Details of the Target

General Information of Target

Target ID LDTP06088
Target Name Translation initiation factor eIF2B subunit alpha (EIF2B1)
Gene Name EIF2B1
Gene ID 1967
Synonyms
EIF2BA; Translation initiation factor eIF2B subunit alpha; eIF2B GDP-GTP exchange factor subunit alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVD
SSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK
DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLD
AAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP
LNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL
IKLYL
Target Bioclass
Other
Family
EIF-2B alpha/beta/delta subunits family
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Uniprot ID
Q14232
Ensemble ID
ENST00000424014.7
HGNC ID
HGNC:3257

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.D248G .
SSP25 SNV: p.G44D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C115(0.84); C218(0.77)  LDD2089  [2]
AHL-Pu-1
 Probe Info  		C169(11.34)  LDD0171  [3]
IPM
 Probe Info  		C218(6.50)  LDD1701  [2]
DBIA
 Probe Info  		C218(1.37)  LDD0080  [4]
ATP probe
 Probe Info  		K110(0.00); K88(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C169(0.00); C115(0.00); C218(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C169(0.00); C115(0.00); C218(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		C115(0.00); C218(0.00)  LDD0217  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C169(0.00); C89(0.00); C115(0.00); C218(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C115(0.72)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C115(1.10)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C115(1.10); C218(0.86)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C218(1.38)  LDD2152  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C115(0.58); C218(0.50)  LDD2132  [2]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C115(0.88)  LDD2131  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C169(11.34)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C115(0.81); C218(0.85)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C218(0.93)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C218(1.11)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C218(0.93)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C218(1.04)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C218(0.89)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C218(1.10)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C218(0.99)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C218(0.90)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C218(1.05)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C218(1.06)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C218(1.14)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C218(0.86)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C218(0.85)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C218(0.85)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C218(0.80)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C115(1.12); C218(1.08)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C115(1.05); C218(1.02)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C115(1.10); C218(0.91)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C115(1.05); C218(0.96)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C115(1.01); C218(0.91)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C115(1.09); C218(1.11)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C115(0.99); C218(0.93)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C218(1.05)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C115(1.15); C218(1.00)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C115(1.18); C218(1.01)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C115(1.09); C218(0.93)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C115(1.02); C218(1.41)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C115(1.02); C218(0.98)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C115(1.00); C218(1.07)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C115(1.00); C218(1.15)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C115(1.15); C218(1.33)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C218(1.46)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C218(1.36)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C218(1.22)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C218(1.23)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C218(0.99)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C218(1.17)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C218(0.98)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C218(1.11)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C218(1.00)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C218(1.11)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C218(0.82)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C218(0.84)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C218(0.86)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C218(0.88)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C218(0.90)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C218(1.03)  LDD0579  [4]
 LDCM0263  AC143 HEK-293T C218(1.12)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C218(1.13)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C218(0.98)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C218(1.13)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C218(1.35)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C218(1.19)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C218(1.07)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C218(0.92)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C218(1.15)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C218(1.04)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C218(1.18)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C218(1.16)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C218(1.34)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C218(1.06)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C218(1.16)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C218(1.53)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C218(1.04); C115(1.13)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C115(0.81); C218(0.97)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C218(0.99); C115(1.09)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C218(0.89); C115(1.01)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C218(1.06); C115(1.10)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C115(0.78); C218(0.89)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C218(0.97); C115(1.00)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C115(0.92); C218(1.11)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C218(1.08); C115(1.09)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C115(1.06); C218(1.04)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C115(1.11); C218(0.98)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C115(0.97); C218(0.99)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C115(1.07); C218(1.17)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C115(0.94); C218(1.04)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C218(0.97); C115(1.03)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C115(1.02); C218(1.06)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C115(1.32); C218(1.06)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C115(1.01); C218(1.06)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C115(1.01); C218(1.04)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C115(1.29); C218(0.91)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C115(1.02); C218(1.49)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C115(0.93); C218(1.37)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C115(0.83); C218(1.24)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C115(0.94); C218(1.31)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C115(1.05); C218(1.50)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C115(0.89); C218(0.96)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C115(0.87); C218(1.19)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C115(0.69); C218(1.11)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C115(0.69); C218(1.34)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C115(0.62); C218(1.03)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C115(0.73); C218(1.29)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C115(0.67); C218(1.09)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C218(0.79); C115(0.88)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C218(0.85); C115(0.85)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C218(0.63); C115(0.93)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C218(0.83); C115(0.85)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C115(0.86); C218(1.01)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C218(0.71); C115(0.85)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C218(0.90); C115(0.94)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C218(0.95); C115(1.07)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C115(0.90); C218(0.95)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C218(0.79); C115(0.86)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C115(0.86); C218(0.97)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C218(0.67); C115(0.68)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C115(0.87)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C115(0.83)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C115(0.87)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C218(0.80)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C115(0.71)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C115(0.80)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C115(0.73)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C115(0.74)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C115(0.75)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C115(0.88)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C115(0.84)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C115(0.65)  LDD0648  [4]
 LDCM0332  AC68 HEK-293T C115(1.06); C218(1.01)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C115(1.05); C218(1.07)  LDD0931  [4]
 LDCM0334  AC7 HCT 116 C218(0.88)  LDD0651  [4]
 LDCM0335  AC70 HEK-293T C115(1.12); C218(1.06)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C115(1.08); C218(1.06)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C115(0.92); C218(1.02)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C115(1.02); C218(1.11)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C115(1.28); C218(1.12)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C115(1.19); C218(1.02)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C115(1.06); C218(0.99)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C115(1.06); C218(1.11)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C115(0.95); C218(1.07)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C115(1.02); C218(1.11)  LDD0942  [4]
 LDCM0345  AC8 HCT 116 C218(0.91)  LDD0662  [4]
 LDCM0346  AC80 HEK-293T C115(0.96); C218(1.15)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C115(0.96); C218(1.05)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C115(0.93); C218(1.34)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C218(1.00)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C218(1.07)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C218(1.19)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C218(0.85)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C218(0.81)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C218(0.80)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C218(0.83)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C218(0.80)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C218(1.15)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C218(1.09)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C218(1.03)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C218(1.88)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C218(0.79)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C218(1.62)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C218(0.78)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C218(0.80)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C218(0.97)  LDD0683  [4]
 LDCM0545  Acetamide MDA-MB-231 C218(0.72)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C218(1.05)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C218(0.87)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C218(0.77)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 13.47  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C218(1.11)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C218(0.87); C115(1.07)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C115(0.79); C218(0.80)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C115(0.88); C218(0.96)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C218(0.83)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C218(0.96)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C218(0.99)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C218(0.91)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C218(0.94); C115(0.97)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C115(0.69); C218(0.77)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C218(0.97); C115(0.97)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C218(0.94); C115(0.95)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C218(0.94); C115(0.97)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C115(0.88); C218(0.95)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C115(0.83); C218(0.87)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C218(0.91); C115(0.91)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C115(1.05); C218(0.98)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C115(1.17); C218(1.03)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C115(0.83); C218(1.17)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C115(1.20); C218(0.99)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C115(1.06); C218(1.00)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C115(0.76); C218(1.18)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C115(0.92); C218(1.13)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C115(0.86); C218(1.08)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C218(0.91); C115(0.91)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C115(0.77); C218(1.16)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C115(0.84); C218(1.17)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C218(0.68); C115(0.90)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C218(0.68); C115(0.84)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C218(0.70); C115(0.90)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C115(1.08)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C115(0.86)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C115(0.87)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C115(0.96)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C115(0.83); C218(1.04)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C218(0.89); C115(0.90)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C115(0.78); C218(1.04)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C218(1.08)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C218(0.94)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C218(0.55)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C218(1.05)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C218(0.87); C115(1.11)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C218(0.87)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C218(0.55)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C218(0.74)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C218(1.62)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C218(0.98)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C218(1.09)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C218(0.88)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C218(1.03)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C218(0.86)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C218(0.81)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C115(0.90); C218(0.85)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C218(0.84)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C115(0.70); C218(1.02)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C115(0.52); C218(1.01)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C115(0.49); C218(0.79)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C115(0.57); C218(0.77)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C115(0.60); C218(0.76)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C115(0.69); C218(0.86)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C115(0.63); C218(0.80)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C115(0.58); C218(0.89)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C115(0.88); C218(1.00)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C115(0.73); C218(0.80)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C115(0.80); C218(0.96)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C115(0.50); C218(0.75)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C115(0.52); C218(0.70)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C115(0.57); C218(0.80)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C115(0.50); C218(0.95)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C218(0.83)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C218(0.86)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C218(0.82)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C218(1.12)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C115(1.01); C218(1.13)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C218(0.99)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C218(0.96)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C218(0.84)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C218(0.82)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C218(0.80)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C218(0.98)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C218(0.88)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C218(0.94)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C218(0.84)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C218(0.96)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C115(0.88); C218(0.82)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C218(0.88)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C115(0.97); C218(0.90)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C115(1.06); C218(0.91)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C115(0.80); C218(0.87)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C115(1.00); C218(0.87)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C115(0.88); C218(1.04)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C115(0.92); C218(1.02)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C115(0.88); C218(0.95)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C115(0.84); C218(0.75)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C115(0.89); C218(0.81)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C115(0.92); C218(0.97)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C115(1.06); C218(0.83)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C115(0.84); C218(1.07)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C115(0.92); C218(1.21)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C115(1.00); C218(1.03)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C115(0.96); C218(1.05)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C218(0.77)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C218(0.88)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C218(0.99)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C218(0.87)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C115(0.81); C218(0.73)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C218(0.79)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C218(0.92)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C218(0.85)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C218(0.82)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C218(0.69)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C218(0.92)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C218(1.07)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C218(0.95)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C218(0.87)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C218(0.72)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C115(0.89); C218(0.88)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C218(1.01)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C115(0.87); C218(0.82)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C115(0.77); C218(0.89)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C115(0.86); C218(1.07)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C115(0.85); C218(0.87)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C115(0.87); C218(0.85)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C115(0.97); C218(0.88)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C115(0.90); C218(0.83)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C115(0.80); C218(0.84)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C115(0.94); C218(0.97)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C218(0.90); C115(0.88); C57(1.04); C169(0.93)  LDD1698  [14]
 LDCM0625  F8 Ramos C115(0.63); C218(0.84)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C115(0.96); C218(0.61)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C115(20.00)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C115(0.89); C218(0.67)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C115(1.84); C218(0.90)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C115(0.46); C218(0.81)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C115(0.78); C218(0.52)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C115(1.14); C218(0.69)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C115(0.86); C218(0.11)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C115(1.37); C218(0.79)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C115(2.12); C218(0.73)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C115(1.34); C218(1.12)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C115(1.51); C218(0.94)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C115(0.69); C218(0.59)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C115(0.85); C218(0.80)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C115(1.34); C218(0.76)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C115(0.87); C218(0.70)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C115(0.54); C218(0.81)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C115(1.39); C218(1.63)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C115(1.31); C218(1.22)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C115(0.82); C218(0.60)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C115(0.64); C218(0.56)  LDD2188  [15]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C218(1.37)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C218(1.65)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C218(1.62)  LDD0082  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C115(0.84); C218(0.77)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C115(1.66); C218(1.19)  LDD2093  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C218(1.57)  LDD2096  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C115(1.33); C218(0.93)  LDD2099  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C218(0.80)  LDD2101  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C115(1.00); C218(1.01)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C218(0.53)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C115(1.52); C218(1.03)  LDD2111  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C115(0.41)  LDD2115  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C115(0.10)  LDD2116  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C115(0.22); C218(0.84)  LDD2118  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C218(1.73)  LDD2119  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C115(0.43); C218(1.40)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C218(1.05)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C115(1.24); C218(0.90)  LDD2123  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C218(0.58)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C115(0.98)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C115(0.10); C218(0.92)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C115(1.34); C218(0.81)  LDD2127  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C218(1.11)  LDD2128  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C115(1.49); C218(1.06)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C218(0.58)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C218(0.44)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C115(1.75); C218(1.12)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C115(1.76); C218(1.07)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C115(1.31); C218(0.83)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C115(1.39); C218(0.69)  LDD2140  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C115(0.45)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C115(2.13); C218(1.99)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C218(0.90)  LDD2146  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C115(0.99); C218(3.52)  LDD2147  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C115(0.46)  LDD2148  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C218(0.78)  LDD2149  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C169(0.98)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Tripartite motif-containing protein 59 (TRIM59) TRIM/RBCC family Q8IWR1
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) BZIP family Q9Y2D1
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Translation initiation factor eIF2B subunit alpha (EIF2B1) EIF-2B alpha/beta/delta subunits family Q14232
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Mediator of RNA polymerase II transcription subunit 29 (MED29) Mediator complex subunit 29 family Q9NX70
Protein RD3 (RD3) . Q7Z3Z2
Uncharacterized protein C1orf50 (C1orf50) . Q9BV19

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.