Details of the Target

General Information of Target

Target ID LDTP02995
Target Name NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2)
Gene Name NDUFV2
Gene ID 4729
Synonyms
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; NDUFV2; EC 7.1.1.2; NADH-ubiquinone oxidoreductase 24 kDa subunit
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFFSAALRARAAGLTAHWGRHVRNLHKTVMQNGAGGALFVHRDTPENNPDTPFDFTPENY
KRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYT
MYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGAC
VNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKG
PGFGVQAGL
Target Bioclass
Enzyme
Family
Complex I 24 kDa subunit family
Subcellular location
Mitochondrion inner membrane
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (Probable). Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone (Probable). Contains one iron-sulfur cluster (Probable).
Uniprot ID
P19404
Ensemble ID
ENST00000318388.11
HGNC ID
HGNC:7717
ChEMBL ID
CHEMBL2363065

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y60(12.82)  LDD3495  [1]
m-APA
 Probe Info  		11.83  LDD0403  [2]
DBIA
 Probe Info  		C225(1.01)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C140(0.00); C135(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C225(0.00); C140(0.00); C135(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C225(0.00); C140(0.00); C135(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Phosphinate-6
 Probe Info  		C140(0.00); C225(0.00)  LDD0018  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
MPP-AC
 Probe Info  		N.A.  LDD0428  [8]
NAIA_5
 Probe Info  		C140(0.00); C135(0.00)  LDD2223  [9]
TER-AC
 Probe Info  		N.A.  LDD0426  [8]
TPP-AC
 Probe Info  		N.A.  LDD0427  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		9.39  LDD0472  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [10]
FFF probe3
 Probe Info  		5.50  LDD0465  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C225(1.01)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C225(1.10)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C225(1.02)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C225(1.04)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C225(1.01)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C225(1.11)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C225(1.05)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C225(1.15)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C225(1.17)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C225(1.20)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C225(0.97)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C225(0.93)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C225(1.11)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C225(0.89)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C225(1.01)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C225(1.08)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C225(1.08)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C225(1.05)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C225(1.02)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C225(1.08)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C225(1.09)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C225(1.03)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C225(1.21)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C225(1.07)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C225(0.99)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C225(0.84)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C225(1.19)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C225(0.97)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C225(0.81)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C225(0.96)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C225(0.85)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C225(1.06)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C225(1.29)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C225(1.08)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C225(1.20)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C225(0.96)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C225(1.07)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C225(1.24)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C225(1.36)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C225(1.17)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C225(1.05)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C225(1.06)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C225(1.30)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C225(1.27)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C225(1.09)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C225(1.19)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C225(1.11)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C225(1.07)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C225(1.04)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C225(1.01)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C225(1.23)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C225(1.18)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C225(1.07)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C225(1.45)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C225(1.24)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C225(1.09)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C225(1.14)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C225(1.13)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C225(1.20)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C225(1.23)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C225(1.24)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C225(1.14)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C225(1.09)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C225(1.10)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C225(0.95)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C225(0.70)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C225(0.93)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C225(0.90)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C225(1.02)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C225(0.87)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C225(0.94)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C225(0.78)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C225(0.99)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C225(1.03); C140(1.01)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C225(0.95); C140(0.97)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C225(0.90); C140(1.00)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C225(0.95); C140(0.87)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C225(0.95); C140(1.15)  LDD1528  [11]
 LDCM0290  AC3 HCT 116 C225(0.90)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C225(0.93); C140(0.93)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C225(1.11); C140(1.00)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C225(1.10); C140(0.99)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C225(1.19); C140(0.88)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C225(1.04); C140(0.93)  LDD1534  [11]
 LDCM0296  AC35 HCT 116 C225(1.12)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C225(1.12)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C225(1.60)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C225(1.05)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C225(1.13)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C225(0.96)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C225(1.69)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C225(1.24)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C225(1.17)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C225(1.60)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C225(1.53)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C225(1.43)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C225(1.04); C140(0.96)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C225(1.16); C140(1.08)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C225(1.10); C140(0.97)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C225(1.13); C140(0.92)  LDD1550  [11]
 LDCM0312  AC5 HCT 116 C225(0.91)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C225(0.90); C140(1.08)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C225(0.99); C140(1.04)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C225(1.06); C140(0.95)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C225(1.17); C140(0.95)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C225(1.05); C140(1.00)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C225(1.11); C140(1.01)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C225(1.04); C140(0.85)  LDD1558  [11]
 LDCM0320  AC57 HCT 116 C225(1.38)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C225(1.32)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C225(1.27)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C225(1.14)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C225(1.61)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C225(1.47)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C225(1.12)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C225(1.49)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C225(1.20)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C225(0.80)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C225(0.79)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C225(0.48)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C225(0.61)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C225(0.65)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C225(0.97)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C225(1.06)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C225(0.80)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C225(1.02)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C225(1.06)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C225(0.83)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C225(1.16)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C225(1.00)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C225(0.64)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C225(0.75)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C225(0.89)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C225(1.09)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C225(1.05)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C225(1.01)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C225(0.95)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C225(1.26)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C225(1.26)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C225(1.20)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C225(1.23)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C225(1.05)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C225(1.18)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C225(1.21)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C225(1.07)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C225(1.39)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C225(1.33)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C225(1.09)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C225(1.44)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C225(1.23)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C225(1.47)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C225(1.39)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C225(0.71)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C225(0.95)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C225(1.08)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C225(1.10)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C225(1.11)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.83  LDD0403  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C225(1.10)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C225(1.35)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C225(1.00)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C225(1.19)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C225(0.99)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C225(1.02)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C225(1.10)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C225(0.92)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C225(0.62)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C225(0.81)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C225(0.81)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C225(0.92)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C225(1.37)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C225(0.95)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C225(0.92)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C225(0.87); C140(1.00)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C225(1.11); C140(1.04)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C225(1.00); C140(0.94)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C225(1.05); C140(0.98)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C225(1.11); C140(1.02)  LDD1590  [11]
 LDCM0387  CL117 HCT 116 C225(1.23)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C225(1.17)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C225(1.31)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C225(1.30)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C225(1.34)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C225(1.04); C140(0.94)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C225(1.03); C140(0.92)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C225(0.98); C140(0.89)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C225(0.98); C140(1.05)  LDD1599  [11]
 LDCM0396  CL125 HCT 116 C225(0.98)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C225(1.10)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C225(1.27)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C225(1.47)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C225(1.03)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C225(1.10)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C225(0.96)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C225(1.17)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C225(0.98)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C225(1.32)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C225(1.12)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C225(0.98)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C225(1.43)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C225(1.25)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C225(0.67)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C225(1.23)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C225(1.11)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C225(1.33)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C225(0.91)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C225(1.47)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C225(1.37)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C225(1.24)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C225(1.07)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C225(1.24)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C225(1.16)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C225(1.12)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C225(1.40)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C225(1.15)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C225(1.14)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C225(1.22)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C225(1.06)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C225(1.07)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C225(1.04)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C225(1.33)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C225(1.12)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C225(1.03)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C225(1.12)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C225(1.12)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C225(1.08)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C225(1.15)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C225(1.21)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C225(1.21)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C225(1.37)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C225(0.78)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C225(1.03)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C225(1.09)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C225(1.20)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C225(1.06)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C225(1.08)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C225(1.14)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C225(0.98)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C225(1.06)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C225(1.37)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C225(1.20)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C225(1.11)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C225(1.13)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C225(1.18); C140(0.93)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C225(1.11); C140(0.99)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C225(1.13); C140(1.00)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C225(0.95); C140(0.92)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C225(1.25); C140(1.00)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C225(1.08); C140(0.91)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C225(1.03); C140(1.10)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C225(1.13); C140(0.84)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C225(1.22); C140(0.88)  LDD1664  [11]
 LDCM0462  CL7 HCT 116 C225(1.06)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C225(1.08); C140(1.04)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C225(1.27); C140(0.91)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C225(1.27); C140(0.85)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C225(0.85); C140(0.91)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C225(1.03); C140(0.91)  LDD1670  [11]
 LDCM0469  CL76 HCT 116 C225(1.08)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C225(0.92)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C225(1.18)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C225(1.41)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C225(1.96)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C225(1.14)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C225(1.39)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C225(1.08)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C225(0.99)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C225(0.75)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C225(1.06)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C225(0.75)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C225(1.17)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C225(1.11)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C225(0.63)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C225(1.09)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C225(0.79)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C225(1.00)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C225(0.99)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C225(1.03)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C225(1.12)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C225(1.26)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C225(1.03)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C225(1.03)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C225(1.10)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C225(1.08)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C225(1.25); C140(1.04)  LDD1698  [11]
 LDCM0625  F8 Ramos C225(1.15)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C225(0.97)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C225(1.82)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C225(0.80)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C225(1.46)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C225(0.86)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C225(0.79)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C225(1.01)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C225(0.99)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C225(1.08)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C225(0.96)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C225(0.92)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C225(1.14)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C225(0.92)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C225(1.01); C140(1.04)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C225(0.66)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C225(0.61)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C225(1.61)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C225(0.98)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C225(0.93)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C225(0.66)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C225(0.87)  LDD2188  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C225(0.94); C140(1.03)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C225(0.99); C140(1.01)  LDD1497  [11]
 LDCM0024  KB05 HEK-293T C225(0.99); C140(0.80)  LDD1502  [11]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0131  RA190 MM1.R C225(1.53)  LDD0304  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) MsrB Met sulfoxide reductase family Q9Y3D2
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
Proprotein convertase subtilisin/kexin type 7 (PCSK7) Peptidase S8 family Q16549
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Ras-related protein Rab-38 (RAB38) Rab family P57729
Thioredoxin (TXN) Thioredoxin family P10599
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
RING finger protein 112 (RNF112) GB1/RHD3 GTPase family Q9ULX5
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Occludin (OCLN) ELL/occludin family Q16625
Sortilin-related receptor (SORL1) VPS10-related sortilin family Q92673
Vacuolar protein sorting-associated protein 26A (VPS26A) VPS26 family O75436
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Jade-3 (JADE3) JADE family Q92613
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger protein 19 (ZNF19) Krueppel C2H2-type zinc-finger protein family P17023
Zinc finger protein 232 (ZNF232) Krueppel C2H2-type zinc-finger protein family Q9UNY5
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
PHD finger protein 19 (PHF19) Polycomblike family Q5T6S3
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Cyclin-C (CCNC) Cyclin family P24863
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) EIF-2-beta/eIF-5 family P20042
Protein FAM114A2 (FAM114A2) FAM114 family Q9NRY5
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Histone H2A type 3 (H2AC25) Histone H2A family Q7L7L0
Histone H3.2 (H3C15; H3C14; H3C13) Histone H3 family Q71DI3
Iron-sulfur cluster co-chaperone protein HscB (HSCB) HscB family Q8IWL3
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) NHER family Q5T2W1
Nucleosome assembly protein 1-like 3 (NAP1L3) Nucleosome assembly protein (NAP) family Q99457
Pre-mRNA-splicing factor SLU7 (SLU7) SLU7 family O95391
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) SNF5 family Q12824
Spermatogenesis-associated protein 2-like protein (SPATA2L) SPATA2 family Q8IUW3
Tubulin beta chain (TUBB) Tubulin family P07437
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Fanconi anemia group G protein (FANCG) . O15287
Galectin-9C (LGALS9C) . Q6DKI2
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Melanoma-associated antigen 2 (MAGEA2; MAGEA2B) . P43356
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Spermatogenesis-associated protein 22 (SPATA22) . Q8NHS9
Splicing regulator RBM11 (RBM11) . P57052
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698
Superkiller complex protein 8 (SKIC8) . Q9GZS3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.