9 HCT 116 C504(0.86)  LDD0801  [20]
 LDCM0485  CL90 HCT 116 C235(0.89); C504(0.96)  LDD0802  [20]
 LDCM0486  CL91 HEK-293T C504(1.09); C235(1.01); C67(1.37)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C504(1.05); C235(0.86); C456(1.00); C67(1.08)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C504(1.17); C235(0.81); C456(1.14)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C504(1.10); C235(0.87); C456(1.04)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C504(1.00); C235(0.60); C456(0.76); C67(1.24)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C504(0.84); C235(0.79); C456(1.02); C67(1.43)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C504(0.93); C235(0.83); C456(1.00)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C504(1.12); C235(0.95); C456(1.00)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C504(1.04); C235(1.06); C456(0.87)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C504(0.92); C235(1.04); C456(0.92)  LDD1698  [19]
 LDCM0625  F8 Ramos C456(0.60)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C456(0.65)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C456(2.30)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C456(0.66)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C456(1.07)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C456(0.85)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C456(0.77)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C456(0.76)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C456(0.69)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C456(0.99)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C456(0.97)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C456(1.35)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C456(0.85)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C456(0.66)  LDD2201  [21]
 LDCM0468  Fragment33 PaTu 8988t C504(0.82)  LDD1347  [20]
 LDCM0596  Fragment38 Ramos C456(1.20)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C456(0.84)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C235(0.15)  LDD0744  [20]
 LDCM0610  Fragment52 Ramos C456(1.81)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C456(1.15)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C456(0.64)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C456(0.66)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y161(0.78)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y161(1.00)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y161(0.38)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y161(1.18)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y161(1.31)  LDD0268  [6]
 LDCM0107  IAA HeLa C504(0.00); C235(0.00); H357(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C504(0.98); C456(1.07); C235(1.32); C67(0.85)  LDD1492  [19]
 LDCM0023  KB03 Jurkat C504(6.05)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C504(1.28)  LDD3310  [22]
 LDCM0109  NEM HeLa H393(0.00); H357(0.00); C504(0.00); H443(0.00)  LDD0223  [15]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C456(1.02)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C456(0.20)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C235(1.51); C456(0.91); C504(1.05)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C504(0.84)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C456(0.47)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C456(0.52)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C456(1.16); C504(1.04)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C235(1.07); C456(0.57); C504(0.61)  LDD2109  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C456(0.60)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C456(0.65)  LDD2118  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C456(0.25)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C235(1.13); C456(0.80)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C235(1.12); C504(1.06)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C456(0.46)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C235(1.23)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C235(1.92)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C504(1.36)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C235(1.37); C504(0.84)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C235(0.98); C456(0.92)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C456(2.77)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C235(1.19); C456(0.88); C504(0.82)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C504(0.61)  LDD2141  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C456(0.22); C504(0.23)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C235(1.00)  LDD2146  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C456(0.36)  LDD2151  [4]
 LDCM0021  THZ1 HCT 116 C504(1.03)  LDD2173  [20]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Succinic Acid Small molecular drug DB00139
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ethylmercurithiosalicylic Acid . DB02731

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840