Details of the Target

General Information of Target

Target ID LDTP04273
Target Name DNA primase large subunit (PRIM2)
Gene Name PRIM2
Gene ID 5558
Synonyms
PRIM2A; DNA primase large subunit; DNA primase 58 kDa subunit; p58
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLG
VSYVKGTEQYQSKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWF
IQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLSGLKLGF
ESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAV
QSDERLQPLLNHLSHSYTGQDYSTQGNVGKISLDQIDLLSTKSFPPCMRQLHKALRENHH
LRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRT
DYTPFSCLKIILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHY
QVACQKYFEMIHNVDDCGFSLNHPNQFFCESQRILNGGKDIKKEPIQPETPQPKPSVQKT
KDASSALASLNSSLEMDMEGLEDYFSEDS
Target Bioclass
Enzyme
Family
Eukaryotic-type primase large subunit family
Function
Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit. Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch.
Uniprot ID
P49643
Ensemble ID
ENST00000274891.10
HGNC ID
HGNC:9370
ChEMBL ID
CHEMBL2363042

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.F447L .
MEWO SNV: p.F104C DBIA    Probe Info 
MFE296 SNV: p.S263N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.93  LDD0402  [1]
Probe 1
 Probe Info  		Y93(201.52)  LDD3495  [2]
BTD
 Probe Info  		C424(0.79)  LDD2089  [3]
AHL-Pu-1
 Probe Info  		C449(4.58)  LDD0168  [4]
DBIA
 Probe Info  		C111(4.94)  LDD0209  [5]
HHS-475
 Probe Info  		Y381(0.88)  LDD0264  [6]
HHS-465
 Probe Info  		Y381(4.53)  LDD2237  [7]
Acrolein
 Probe Info  		N.A.  LDD0222  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C424(0.00); C111(0.00); C384(0.00); C367(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C384(0.00); C25(0.00); C367(0.00); C111(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C384(0.00); C111(0.00); C25(0.00); C367(0.00)  LDD0037  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0147  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		8.30  LDD0443  [14]
NAIA_5
 Probe Info  		C424(0.00); C111(0.00); C367(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		54.95  LDD1948  [16]
FFF probe11
 Probe Info  		20.00  LDD0472  [17]
FFF probe13
 Probe Info  		12.85  LDD0475  [17]
EN
 Probe Info  		1.51  LDD0418  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C424(0.86)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C424(1.33)  LDD2152  [3]
 LDCM0025  4SU-RNA HEK-293T C449(4.58)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C449(5.58)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C111(0.96); C287(1.02)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C111(0.90); C384(1.00); C437(1.05); C449(1.05)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C111(0.67)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C111(0.65)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C111(0.51)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C111(0.72)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C111(0.58)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C111(0.62)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C111(0.64)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C111(0.59)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C111(0.57)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C111(0.58)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C111(1.08); C384(1.24); C437(1.19); C449(1.19)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C111(0.58)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C111(0.57)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C111(0.59)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C111(0.91); C287(0.99); C384(0.97); C437(0.88)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C111(0.76); C287(1.03); C384(0.69); C437(0.77)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C111(0.82); C287(0.98); C384(0.88); C437(0.79)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C111(0.67); C287(1.28); C384(0.71); C437(0.90)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C111(0.77); C287(1.27); C384(1.00); C437(0.74)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C111(0.89); C287(1.21); C384(0.92); C437(0.81)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C111(0.80); C287(1.04); C384(1.14); C437(0.90)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C111(0.95); C384(1.02); C437(1.24); C449(1.24)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C111(0.80); C287(0.95); C384(1.21); C437(0.89)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C111(1.16); C287(1.44); C384(1.27); C437(0.85)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C111(0.77); C287(0.96); C384(0.66); C437(0.97)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C111(0.95); C287(0.78); C384(1.18); C437(0.81)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C111(0.85); C287(1.31); C384(0.95); C437(1.07)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C111(0.71); C287(0.90); C384(0.94); C437(1.00)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C111(0.73); C287(0.91); C384(0.94); C437(0.90)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C111(0.86); C287(0.98); C384(0.92); C437(0.98)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C111(1.00); C287(0.56); C384(0.53); C437(0.45)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C111(0.80); C287(1.11); C384(0.71); C437(0.70)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C111(0.99); C287(0.77); C384(0.72); C437(0.74)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C111(1.00); C287(1.09); C384(0.76); C437(0.88)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C111(0.77); C287(1.12); C384(1.10); C437(0.74)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C111(0.94); C287(0.86); C384(0.78); C437(0.65)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C111(0.78); C287(0.84); C384(0.66); C437(0.55)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C111(0.95); C287(0.90); C384(0.69); C437(0.62)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C111(0.82); C287(0.90); C384(0.75); C437(0.85)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C111(0.81); C287(1.02); C384(0.84); C437(0.94)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C111(0.64); C287(0.83); C384(0.86); C437(0.71)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C111(0.85); C287(1.14); C384(0.77); C437(0.58)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C111(1.08); C384(0.83); C437(1.35); C449(1.35)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C111(0.74); C287(0.99); C384(0.80); C437(0.54)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C111(0.76); C287(0.99); C384(0.79); C437(0.62)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C111(0.68); C287(0.94); C384(0.82); C437(0.76)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C111(0.78); C384(0.84); C437(0.98); C449(0.98)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C111(0.77); C384(1.00); C437(1.05); C449(1.05)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C111(0.86); C384(0.99); C437(1.20); C449(1.20)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C384(0.85); C111(0.88); C437(0.90); C449(0.90)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C384(0.86); C111(1.01); C437(1.22); C449(1.22)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C384(0.73); C111(1.02); C437(1.44); C449(1.44)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C384(0.80); C111(0.92); C437(1.06); C449(1.06)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C111(0.90); C437(1.16); C449(1.16); C384(1.27)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C111(0.78); C384(0.85); C437(0.92); C449(0.92)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C437(0.88); C449(0.88); C111(0.92); C384(1.09)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C384(0.74); C437(0.83); C449(0.83); C111(0.91)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C384(0.58); C437(0.81); C449(0.81); C111(1.07)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C111(1.26); C384(0.93); C437(0.65); C449(0.65)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C111(0.84); C384(0.81); C437(0.79); C449(0.79)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C111(1.15); C384(1.09); C437(1.06); C449(1.06)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C111(0.92); C384(1.27); C437(1.13); C449(1.13)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C111(0.73); C367(0.90); C384(1.32); C437(1.38)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C111(0.74); C367(0.88); C384(1.00); C437(1.26)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C111(0.64); C367(0.89); C384(0.94); C437(1.04)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C287(0.94); C111(1.02)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C111(0.60); C367(0.97); C437(1.07); C449(1.07)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C111(0.55); C384(1.01); C367(1.04); C437(1.04)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C111(0.73); C367(0.94); C384(0.96); C437(1.02)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C111(0.58); C367(0.96); C384(1.03); C437(1.23)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C111(0.78); C367(0.86); C437(1.00); C449(1.00)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C287(0.89); C111(1.24)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C287(0.91); C111(1.67)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C287(1.00); C111(1.20)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C287(1.02); C111(2.07)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C111(1.10); C287(1.11)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C111(1.04); C287(1.04)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C287(0.93); C111(1.25)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C287(0.94); C111(1.52)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C287(1.00); C111(1.99)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C287(1.00); C111(1.09)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C111(0.81); C287(0.91)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C384(0.76); C367(0.99); C111(1.24)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C111(0.92); C384(0.98); C367(0.98)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C384(0.82); C111(0.87); C367(1.02)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C384(0.81); C111(0.97); C367(1.04)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C384(0.84); C367(1.03); C111(1.05)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C111(0.92); C287(1.16)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C384(0.67); C111(0.85); C367(1.08)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C384(0.82); C367(1.01); C111(1.05)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C384(0.83); C367(1.06); C111(1.56)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C384(0.92); C367(1.06); C111(1.28)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C384(0.80); C111(0.89); C367(1.01)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C384(0.79); C111(0.90); C367(0.99)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C111(0.83); C384(0.99); C287(1.02); C437(1.24)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C384(0.73); C287(0.87); C111(0.96); C437(1.45)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C287(0.90); C384(1.11); C111(1.23); C437(1.48)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C287(0.69); C384(0.71); C111(0.86); C437(1.03)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C111(1.02); C287(1.17)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C384(0.65); C287(0.75); C111(0.87); C437(1.27)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C384(1.03); C287(1.04); C437(1.35); C449(1.35)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C384(0.88); C111(0.89); C287(1.05); C437(1.33)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C384(0.79); C287(0.94); C111(1.10); C437(1.47)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C384(0.73); C287(0.77); C111(1.07); C437(1.20)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C384(0.59); C287(0.66); C437(0.89); C449(0.89)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C384(0.58); C287(0.66); C437(0.97); C449(0.97)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C367(0.85); C437(0.87); C449(0.87); C287(0.89)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C437(0.89); C449(0.89); C287(0.93); C111(0.98)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C287(0.91); C384(0.96); C367(0.97); C111(1.07)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C111(0.82); C437(0.91); C449(0.91); C384(1.01)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C111(0.88); C367(1.02); C384(1.04); C287(1.10)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C287(1.01); C111(1.03); C367(1.05); C384(1.07)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C384(0.74); C287(0.74); C367(0.93); C111(1.10)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C111(0.80); C367(1.02); C287(1.06); C437(1.15)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C384(0.73); C287(0.92); C111(0.92); C367(0.97)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C111(0.91); C384(0.92); C367(0.94); C287(1.07)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C437(0.88); C449(0.88); C111(0.95); C367(1.00)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C287(0.53); C111(0.88); C384(1.01); C367(1.05)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C287(0.83); C384(0.92); C111(0.97); C437(1.41)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C287(0.72); C384(0.78); C437(0.99); C449(0.99)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C111(0.98); C437(1.00); C449(1.00); C384(1.60)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C287(0.71); C384(0.75); C111(0.93); C437(1.05)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C384(0.92); C287(0.97); C437(1.11); C449(1.11)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C437(0.84); C449(0.84); C384(0.97); C111(0.97)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C384(0.65); C437(0.78); C449(0.78); C287(0.84)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C287(0.76); C384(0.80); C111(1.30); C437(1.30)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C384(0.52); C287(0.72); C437(1.06); C449(1.06)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C384(0.67); C287(0.80); C111(1.02); C437(1.17)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C287(0.71); C384(0.73); C111(0.87); C437(1.15)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C287(0.92); C111(0.94); C437(1.01); C449(1.01)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C287(0.97); C437(0.99); C449(0.99); C111(1.11)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C111(0.85); C437(1.00); C449(1.00); C384(1.22)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C384(0.71); C287(0.86); C111(1.00); C437(1.08)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C437(0.86); C449(0.86); C287(0.94); C111(1.06)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C384(0.58); C287(0.76); C437(0.79); C449(0.79)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C367(0.26); C437(0.50); C449(0.50); C384(0.63)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C367(0.30); C437(0.54); C449(0.54); C287(0.80)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C367(0.31); C437(0.52); C449(0.52); C111(0.98)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C367(0.28); C437(0.66); C449(0.66); C287(0.91)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C367(0.26); C437(0.49); C449(0.49); C384(0.83)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C367(0.28); C437(0.57); C449(0.57); C287(0.84)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C367(0.25); C437(0.48); C449(0.48); C111(0.78)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C367(0.26); C437(0.55); C449(0.55); C384(0.93)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C367(0.26); C437(0.53); C449(0.53); C384(0.66)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C367(0.27); C437(0.51); C449(0.51); C384(0.67)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C367(0.32); C437(0.47); C449(0.47); C111(0.78)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C367(0.30); C437(0.47); C449(0.47); C384(0.98)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C367(0.29); C437(0.57); C449(0.57); C111(0.70)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C367(0.29); C437(0.53); C449(0.53); C111(0.90)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C367(0.25); C437(0.59); C449(0.59); C384(0.72)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C111(0.64)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C111(0.52)  LDD0683  [19]
 LDCM0248  AKOS034007472 HCT 116 C111(1.15); C384(1.04); C437(1.20); C449(1.20)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C111(0.99); C384(1.06); C437(1.06); C449(1.06)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C111(0.84); C384(1.00); C437(1.23); C449(1.23)  LDD0592  [19]
 LDCM0156  Aniline NCI-H1299 11.58  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C384(1.10); C111(1.13)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C384(0.94); C111(0.99)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C111(0.96); C287(0.98)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C111(0.84); C437(1.28); C449(1.28); C384(1.28)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C111(0.99); C384(1.28); C437(1.34); C449(1.34)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C111(0.97); C384(1.29); C437(1.40); C449(1.40)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C111(0.97); C384(1.26); C437(1.31); C449(1.31)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C111(0.48); C367(0.92); C437(1.07); C449(1.07)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C111(0.51); C384(0.91); C367(0.98); C437(1.08)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C111(0.58); C384(0.86); C367(0.97); C437(1.10)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C111(0.54); C367(0.85); C437(1.19); C449(1.19)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C111(0.60); C367(0.93); C437(1.03); C449(1.03)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C111(0.95); C384(1.04)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C111(0.71); C367(0.98); C384(1.12); C437(1.23)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C111(0.68); C367(0.90); C384(0.98); C437(1.36)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C287(0.97); C111(1.22)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C111(0.99); C287(1.10)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C111(0.82); C287(1.41)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C111(0.91); C287(1.04)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C111(1.01); C287(1.09)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C384(0.61); C367(1.15); C111(1.27)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C111(0.89); C384(0.91); C367(0.92)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C384(0.78); C367(1.00); C111(1.18)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C111(0.97); C384(1.18)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C367(1.03); C384(1.09); C111(1.65)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C384(0.41); C287(0.45); C437(0.93); C449(0.93)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C111(0.89); C287(1.10); C384(1.22); C437(1.41)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C111(0.81); C384(1.16); C287(1.56); C437(2.24)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C287(0.81); C111(0.89); C384(1.04); C437(1.28)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C367(0.87); C287(0.92); C111(0.94); C437(0.98)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C437(0.75); C449(0.75); C367(0.89); C384(0.99)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C384(0.82); C367(0.95); C437(0.97); C449(0.97)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C367(0.86); C111(0.89); C287(0.93); C437(0.96)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C111(0.94); C384(0.96)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C384(1.06); C111(1.17)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C384(1.06); C111(1.09)  LDD0719  [19]
 LDCM0403  CL16 HCT 116 C384(0.63); C437(0.77); C449(0.77); C111(0.83)  LDD0720  [19]
 LDCM0404  CL17 HCT 116 C111(0.67); C437(0.72); C449(0.72); C287(1.04)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C384(0.59); C111(0.72); C437(0.91); C449(0.91)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C384(0.66); C111(0.68); C437(0.93); C449(0.93)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C111(0.78); C384(0.97)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C384(0.54); C111(0.65); C437(0.88); C449(0.88)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C111(0.67); C287(0.91); C437(0.94); C449(0.94)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C384(0.42); C111(0.73); C437(0.76); C449(0.76)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C111(0.57); C287(0.74); C384(0.88); C437(0.96)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C384(0.61); C111(0.75); C437(0.76); C449(0.76)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C111(0.68); C287(0.76); C384(0.65); C437(0.81)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C111(0.78); C287(0.89); C384(0.54); C437(0.95)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C111(0.76); C287(1.08); C384(0.66); C437(0.77)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C111(0.69); C287(0.74); C384(0.78); C437(0.83)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C111(0.91); C287(1.12); C384(0.87); C437(0.96)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C111(1.02); C384(1.14)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C111(0.68); C287(0.91); C384(0.67); C437(0.98)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C111(0.79); C287(0.94); C384(1.06); C437(1.16)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C111(0.55); C287(0.80); C384(0.91); C437(0.95)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C111(0.64); C287(1.24); C384(0.89); C437(2.17)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C111(0.68); C287(0.78); C384(0.90); C437(0.93)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C111(0.83); C287(0.64); C384(0.98); C437(0.78)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C111(0.68); C287(0.75); C384(0.81); C437(0.94)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C111(0.59); C287(0.66); C384(1.13); C437(0.77)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C111(0.75); C287(0.89); C384(1.11); C437(0.94)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C111(1.06); C384(0.97)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C111(0.64); C287(0.84); C384(1.04); C437(1.17)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C111(0.67); C287(0.94); C384(1.09); C437(0.89)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C111(0.92); C287(0.64); C384(1.01); C437(0.79)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C111(0.77); C287(0.57); C384(1.10); C437(0.84)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C111(0.88); C287(0.95); C384(1.09); C437(1.12)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C111(0.67); C287(0.87); C384(0.95); C437(0.94)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C111(1.02)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C111(1.27)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C111(1.17)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C111(1.10)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C111(0.95); C384(1.10)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C111(1.21)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C111(1.13)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C111(1.09)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C111(1.04)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C111(0.89)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C111(1.16)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C111(1.04)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C111(1.18)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C111(0.94)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C111(1.04)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C111(0.96); C384(0.78)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C111(1.14)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C111(1.05); C287(1.18); C384(1.08); C449(1.23)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C111(1.19); C287(1.18); C384(1.23); C449(1.01)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C111(0.88); C287(1.10); C384(0.90); C449(1.32)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C111(1.01); C287(1.52); C384(1.23); C449(1.36)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C111(1.09); C287(1.31); C384(0.93); C449(1.40)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C111(1.12); C287(1.07); C384(1.03); C449(1.11)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C111(0.82); C287(1.27); C384(1.09); C449(1.50)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C111(0.63); C287(1.17); C384(0.82); C449(1.64)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C111(1.03); C287(1.22); C384(1.16); C449(1.29)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C111(0.99); C384(0.85)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C111(0.80); C287(1.11); C384(0.83); C449(1.05)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C111(0.94); C287(0.98); C384(1.15); C449(1.22)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C111(1.20); C287(1.19); C384(0.91); C449(1.34)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C111(0.97); C287(1.31); C384(1.02); C449(1.37)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C111(0.76); C287(1.24); C384(1.03); C449(1.49)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C111(0.83); C287(0.88); C384(0.72); C437(1.21)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C111(0.90); C287(0.73); C384(1.54); C437(1.05)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C111(0.88); C287(0.75); C384(0.91); C437(0.91)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C111(0.90); C287(0.74); C384(0.78); C437(0.80)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C111(0.91); C384(1.02)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C111(0.83); C287(0.90); C384(0.88); C437(0.80)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C111(0.95); C287(0.79); C384(0.88); C437(1.08)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C111(0.86); C287(0.57); C384(0.66); C437(0.78)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C111(0.81); C287(0.73); C384(1.07); C437(0.96)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C111(0.96); C287(0.59); C384(0.67); C437(0.64)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C111(0.85); C287(0.85); C384(0.87); C437(1.00)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C111(0.85); C287(0.78); C384(1.15); C437(0.59)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C111(0.86); C287(1.00); C384(1.10); C437(0.97)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C111(0.93); C287(0.63); C384(0.64); C437(0.81)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C111(1.15); C287(0.50); C384(0.66); C437(1.29)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C111(0.88); C384(1.07)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C111(0.97); C287(1.54); C384(1.32); C437(1.01)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C111(0.92); C287(1.10)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C111(0.89); C287(1.25)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C111(1.09); C287(1.09)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C111(0.93); C287(1.30)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C111(1.01); C287(1.15)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C111(0.99); C287(1.15)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C111(0.97); C287(1.09)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C111(1.00); C287(1.13)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C111(0.96); C287(1.12)  LDD0811  [19]
 LDCM0495  E2913 HEK-293T C111(1.04); C25(1.03); C449(0.99)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C384(2.03); C111(1.41)  LDD1702  [3]
 LDCM0163  Entinostat Hep-G2 1.51  LDD0418  [18]
 LDCM0572  Fragment10 Ramos C111(0.81)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C111(0.16)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C111(0.61)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C111(0.66)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C111(0.50)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C111(0.67)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C111(1.30)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C111(1.96)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C111(0.93)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C111(0.37)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C111(1.24)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C111(1.67)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C111(0.57)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C111(0.86); C287(1.10); C384(1.15); C449(1.48)  LDD0785  [19]
 LDCM0596  Fragment38 Ramos C111(0.82)  LDD2203  [21]
 LDCM0427  Fragment51 HCT 116 C111(0.63); C287(0.57); C384(0.98); C437(0.60)  LDD0744  [19]
 LDCM0610  Fragment52 Ramos C111(0.86)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C111(1.37)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C367(0.72)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C111(0.61)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y381(0.88)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y381(0.97)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y381(0.42)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y381(1.23)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y381(1.45)  LDD0268  [6]
 LDCM0022  KB02 HEK-293T C111(1.01); C449(0.98)  LDD1492  [20]
 LDCM0023  KB03 Jurkat C111(4.94)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C424(3.42)  LDD3310  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C424(0.79)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C384(0.93)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C384(0.97)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C424(1.12)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C384(1.00)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C424(0.34)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C384(0.89)  LDD2098  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C384(1.01)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C367(0.86)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C424(0.46)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C424(0.78)  LDD2111  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C424(0.83)  LDD2118  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C424(0.73)  LDD2122  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C424(0.78)  LDD2146  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C384(0.59)  LDD2150  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C384(1.83)  LDD2153  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA primase small subunit (PRIM1) Eukaryotic-type primase small subunit family P49642
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Replication protein A 32 kDa subunit (RPA2) Replication factor A protein 2 family P15927
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Expanding the "minimalist" small molecule tagging approach to different bioactive compounds. Org Biomol Chem. 2019 Mar 13;17(11):3010-3017. doi: 10.1039/c8ob03175d.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840