Details of the Target

General Information of Target

Target ID LDTP12906
Target Name Sacsin (SACS)
Gene Name SACS
Gene ID 26278
Synonyms
KIAA0730; Sacsin; DnaJ homolog subfamily C member 29; DNAJC29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSA
PNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQ
TAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYR
QVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGII
KVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNM
TGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHS
QEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGL
VTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPI
NRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQ
AEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSK
DSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENK
NWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQED
FCGPEHSTEL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.
Uniprot ID
Q9NZJ4
Ensemble ID
ENST00000382292.9
HGNC ID
HGNC:10519

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 Substitution: p.A2782I DBIA    Probe Info 
AGS SNV: p.D3341V .
CCK81 SNV: p.S3975R .
COLO678 SNV: p.A248E .
COLO792 SNV: p.P3987S DBIA    Probe Info 
HCT15 SNV: p.L2285I; p.C2319Ter; p.A2368V; p.C2514R .
HGC27 SNV: p.E2544Ter .
HSC4 SNV: p.A610G .
HT SNV: p.K3988N .
HT115 SNV: p.T1822A; p.L4041I; p.R4069I .
HT29 SNV: p.S409F .
HT3 SNV: p.K115N .
IGR1 SNV: p.P204S DBIA    Probe Info 
KMS27 SNV: p.G1548R DBIA    Probe Info 
KYSE150 SNV: p.G402R .
MCC13 SNV: p.P1615S DBIA    Probe Info 
MCC26 SNV: p.N4063T DBIA    Probe Info 
MDAMB231 SNV: p.K3116N .
MEWO SNV: p.L83S; p.P2063S; p.P4342A DBIA    Probe Info 
MFE296 SNV: p.R4448H DBIA    Probe Info 
MFE319 Deletion: p.S791QfsTer4
SNV: p.G2129R;p.V3895A		 .
MOLT4 SNV: p.A3279T IA-alkyne    Probe Info 
NCIH1048 SNV: p.S3617P; p.M3942V .
NCIH1155 SNV: p.E799V DBIA    Probe Info 
NCIH1792 SNV: p.Y576F .
NCIH1793 SNV: p.D2244Y .
NCIH2172 SNV: p.T2808I .
NCIH2286 SNV: p.G400V .
NCIH2291 SNV: p.H2651L .
NCIH358 SNV: p.M1149I DBIA    Probe Info 
NCIH716 Substitution: p.E48C .
OCIAML2 SNV: p.V3345I DBIA    Probe Info 
OVK18 Deletion: p.S791QfsTer4
SNV: p.G3684R		 .
P31FUJ SNV: p.E3377Ter DBIA    Probe Info 
RKO SNV: p.Y1697C DBIA    Probe Info 
RL SNV: p.D4256G .
SKMEL28 SNV: p.F2678L DBIA    Probe Info 
SKN SNV: p.I1255M .
SUIT2 SNV: p.P3971H .
SW1271 SNV: p.P10T; p.H2362Y .
SW403 SNV: p.S3357I; p.E3509Ter DBIA    Probe Info 
SW620 SNV: p.K637E DBIA    Probe Info 
TE4 SNV: p.G606V .
TOV21G SNV: p.W29Ter .
U87MG SNV: p.S2273Ter;p.N2295K
Substitution: p.S2265C		 DBIA    Probe Info 
YSCCC SNV: p.H1085N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.49  LDD0402  [1]
BTD
 Probe Info  		C2182(0.98)  LDD2109  [2]
AHL-Pu-1
 Probe Info  		C1118(2.13)  LDD0168  [3]
DBIA
 Probe Info  		C2514(1.17); C360(1.06); C2976(0.99); C1889(0.97)  LDD0078  [4]
CY4
 Probe Info  		Q4576(0.00); Q4577(0.00)  LDD0247  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C3655(0.00); C2097(0.00); C2100(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C3655(0.00); C360(0.00); C2856(0.00); C2484(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		C991(0.00); C1118(0.00); C360(0.00)  LDD0005  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [8]
AOyne
 Probe Info  		10.90  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1118(2.13)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C2976(5.74)  LDD0372  [3]
 LDCM0214  AC1 HCT 116 C2424(1.41); C1742(1.37); C1889(1.00); C2042(1.55)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C1742(1.06); C1872(0.92); C1889(1.14); C2271(1.41)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C2424(1.29); C1742(0.78); C1872(0.95); C1889(1.04)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C2424(0.99); C1742(0.83); C1872(0.98); C1889(0.88)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C2424(0.80); C1742(0.91); C1872(0.90); C1889(0.86)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C2424(1.59); C1742(1.03); C1872(1.03); C1889(1.17)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C2424(1.38); C1742(0.91); C1872(1.11); C1889(1.03)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C2424(0.92); C1742(0.90); C1872(1.06); C1889(1.02)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C2424(1.24); C1742(1.01); C1872(0.85); C1889(0.95)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C2424(0.86); C1742(0.94); C1872(0.90); C1889(0.85)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C2424(1.19); C1742(0.93); C1872(0.81); C1889(0.95)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C2424(0.94); C1742(0.88); C1872(0.96); C1889(0.86)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C1742(1.07); C1872(1.03); C1889(1.17); C2271(1.31)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C2424(1.36); C1742(1.27); C1872(1.07); C1889(0.79)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C2424(1.64); C1742(1.24); C1872(1.10); C1889(0.78)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C2424(0.94); C1742(1.02); C1872(0.79); C1889(0.78)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C2424(0.71); C1398(1.00); C1399(1.00); C1401(1.00)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C2424(0.85); C1398(1.23); C1399(1.23); C1401(1.23)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C2424(1.47); C1398(1.29); C1399(1.29); C1401(1.29)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C2424(1.26); C1398(1.47); C1399(1.47); C1401(1.47)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C2424(1.21); C1398(1.12); C1399(1.12); C1401(1.12)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C2424(1.08); C1398(1.08); C1399(1.08); C1401(1.08)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C2424(1.08); C1398(1.34); C1399(1.34); C1401(1.34)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C1742(0.93); C1872(1.10); C1889(1.02); C2271(1.02)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C2424(5.11); C1398(1.41); C1399(1.41); C1401(1.41)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C2424(0.96); C1398(1.34); C1399(1.34); C1401(1.34)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C2424(1.20); C1398(1.51); C1399(1.51); C1401(1.51)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C2424(0.97); C1398(1.20); C1399(1.20); C1401(1.20)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C2424(0.93); C1398(1.18); C1399(1.18); C1401(1.18)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C2424(1.07); C1398(1.13); C1399(1.13); C1401(1.13)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C2424(1.10); C1398(1.49); C1399(1.49); C1401(1.49)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C2424(0.84); C1398(1.24); C1399(1.24); C1401(1.24)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C17(1.69); C1872(1.40); C1889(1.25); C20(1.69)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C17(0.98); C1872(0.97); C1889(0.79); C20(0.98)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C17(1.25); C1872(1.17); C1889(1.14); C20(1.25)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C17(1.12); C1872(0.62); C1889(1.06); C20(1.12)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C17(1.32); C1872(2.23); C1889(0.97); C20(1.32)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C17(1.74); C1872(1.81); C1889(1.05); C20(1.74)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C17(1.17); C1872(1.40); C1889(1.26); C20(1.17)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C17(1.22); C1872(1.42); C1889(1.24); C20(1.22)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C17(1.17); C1872(1.62); C1889(0.97); C20(1.17)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C17(1.13); C1872(1.52); C1889(0.85); C20(1.13)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C17(1.29); C1872(1.59); C1889(1.16); C20(1.29)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C17(1.38); C1872(1.50); C1889(0.99); C20(1.38)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C1742(0.99); C1872(0.95); C1889(1.15); C2271(1.16)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C17(1.34); C1872(1.72); C1889(1.05); C20(1.34)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C17(1.18); C1872(1.66); C1889(1.01); C20(1.18)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C17(1.26); C1872(1.67); C1889(0.91); C20(1.26)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C2424(1.72); C1742(0.67); C2467(0.96); C2471(0.96)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C2514(0.83); C638(1.00); C643(1.10); C3990(1.13)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C2514(0.89); C643(0.96); C3990(0.99); C638(1.01)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C2514(0.89); C2097(1.09); C2100(1.09); C3996(1.11)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C2514(0.96); C643(1.00); C3990(1.00); C3996(1.02)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C2514(1.14); C643(1.26); C638(1.34); C3694(1.42)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C2514(1.12); C3996(1.18); C2467(1.22); C2471(1.22)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C2514(0.73); C395(0.92); C1872(0.99); C4474(1.00)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C2514(0.96); C643(1.02); C2467(1.04); C2471(1.04)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C2467(0.94); C2471(0.94); C638(0.97); C2271(1.03)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C638(1.03); C643(1.11); C3990(1.16); C2514(1.18)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C2514(0.86); C638(1.30); C643(1.39); C3990(1.47)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C2424(1.38); C2097(1.33); C2100(1.33); C2271(1.18)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C2424(1.17); C2097(1.41); C2100(1.41); C2271(1.16)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C2424(1.09); C2097(1.00); C2100(1.00); C2271(1.04)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C2424(0.77); C2097(0.97); C2100(0.97); C2271(0.99)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C395(0.79); C2424(0.86); C3139(0.90); C1889(0.97)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C3756(0.61); C395(0.64); C1889(0.84); C2562(0.85)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C395(0.71); C2271(0.93); C3139(0.93); C638(0.95)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C360(0.94); C1889(0.97); C2467(1.04); C2471(1.04)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C395(0.58); C2424(0.82); C2467(0.85); C2471(0.85)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C395(0.60); C2424(0.86); C3139(0.86); C2271(0.89)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C395(0.71); C2424(0.78); C1889(0.81); C2695(0.89)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C395(0.72); C1889(0.76); C2424(0.85); C3139(0.87)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C1889(0.80); C2424(0.84); C395(0.86); C3139(0.90)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C3990(0.86); C3996(0.86); C3756(0.89); C3139(0.89)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C3694(0.65); C3704(0.65); C2042(0.71); C3990(0.81)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C2042(0.72); C3990(0.86); C3996(0.86); C1742(0.88)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C2042(0.57); C1742(0.61); C638(0.81); C2695(0.84)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C2042(0.44); C3694(0.72); C3704(0.72); C1742(0.78)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C360(0.93); C3694(1.04); C3704(1.04); C1889(1.06)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C2042(0.45); C3990(0.83); C3996(0.83); C2695(0.85)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C2042(0.62); C1742(0.75); C2695(0.89); C638(0.90)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C2042(0.44); C3694(0.74); C3704(0.74); C2695(0.79)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C2042(0.79); C3990(0.89); C3996(0.89); C2695(0.90)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C2042(0.64); C1398(0.77); C1399(0.77); C3694(0.85)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C3756(0.55); C643(0.83); C2562(0.85); C2514(0.86)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C2467(0.75); C2695(0.77); C1889(0.77); C3756(0.77)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C2467(0.78); C3756(0.83); C360(0.84); C2695(0.85)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C2695(0.80); C395(0.86); C2562(0.86); C360(0.86)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C1889(0.84); C2562(0.91); C2514(0.93); C2471(0.94)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C360(0.88); C3694(1.07); C3704(1.07); C2042(1.11)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C395(0.72); C2695(0.88); C2471(1.00); C3756(1.03)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C1889(0.82); C2467(0.83); C2042(0.87); C360(0.89)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C1889(0.92); C2042(0.93); C360(0.97); C2562(0.99)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C395(0.81); C3756(0.86); C2042(0.89); C2695(0.94)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C395(0.86); C2042(0.88); C643(1.00); C1889(1.00)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C395(0.97); C2042(1.00); C2471(1.02); C643(1.03)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C395(0.71); C3990(0.95); C3996(0.95); C2467(0.95)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C395(0.90); C1742(0.90); C2514(0.91); C3990(0.94)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C395(0.69); C2514(0.89); C3990(0.90); C3996(0.90)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C1742(0.67); C395(0.88); C3990(0.99); C3996(0.99)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C360(0.94); C2467(0.98); C2471(0.98); C3694(0.99)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C1742(0.54); C395(0.91); C2514(0.97); C2562(1.06)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C1742(0.62); C395(0.73); C3990(0.83); C3996(0.83)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C1742(0.51); C395(0.73); C3990(0.86); C3996(0.86)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C1742(0.50); C2514(0.90); C3139(1.01); C3990(1.04)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C1742(0.49); C395(0.73); C2514(0.87); C1889(1.04)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C1742(0.38); C395(0.83); C2514(1.06); C2562(1.06)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C1742(0.50); C2514(0.80); C395(1.00); C2562(1.21)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C3139(0.55); C1742(0.81); C2471(0.93); C2514(0.94)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C2471(0.90); C2467(0.90); C3139(0.93); C2562(0.99)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C3139(0.66); C2467(0.68); C2471(0.91); C1872(0.97)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C2514(0.86); C1872(0.98); C3990(1.01); C3996(1.01)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C2467(0.67); C3139(0.70); C2514(0.81); C2471(0.91)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C3139(0.66); C2514(0.92); C1872(0.94); C2471(0.95)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C3139(0.54); C2514(0.74); C2467(0.76); C2471(0.90)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C2467(0.61); C3139(0.64); C2514(0.81); C1872(0.86)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C3139(0.67); C2514(0.70); C2467(0.74); C2471(0.95)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C2467(0.79); C3139(0.81); C1872(0.89); C2471(0.90)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C3139(0.78); C2514(0.88); C2467(0.89); C2471(0.90)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C2467(0.56); C3139(0.69); C2471(0.83); C1872(0.83)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C2514(0.91); C360(0.97); C2471(1.03); C2467(1.10)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C17(0.88); C20(0.88); C360(0.88); C2514(0.98)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C2514(0.89); C4474(1.00); C2467(1.00); C2471(1.00)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C1758(0.79); C360(0.86); C3139(0.97); C4474(0.99)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C17(0.81); C20(0.81); C2514(0.91); C1889(0.92)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C1889(0.92); C2471(0.93); C360(0.96); C17(0.97)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C1758(0.85); C17(1.02); C20(1.02); C360(1.11)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C17(0.75); C20(0.75); C1758(0.81); C2514(0.92)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C1758(0.58); C360(0.92); C3139(1.18); C2514(1.21)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C2514(0.83); C3139(0.90); C360(0.94); C17(1.03)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C2097(0.89); C2100(0.89); C17(0.93); C20(0.93)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C2514(0.84); C3139(0.87); C1889(0.94); C360(0.96)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C2471(0.99); C2424(1.02); C1889(1.05); C4474(1.06)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C2514(0.88); C1872(0.96); C2695(0.97); C4474(0.98)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C2514(0.74); C17(0.86); C20(0.86); C1742(0.97)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C1758(0.40); C4474(0.95); C2471(0.95); C360(1.01)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C1758(0.38); C2514(0.83); C360(1.01); C3139(1.11)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C395(0.85); C1742(0.90); C1398(0.92); C1399(0.92)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C395(0.84); C2097(0.97); C2100(0.97); C2695(0.98)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C395(0.59); C638(0.94); C643(0.94); C2514(0.97)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C395(0.80); C1398(0.81); C1399(0.81); C1401(0.81)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C2424(0.76); C395(0.85); C1398(0.89); C1399(0.89)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C395(0.81); C2424(0.84); C2467(0.87); C2471(0.87)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C395(0.82); C2097(0.97); C2100(0.97); C2695(1.00)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C2097(0.74); C2100(0.74); C2424(0.82); C2467(0.87)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C2514(0.78); C1742(0.86); C2695(0.93); C395(1.01)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C2514(0.90); C1742(0.93); C395(0.94); C2097(1.01)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C395(0.64); C2097(0.90); C2100(0.90); C638(0.90)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C395(0.69); C2514(0.75); C2424(0.85); C638(0.92)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C2097(0.79); C2100(0.79); C2424(0.79); C1889(0.89)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C395(0.64); C2514(0.75); C2424(0.85); C1742(0.88)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C2097(0.74); C2100(0.74); C395(0.78); C1398(0.85)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C2271(0.71); C2467(0.82); C2471(0.82); C395(0.83)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C2271(0.64); C3756(0.66); C395(0.68); C2097(0.72)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C1742(1.01); C1872(1.12); C1889(1.22); C2271(1.06)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C1872(0.94); C3990(1.01); C3996(1.01); C4474(1.02)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C2514(0.74); C1872(0.82); C1889(1.02); C3990(1.24)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C2514(1.17); C360(1.06); C2976(0.99); C1889(0.97)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C1758(0.65); C2042(0.76); C2514(0.79); C360(0.85)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C1758(0.93); C2514(0.96); C360(1.07); C2042(1.09)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C1889(0.88); C2467(0.96); C2471(0.96); C360(0.99)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C2514(0.82); C395(0.93); C2467(0.95); C2471(0.95)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C2467(0.87); C2471(0.87); C4474(0.98); C1742(1.00)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C2514(0.69); C395(0.85); C4474(0.93); C1742(0.96)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C2514(0.83); C2467(0.91); C2471(0.91); C4474(0.91)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C395(0.78); C2424(0.92); C1889(0.97); C3139(1.01)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C395(0.81); C1872(1.03); C2695(1.04); C360(1.08)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C395(0.72); C1872(1.01); C3139(1.02); C360(1.08)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C395(0.80); C360(1.05); C2271(1.05); C1872(1.09)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C395(0.74); C638(0.92); C3139(0.93); C2271(0.94)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C2514(0.77); C360(0.98); C1758(1.11); C2042(1.19)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C395(0.75); C3139(0.94); C2271(1.04); C360(1.07)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C3756(0.76); C395(0.77); C1889(0.86); C2424(0.89)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C1742(0.60); C2042(0.70); C3756(0.78); C3694(0.82)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C2042(0.41); C2424(0.78); C1398(0.79); C1399(0.79)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C2042(0.38); C3694(0.63); C3704(0.63); C2695(0.74)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C2042(0.43); C3990(0.83); C3996(0.83); C2695(0.85)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C2042(0.66); C3694(0.79); C3704(0.79); C3990(0.88)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C2042(0.93); C3756(1.05); C4474(1.10); C2514(1.11)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C3756(0.82); C1889(0.90); C2471(0.90); C2562(0.93)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C3756(0.76); C395(0.82); C2514(0.95); C3990(0.98)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C360(1.08); C2514(1.19); C2042(1.19); C2471(1.24)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C1889(0.83); C2562(0.84); C3756(0.90); C2467(0.91)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C395(0.53); C2271(0.80); C1742(0.82); C1758(0.84)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C1742(0.64); C2514(0.83); C395(0.99); C3990(1.05)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C1742(0.76); C2514(0.76); C1758(1.01); C395(1.03)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C1742(0.60); C395(0.75); C2514(0.79); C3990(1.07)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C3139(0.57); C2467(0.79); C2562(0.83); C2042(0.91)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C3139(0.46); C2042(0.76); C2467(0.82); C1742(0.82)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C2467(0.64); C3139(0.89); C1742(0.94); C2562(0.97)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C3139(0.75); C1742(0.83); C2471(0.89); C2467(0.92)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C360(0.96); C2514(1.02); C1758(1.05); C3990(1.08)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C2042(0.85); C1758(0.96); C360(1.02); C395(1.03)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C1758(0.89); C2514(1.00); C3990(1.02); C3996(1.02)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C395(0.67); C2695(0.70); C3990(0.77); C3996(0.77)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C2042(0.79); C1872(0.79); C2695(0.80); C2271(0.92)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C2467(0.80); C1872(0.81); C2471(0.85); C2514(0.87)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C2695(0.87); C2042(0.89); C2467(0.91); C2471(0.94)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C2514(0.71); C3990(0.80); C3996(0.80); C1758(0.81)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C2467(0.68); C2042(0.77); C2695(0.86); C395(0.87)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C1872(0.85); C2042(0.85); C2695(0.89); C395(0.98)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C2042(0.73); C2695(0.95); C395(1.09); C360(1.10)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C2695(0.69); C395(0.73); C1872(0.79); C3990(0.82)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C17(1.36); C1742(1.62); C1872(0.85); C20(1.36)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C17(1.71); C1742(1.85); C1872(0.87); C20(1.71)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C17(1.26); C1742(1.23); C1872(0.83); C20(1.26)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C17(1.25); C1742(1.41); C1872(0.88); C20(1.25)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C17(1.42); C1742(1.22); C1872(1.03); C20(1.42)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C17(1.26); C1742(1.55); C1872(1.16); C20(1.26)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C1742(0.94); C1758(0.88); C2042(0.94); C2467(1.00)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C17(1.05); C1742(1.16); C1872(1.18); C20(1.05)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C1398(1.13); C1399(1.13); C1742(0.93); C1872(0.85)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C1398(1.11); C1399(1.11); C1742(1.05); C1889(1.22)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C1398(0.86); C1399(0.86); C1742(1.23); C1889(1.02)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C1398(1.37); C1399(1.37); C1742(1.23); C1889(1.32)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C1398(1.21); C1399(1.21); C1742(1.24); C1889(1.03)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C1398(1.17); C1399(1.17); C1742(1.31); C1889(1.25)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C1398(1.50); C1399(1.50); C1742(1.28); C1889(1.32)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C1398(1.28); C1399(1.28); C1742(1.16); C1889(0.98)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C1742(0.95); C1758(0.94); C2042(1.01); C2467(0.87)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C1398(1.13); C1399(1.13); C1742(1.41); C1889(1.00)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C1398(1.49); C1399(1.49); C1742(1.11); C1889(1.29)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C1398(1.83); C1399(1.83); C1742(1.27); C1889(1.19)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C1398(1.58); C1399(1.58); C1742(1.38); C1889(1.05)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C1398(1.40); C1399(1.40); C1742(1.25); C1889(1.14)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C1398(1.76); C1399(1.76); C1742(1.60); C1889(1.14)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C2424(0.79); C1398(0.66); C1399(0.66); C1401(0.66)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C2424(0.97); C1398(0.61); C1399(0.61); C1401(0.61)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C2424(0.81); C1398(0.66); C1399(0.66); C1401(0.66)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C2424(1.40); C1398(0.73); C1399(0.73); C1401(0.73)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C1742(1.12); C1758(0.81); C2042(0.83); C2467(0.94)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C2424(1.03); C1398(0.75); C1399(0.75); C1401(0.75)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C2424(0.85); C1398(0.79); C1399(0.79); C1401(0.79)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C2424(1.18); C1398(0.70); C1399(0.70); C1401(0.70)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C2424(0.74); C1398(0.63); C1399(0.63); C1401(0.63)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C2424(1.04); C1398(0.87); C1399(0.87); C1401(0.87)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C2424(0.91); C1398(0.73); C1399(0.73); C1401(0.73)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C2424(0.94); C1398(0.77); C1399(0.77); C1401(0.77)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C2424(2.42); C1398(0.79); C1399(0.79); C1401(0.79)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C2424(1.24); C1398(0.68); C1399(0.68); C1401(0.68)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C2424(1.66); C1398(0.72); C1399(0.72); C1401(0.72)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C1742(1.21); C1758(0.77); C2042(1.14); C2467(1.15)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C2424(1.12); C1398(0.63); C1399(0.63); C1401(0.63)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C1398(0.99); C1399(0.99); C1401(0.99); C1742(1.05)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C1398(1.02); C1399(1.02); C1401(1.02); C1742(1.15)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C1398(1.06); C1399(1.06); C1401(1.06); C1742(1.11)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C1398(1.18); C1399(1.18); C1401(1.18); C1742(1.21)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C1398(1.14); C1399(1.14); C1401(1.14); C1742(1.07)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C1398(1.12); C1399(1.12); C1401(1.12); C1742(1.31)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C1398(1.05); C1399(1.05); C1401(1.05); C1742(0.96)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C1398(0.82); C1399(0.82); C1401(0.82); C1742(1.04)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C1398(1.02); C1399(1.02); C1401(1.02); C1742(0.81)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C1742(1.34); C1758(0.83); C2042(1.32); C2467(1.24)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C1398(0.88); C1399(0.88); C1401(0.88); C1742(0.89)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C1398(0.69); C1399(0.69); C1401(0.69); C1742(0.90)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C1398(0.76); C1399(0.76); C1401(0.76); C1742(0.81)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C1398(0.85); C1399(0.85); C1401(0.85); C1742(0.89)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C1398(0.81); C1399(0.81); C1401(0.81); C1742(0.88)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C1742(1.01); C1889(1.02); C2467(1.11); C2471(1.07)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C1742(0.86); C1889(1.02); C2467(0.96); C2471(0.89)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C1742(1.09); C1889(1.04); C2467(1.10); C2471(1.09)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C1742(1.16); C1889(1.65); C2467(1.31); C2471(1.20)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C1742(1.32); C1758(1.08); C2042(1.02); C2467(1.83)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C1742(1.14); C1889(1.57); C2467(1.17); C2471(1.12)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C1742(1.09); C1889(0.95); C2467(1.12); C2471(1.02)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C1742(1.42); C1889(1.16); C2467(1.67); C2471(1.38)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C1742(1.09); C1889(1.09); C2467(1.59); C2471(1.28)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C1742(1.76); C1889(0.97); C2467(2.08); C2471(1.55)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C1742(1.17); C1889(1.19); C2467(1.15); C2471(1.04)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C1742(0.96); C1889(1.39); C2467(1.03); C2471(1.00)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C1742(1.07); C1889(1.13); C2467(1.21); C2471(1.02)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C1742(1.23); C1889(1.13); C2467(1.41); C2471(1.12)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C1742(2.00); C1889(1.04); C2467(2.39); C2471(1.75)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C1742(1.55); C1758(0.98); C2042(0.94); C2467(0.95)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C1742(0.99); C1889(1.27); C2467(1.26); C2471(1.12)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C2424(0.91); C1742(1.39); C1889(1.03); C2042(1.48)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C2424(0.79); C1742(1.13); C1889(0.90); C2042(1.05)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C2424(0.89); C1742(1.11); C1889(0.91); C2042(0.92)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C2424(0.83); C1742(1.21); C1889(1.06); C2042(1.12)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C2424(0.82); C1742(1.26); C1889(0.97); C2042(1.16)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C2424(0.87); C1742(1.29); C1889(1.00); C2042(1.00)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C2424(1.02); C1742(1.37); C1889(1.17); C2042(1.25)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C2424(1.05); C1742(1.16); C1889(1.01); C2042(1.32)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C2424(1.13); C1742(1.30); C1889(1.21); C2042(1.29)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C2182(0.67); C2444(1.01); C1438(1.12); C2271(1.00)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C3752(0.66)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C1398(1.01); C1399(1.01); C1401(1.01); C1742(0.85)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C1398(1.64); C1399(1.64); C1742(1.32); C1889(1.00)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C638(2.10); C643(2.10); C2976(1.41); C2471(1.33)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C638(2.63); C643(2.63); C2976(1.23); C2471(1.55)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C638(2.10); C643(2.10); C2976(1.55); C2471(1.44)  LDD0082  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2182(0.98)  LDD2109  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C732(1.19)  LDD2140  [2]
 LDCM0021  THZ1 HCT 116 C4420(1.37); C2514(1.16); C360(1.17)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sacsin (SACS) . Q9NZJ4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402