Details of the Target

General Information of Target

Target ID LDTP03651
Target Name General transcription factor IIH subunit 1 (GTF2H1)
Gene Name GTF2H1
Gene ID 2965
Synonyms
BTF2; General transcription factor IIH subunit 1; Basic transcription factor 2 62 kDa subunit; BTF2 p62; General transcription factor IIH polypeptide 1; TFIIH basal transcription factor complex p62 subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKT
Target Bioclass
Other
Family
TFB1 family
Subcellular location
Nucleus
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Uniprot ID
P32780
Ensemble ID
ENST00000265963.9
HGNC ID
HGNC:4655

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L376H DBIA    Probe Info 
CHL1 SNV: p.P416L DBIA    Probe Info 
FTC133 SNV: p.R542Q DBIA    Probe Info 
MOLT4 SNV: p.S333N IA-alkyne    Probe Info 
OVK18 SNV: p.D121E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Jackson_1
 Probe Info  		20.00  LDD0122  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TH211
 Probe Info  		Y186(6.98)  LDD0257  [4]
STPyne
 Probe Info  		K504(1.22)  LDD0277  [5]
Probe 1
 Probe Info  		Y200(70.92); Y360(3.38)  LDD3495  [6]
BTD
 Probe Info  		C506(1.87)  LDD2090  [7]
AHL-Pu-1
 Probe Info  		C344(3.40)  LDD0170  [8]
DBIA
 Probe Info  		C506(0.99)  LDD0078  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C246(0.00); C478(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C478(0.00); C246(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C246(0.00); C478(0.00); C506(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NAIA_5
 Probe Info  		C246(0.00); C506(0.00)  LDD2224  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
IPM
 Probe Info  		C246(0.00); C506(0.00)  LDD0147  [14]
TFBX
 Probe Info  		C246(0.00); C506(0.00)  LDD0148  [14]
Phosphinate-6
 Probe Info  		C246(0.00); C506(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C506(0.98)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C506(1.88)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C506(1.27)  LDD2117  [7]
 LDCM0025  4SU-RNA DM93 C344(3.40)  LDD0170  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C344(2.10)  LDD0171  [8]
 LDCM0214  AC1 HCT 116 C246(0.83); C506(1.19)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C246(0.86); C506(1.28)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C246(1.44); C506(1.06)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C246(1.50); C506(1.08)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C246(1.33); C506(1.13)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C246(1.30); C506(1.30)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C246(1.24); C506(1.17)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C246(1.48); C506(1.18)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C246(1.42); C506(1.21)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C246(1.33); C506(1.09)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C246(1.41); C506(0.92)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C246(1.17); C506(0.91)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C246(0.79); C506(1.28)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C246(1.45); C506(0.98)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C246(1.40); C506(0.99)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C246(1.38); C506(1.04)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C246(1.15); C506(1.13)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C246(1.17); C506(0.93)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C246(1.05); C506(0.86)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C246(1.28); C506(0.97)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C246(1.25); C506(0.98)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C246(1.04); C506(1.08)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C246(1.36); C506(0.86)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C246(0.76); C506(1.24)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C246(1.23); C506(0.90)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C246(0.93); C506(1.09)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C246(1.05); C506(0.89)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C246(1.02); C506(1.43)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C246(1.28); C506(0.95)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C246(1.23); C506(0.86)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C246(1.26); C506(0.85)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C246(1.07); C506(0.95)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C246(0.97); C478(0.92)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C246(1.07); C478(1.01)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C246(1.18); C478(0.86)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C246(1.16); C478(0.95)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C246(1.58); C478(1.09)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C246(1.27); C478(1.05)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C246(1.26); C478(0.96)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C246(1.26); C478(0.92)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C246(1.30); C478(0.98)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C246(1.22); C478(1.01)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C246(1.04); C478(0.93)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C246(1.47); C478(0.97)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C246(0.75); C506(1.23)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C246(1.54); C478(0.97)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C246(1.28); C478(0.96)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C246(1.38); C478(1.10)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C246(1.10); C506(1.16)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C506(1.15); C246(1.32)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C506(1.06); C246(1.20)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C506(1.27); C246(1.28)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C506(1.23); C246(1.26)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C506(1.56); C246(1.61)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C506(1.44); C246(1.48)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C246(0.84); C506(1.31)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C506(1.07); C246(1.20)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C506(1.05); C246(1.20)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C506(1.12); C246(1.29)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C506(1.53); C246(1.74)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C246(1.62); C506(1.12)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C246(1.46); C506(1.19)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C246(1.17); C506(0.93)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C246(1.36); C506(0.87)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C478(0.90); C246(1.02); C506(1.12)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C478(0.71); C246(0.80); C506(1.22)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C478(0.77); C246(0.91); C506(1.20)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C246(0.92); C506(1.14)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C478(0.78); C246(1.10); C506(1.21)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C246(0.82); C478(0.88); C506(1.06)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C478(0.84); C246(1.01); C506(1.10)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C478(0.89); C246(0.91); C506(0.97)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C478(0.88); C506(0.98); C246(1.15)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C246(0.87); C506(0.90); C478(1.11)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C478(1.02); C246(1.04); C506(1.06)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C506(1.01); C246(1.07); C478(1.24)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C246(0.99); C506(1.05); C478(1.18)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C246(1.11); C478(1.13); C506(1.18)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C246(0.91); C506(1.08)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C246(1.19); C506(1.20); C478(1.28)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C246(0.97); C506(1.00); C478(1.04)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C506(1.08); C246(1.10); C478(1.30)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C246(0.97); C478(0.99); C506(1.00)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C506(1.00); C246(1.01); C478(1.07)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C506(0.82); C246(0.91)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C506(0.87); C246(0.92)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C506(0.87); C246(0.97)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C506(0.84); C246(1.07)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C246(0.94); C506(1.02)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C246(0.90); C506(1.14)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C506(1.01); C246(1.04)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C506(1.02); C246(1.10)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C506(0.98); C246(1.01)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C506(1.08); C246(1.16)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C506(1.02); C246(1.03)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C246(0.98); C506(1.00)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C181(0.96); C478(1.09); C506(1.11); C246(1.45)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C181(0.96); C478(1.01); C506(1.11); C246(1.11)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C478(0.75); C506(1.07); C246(1.13); C181(1.22)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C478(0.78); C246(1.27); C506(1.29); C181(1.46)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C246(0.89); C506(1.18)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C478(1.02); C181(1.24); C506(1.26); C246(1.48)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C506(1.03); C246(1.23); C478(1.36); C181(1.45)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C506(1.05); C478(1.11); C246(1.19); C181(1.24)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C478(0.79); C181(1.01); C246(1.04); C506(1.11)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C478(0.92); C506(1.12); C181(1.13); C246(1.30)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C181(0.91); C478(0.93); C246(0.97); C506(1.25)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C478(1.14); C246(1.19); C506(1.52); C181(1.52)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C246(1.04); C506(1.23)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C246(1.03); C506(1.31)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C246(1.01); C506(1.35)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C246(0.98); C506(1.27)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C246(0.97); C506(1.36)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C246(0.86); C506(1.22)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C246(0.84); C506(1.44)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C246(0.76); C506(1.35)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C246(0.85); C506(1.34)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C246(0.93); C506(1.52)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C246(0.86); C506(1.43)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C246(0.95); C506(1.66)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C478(0.94); C246(1.03); C506(1.09)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C478(0.88); C246(1.03); C506(1.10)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C246(0.92); C506(1.17)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C478(0.84); C246(1.05); C506(1.24)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C246(1.01); C506(1.08); C478(1.12)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C478(0.94); C246(1.09); C506(1.14)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C478(0.86); C246(1.29); C506(1.50)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C478(0.94); C246(1.24); C506(1.45)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C478(0.94); C246(1.32); C506(1.38)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C478(0.92); C246(1.09); C506(1.24)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C478(0.90); C506(1.11); C246(1.13)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C478(0.86); C246(1.04); C506(1.08)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C478(1.04); C246(1.06); C506(1.20)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C246(0.84); C506(1.21)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C478(0.91); C246(1.15); C506(1.20)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C478(0.79); C246(1.03); C506(1.07)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C478(1.09); C246(1.50); C506(1.54)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C246(1.02); C506(1.51)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C246(1.04); C506(1.44)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C246(1.14); C506(1.24)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C246(1.10); C506(1.22)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C506(1.04); C246(1.10)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C246(1.01); C506(1.14)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C246(1.10); C506(1.20)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C246(0.83); C506(1.08)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C246(0.84); C506(1.39)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C246(1.03); C506(1.41)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C246(0.99); C506(1.22)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C246(0.75); C506(1.16)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C246(0.99); C506(1.11)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C246(0.64); C506(1.19)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C246(0.76); C506(1.43)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C506(1.41); C246(1.43)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C506(1.08); C246(1.38)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C506(0.68)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C246(0.85); C506(1.19)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C246(0.85); C506(1.28)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C246(0.99); C506(1.92)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 12.92  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C506(0.99)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C506(0.51)  LDD2091  [7]
 LDCM0632  CL-Sc Hep-G2 C246(20.00)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C246(1.01); C506(1.11)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C246(0.95); C506(1.00)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C246(0.91); C506(1.23)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C246(0.96); C506(1.38)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C246(0.91); C506(1.08)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C246(0.83); C506(1.06)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C246(0.93); C506(1.11)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C478(0.82); C246(0.86); C506(1.31)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C478(0.75); C246(0.84); C506(1.18)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C246(0.86); C478(0.89); C506(1.12)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C478(0.83); C246(0.91); C506(1.38)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C478(0.80); C246(0.86); C506(1.21)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C246(0.87); C506(0.97)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C478(0.76); C246(0.89); C506(0.99)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C478(0.85); C506(0.98); C246(1.01)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C246(0.86); C506(1.06); C478(1.52)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C478(0.99); C246(1.07); C506(1.09)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C246(1.07); C506(1.14); C478(1.53)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C246(1.09); C506(1.15); C478(1.18)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C246(1.02); C506(1.08); C478(1.29)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C246(1.14); C506(1.18)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C506(0.97); C246(0.99)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C506(0.96); C246(1.16)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C506(0.94); C246(1.06)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C246(1.08); C506(1.11)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C478(0.73); C506(0.87); C181(1.05); C246(1.21)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C478(1.08); C246(1.20); C506(1.20); C181(1.23)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C478(0.96); C506(1.09); C246(1.09); C181(1.23)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C181(1.04); C478(1.06); C246(1.26); C506(1.31)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C506(1.07); C246(1.08)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C246(0.87); C506(1.04)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C506(1.10); C246(1.15)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C246(1.02); C506(1.27)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C246(0.97); C506(1.10)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C246(0.99); C506(1.10)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C246(0.91); C506(1.08)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C506(1.01)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C506(0.94)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C506(0.95)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C506(0.98)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C246(1.02); C506(1.04)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C506(1.08)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C506(0.97)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C506(0.94)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C506(1.08)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C506(1.04)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C506(0.98)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C506(1.08)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C506(1.02)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C506(1.05)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C506(0.96)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C246(0.95); C506(1.02)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C506(0.93)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C181(0.98); C246(0.95); C478(0.73); C506(0.99)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C181(0.89); C246(0.88); C478(0.65); C506(0.97)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C181(0.85); C246(0.98); C478(0.57); C506(1.13)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C181(0.95); C246(0.98); C478(0.60); C506(0.97)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C181(1.14); C246(0.95); C478(0.66); C506(1.01)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C181(1.22); C246(0.97); C478(0.67); C506(0.92)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C181(1.28); C246(1.01); C478(0.57); C506(0.95)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C181(1.08); C246(0.96); C478(0.62); C506(0.97)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C246(0.95); C506(1.02)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C181(1.69); C246(0.91); C478(0.65); C506(0.96)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C181(0.89); C246(0.89); C478(0.68); C506(0.91)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C181(1.45); C246(1.02); C478(0.60); C506(0.96)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C181(1.19); C246(0.96); C478(0.62); C506(0.91)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C181(0.90); C246(1.01); C478(0.55); C506(0.87)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C181(1.08); C246(1.04); C478(0.54); C506(0.89)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C181(0.94); C246(1.03); C478(1.04); C506(1.08)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C181(1.31); C246(0.98); C478(0.91); C506(0.80)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C181(0.83); C246(0.97); C478(0.93); C506(0.98)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C181(0.88); C246(1.02); C478(1.20); C506(1.11)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C246(0.96); C506(0.95)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C181(0.97); C246(0.89); C478(1.08); C506(0.96)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C181(0.95); C246(1.04); C478(1.02); C506(0.98)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C181(0.87); C246(1.15); C478(0.97); C506(1.00)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C181(2.02); C246(0.96); C478(0.85); C506(1.00)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C181(0.87); C246(0.97); C478(0.91); C506(0.89)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C181(0.88); C246(0.93); C478(0.98); C506(0.82)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C181(1.32); C246(0.90); C478(0.95); C506(0.86)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C181(1.67); C246(0.91); C478(0.97); C506(0.80)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C181(1.15); C246(0.97); C478(1.07); C506(0.95)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C181(1.05); C246(0.97); C478(1.18); C506(0.80)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C246(1.05); C506(1.00)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C181(0.81); C246(1.00); C478(0.95); C506(0.92)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C181(1.20); C246(0.87); C506(1.06)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C181(1.26); C246(1.09); C506(1.12)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C181(1.25); C246(0.92); C506(1.18)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C181(1.14); C246(1.07); C506(1.22)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C181(1.28); C246(1.01); C506(1.13)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C181(1.08); C246(1.07); C506(1.27)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C181(1.51); C246(1.22); C506(1.23)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C181(2.14); C246(1.03); C506(1.13)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C181(1.83); C246(1.13); C506(1.12)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C246(1.03); C506(1.00)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C181(1.38); C246(1.20); C506(1.16)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C181(1.57); C246(1.02); C506(1.26)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C181(1.67); C246(1.11); C506(1.12)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C181(2.07); C246(1.08); C506(1.12)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C181(1.72); C246(1.01); C506(1.19)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C181(0.91); C246(0.94); C506(0.95)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C181(1.76); C246(0.95); C506(0.91)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C181(1.45); C246(0.93); C506(0.95)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C181(0.95); C246(0.98); C506(0.92)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C246(1.00); C506(1.08)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C181(1.03); C246(0.95); C506(0.79)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C181(0.98); C246(0.89); C506(0.79)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C181(0.70); C246(0.90); C506(0.80)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C181(0.92); C246(1.01); C506(0.87)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C181(0.68); C246(1.02); C506(0.95)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C181(0.89); C246(1.00); C506(0.98)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C181(1.01); C246(0.95); C506(0.91)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C181(1.18); C246(1.02); C506(0.89)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C181(1.49); C246(0.94); C506(0.87)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C181(1.15); C246(0.98); C506(0.86)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C246(1.06); C506(1.17)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C181(1.92); C246(0.87); C506(0.89)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C246(0.94); C506(0.98)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C246(0.76); C506(0.98)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C246(0.82); C506(1.00)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C246(0.86); C506(1.03)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C246(0.91); C506(1.02)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C246(0.99); C506(0.95)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C246(0.95); C506(1.06)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C246(0.92); C506(1.20)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C246(0.88); C506(1.18)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C246(0.91); C181(0.99); C478(0.89)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C506(3.18)  LDD1702  [7]
 LDCM0625  F8 Ramos C506(0.81); C344(1.54)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C506(3.55); C344(2.07)  LDD2189  [19]
 LDCM0574  Fragment12 Ramos C344(0.49)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C506(0.93); C344(0.56)  LDD2192  [19]
 LDCM0579  Fragment20 Ramos C506(1.07); C344(0.39)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C506(1.13); C344(0.55)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C506(0.75)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C506(0.78); C344(1.12)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C506(0.60); C344(0.74)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C506(1.46)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C506(0.74); C344(0.41)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C344(0.87)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C181(1.28); C246(1.08); C506(1.12)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C506(1.00); C344(0.62)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C506(1.11)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C181(3.24); C246(0.97); C478(0.61); C506(1.15)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C344(0.75)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C506(0.77); C344(1.16)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C506(1.92)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C506(1.60); C344(0.48)  LDD2188  [19]
 LDCM0022  KB02 HCT 116 C246(1.67)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C246(1.74)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C246(2.18)  LDD0082  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C506(1.43)  LDD2102  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C506(1.87)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C506(1.59)  LDD2092  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C506(1.32)  LDD2094  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C506(2.07)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C506(1.04)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C506(1.65)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C506(1.12)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C506(1.03)  LDD2108  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C506(0.95)  LDD2114  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C506(0.90)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C506(0.72)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C506(1.44)  LDD2124  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C506(0.71)  LDD2129  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C506(1.32)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C506(0.92)  LDD2137  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C506(9.64)  LDD2145  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 1 (KLF1) Krueppel C2H2-type zinc-finger protein family Q13351
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ELL-associated factor 1 (EAF1) EAF family Q96JC9
General transcription factor IIH subunit 2 (GTF2H2) GTF2H2 family Q13888
General transcription factor IIE subunit 1 (GTF2E1) TFIIE alpha subunit family P29083
DNA repair protein complementing XP-C cells (XPC) XPC family Q01831
Four and a half LIM domains protein 2 (FHL2) . Q14192

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578