Details of the Target

General Information of Target

Target ID LDTP00350
Target Name AT-rich interactive domain-containing protein 1A (ARID1A)
Gene Name ARID1A
Gene ID 8289
Synonyms
BAF250; BAF250A; C1orf4; OSA1; SMARCF1; AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; B120; BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A; Osa homolog 1; hOSA1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; hELD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEG
PAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLTEP
PGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG
LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPG
SGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLT
SPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA
PMSPGSSGGGGQPLARTPQPSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQ
PYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPYGQQGPSGYGQQGQTPYYNQQSPHPQQ
QQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQST
TQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPP
QELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPG
VSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVP
GNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQPSGGQ
IHTGMGSYQQNSMGSYGPQGGQYGPQGGYPRQPNYNALPNANYPSAGMAGGINPMGAGGQ
MHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQETAVA
MHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYSMGGTMANNSAG
MAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPER
KMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNL
NVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGS
MQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFNDGSDSTFQ
KRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPY
SRAAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMSTGAPQPNLMPSNPDSGMYS
PSRYPPQQQQQQQQRHDSYGNQFSTQGTPSGSPFPSQQTTMYQQQQQNYKRPMDGTYGPP
AKRHEGEMYSVPYSTGQGQPQQQQLPPAQPQPASQQQAAQPSPQQDVYNQYGNAYPATAT
AATERRPAGGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQMMGGPIQASAEVAQQGTMWQG
RNDMTYNYANRQSTGSAPQGPAYHGVNRTDEMLHTDQRANHEGSWPSHGTRQPPYGPSAP
VPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPV
PASHIAPAPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGL
LAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPG
QRTLLDPGRFSKVSSPAPMEGGEEEEELLGPKLEEEEEEEVVENDEEIAFSGKDKPASEN
SEEKLISKFDKLPVKIVQKNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFE
SKTELLPSRPHAPCPPAPRKHVTTAEGTPGTTDQEGPPPDGPPEKRITATMDDMLSTRSS
TLTEDGAKSSEAIKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKR
CVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQG
VSCNKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQ
DPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKN
PVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQN
PPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLF
LIGQS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Uniprot ID
O14497
Ensemble ID
ENST00000324856.13
HGNC ID
HGNC:11110

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.D1850GfsTer4 DBIA    Probe Info 
A2780 Deletion: p.R1721HfsTer4
SNV: p.Q1430Ter		 DBIA    Probe Info 
A3KAW SNV: p.P98S .
AN3CA Deletion: p.D1850TfsTer33; p.E2054_L2061del .
CAKI1 Insertion: p.Q372AfsTer28 DBIA    Probe Info 
CAL51 Deletion: p.D1850TfsTer33
SNV: p.R1276Ter		 .
CASKI SNV: p.G351R DBIA    Probe Info 
CCFSTTG1 SNV: p.P1144T .
COLO792 SNV: p.S764F DBIA    Probe Info 
EFO27 Deletion: p.G285EfsTer78
SNV: p.R1722Ter		 DBIA    Probe Info 
GB2 SNV: p.Q515Ter; p.S2096Ter .
HCT15 SNV: p.R270H .
HEC1 SNV: p.G1761C; p.Q1835Ter; p.Q2115Ter .
HEC1B SNV: p.G1761C; p.Q1835Ter; p.Q2115Ter .
HT1197 SNV: p.S2256Ter; p.S2264L .
HT1376 Deletion: p.S186RfsTer209
SNV: p.T1302S		 DBIA    Probe Info 
HUH28 SNV: p.S178I; p.M759V DBIA    Probe Info 
ICC3 Insertion: p.S617LfsTer6 .
ICC4 SNV: p.G410Ter DBIA    Probe Info 
IGR1 SNV: p.P776S DBIA    Probe Info 
IGROV1 Deletion: p.G276EfsTer87
Insertion: p.D1850GfsTer4		 DBIA    Probe Info 
IM95 Insertion: p.D1850GfsTer4 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.A339LfsTer24; p.F2141SfsTer59 DBIA    Probe Info 
JURKAT Deletion: p.Q1519RfsTer8 Compound 10    Probe Info 
KARPAS422 Deletion: p.Q2176RfsTer48 .
KMCH1 Deletion: p.Y1055CfsTer49 .
KMS12BM SNV: p.R1671W DBIA    Probe Info 
KU1919 SNV: p.Y1052Ter DBIA    Probe Info 
LNCaP clone FGC Deletion: p.G285EfsTer78 DBIA    Probe Info 
LOXIMVI SNV: p.Q1212Ter DBIA    Probe Info 
LS180 Deletion: p.K1094SfsTer67 DBIA    Probe Info 
MCC13 SNV: p.R2183C DBIA    Probe Info 
MFE296 Deletion: p.G276EfsTer87
SNV: p.Q185Ter		 .
MFE319 Deletion: p.Q1741SfsTer20
SNV: p.P1576L;p.D2277G		 .
MIAPACA2 SNV: p.Q321Ter; p.P1940L .
MKN45 Deletion: p.Q321GfsTer70 DBIA    Probe Info 
MOLT4 SNV: p.A873V; p.S2002F IA-alkyne    Probe Info 
NCIH1048 Deletion: p.G85RfsTer25 .
NCIH1793 SNV: p.C884Ter DBIA    Probe Info 
NCIH2172 Deletion: p.R1721DfsTer4
SNV: p.L24M		 DBIA    Probe Info 
NCIH2286 Insertion: p.A339VfsTer61
Substitution: p.G927Ter		 .
NUGC3 Insertion: p.D1850GfsTer4 DBIA    Probe Info 
OAW42 Deletion: p.P559LfsTer63
Insertion: p.A1119CfsTer4		 DBIA    Probe Info 
OCUM1 Deletion: p.Q1131SfsTer30 DBIA    Probe Info 
ONS76 SNV: p.V1464F DBIA    Probe Info 
OV56 Insertion: p.D2178GfsTer47 DBIA    Probe Info 
OVISE Deletion: p.Q542RfsTer77;p.Q543SfsTer76
Insertion: p.H203QfsTer197		 DBIA    Probe Info 
OVK18 Deletion: p.G276EfsTer87; p.Y592IfsTer27 .
OVTOKO Deletion: p.Q2209SfsTer22 .
P31FUJ Deletion: p.T1514RfsTer13 DBIA    Probe Info 
RKO Deletion: p.P1115QfsTer46; p.D1850TfsTer33 DBIA    Probe Info 
RL952 Deletion: p.M651WfsTer7
SNV: p.R693Ter		 .
RVH421 SNV: p.Q605Ter .
SKMEL28 SNV: p.P1456L DBIA    Probe Info 
SKOV3 SNV: p.Q586Ter DBIA    Probe Info 
SNGM Deletion: p.D1850TfsTer33; p.F2141SfsTer59 DBIA    Probe Info 
SNU1 Deletion: p.Q372SfsTer19;p.Q1519RfsTer8
Insertion: p.D1850GfsTer4
SNV: p.P121S		 DBIA    Probe Info 
SNU423 SNV: p.G623Ter .
SNU449 Insertion: p.E2250RfsTer28 DBIA    Probe Info 
SUDHL6 SNV: p.Q200Ter .
SUIT2 SNV: p.Q546Ter .
SW948 SNV: p.G701A DBIA    Probe Info 
TCCSUP Deletion: p.Q1452RfsTer29 .
TOV21G Insertion: p.Y551LfsTer72 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.08  LDD0402  [1]
TH211
 Probe Info  		Y1523(11.79)  LDD0260  [2]
Probe 1
 Probe Info  		Y308(69.97); Y311(32.28); Y316(92.92); Y1027(16.08)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C336(2.09); C1827(3.45)  LDD0169  [4]
HHS-475
 Probe Info  		Y1523(0.42); Y1233(0.68); Y1226(1.33)  LDD0264  [5]
HHS-465
 Probe Info  		Y1281(10.00); Y1285(10.00); Y1506(8.69)  LDD2237  [6]
DBIA
 Probe Info  		C336(1.06); C2043(1.01)  LDD0078  [7]
CY4
 Probe Info  		N.A.  LDD0247  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1968(0.00); C1827(0.00); C1874(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C1981(0.00); C1983(0.00); C1827(0.00); C1874(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C1968(0.00); C1827(0.00); C1874(0.00); C2052(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		C336(0.00); C1827(0.00); C1968(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C2163(0.00); C1981(0.00)  LDD0027  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		N.A.  LDD0005  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
VSF
 Probe Info  		C1827(0.00); C336(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		C1874(0.00); C336(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		9.40  LDD0443  [18]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
HHS-482
 Probe Info  		Y1523(0.85)  LDD2239  [6]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		9.08  LDD0471  [19]
FFF probe3
 Probe Info  		6.01  LDD0465  [19]
Photonaproxen
 Probe Info  		N.A.  LDD0157  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C336(2.09); C1827(3.45)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C336(1.01); C1099(0.89); C1105(0.89); C1827(1.12)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C336(0.83); C1827(0.99); C1968(1.13); C1981(1.16)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C1099(0.72); C1105(0.72); C1827(0.56); C1981(0.99)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C1099(0.92); C1105(0.92); C1827(0.90); C1981(0.88)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C1099(0.90); C1105(0.90); C1827(0.57); C1981(0.91)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C1099(1.07); C1105(1.07); C1827(0.85); C1981(1.02)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C1099(1.05); C1105(1.05); C1827(0.88); C1981(0.87)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C1099(0.88); C1105(0.88); C1827(1.05); C1981(0.99)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C1099(1.00); C1105(1.00); C1827(1.08); C1981(1.19)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C1099(0.92); C1105(0.92); C1827(0.67); C1981(0.96)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C1099(0.66); C1105(0.66); C1827(0.80); C1981(0.97)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C1099(1.08); C1105(1.08); C1827(0.80); C1981(0.85)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C336(1.04); C1827(1.28); C1968(1.26); C1981(1.25)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C1099(0.89); C1105(0.89); C1827(0.93); C1981(1.01)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C1099(0.85); C1105(0.85); C1827(0.95); C1981(0.95)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C1099(0.93); C1105(0.93); C1827(0.61); C1981(0.87)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C336(1.13); C1105(0.74); C1827(1.06); C1981(0.87)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C336(1.06); C1105(0.99); C1827(1.22); C1981(0.95)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C336(1.12); C1105(1.09); C1827(1.35); C1981(0.96)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C336(1.34); C1105(1.01); C1827(1.00); C1981(0.90)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C336(1.39); C1105(0.88); C1827(1.11); C1981(1.03)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C336(1.15); C1105(1.03); C1827(0.96); C1981(1.01)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C336(1.29); C1105(1.02); C1827(1.07); C1981(1.22)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C336(0.87); C1827(1.17); C1968(1.20); C1981(1.29)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C336(1.33); C1105(0.75); C1827(0.91); C1981(0.63)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C336(1.48); C1105(0.89); C1827(0.91); C1981(1.52)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C336(1.06); C1105(0.72); C1827(1.34); C1981(0.76)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C336(1.57); C1105(0.91); C1827(0.98); C1981(2.15)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C336(1.92); C1105(0.87); C1827(1.15); C1981(1.28)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C336(1.34); C1105(0.91); C1827(0.93); C1981(0.68)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C336(1.00); C1105(0.99); C1827(1.14); C1981(0.67)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C336(1.21); C1105(0.99); C1827(1.09); C1981(0.93)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C336(0.66); C1099(1.01); C1105(1.24); C1981(1.25)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C336(0.38); C1099(1.12); C1105(1.16); C1981(1.53)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C336(0.34); C1099(1.12); C1105(1.07); C1981(1.18)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C336(0.55); C1099(1.06); C1105(1.12); C1981(1.04)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C336(0.36); C1099(1.09); C1105(1.42); C1981(0.92)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C336(0.50); C1099(0.97); C1105(1.66); C1981(1.18)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C336(0.66); C1099(1.18); C1105(1.10); C1981(1.31)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C336(0.48); C1099(1.06); C1105(1.48); C1981(1.19)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C336(0.48); C1099(1.17); C1105(1.13); C1981(1.01)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C336(0.44); C1099(0.92); C1105(0.98); C1981(0.98)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C336(0.57); C1099(1.00); C1105(1.36); C1981(1.12)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C336(0.52); C1099(1.06); C1105(1.02); C1981(1.21)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C336(1.44); C1827(0.98); C1968(1.09); C1981(1.22)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C336(0.50); C1099(0.99); C1105(1.23); C1981(1.33)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C336(0.49); C1099(1.19); C1105(1.15); C1981(1.07)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C336(0.45); C1099(1.23); C1105(1.24); C1981(1.09)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C1105(0.95); C1827(0.89); C1874(0.89); C1981(0.99)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C1827(0.94); C1105(1.17); C2043(1.27); C1874(1.45)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C1105(0.88); C1827(0.92); C1874(1.04); C2043(1.12)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C1827(0.89); C1105(1.13); C1874(1.20); C2043(1.22)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C1827(0.98); C1105(1.00); C1981(1.24); C1983(1.24)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C1827(0.83); C1105(1.20); C2043(1.68); C1874(1.91)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C1827(0.91); C1105(1.05); C2043(1.38); C1981(1.46)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C336(0.91); C1983(0.99); C2052(1.04); C1981(1.06)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C1827(0.87); C1874(1.03); C2043(1.06); C1981(1.07)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C1874(0.94); C1981(0.99); C1983(0.99); C2043(1.01)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C1827(0.74); C1105(0.85); C1874(1.11); C2043(1.28)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C1827(0.88); C1105(1.24); C2043(1.77); C1981(2.26)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C1105(1.31); C1827(0.82); C1874(1.40); C1981(1.19)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C1105(1.15); C1827(0.94); C1874(1.27); C1981(1.27)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C1105(0.98); C1827(0.92); C1874(1.06); C1981(1.07)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C1105(1.15); C1827(0.89); C1874(1.13); C1981(1.16)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C336(0.33); C1827(0.92); C2043(0.99); C1968(1.17)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C336(0.61); C1827(0.89); C1983(1.07); C1981(1.18)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C336(0.53); C1983(0.97); C1827(0.98); C2043(1.12)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C1968(0.92); C336(0.95); C2052(0.98); C1099(1.05)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C336(0.43); C2043(0.99); C1827(1.09); C1968(1.21)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C336(0.46); C1827(0.89); C2043(1.05); C1968(1.18)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C336(0.34); C1981(0.97); C1983(0.99); C2043(1.01)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C336(0.35); C1827(0.95); C2043(1.04); C1968(1.05)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C336(0.50); C2043(0.90); C1827(0.90); C1981(1.06)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C2052(0.82); C1981(0.94); C1983(0.94); C2043(0.95)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C2052(0.81); C1099(1.12); C1981(1.15); C1983(1.15)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C2052(0.66); C1981(0.96); C1983(0.96); C1099(1.05)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C2052(0.73); C1981(1.01); C1983(1.01); C1827(1.08)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C2052(0.72); C1099(1.05); C1968(1.24); C2043(1.27)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C336(0.75); C1968(1.06); C1099(1.06); C1105(1.06)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C2052(0.93); C1981(0.98); C1983(0.98); C1099(1.16)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C2052(0.85); C1981(0.96); C1983(0.96); C1099(1.02)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C2052(0.76); C1981(1.17); C1983(1.17); C1099(1.31)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C2052(0.77); C2043(0.99); C1099(1.06); C1981(1.10)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C2052(0.76); C1099(0.88); C1981(0.98); C1983(0.98)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C1827(0.78); C2043(0.84); C1968(0.94); C1981(1.06)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C1968(0.81); C2043(0.90); C1827(0.92); C1981(1.01)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C1827(0.82); C1968(0.83); C2043(0.88); C1981(1.28)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C1827(0.96); C1968(0.97); C2043(1.02); C1981(1.08)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C1827(0.91); C1968(0.99); C2043(1.05); C1981(1.19)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C336(0.82); C1099(0.86); C1105(0.86); C1968(1.06)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C1827(0.82); C2043(1.10); C1968(1.14); C1981(1.20)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C1968(0.90); C1827(0.94); C2043(1.01); C1981(1.28)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C1827(0.84); C2043(1.06); C1968(1.07); C1981(1.09)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C1968(1.00); C1827(1.03); C2043(1.12); C1981(1.39)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C1827(0.69); C2043(1.02); C1968(1.08); C1981(1.33)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C1827(0.62); C2043(1.05); C1968(1.09); C1981(1.38)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C1981(0.77); C1983(1.03); C2043(1.07); C1827(1.16)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C1981(0.92); C1827(1.02); C1983(1.08); C2043(1.13)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C1981(0.73); C1827(1.03); C1983(1.06); C2043(1.24)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C1827(1.23); C1981(1.26); C1983(1.33); C2043(1.42)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C336(0.71); C1099(0.83); C1105(0.83); C2052(1.05)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C1827(0.94); C1981(1.29); C2043(1.34); C1983(1.43)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C1981(0.81); C1983(0.90); C1827(0.94); C2043(1.00)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C1827(0.90); C1981(1.06); C2043(1.12); C1983(1.16)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C1983(0.97); C1981(1.00); C1827(1.02); C2043(1.13)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C1827(0.85); C1983(0.90); C1981(1.06); C2043(1.15)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C1981(0.96); C2043(1.27); C1983(1.39); C1827(1.58)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C1827(1.09); C2043(1.48); C1981(1.61); C1983(1.64)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C1827(0.83); C2043(1.00); C1981(1.03); C1874(1.12)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C1827(1.00); C1981(1.02); C1874(1.03); C2043(1.10)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C1827(0.95); C2043(1.17); C1981(1.24); C1874(1.47)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1981(1.01); C1983(1.02); C2052(1.04); C336(1.06)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C1827(0.85); C2043(1.05); C1981(1.16); C1874(1.35)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C1827(0.92); C1981(1.02); C2043(1.11); C1874(1.11)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C1827(0.90); C2043(1.01); C1874(1.29); C1983(1.38)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C1827(0.75); C2043(1.01); C1981(1.13); C1874(1.55)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C1827(0.83); C2043(1.13); C1981(1.29); C1874(1.44)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C1827(0.95); C1874(1.13); C2043(1.16); C1981(1.20)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C1981(1.06); C1827(1.10); C1874(1.13); C2043(1.14)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C1827(0.82); C2043(1.10); C1981(1.22); C1874(1.63)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C336(0.74); C1827(0.96); C1099(0.96); C1105(0.96)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C1827(0.80); C1983(1.04); C336(1.04); C1099(1.06)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C336(0.93); C2052(1.10); C1981(1.11); C1968(1.12)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C336(0.92); C1099(1.02); C1105(1.02); C1983(1.13)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C336(0.64); C1981(0.78); C1827(0.79); C1983(0.84)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C1099(1.02); C1105(1.02); C1827(1.05); C1981(1.15)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C1099(1.06); C1105(1.06); C1827(1.16); C1983(1.24)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C1827(0.90); C1983(1.17); C336(1.20); C1099(1.21)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C1827(1.21); C1099(1.38); C1105(1.38); C2043(1.73)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C1827(0.92); C1099(0.97); C1105(0.97); C1983(1.24)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C1099(0.90); C1105(0.90); C1981(0.98); C1983(1.00)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C1981(0.78); C1983(0.89); C1827(0.99); C1099(1.05)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C1099(0.93); C1105(0.93); C336(0.93); C1827(1.00)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C336(0.85); C1968(1.11); C2052(1.12); C1981(1.13)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C336(0.96); C1827(0.99); C1099(0.99); C1105(0.99)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C336(0.80); C1981(0.85); C1099(0.89); C1105(0.89)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C1827(0.97); C1099(1.29); C1105(1.29); C1983(1.32)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C1827(1.09); C1981(1.33); C1983(1.42); C2043(1.54)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C1827(1.11); C1981(1.20); C1983(1.32); C2043(1.47)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C1981(0.98); C1874(1.09); C1983(1.10); C336(1.27)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C1981(1.05); C1827(1.06); C1983(1.10); C2043(1.18)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C1983(1.00); C1981(1.01); C1827(1.05); C1874(1.06)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C1981(1.04); C1827(1.07); C1983(1.08); C1874(1.13)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C1827(0.94); C2043(1.30); C1983(1.38); C1981(1.47)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C1874(0.86); C336(0.92); C2043(1.04); C1827(1.09)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C1983(1.30); C1827(1.31); C1981(1.33); C2043(1.67)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C1827(1.32); C1983(1.46); C2043(1.51); C1981(1.57)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C1983(1.01); C1981(1.01); C1874(1.14); C2043(1.21)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C1874(1.06); C1983(1.09); C2043(1.14); C1981(1.24)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1827(1.00); C1874(1.11); C2043(1.13); C1981(1.15)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C2043(1.19); C1983(1.31); C1827(1.34); C1981(1.49)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C1981(1.03); C1983(1.15); C1874(1.41); C1827(1.41)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C1099(0.92); C1105(0.92); C1827(1.09); C1983(1.14)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C1827(0.47); C1983(0.77); C1981(0.81); C2043(0.90)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C336(0.81); C1827(1.14); C1968(1.19); C1981(1.06)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C2052(1.03); C2043(1.15); C336(1.19); C1983(1.20)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C336(0.94); C1827(1.16); C2052(1.17); C1983(1.47)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C336(1.06); C2043(1.01)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C1827(1.16); C336(1.10); C1827(0.26)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C2043(0.93); C336(0.98); C1827(1.07); C1981(1.08)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C336(0.48); C1981(0.91); C2043(1.02); C1983(1.06)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C1099(0.85); C1105(0.85); C336(0.91); C2052(0.96)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C1827(0.93); C1981(1.09); C1983(1.14); C2052(1.17)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C1827(0.93); C1983(1.00); C2052(1.04); C2043(1.09)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C1827(0.97); C2052(0.98); C2043(1.10); C1981(1.11)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C1827(1.00); C2043(1.12); C2052(1.12); C1983(1.12)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C336(0.33); C1827(0.91); C1968(1.04); C2043(1.20)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C336(0.25); C1827(0.84); C1968(1.21); C1983(1.44)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C336(0.26); C1827(0.98); C1968(1.27); C1983(1.43)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C336(0.24); C1827(0.90); C1981(1.37); C1983(1.42)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C336(0.32); C1827(1.03); C1968(1.14); C1981(1.17)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C336(0.68); C1983(0.83); C1981(0.85); C1827(0.91)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C336(0.23); C1827(0.94); C2043(1.15); C1968(1.24)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C336(0.33); C1827(1.00); C2043(1.17); C1968(1.17)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C2052(0.62); C1981(0.91); C1983(0.91); C1827(0.99)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C2052(0.74); C1981(0.90); C1983(0.90); C1099(0.96)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C1099(0.90); C2052(0.91); C1968(0.99); C1981(0.99)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C2052(0.65); C1981(0.82); C1983(0.82); C1099(1.05)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C1099(0.90); C2052(0.93); C2043(0.99); C1981(1.08)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C1827(0.81); C1968(1.27); C1981(1.36); C1983(1.36)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C1968(1.00); C2043(1.03); C1827(1.09); C1981(1.16)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C1968(0.95); C2043(1.08); C1827(1.19); C1981(1.20)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C336(0.36); C1981(0.67); C1983(1.07); C1827(1.15)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C1968(0.96); C1827(1.05); C2043(1.06); C1981(1.22)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C1983(0.64); C1981(0.93); C2043(0.93); C1827(1.23)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C1981(0.77); C1983(0.98); C1827(1.07); C2043(1.19)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C1981(0.80); C1827(1.01); C1983(1.19); C2043(1.29)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C1827(0.97); C1981(1.07); C1983(1.17); C2043(1.30)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C1827(1.08); C2043(1.12); C1983(1.27); C1981(1.29)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C2043(1.04); C1981(1.10); C1874(1.12); C1827(1.15)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C1981(0.99); C1827(1.03); C2043(1.08); C1874(1.19)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C1827(0.91); C1874(1.14); C2043(1.23); C1981(1.30)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C336(0.52); C1981(0.84); C1983(0.99); C1827(0.99)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C336(0.77); C1981(0.81); C2043(0.92); C1983(1.01)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C1827(0.87); C1981(0.98); C1983(1.08); C2043(1.09)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C336(0.95); C1983(0.98); C1827(1.07); C2043(1.12)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C1827(0.69); C1874(0.91); C2043(1.01); C336(1.19)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C1874(0.98); C2043(1.06); C1827(1.10); C336(1.31)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C1874(0.94); C1827(1.00); C2043(1.02); C1983(1.13)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C1981(0.86); C336(0.88); C1983(0.92); C2043(0.94)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C1874(0.96); C336(1.04); C1827(1.10); C2043(1.18)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C1874(0.80); C1827(0.85); C336(1.06); C1983(1.09)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C336(0.98); C1827(1.00); C1874(1.09); C1983(1.11)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C1983(0.88); C1874(1.03); C2043(1.07); C336(1.21)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C336(0.84); C1983(0.99); C1874(1.04); C1827(1.10)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C336(1.03); C1827(1.08); C1874(1.18); C1983(0.72)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C336(1.30); C1827(1.13); C1874(1.23); C1983(0.94)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C336(0.91); C1827(1.07); C1874(0.99); C1983(0.89)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C336(1.13); C1827(1.13); C1874(1.08); C1983(1.00)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C336(1.17); C1827(1.15); C1874(0.99); C1983(0.83)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C336(0.79); C1827(0.98); C1981(0.76); C1983(0.88)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C336(0.98); C1827(1.12); C1874(1.06); C1983(0.87)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C336(1.04); C1827(0.98); C1981(0.96); C1983(1.00)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C1827(1.08); C1981(0.70); C1983(0.76); C2043(1.16)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C1827(1.13); C1981(1.18); C1983(1.01); C2043(1.14)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C1827(1.10); C1981(1.17); C1983(1.10); C2043(1.40)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C1827(1.12); C1981(0.90); C1983(0.96); C2043(1.19)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C1827(1.00); C1981(0.92); C1983(0.90); C2043(1.17)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C1827(1.05); C1981(1.18); C1983(1.02); C2043(1.29)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C1827(1.00); C1981(1.09); C1983(0.93); C2043(1.26)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C336(0.81); C1827(0.97); C1981(0.69); C1983(0.87)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C1827(0.98); C1981(1.08); C1983(0.87); C2043(1.14)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C1827(1.05); C1981(0.97); C1983(0.82); C2043(1.24)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C1827(0.93); C1981(1.61); C1983(1.15); C2043(1.48)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C1827(1.02); C1981(1.59); C1983(1.13); C2043(1.26)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C1827(1.05); C1981(0.97); C1983(0.92); C2043(1.16)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C1827(1.09); C1981(0.88); C1983(0.79); C2043(1.35)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C336(1.02); C1099(1.02); C1827(1.07); C1874(1.38)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C336(0.91); C1099(1.40); C1827(1.07); C1874(1.46)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C336(1.24); C1099(1.53); C1827(1.10); C1874(1.19)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C336(0.79); C1099(0.93); C1827(0.96); C1874(0.92)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C336(0.96); C1827(0.99); C1981(1.44); C1983(1.22)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C336(1.09); C1099(1.18); C1827(0.98); C1874(1.06)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C336(0.96); C1099(1.20); C1827(1.04); C1874(1.14)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C336(1.36); C1099(1.15); C1827(1.28); C1874(1.71)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C336(1.35); C1099(1.61); C1827(0.98); C1874(1.23)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C336(1.30); C1099(1.18); C1827(1.00); C1874(1.04)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C336(1.16); C1099(0.97); C1827(0.99); C1874(0.97)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C336(1.01); C1099(1.29); C1827(0.92); C1874(1.15)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C336(1.12); C1099(1.17); C1827(0.99); C1874(1.19)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C336(2.10); C1099(1.38); C1827(1.07); C1874(1.10)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C336(1.00); C1099(1.03); C1827(0.93); C1874(1.12)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C336(1.14); C1827(1.04); C1981(1.14); C1983(0.96)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C336(1.02); C1099(1.50); C1827(1.12); C1874(1.13)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C1827(1.09); C1981(1.07); C1983(1.07); C2043(1.04)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C1827(1.05); C1981(0.98); C1983(0.98); C2043(1.11)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C1827(1.04); C1981(0.95); C1983(0.95); C2043(1.21)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C1827(1.00); C1981(1.07); C1983(1.07); C2043(1.22)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C1827(0.93); C1981(1.05); C1983(1.05); C2043(1.10)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C1827(1.15); C1981(1.21); C1983(1.21); C2043(1.44)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C1827(0.87); C1981(1.03); C1983(1.03); C2043(1.17)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C1827(0.95); C1981(1.16); C1983(1.16); C2043(1.19)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C1827(1.20); C1981(0.97); C1983(0.97); C2043(1.05)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C336(0.37); C1827(1.01); C1981(1.21); C1983(1.23)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C1827(1.02); C1981(0.86); C1983(0.86); C2043(1.18)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C1827(1.12); C1981(1.02); C1983(1.02); C2043(1.18)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C1827(1.49); C1981(1.01); C1983(1.01); C2043(1.03)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C1827(1.10); C1981(1.10); C1983(1.10); C2043(1.10)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C1827(1.09); C1981(0.99); C1983(0.99); C2043(1.14)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C336(1.35); C1099(1.20); C1827(1.00); C1981(1.05)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C336(1.57); C1099(0.97); C1827(0.93); C1981(1.24)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C336(1.64); C1099(1.08); C1827(1.11); C1981(1.05)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C336(1.47); C1099(1.23); C1827(1.26); C1981(1.34)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C336(4.13); C1827(0.98); C1981(1.05); C1983(0.86)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C336(0.93); C1099(1.14); C1827(0.91); C1981(1.12)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C336(1.21); C1099(1.18); C1827(1.14); C1981(1.47)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C336(1.07); C1099(1.30); C1827(1.32); C1981(1.53)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C336(0.92); C1099(0.93); C1827(1.21); C1981(1.14)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C336(1.46); C1099(0.98); C1827(1.47); C1981(1.45)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C336(2.43); C1099(0.97); C1827(1.10); C1981(1.10)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C336(1.14); C1099(1.23); C1827(0.90); C1981(1.02)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C336(1.77); C1099(1.07); C1827(1.10); C1981(0.97)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C336(1.51); C1099(1.17); C1827(1.19); C1981(1.15)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C336(1.30); C1099(1.06); C1827(1.41); C1981(1.44)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C336(0.50); C1827(1.08); C1981(1.09); C1983(1.09)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C336(1.51); C1099(1.02); C1827(1.01); C1981(0.97)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C336(1.54); C1099(0.95); C1105(0.95); C1827(1.24)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C336(1.58); C1099(0.84); C1105(0.84); C1827(1.17)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C336(0.72); C1099(0.98); C1105(0.98); C1827(1.16)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C336(1.04); C1099(0.93); C1105(0.93); C1827(1.30)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C336(1.24); C1099(0.81); C1105(0.81); C1827(1.23)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C336(1.07); C1099(0.79); C1105(0.79); C1827(1.27)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C336(1.10); C1099(0.85); C1105(0.85); C1827(1.18)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C336(1.19); C1099(0.91); C1105(0.91); C1827(1.27)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C336(0.98); C1099(1.03); C1105(1.03); C1827(1.20)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C2043(0.89); C1827(0.95); C336(1.20); C1968(0.95)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1874(1.18)  LDD1702  [22]
 LDCM0625  F8 Ramos C1874(1.08); C1827(0.84)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C1874(1.68); C1827(0.90)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C1874(0.21); C1827(0.84)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C1874(0.81); C1827(0.50)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C1874(1.04); C1827(0.77)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C1874(0.68); C1827(0.63)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C1874(0.89); C1827(0.67)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C1874(1.20); C1827(0.63)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C1874(1.54); C1827(0.88)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C1874(1.27); C1827(0.62)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C1874(1.07); C1827(0.91)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C1874(1.49)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C1874(1.25); C1827(0.43)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C1874(1.12); C1827(0.45)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C1827(1.13); C1981(0.99); C1983(0.99); C2043(1.10)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C1874(1.22); C1827(0.43)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C1874(0.88); C1827(0.80)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C1827(0.93); C1981(2.00); C1983(1.40); C2043(1.75)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C1874(1.29); C1827(0.76)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C1874(1.06)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C1874(1.40); C1827(0.72)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C1874(0.88); C1827(0.65)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y1523(0.42); Y1233(0.68); Y1226(1.33)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y1233(0.48); Y1523(0.50); Y1226(0.99)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y1233(0.15); Y1523(0.25); Y1226(0.75)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y1523(0.33); Y1233(0.48); Y1226(0.74)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y1523(0.26); Y1233(0.85); Y1226(1.04)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C336(2.93); C2043(1.80); C1874(1.62)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C336(1.67); C2043(1.56); C1874(1.27)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C336(2.68); C2043(1.82); C1874(1.47)  LDD0082  [7]
 LDCM0131  RA190 MM1.R C336(1.67); C1968(1.48)  LDD0304  [24]
 LDCM0021  THZ1 HCT 116 C336(1.17)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable global transcription activator SNF2L2 (SMARCA2) SNF2/RAD54 helicase family P51531
Transcription activator BRG1 (SMARCA4) SNF2/RAD54 helicase family P51532
DNA topoisomerase 2-alpha (TOP2A) Type II topoisomerase family P11388
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hypermethylated in cancer 1 protein (HIC1) Krueppel C2H2-type zinc-finger protein family Q14526
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (SMARCD2) SMARCD family Q92925

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.