Details of the Target

General Information of Target

Target ID LDTP05496
Target Name E3 ubiquitin-protein ligase RING1 (RING1)
Gene Name RING1
Gene ID 6015
Synonyms
RING1A; RNF1; E3 ubiquitin-protein ligase RING1; EC 2.3.2.27; Polycomb complex protein RING1; RING finger protein 1; RING-type E3 ubiquitin transferase RING1; Really interesting new gene 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMT
TKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAH
QDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGE
GDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLG
GGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLA
LRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQ
YTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
Uniprot ID
Q06587
Ensemble ID
ENST00000374656.5
HGNC ID
HGNC:10018

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A673 Substitution: p.G217V DBIA    Probe Info 
HT SNV: p.L375S .
Ishikawa (Heraklio) 02 ER SNV: p.T220I DBIA    Probe Info 
LS180 Deletion: p.E173KfsTer14
SNV: p.D182G;p.G333D		 DBIA    Probe Info 
MCC26 SNV: p.V74F DBIA    Probe Info 
MFE319 SNV: p.R146H DBIA    Probe Info 
NCIH1155 SNV: p.Q26Ter DBIA    Probe Info 
SHP77 SNV: p.G216R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.93  LDD0402  [1]
STPyne
 Probe Info  		K62(1.61); K82(10.00)  LDD0277  [2]
BTD
 Probe Info  		C84(0.65)  LDD2099  [3]
AHL-Pu-1
 Probe Info  		C279(2.24)  LDD0170  [4]
DBIA
 Probe Info  		C69(1.47); C72(1.16)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C279(0.00); C398(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C398(0.00); C69(0.00); C72(0.00); C279(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
IPM
 Probe Info  		C69(0.00); C279(0.00)  LDD0005  [9]
TFBX
 Probe Info  		C84(0.00); C87(0.00); C279(0.00); C398(0.00)  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C48(0.00); C72(0.00); C64(0.00); C84(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		C279(0.00); C398(0.00)  LDD0217  [12]
W1
 Probe Info  		C48(0.00); C51(0.00); C279(0.00); C398(0.00)  LDD0236  [13]
AOyne
 Probe Info  		13.20  LDD0443  [14]
NAIA_5
 Probe Info  		C279(0.00); C398(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C279(2.24)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C332(2.61)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C279(1.43); C398(1.11); C69(0.97); C72(0.97)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C279(1.13); C69(0.84); C72(0.89)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C279(1.28); C69(0.87); C72(0.80)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C279(1.16); C69(0.90); C72(0.80)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C279(1.16); C69(0.84); C72(0.71)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C279(1.34); C69(1.16); C72(1.04)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C279(1.12); C69(0.95); C72(0.87)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C279(1.20); C69(0.98); C72(0.83)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C279(1.44); C69(0.85); C72(0.76)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C279(1.08); C69(0.98); C72(0.77)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C279(1.35); C69(0.93); C72(0.93)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C279(1.18); C69(0.82); C72(0.81)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C279(1.23); C69(0.86); C72(0.86)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C279(1.20); C69(1.02); C72(0.86)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C279(1.39); C69(1.03); C72(0.84)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C279(1.35); C69(0.96); C72(0.77)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C279(0.85); C69(1.00); C72(0.94)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C279(0.97); C69(1.02); C72(0.92)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C279(1.16); C69(0.98); C72(0.90)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C279(1.00); C69(0.92); C72(0.86)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C279(1.08); C69(0.95); C72(0.88)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C279(0.92); C69(0.86); C72(0.81)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C279(0.98); C69(0.90); C72(0.88)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C279(1.16); C69(0.85); C72(0.85)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C279(0.90); C69(1.12); C72(0.94)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C279(1.14); C69(0.82); C72(0.79)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C279(0.82); C69(0.83); C72(0.88)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C279(0.80); C69(0.93); C72(0.92)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C279(0.90); C69(0.88); C72(0.82)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C279(1.01); C69(0.99); C72(0.93)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C279(0.94); C69(0.91); C72(0.82)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C279(0.96); C69(0.81); C72(0.87)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C279(1.22); C69(1.14); C72(1.24)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C279(0.90); C69(1.09); C72(1.04)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C279(1.04); C69(1.00); C72(0.91)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C279(0.93); C69(1.18); C72(1.18)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C279(1.02); C69(0.94); C72(0.75)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C279(1.04); C69(1.01); C72(0.95)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C279(1.10); C69(1.06); C72(1.01)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C279(1.21); C69(0.98); C72(0.88)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C279(1.05); C69(0.96); C72(0.85)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C279(0.99); C69(0.99); C72(0.89)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C279(1.05); C69(1.12); C72(1.10)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C279(1.10); C69(1.19); C72(0.97)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C279(0.97); C69(0.94); C72(0.95)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C279(1.19); C69(1.13); C72(0.95)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C279(1.15); C69(1.15); C72(1.00)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C279(0.87); C69(1.06); C72(0.88)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C279(1.30); C72(0.71); C69(0.79)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C69(0.77); C72(0.79); C279(1.26)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C72(0.75); C69(0.76); C279(0.98)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C72(0.78); C69(0.78); C279(1.13)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C72(0.84); C69(0.85); C279(1.41)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C69(0.98); C72(1.50); C279(1.62)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C69(0.75); C72(1.04); C279(1.31)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C69(0.86); C72(0.88); C279(1.35)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C69(0.65); C72(0.74); C279(1.17)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C69(0.72); C72(0.76); C279(1.15)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C69(0.95); C72(1.02); C279(1.14)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C69(0.89); C72(1.03); C279(1.62)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C279(1.17); C69(0.82); C72(0.81)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C279(1.12); C69(1.02); C72(1.07)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C279(0.96); C69(0.95); C72(0.97)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C279(0.98); C69(1.06); C72(1.07)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C72(0.99); C69(1.04); C279(1.20)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C72(0.76); C69(0.80); C279(0.96)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C72(1.12); C69(1.15); C279(1.24)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C72(0.99); C69(1.04); C398(1.10); C279(1.26)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C72(1.19); C69(1.19); C279(1.25)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C69(1.05); C72(1.05); C279(1.32)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C72(1.04); C69(1.06); C279(1.45)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C72(1.01); C69(1.02); C279(1.42)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C72(1.09); C69(1.11); C279(1.13)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C279(0.93); C69(1.11); C398(1.12); C72(1.25)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C398(1.06); C69(1.07); C72(1.16); C279(1.45)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C69(1.16); C279(1.23); C72(1.25); C398(1.29)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C69(1.11); C279(1.28); C398(1.31); C72(1.33)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C69(1.03); C72(1.05); C398(1.06); C279(1.24)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C69(0.96); C72(0.98); C398(1.09); C279(1.23)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C398(1.08); C279(1.22); C72(1.27); C69(1.29)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C69(0.94); C72(0.97); C398(1.44); C279(1.48)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C69(1.08); C72(1.10); C398(1.26); C279(1.43)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C72(1.11); C69(1.12); C279(1.23); C398(1.63)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C398(1.03); C72(1.12); C69(1.13); C279(1.37)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C279(0.72); C69(0.85); C72(1.05)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C279(0.82); C69(0.89); C72(1.09)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C279(0.65); C69(1.10); C72(1.26)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C69(0.96); C279(1.06); C72(1.09)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C279(0.89); C69(0.94); C72(1.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C69(0.82); C72(0.82); C279(1.08); C398(1.10)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C279(0.87); C69(0.98); C72(1.19)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C69(0.92); C72(0.99); C279(1.08)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C279(0.95); C72(1.04); C69(1.04)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C69(1.03); C72(1.11); C279(1.22)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C279(0.75); C69(1.00); C72(1.17)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C279(0.68); C69(1.04); C72(1.17)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C398(0.83); C72(1.06); C69(1.17); C279(1.25)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C398(0.81); C72(0.95); C69(0.98); C279(1.20)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C398(0.75); C72(1.02); C69(1.05); C279(1.16)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C398(0.84); C72(1.01); C69(1.11); C279(1.54)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C69(0.81); C72(0.81); C398(1.06); C279(1.30)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C398(0.91); C72(1.11); C69(1.23); C279(1.44)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C398(0.96); C72(1.03); C279(1.08); C69(1.17)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C398(1.04); C72(1.06); C279(1.09); C69(1.11)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C279(1.03); C72(1.11); C398(1.17); C69(1.18)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C72(1.03); C69(1.08); C398(1.17); C279(1.40)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C72(1.15); C398(1.20); C69(1.24); C279(1.39)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C398(1.14); C72(1.25); C69(1.35); C279(1.68)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C72(0.86); C69(0.86); C398(0.92); C279(1.68)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C398(0.85); C72(0.85); C69(0.89); C279(1.57)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C72(0.69); C69(0.79); C398(0.90); C279(1.60)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C72(0.91); C69(0.91); C279(1.36)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C72(0.79); C69(0.93); C398(0.94); C279(1.91)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C72(0.73); C69(0.78); C398(0.82); C279(1.53)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C72(0.82); C398(0.84); C69(0.90); C279(1.65)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C72(0.75); C398(0.76); C69(0.82); C279(2.12)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C69(0.87); C72(0.88); C398(0.96); C279(2.33)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C72(0.64); C69(0.71); C398(0.78); C279(1.83)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C72(0.61); C69(0.67); C398(0.83); C279(1.73)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C72(0.57); C69(0.66); C398(0.69); C279(2.08)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C279(1.08); C69(1.08); C72(1.33)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C279(0.88); C69(0.99); C72(1.39)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C69(0.83); C72(0.83); C279(0.99)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C69(1.06); C279(1.28); C72(1.32)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C69(0.89); C279(1.11); C72(1.34)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C69(1.08); C279(1.16); C72(1.27)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C69(1.21); C72(1.42); C279(1.69)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C69(1.03); C72(1.34); C279(2.10)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C69(1.25); C72(1.36); C279(1.96)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C69(1.02); C72(1.33); C279(1.34)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C69(1.17); C72(1.37); C279(1.50)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C69(1.06); C72(1.37); C279(1.83)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C279(1.03); C69(1.05); C72(1.32)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C72(0.82); C69(0.82); C279(1.22)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C69(1.06); C279(1.33); C72(1.47)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C279(0.75); C69(0.89); C72(1.27)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C69(1.10); C72(1.43); C279(2.10)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C72(0.91); C69(1.01); C279(1.79)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C72(0.91); C69(0.99); C279(1.44)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C72(0.75); C69(0.84); C279(1.41)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C72(0.90); C69(0.97); C279(1.43)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C72(1.00); C279(1.08); C69(1.08)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C72(0.99); C69(1.08); C279(1.10)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C72(1.11); C69(1.18); C279(1.53)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C72(0.88); C69(0.94); C279(1.04)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C72(1.03); C69(1.07); C279(1.55)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C72(1.05); C69(1.08); C279(1.50)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C72(1.14); C69(1.19); C279(1.27)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C72(0.92); C69(0.97); C279(1.33)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C72(1.06); C279(1.15); C69(1.16)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C72(0.99); C69(1.01); C279(1.26)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C72(1.04); C69(1.16); C279(1.74)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C72(0.78); C69(0.93); C279(1.80)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C72(0.76); C69(0.82); C279(1.15)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C279(0.97); C69(0.93); C72(1.00)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C69(0.82); C72(0.86); C279(1.10)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C72(0.87); C69(0.91); C279(1.49)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.60  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C69(1.47); C72(1.16)  LDD0078  [5]
 LDCM0630  CCW28-3 231MFP C69(1.53)  LDD2214  [16]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C398(1.00); C279(1.00); C69(1.05); C72(1.06)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C398(0.77); C72(1.05); C69(1.19); C279(1.25)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C69(0.94); C72(0.97); C398(1.13); C279(1.22)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C69(0.87); C72(0.90); C279(1.16)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C279(0.91); C72(0.94); C69(1.09)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C279(0.93); C72(0.98); C69(1.06)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C72(0.91); C69(1.01); C279(1.03)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C72(0.89); C69(0.90); C279(1.09)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C69(0.87); C72(0.87); C279(1.21)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C72(0.94); C69(0.96); C279(1.26)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C72(0.88); C69(0.88); C279(1.03)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C72(1.04); C69(1.08); C279(1.25)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C398(0.93); C72(1.05); C69(1.19); C279(1.19)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C72(0.93); C69(0.97); C279(1.18)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C72(0.85); C69(0.90); C279(1.74)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C69(0.97); C279(0.98); C72(1.07); C398(1.13)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C69(1.03); C72(1.04); C398(1.18); C279(1.31)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C72(1.04); C69(1.06); C279(1.09); C398(1.13)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C398(0.98); C69(1.05); C72(1.07); C279(1.15)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C69(1.10); C72(1.10); C398(1.12); C279(1.14)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C279(0.85); C69(1.10); C72(1.42)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C279(0.77); C72(1.02); C69(1.25)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C72(1.01); C279(1.02); C69(1.03)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C398(1.03); C72(1.13); C69(1.33); C279(1.49)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C279(0.95); C69(1.04); C72(1.08)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C398(0.83); C279(1.19); C72(1.40); C69(1.55)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C398(0.89); C72(0.93); C69(1.03); C279(1.24)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C398(0.76); C72(0.92); C69(0.96); C279(2.66)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C398(0.83); C72(1.02); C69(1.08); C279(1.53)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C398(0.90); C72(1.17); C279(1.26); C69(1.28)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C72(0.68); C69(0.80); C398(0.94); C279(1.36)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C72(0.80); C69(0.92); C398(0.96); C279(1.50)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C398(0.85); C72(0.90); C69(0.93); C279(1.53)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C72(0.92); C398(1.05); C69(1.17); C279(1.32)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C398(0.85); C279(0.93); C72(1.02); C69(1.03)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C398(0.81); C72(1.02); C69(1.09); C279(1.16)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C72(0.87); C279(0.95); C398(1.25); C69(1.32)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C398(0.94); C72(1.07); C279(1.12); C69(1.12)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C398(0.93); C72(0.94); C279(1.31); C69(1.45)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C398(1.02); C72(1.08); C279(1.17); C69(1.39)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C398(0.76); C69(1.00); C72(1.05); C279(1.08)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C72(1.01); C398(1.38); C279(1.41); C69(1.78)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C72(0.87); C398(1.18); C279(1.51); C69(1.53)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C72(0.89); C398(1.44); C69(2.38); C279(2.52)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C72(0.96); C398(1.26); C279(1.29); C69(1.39)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C279(1.66); C398(1.26); C69(1.62); C72(0.86)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C279(1.38); C398(1.17); C69(1.18); C72(0.77)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C279(1.36); C398(1.21); C69(1.26); C72(0.91)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C279(1.18); C398(1.05); C69(1.17); C72(0.90)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C279(1.30); C398(0.96); C69(1.49); C72(0.83)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C279(1.34); C398(1.04); C69(1.40); C72(0.98)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C279(1.05); C398(0.76); C69(0.96); C72(0.94)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C279(1.13); C398(1.24); C69(1.20); C72(0.94)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C279(0.92); C398(0.94); C69(0.91); C72(0.90)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C279(1.24); C398(0.96); C69(0.91); C72(0.84)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C279(3.00); C398(0.90); C69(0.90); C72(0.86)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C279(0.82); C398(0.82); C69(1.03); C72(0.93)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C279(0.95); C398(0.91); C69(1.07); C72(0.99)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C279(0.78); C398(0.87); C69(1.12); C72(1.00)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C279(1.35); C398(1.14); C69(1.10); C72(1.07)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C279(1.07); C398(1.16); C69(1.04); C72(1.01)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C279(0.94); C398(0.93); C69(1.01); C72(1.01)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C279(0.78); C398(0.94); C69(1.08); C72(1.06)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C279(1.16); C398(1.15); C69(1.00); C72(0.95)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C279(0.87); C398(1.01); C69(1.13); C72(1.08)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C279(0.98); C398(1.09); C69(1.07); C72(1.01)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C279(0.87); C398(0.98); C69(0.91); C72(0.85)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C279(0.98); C398(1.07); C69(0.96); C72(0.96)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C279(1.19); C69(0.81); C72(0.73)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C279(1.33); C69(0.81); C72(0.73)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C279(1.23); C69(0.83); C72(0.75)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C279(0.92); C69(1.05); C72(0.83)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C279(1.27); C398(1.18); C69(1.11); C72(1.22)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C279(1.29); C69(0.87); C72(0.94)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C279(1.13); C69(0.81); C72(0.77)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C279(1.17); C69(1.01); C72(0.78)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C279(1.15); C69(1.06); C72(0.85)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C279(1.74); C69(0.92); C72(0.88)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C279(1.17); C69(0.87); C72(0.87)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C279(1.12); C69(1.00); C72(0.86)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C279(1.11); C69(0.98); C72(0.80)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C279(1.21); C69(0.96); C72(0.81)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C279(0.89); C69(0.95); C72(0.97)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C279(1.07); C398(0.87); C69(0.97); C72(0.99)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C279(1.18); C69(1.03); C72(0.81)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C279(1.09); C69(0.91); C72(0.90)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C279(1.21); C69(0.79); C72(0.75)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C279(1.23); C69(0.87); C72(0.85)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C279(1.08); C69(0.84); C72(0.85)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C279(1.08); C69(0.88); C72(0.93)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C279(1.80); C69(0.84); C72(0.87)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C279(1.38); C69(0.97); C72(1.13)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C279(1.14); C69(1.04); C72(1.06)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C279(1.40); C69(1.08); C72(1.06)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C279(1.29); C398(0.93); C69(1.02); C72(1.05)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C279(1.35); C69(1.12); C72(1.16)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C279(1.22); C69(0.83); C72(0.81)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C279(1.06); C69(1.10); C72(1.12)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C279(1.27); C69(0.96); C72(0.97)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C279(1.21); C69(0.93); C72(0.96)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C279(0.78); C69(0.98); C72(0.99)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C279(0.82); C69(0.85); C72(0.83)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C279(0.98); C69(0.93); C72(0.91)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C279(1.18); C69(0.97); C72(0.93)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C279(2.52); C398(0.94); C69(1.16); C72(1.16)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C279(0.78); C69(0.95); C72(0.92)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C279(0.95); C69(0.95); C72(0.92)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C279(1.00); C69(0.98); C72(0.93)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C279(1.28); C69(0.92); C72(0.94)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C279(1.19); C69(0.90); C72(0.92)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C279(1.04); C69(0.92); C72(0.99)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C279(0.87); C69(0.92); C72(0.99)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C279(0.86); C69(0.93); C72(0.98)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C279(1.07); C69(0.95); C72(1.07)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C279(1.72); C69(0.99); C72(0.99)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C279(1.29); C398(0.99); C69(1.10); C72(1.19)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C279(1.09); C69(1.02); C72(1.10)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C279(1.52); C398(0.93); C69(1.15); C72(1.08)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C279(0.97); C398(1.03); C69(1.02); C72(0.98)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C279(1.04); C398(1.11); C69(1.00); C72(1.03)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C279(1.34); C398(1.21); C69(0.94); C72(0.92)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C279(1.28); C398(0.93); C69(0.85); C72(0.83)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C279(0.98); C398(1.03); C69(1.10); C72(1.04)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C279(0.93); C398(1.10); C69(1.01); C72(0.93)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C279(1.33); C398(1.08); C69(0.95); C72(0.93)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C279(1.46); C398(0.98); C69(0.94); C72(0.96)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C279(0.98); C398(1.00); C51(1.11); C69(0.89)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C398(1.35); C69(0.76)  LDD1702  [3]
 LDCM0625  F8 Ramos 0.75; C398(1.35)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos 0.66; C398(0.83)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos 0.69; C398(17.30)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos 1.34; C398(0.48)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C398(1.06)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos 0.79; C398(1.24)  LDD2193  [18]
 LDCM0580  Fragment21 Ramos 0.59; C398(0.71)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C398(0.68)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos 0.55; C398(2.33)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos 0.41; C398(1.25)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos 1.30; C398(0.61)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos 0.95  LDD2200  [18]
 LDCM0590  Fragment32 Ramos 0.94  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C279(1.24); C69(0.91); C72(0.85)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos 1.03; C398(1.07)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos 0.45; C398(0.72)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C279(6.31); C398(0.72); C69(1.08); C72(1.01)  LDD0744  [5]
 LDCM0569  Fragment7 Ramos C398(0.67)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C398(0.65)  LDD2188  [18]
 LDCM0107  IAA HeLa H132(0.00); C72(0.00)  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C69(2.10); C72(2.10); C48(1.95); C51(1.95)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C69(3.46); C72(3.46); C48(2.32); C51(2.32)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C69(1.87); C72(1.87); C48(1.43); C51(1.43)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C84(0.65)  LDD2099  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C398(0.72)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C84(0.72); C398(0.93)  LDD2123  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C398(0.87)  LDD2128  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C398(2.00)  LDD2147  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C69(1.57)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C69(1.21)  LDD2207  [19]
 LDCM0131  RA190 MM1.R C69(1.13); C332(1.10)  LDD0304  [20]
 LDCM0021  THZ1 HCT 116 C48(1.12); C51(1.12)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Ubiquitin carboxyl-terminal hydrolase 11 (USP11) Peptidase C19 family P51784
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
E3 ubiquitin-protein ligase RING2 (RNF2) . Q99496
Polycomb complex protein BMI-1 (BMI1) . P35226
Polycomb group RING finger protein 1 (PCGF1) . Q9BSM1
Polycomb group RING finger protein 2 (PCGF2) . P35227
Polycomb group RING finger protein 3 (PCGF3) . Q3KNV8
Polycomb group RING finger protein 5 (PCGF5) . Q86SE9
Polycomb group RING finger protein 6 (PCGF6) . Q9BYE7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger imprinted 3 (ZIM3) Krueppel C2H2-type zinc-finger protein family Q96PE6
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromobox protein homolog 6 (CBX6) . O95503
Chromobox protein homolog 7 (CBX7) . O95931
Chromobox protein homolog 8 (CBX8) . Q9HC52
RING1 and YY1-binding protein (RYBP) . Q8N488
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
YY1-associated factor 2 (YAF2) . Q8IY57

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.