General Information of Target

Target ID LDTP08317
Target Name RNA N6-adenosine-methyltransferase METTL16 (METTL16)
Gene Name METTL16
Gene ID 79066
Synonyms
METT10D; RNA N6-adenosine-methyltransferase METTL16; Methyltransferase 10 domain-containing protein; Methyltransferase-like protein 16; N6-adenosine-methyltransferase METTL16; EC 2.1.1.348; U6 small nuclear RNA; adenine-(43)-N(6))-methyltransferase; EC 2.1.1.346
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALSKSMHARNRYKDKPPDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRALTCTLL
REDFGLSIDIPLERLIPTVPLRLNYIHWVEDLIGHQDSDKSTLRRGIDIGTGASCIYPLL
GATLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKVPQKTLLMDALKEESEIIYDF
CMCNPPFFANQLEAKGVNSRNPRRPPPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKK
RLRWYSCMLGKKCSLAPLKEELRIQGVPKVTYTEFCQGRTMRWALAWSFYDDVTVPSPPS
KRRKLEKPRKPITFVVLASVMKELSLKASPLRSETAEGIVVVTTWIEKILTDLKVQHKRV
PCGKEEVSLFLTAIENSWIHLRRKKRERVRQLREVPRAPEDVIQALEEKKPTPKESGNSQ
ELARGPQERTPCGPALREGEAAAVEGPCPSQESLSQEENPEPTEDERSEEKGGVEVLESC
QGSSNGAQDQEASEQFGSPVAERGKRLPGVAGQYLFKCLINVKKEVDDALVEMHWVEGQN
RDLMNQLCTYIRNQIFRLVAVN
Target Bioclass
Enzyme
Family
Methyltransferase superfamily, METTL16/RlmF family
Subcellular location
Nucleus
Function
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs. Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA. Specifically binds the 3'-end of the MALAT1 long non-coding RNA.
Uniprot ID
Q86W50
Ensemble ID
ENST00000263092.11
HGNC ID
HGNC:28484

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.F188LfsTer10 DBIA    Probe Info 
JURKAT Deletion: p.R241DfsTer2 .
MCC13 SNV: p.P449S DBIA    Probe Info 
MFE319 SNV: p.W287Ter DBIA    Probe Info 
TOV21G SNV: p.R388C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
15.00  LDD0402  [1]
STPyne
 Probe Info 
K259(8.19)  LDD0277  [2]
BTD
 Probe Info 
C253(1.21)  LDD2093  [3]
AHL-Pu-1
 Probe Info 
C448(6.75)  LDD0169  [4]
DBIA
 Probe Info 
C276(1.00)  LDD0078  [5]
ATP probe
 Probe Info 
N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info 
C57(0.00); C253(0.00); C548(0.00); C432(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info 
C57(0.00); C253(0.00); C432(0.00); C362(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info 
C57(0.00); C253(0.00); C548(0.00); C432(0.00)  LDD0037  [7]
NAIA_4
 Probe Info 
C253(0.00); C448(0.00); C480(0.00)  LDD2226  [8]
Compound 11
 Probe Info 
C253(0.00); C276(0.00)  LDD2213  [9]
ENE
 Probe Info 
C253(0.00); C432(0.00)  LDD0006  [10]
IPM
 Probe Info 
C276(0.00); C432(0.00); C253(0.00)  LDD0005  [10]
NPM
 Probe Info 
N.A.  LDD0016  [10]
PF-06672131
 Probe Info 
N.A.  LDD0017  [11]
TFBX
 Probe Info 
C253(0.00); C57(0.00); C518(0.00); C432(0.00)  LDD0148  [12]
VSF
 Probe Info 
N.A.  LDD0007  [10]
Ox-W18
 Probe Info 
N.A.  LDD2175  [13]
Acrolein
 Probe Info 
N.A.  LDD0217  [14]
W1
 Probe Info 
N.A.  LDD0236  [15]
AOyne
 Probe Info 
15.00  LDD0443  [16]
NAIA_5
 Probe Info 
C253(0.00); C181(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C253(1.33)  LDD2112  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C448(6.75)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C247(0.80); C253(0.93); C276(1.29); C432(1.11)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C181(0.86); C183(0.86); C247(0.84); C253(1.09)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C247(0.85); C253(1.32); C276(1.25); C548(0.86)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C247(0.93); C253(1.21); C276(1.26); C548(1.00)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C247(0.71); C253(1.14); C276(1.34); C548(0.88)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C247(0.84); C253(1.47); C276(1.85); C548(0.82)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C247(0.78); C253(1.16); C276(1.67); C548(0.81)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C247(0.74); C253(1.34); C276(1.38); C548(0.78)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C247(0.74); C253(1.42); C276(1.30); C548(0.85)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C247(0.76); C253(1.06); C276(1.49); C548(0.88)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C247(0.78); C253(1.12); C276(1.09); C548(0.75)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C247(0.76); C253(0.84); C276(1.05); C548(0.78)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C181(0.92); C183(0.92); C247(0.87); C253(1.08)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C247(0.80); C253(1.00); C276(1.16); C548(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C247(0.74); C253(1.04); C276(1.28); C548(0.83)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C247(0.79); C253(1.05); C276(1.18); C548(0.79)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C247(0.91); C253(1.06); C276(0.93); C548(1.08)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C247(0.99); C253(1.25); C276(0.58); C548(0.81)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C247(0.99); C253(1.38); C276(0.86); C548(0.76)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C247(0.88); C253(1.43); C276(0.64); C548(0.75)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C247(0.99); C253(1.18); C276(0.71); C548(0.79)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C247(0.97); C253(1.14); C276(0.67); C548(0.85)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C247(0.90); C253(1.21); C276(0.54); C548(0.79)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C181(1.11); C183(1.11); C247(1.04); C253(1.07)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C247(0.89); C253(1.12); C276(0.70); C548(0.84)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C247(1.10); C253(1.14); C276(1.03); C548(0.78)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C247(1.02); C253(1.19); C276(0.50); C548(0.85)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C247(1.25); C253(1.11); C276(0.65); C548(0.81)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C247(1.12); C253(1.04); C276(0.26); C548(0.85)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C247(0.95); C253(1.14); C276(0.64); C548(0.95)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C247(1.08); C253(1.33); C276(0.93); C548(0.73)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C247(1.08); C253(1.34); C276(1.02); C548(0.77)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C247(1.11); C253(1.23); C57(1.07)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C247(1.09); C253(1.03); C57(1.10)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C247(0.99); C253(1.27); C57(1.19)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C247(0.99); C253(0.97); C57(1.23)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C247(1.08); C253(1.12); C57(1.30)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C247(0.96); C253(1.20); C57(1.16)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C247(1.04); C253(1.27); C57(1.26)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C247(1.00); C253(1.27); C57(1.09)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C247(1.07); C253(1.19); C57(1.31)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C247(1.16); C253(1.18); C57(1.26)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C247(1.10); C253(1.37); C57(1.38)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C247(1.05); C253(1.30); C57(1.43)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C181(1.08); C183(1.08); C247(0.78); C253(0.92)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C247(1.08); C253(1.43); C57(1.61)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C247(1.04); C253(1.34); C57(1.61)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C247(0.91); C253(1.12); C57(1.38)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C247(0.71); C548(0.77); C276(1.15); C253(1.16)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C276(0.87); C181(0.95); C183(0.95); C247(0.99)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C548(0.74); C247(0.80); C276(0.94); C432(1.06)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C548(0.63); C181(0.73); C183(0.73); C276(0.93)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C276(0.84); C548(0.89); C181(0.98); C183(0.98)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C548(0.73); C181(0.80); C183(0.80); C247(0.81)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C548(0.76); C181(0.85); C183(0.85); C276(0.95)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C247(0.84); C276(0.86); C253(0.98); C181(0.99)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C276(0.80); C548(0.85); C432(1.04); C247(1.12)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C181(0.75); C183(0.75); C548(0.86); C276(0.88)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C181(0.70); C183(0.70); C548(0.79); C432(0.93)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C548(0.72); C432(0.73); C181(0.80); C183(0.80)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C181(0.84); C183(0.84); C247(1.27); C253(1.35)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C181(1.09); C183(1.09); C247(1.43); C253(1.31)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C181(0.92); C183(0.92); C247(1.25); C253(1.08)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C181(0.95); C183(0.95); C247(1.18); C253(1.03)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C432(0.92); C181(0.96); C183(0.96); C247(0.97)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C181(0.77); C183(0.77); C548(0.81); C432(0.87)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C548(0.80); C181(0.82); C183(0.82); C247(0.86)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C548(0.86); C247(0.92); C253(1.01); C276(1.22)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C181(0.90); C183(0.90); C247(1.00); C548(1.12)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C432(0.75); C181(0.79); C183(0.79); C247(0.99)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C548(0.86); C181(0.88); C183(0.88); C247(1.02)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C181(0.83); C183(0.83); C247(0.96); C548(0.96)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C181(0.91); C183(0.91); C247(0.99); C276(1.06)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C548(0.77); C247(0.85); C276(1.06); C253(1.13)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C247(0.87); C548(1.02); C276(1.24); C253(1.25)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C247(0.78); C548(0.98); C253(1.21); C276(1.22)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C247(0.85); C548(0.85); C253(1.17); C276(1.32)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C247(0.73); C548(1.00); C276(1.18); C253(1.22)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C548(0.87); C247(0.96); C253(1.00); C57(1.27)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C247(0.82); C548(1.06); C253(1.23); C276(1.24)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C247(0.66); C548(1.02); C253(1.24); C276(1.28)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C247(0.72); C548(0.98); C253(1.51); C276(1.53)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C247(0.73); C548(1.04); C253(1.20); C276(1.41)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C247(0.76); C548(0.80); C253(1.32); C276(1.48)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C253(0.91); C548(0.92); C276(0.98); C247(1.44)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C548(0.99); C276(1.00); C253(1.02); C247(1.33)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C276(0.87); C253(1.05); C247(1.13); C548(1.21)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C253(0.90); C276(0.99); C548(1.06); C247(1.23)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C253(0.91); C548(0.94); C247(1.05); C276(1.06)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C432(0.81); C247(0.93); C253(0.96); C548(1.07)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C253(0.83); C548(0.93); C276(1.05); C247(1.11)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C548(1.04); C276(1.07); C247(1.07); C253(1.17)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C253(0.95); C548(1.08); C276(1.11); C247(1.23)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C253(0.95); C548(1.03); C247(1.07); C276(1.11)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C253(0.94); C276(1.05); C247(1.10); C548(1.13)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C253(0.95); C276(1.00); C247(1.09); C548(1.13)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C548(1.13); C253(1.17); C276(1.18); C247(1.36)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C247(0.86); C548(0.89); C253(1.00); C276(1.19)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C247(0.72); C548(0.98); C253(1.06); C276(1.16)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C247(0.98); C548(1.03); C253(1.22); C276(1.58)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C253(0.91); C247(0.92); C432(1.00); C548(1.05)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C247(0.96); C548(1.09); C253(1.30); C276(1.43)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C247(1.08); C276(1.19); C253(1.20); C548(1.27)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C548(0.97); C253(1.06); C247(1.19); C276(1.24)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C548(0.97); C247(1.00); C253(1.05); C276(1.33)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C548(0.95); C253(1.01); C247(1.05); C276(1.30)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C548(1.01); C247(1.01); C253(1.11); C276(1.51)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C548(1.07); C247(1.09); C253(1.13); C276(1.76)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C181(0.49); C183(0.49); C247(0.81); C548(0.89)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C181(0.44); C183(0.44); C247(0.78); C548(0.85)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C181(0.61); C183(0.61); C247(0.79); C548(0.79)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C247(0.83); C181(0.88); C183(0.88); C276(0.99)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C181(0.43); C183(0.43); C247(0.65); C548(0.88)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C181(0.41); C183(0.41); C247(0.64); C548(0.89)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C181(0.56); C183(0.56); C247(0.81); C548(0.92)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C181(0.40); C183(0.40); C247(0.70); C548(0.74)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C181(0.47); C183(0.47); C247(0.82); C548(0.90)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C181(0.48); C183(0.48); C247(0.77); C548(0.79)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C181(0.43); C183(0.43); C247(0.77); C548(0.86)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C181(0.44); C183(0.44); C548(0.69); C247(0.72)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C181(0.90); C183(0.90); C247(0.94); C57(1.03)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C181(0.90); C183(0.90); C57(0.92); C247(0.96)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C181(0.85); C183(0.85); C247(0.86); C276(0.87)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C181(0.86); C183(0.86); C247(0.95); C548(0.97)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C57(0.89); C181(0.91); C183(0.91); C276(0.92)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C181(0.91); C183(0.91); C57(0.94); C247(1.00)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C181(0.91); C183(0.91); C548(1.06); C57(1.06)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C57(0.77); C181(0.87); C183(0.87); C247(1.03)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C181(0.86); C183(0.86); C57(0.98); C548(0.99)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C57(0.84); C247(1.07); C276(1.08); C181(1.13)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C57(0.87); C181(0.98); C183(0.98); C247(1.03)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C181(0.72); C183(0.72); C247(0.84); C57(0.91)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C181(0.97); C183(0.97); C57(1.09); C276(1.13)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C276(0.98); C247(1.00); C432(1.09); C181(1.10)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C57(0.84); C181(0.87); C183(0.87); C276(0.97)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C181(0.75); C183(0.75); C57(0.87); C276(1.01)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C57(0.88); C181(1.06); C183(1.06); C247(1.07)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C181(0.75); C183(0.75); C548(0.83); C247(1.08)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C181(0.70); C183(0.70); C548(0.83); C247(1.02)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C548(0.70); C181(0.72); C183(0.72); C247(0.88)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C548(0.73); C247(1.05); C276(1.08); C181(1.11)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C181(0.75); C183(0.75); C548(0.90); C247(0.98)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C548(0.81); C181(0.81); C183(0.81); C247(1.06)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C548(0.78); C181(0.91); C183(0.91); C247(0.94)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C276(1.13); C253(1.13); C247(1.23); C548(1.23)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C548(0.74); C181(0.80); C183(0.80); C247(1.03)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C548(0.73); C181(0.85); C183(0.85); C247(1.00)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C548(0.68); C181(0.85); C183(0.85); C247(0.95)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C548(0.67); C181(0.73); C183(0.73); C253(1.01)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C181(0.63); C183(0.63); C548(0.70); C247(0.76)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C548(0.62); C181(0.73); C183(0.73); C247(0.93)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C548(0.64); C181(0.84); C183(0.84); C247(1.12)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C247(0.68); C548(0.68); C57(1.20); C253(1.73)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C57(0.64); C548(0.72); C247(0.90); C276(1.06)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C181(1.20); C183(1.20); C247(0.86); C253(0.96)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C247(0.80); C548(0.89); C276(0.91); C181(1.01)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C247(0.84); C181(0.90); C183(0.90); C432(0.97)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.09  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C276(1.00)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C548(20.00); C253(1.19); C253(0.39)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C247(0.85); C432(0.90); C181(0.98); C183(0.98)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C181(0.67); C183(0.67); C432(0.70); C548(0.83)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C432(0.70); C548(0.78); C247(0.97); C253(1.03)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C247(0.79); C276(0.83); C548(0.84); C253(0.96)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C432(0.78); C247(0.79); C181(0.90); C183(0.90)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C276(0.77); C247(0.97); C253(0.98); C548(1.02)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C247(0.81); C432(0.97); C548(1.00); C181(1.02)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C181(0.68); C183(0.68); C432(0.77); C548(0.85)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C181(0.55); C183(0.55); C432(0.65); C247(0.88)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C432(0.63); C181(0.72); C183(0.72); C548(0.88)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C432(0.70); C181(0.77); C183(0.77); C247(0.98)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C548(0.70); C247(0.81); C181(0.86); C183(0.86)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C181(0.65); C183(0.65); C548(0.78); C432(0.86)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C181(0.70); C183(0.70); C432(0.73); C247(0.83)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C181(0.65); C183(0.65); C548(0.79); C247(0.86)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C548(0.83); C247(0.95); C276(1.12); C253(2.08)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C247(0.80); C548(0.87); C253(1.39); C276(1.40)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C247(0.69); C548(0.97); C276(1.29); C253(1.53)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C247(0.83); C548(0.95); C253(1.33); C276(1.35)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C247(0.77); C548(1.05); C253(1.26); C276(1.34)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C253(0.83); C548(1.13); C247(1.24); C276(1.34)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C253(1.12); C548(1.14); C276(1.17); C247(1.19)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C548(0.92); C253(1.13); C247(1.14); C276(1.19)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C432(0.66); C548(0.73); C181(0.81); C183(0.81)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C548(0.99); C253(1.02); C276(1.05); C247(1.09)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C548(0.93); C247(0.98); C276(1.08); C253(1.13)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C247(0.93); C548(1.01); C253(1.05); C276(1.30)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C247(0.86); C548(0.93); C253(1.00); C276(1.27)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C247(0.90); C548(1.06); C253(1.15); C276(1.48)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C181(0.66); C183(0.66); C548(0.92); C247(0.96)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C181(0.54); C183(0.54); C247(0.71); C548(0.75)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C181(0.61); C183(0.61); C247(0.78); C548(0.97)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C181(0.63); C183(0.63); C247(0.87); C548(1.02)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C181(0.63); C183(0.63); C432(0.75); C247(0.82)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C432(0.68); C548(0.75); C181(0.80); C183(0.80)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C432(0.56); C181(0.63); C183(0.63); C247(0.85)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C432(0.77); C247(0.79); C548(0.96); C276(1.18)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C548(0.67); C247(0.73); C432(0.96); C276(1.21)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C247(0.62); C548(0.71); C432(0.72); C253(1.01)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C548(0.65); C247(0.72); C432(0.85); C253(0.99)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C432(0.55); C181(0.76); C183(0.76); C247(0.87)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C548(0.73); C247(0.77); C432(0.93); C253(1.12)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C247(0.66); C548(0.69); C432(0.75); C276(1.06)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C548(0.69); C247(0.75); C432(0.77); C253(1.04)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C247(0.75); C548(0.80); C432(1.04); C253(1.16)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C548(0.76); C247(0.79); C432(0.90); C253(1.04)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C247(0.75); C253(1.12); C276(1.26); C432(0.89)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C247(0.79); C253(1.15); C276(1.28); C432(0.78)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C247(0.73); C253(1.03); C276(1.14); C432(0.76)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C247(0.66); C253(1.21); C276(1.15); C432(0.92)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C247(0.69); C253(1.10); C276(1.14); C432(0.90)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C181(0.79); C183(0.79); C247(0.93); C253(1.00)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C247(0.81); C253(1.23); C276(1.20); C432(0.88)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C247(0.94); C253(1.09); C276(0.94); C432(1.40)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C247(0.83); C253(1.28); C276(1.22); C432(1.40)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C247(0.75); C253(1.57); C276(1.14); C432(2.89)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C247(0.88); C253(1.24); C276(1.56); C432(1.47)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C247(0.89); C253(1.38); C276(1.21); C432(3.31)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C247(0.91); C253(1.30); C276(1.51); C432(1.60)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C247(0.98); C253(1.33); C276(1.27); C432(2.09)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C247(0.99); C253(1.24); C276(1.02); C432(1.77)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C181(0.78); C183(0.78); C247(0.74); C253(0.99)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C247(0.92); C253(1.59); C276(1.02); C432(2.46)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C247(0.88); C253(1.23); C276(1.18); C432(2.08)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C247(1.11); C253(1.21); C276(1.11); C432(2.74)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C247(0.94); C253(1.27); C276(1.18); C432(2.12)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C247(0.75); C253(1.24); C276(1.52); C432(3.38)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C247(0.82); C253(1.37); C276(1.67); C432(3.03)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C181(1.63); C183(1.63); C247(1.00); C253(1.26)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C181(1.37); C183(1.37); C247(1.07); C253(1.03)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C181(1.64); C183(1.64); C247(1.06); C253(1.29)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C181(1.03); C183(1.03); C247(1.01); C253(1.27)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C181(0.77); C183(0.77); C247(0.87); C253(0.99)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C181(1.26); C183(1.26); C247(0.95); C253(1.06)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C181(1.60); C183(1.60); C247(0.97); C253(1.16)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C181(1.32); C183(1.32); C247(0.86); C253(1.08)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C181(1.55); C183(1.55); C247(1.01); C253(0.89)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C181(1.45); C183(1.45); C247(0.95); C253(0.80)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C181(1.41); C183(1.41); C247(1.10); C253(0.89)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C181(1.30); C183(1.30); C247(1.05); C253(0.87)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C181(1.37); C183(1.37); C247(0.92); C253(0.99)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C181(1.47); C183(1.47); C247(0.94); C253(1.00)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C181(1.37); C183(1.37); C247(1.06); C253(0.93)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C181(0.60); C183(0.60); C247(0.64); C253(1.23)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C181(1.11); C183(1.11); C247(1.00); C253(1.02)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C247(0.96); C253(1.17); C276(1.11); C432(1.62)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C247(1.06); C253(1.25); C276(1.53); C432(1.66)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C247(0.89); C253(1.48); C276(1.67); C432(1.28)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C247(0.81); C253(1.67); C276(1.73); C432(1.48)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C247(0.94); C253(1.22); C276(1.20); C432(1.41)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C247(0.95); C253(1.96); C276(1.65); C432(1.37)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C247(0.95); C253(1.40); C276(1.68); C432(1.23)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C247(0.69); C253(1.50); C276(1.51); C432(1.76)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C247(0.55); C253(1.14); C276(1.30); C432(1.57)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C181(0.73); C183(0.73); C247(0.77); C253(1.17)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C247(0.76); C253(1.28); C276(1.68); C432(1.42)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C247(0.98); C253(1.50); C276(1.76); C432(1.61)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C247(0.97); C253(1.09); C276(1.26); C432(1.61)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C247(0.83); C253(1.45); C276(1.74); C432(2.10)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C247(0.87); C253(1.59); C276(1.66); C432(1.62)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C181(1.19); C183(1.19); C247(1.04); C253(1.10)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C181(0.83); C183(0.83); C247(1.08); C253(1.18)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C181(0.85); C183(0.85); C247(1.05); C253(1.25)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C181(0.90); C183(0.90); C247(1.09); C253(1.46)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C181(0.75); C183(0.75); C247(0.79); C253(2.01)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C181(0.53); C183(0.53); C247(1.07); C253(1.08)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C181(0.99); C183(0.99); C247(1.15); C253(1.23)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C181(0.93); C183(0.93); C247(1.24); C253(1.40)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C181(0.98); C183(0.98); C247(1.15); C253(1.41)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C181(0.82); C183(0.82); C247(0.97); C253(1.69)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C181(0.77); C183(0.77); C247(1.03); C253(1.14)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C181(1.16); C183(1.16); C247(1.03); C253(1.16)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C181(0.93); C183(0.93); C247(1.09); C253(1.29)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C181(0.85); C183(0.85); C247(1.21); C253(1.28)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C181(1.02); C183(1.02); C247(1.10); C253(1.76)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C181(0.87); C183(0.87); C247(0.72); C253(1.14)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C181(1.24); C183(1.24); C247(1.01); C253(1.43)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C247(1.03); C253(1.10); C276(1.10); C432(1.27)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C247(1.04); C253(1.03); C276(1.20); C432(1.18)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C247(1.11); C253(0.99); C276(1.20); C432(1.01)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C247(0.83); C253(0.99); C276(1.25); C432(1.07)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C247(0.89); C253(1.21); C276(1.37); C432(0.71)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C247(0.96); C253(1.03); C276(1.33); C432(0.93)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C247(0.83); C253(1.11); C276(1.40); C432(1.01)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C247(0.88); C253(1.11); C276(1.37); C432(1.08)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C247(0.93); C253(1.00); C276(1.44); C432(1.10)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C432(0.85)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C432(0.95); C276(0.92); C57(0.98); C548(0.97)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C253(1.63); C276(1.11); C432(0.99); C518(0.97)  LDD1702  [3]
 LDCM0625  F8 Ramos C432(0.88); C57(2.16); C276(1.46); C253(1.40)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C432(1.25); C57(1.01); C276(4.01); C253(3.27)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C432(0.66); C57(0.34); C276(10.79); C253(1.48)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C432(0.78); C57(0.68); C276(1.08); C253(0.99)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C432(1.30); C57(0.93); C276(1.11); C253(1.35)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C432(0.71); C57(0.73); C276(0.61); C253(0.29)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C432(0.87); C57(0.66); C253(1.27)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C432(1.40); C57(1.00); C276(1.11); C253(1.00)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C432(1.52); C57(1.11); C276(1.33); C253(1.15)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C432(1.35); C57(1.21); C276(1.14); C253(1.06)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C432(0.67); C57(0.76); C276(0.72); C253(0.98)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C432(2.11); C57(1.14); C276(1.33); C253(1.45)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C432(1.77); C57(0.93); C276(1.10); C253(1.02)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C432(0.73); C57(0.49); C276(1.30); C253(1.63)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C247(0.87); C253(1.26); C276(1.48); C432(1.76)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C432(1.44); C57(0.57); C276(0.79); C253(1.21)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C432(1.00); C57(1.25); C276(1.53); C253(0.79)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C247(0.92); C253(2.31); C276(1.99); C432(2.98)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C432(1.13); C57(0.95); C276(1.15); C253(2.29)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C432(1.42); C57(1.27); C276(1.19); C253(1.64)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C432(0.66); C57(0.52); C276(0.92); C253(1.35)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C432(0.91); C57(1.23); C276(3.52); C253(1.31)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C247(2.27); C276(1.61)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C247(2.44); C276(1.56)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C247(3.76); C276(1.35)  LDD0082  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C253(1.21)  LDD2093  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C253(0.96)  LDD2097  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C253(0.98); C57(1.14)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C432(0.96)  LDD2100  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C253(0.81)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C253(0.90); C57(1.08)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C253(1.12)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C57(0.63)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C253(1.23)  LDD2111  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C253(1.73)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C432(0.67)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C253(1.51)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C253(0.96); C57(1.23)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C432(0.82)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C253(0.84)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C432(1.02)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C253(0.97); C57(0.80)  LDD2127  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C253(1.12)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C276(1.21)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C253(1.03); C57(0.83)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C253(0.89)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C253(1.20)  LDD2141  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C253(1.03)  LDD2146  [3]
 LDCM0131  RA190 MM1.R C480(1.34); C448(1.26); C276(1.09)  LDD0304  [19]
 LDCM0021  THZ1 HCT 116 C276(1.18); C432(1.23)  LDD2173  [5]

References

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Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD041264
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD036569
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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