Details of the Target

General Information of Target

Target ID LDTP12417
Target Name Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B)
Gene Name RPRD1B
Gene ID 58490
Synonyms
C20orf77; CREPT; Regulation of nuclear pre-mRNA domain-containing protein 1B; Cell cycle-related and expression-elevated protein in tumor
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASDLDFSPPEVPEPTFLENLLRYGLFLGAIFQLICVLAIIVPIPKSHEAEAEPSEPRSA
EVTRKPKAAVPSVNKRPKKETKKKR
Target Bioclass
Other
Family
UPF0400 (RTT103) family
Subcellular location
Nucleus
Function
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
Uniprot ID
Q9NQG5
Ensemble ID
ENST00000373433.9
HGNC ID
HGNC:16209

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.56  LDD0402  [1]
TH211
 Probe Info  		Y117(12.59)  LDD0260  [2]
TH216
 Probe Info  		Y61(20.00)  LDD0259  [2]
STPyne
 Probe Info  		K35(7.59); K73(1.11)  LDD0277  [3]
IPM
 Probe Info  		N.A.  LDD0241  [4]
Probe 1
 Probe Info  		Y261(14.29)  LDD3495  [5]
BTD
 Probe Info  		C100(1.25)  LDD2099  [6]
HHS-475
 Probe Info  		Y279(0.77)  LDD0264  [7]
HHS-465
 Probe Info  		Y61(2.65)  LDD2237  [8]
DBIA
 Probe Info  		C100(1.22)  LDD0078  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C234(0.00); C100(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C234(0.00); C100(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		C100(0.00); C234(0.00)  LDD0026  [13]
TFBX
 Probe Info  		C100(0.00); C234(0.00)  LDD0027  [13]
1d-yne
 Probe Info  		N.A.  LDD0356  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
1c-yne
 Probe Info  		K266(0.00); K200(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
W1
 Probe Info  		N.A.  LDD0236  [4]
NAIA_5
 Probe Info  		C100(0.00); C234(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		18.33  LDD0475  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C100(0.86)  LDD2117  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C100(7.76)  LDD0372  [20]
 LDCM0214  AC1 HCT 116 C234(0.97)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C100(1.18); C234(0.86)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C100(1.26); C234(0.83)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C100(1.32); C234(0.95)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C100(1.35); C234(0.79)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C100(1.26); C234(0.86)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C100(1.01); C234(0.97)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C100(1.33); C234(0.90)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C100(1.37); C234(0.92)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C100(1.26); C234(0.89)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C100(1.41); C234(0.81)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C100(1.25); C234(0.83)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C100(1.29); C234(0.98)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C100(1.39); C234(0.96)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C100(1.41); C234(1.04)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C100(1.22); C234(1.05)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C100(1.17); C234(0.95)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C100(1.15); C234(0.83)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C100(1.03); C234(0.91)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C100(1.04); C234(0.89)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C100(1.04); C234(0.73)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C100(1.00); C234(0.85)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C100(1.02); C234(0.77)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C100(1.18); C234(0.95)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C100(0.96); C234(1.03)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C100(1.00); C234(0.88)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C100(1.07); C234(0.81)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C100(1.01); C234(0.88)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C100(0.98); C234(0.90)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C100(1.13); C234(0.84)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C100(1.10); C234(0.94)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C100(1.02); C234(0.96)  LDD0562  [9]
 LDCM0246  AC128 HEK-293T C100(0.73); C234(1.08)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C100(1.16); C234(1.14)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C100(0.87); C234(0.99)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C100(0.73); C234(1.12)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C100(0.76); C234(1.38)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C100(0.79); C234(1.02)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C100(0.71); C234(0.95)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C100(0.60); C234(0.98)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C100(0.77); C234(0.98)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C100(0.75); C234(1.18)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C100(0.71); C234(0.98)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C100(0.58); C234(1.07)  LDD0856  [9]
 LDCM0259  AC14 HCT 116 C100(1.21); C234(0.90)  LDD0576  [9]
 LDCM0260  AC140 HEK-293T C100(0.81); C234(0.98)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C100(0.69); C234(1.04)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C100(0.63); C234(0.95)  LDD0860  [9]
 LDCM0263  AC143 HCT 116 C234(0.96); C100(1.01)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C234(1.10); C100(1.13)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C100(0.99); C234(1.00)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C100(0.83); C234(1.03)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C234(0.94); C100(0.99)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C100(0.87); C234(1.05)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C234(0.88); C100(0.97)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C234(1.09); C100(1.18)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C100(1.00); C234(1.02)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C234(0.92); C100(0.93)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C100(0.81); C234(0.93)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C100(0.84); C234(1.35)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C100(0.85); C234(1.07)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C100(0.85); C234(0.97)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C100(0.92); C234(1.12)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C100(0.88); C234(1.16)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C100(0.86); C234(0.90)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C100(0.87); C234(0.96)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C100(0.87); C234(1.01)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C234(0.88)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C100(0.91); C234(1.45)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C100(0.87); C234(0.95)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C234(0.83); C100(0.85)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C100(0.80); C234(0.98)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C100(0.82); C234(1.15)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C100(1.21)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C100(1.50)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C100(1.11)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C100(1.56)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C100(1.49)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C234(0.88)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C100(1.72)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C100(1.45)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C100(1.73)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C100(1.34)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C100(1.39)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C100(0.93)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C100(1.01)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C100(0.89)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C100(0.86)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C100(0.88)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C234(0.92)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C100(0.87)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C100(0.96)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C100(0.88)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C100(1.05)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C100(1.02)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C100(0.91)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C100(1.15)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C100(0.99)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C100(1.04)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C100(1.29)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C234(0.92)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C100(1.15)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C100(1.11)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C100(1.20)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C100(1.11)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C100(1.17)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C100(1.23)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C100(1.23)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C100(1.22)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C100(1.37)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C100(1.31)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C234(1.23); C100(1.24)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C100(1.12)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C100(1.27)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C100(1.34)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C100(1.33)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C100(1.44)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C100(1.52)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C100(1.70)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C100(1.53)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C100(0.98)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C100(1.00)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C234(0.83); C100(1.10)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C100(0.97)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C100(0.86)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C100(1.02)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C100(1.11)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C100(0.94)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C100(0.92)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C100(1.12)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C100(1.09)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C100(0.91)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C100(1.06)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C234(0.95); C100(1.26)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C100(0.91)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C100(0.98)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C100(1.03)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C234(1.15); C100(1.18)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C100(1.14); C234(1.17)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C234(0.96); C100(1.17)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C100(1.01); C234(1.11)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C234(0.98); C100(1.02)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C100(0.99); C234(1.03)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C100(1.06); C234(1.25)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C234(0.94); C100(0.99)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C234(0.91); C100(1.12)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C100(0.99); C234(0.99)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C100(0.88); C234(0.92)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C100(0.81); C234(1.02)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C100(0.75); C234(1.12)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C100(0.79); C234(1.04)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C234(0.89); C100(0.91)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C234(0.91); C100(1.23)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C234(0.80); C100(1.14)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C100(1.11); C234(1.02)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C234(0.85); C100(1.12)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C234(1.09); C100(1.46)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 12.31  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C100(1.22)  LDD0078  [9]
 LDCM0632  CL-Sc Hep-G2 C100(1.90); C234(1.04)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C234(0.95); C100(1.00)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C100(0.95); C234(1.03)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C234(0.97)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C234(1.06); C100(1.21)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C234(0.75); C100(1.09)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C234(0.76); C100(1.04)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C234(0.93); C100(1.10)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C234(0.93); C100(1.12)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C234(0.93); C100(1.14)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C234(0.96); C100(1.07)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C234(0.94); C100(1.02)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C100(0.96); C234(0.97)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C100(1.09); C234(1.22)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C234(0.85); C100(0.89)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C100(0.93); C234(0.98)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C100(1.10)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C100(1.33)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C100(1.42)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C100(1.16)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C100(1.45)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C100(0.94)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C100(0.96)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C100(1.04)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C100(1.08); C234(1.41)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C100(0.92)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C100(1.10)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C100(1.17)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C100(1.15)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C100(1.13)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C100(0.95)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C100(1.08)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C100(1.08)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C100(1.37)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C234(1.02); C100(1.16)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C100(1.00); C234(1.03)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C100(0.97); C234(1.03)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C100(1.19)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C100(0.97); C234(1.17)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C234(0.91); C100(0.92)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C100(0.89); C234(1.38)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C100(1.06); C234(1.06)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C100(0.86); C234(1.12)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C100(0.77); C234(0.86)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C100(0.87); C234(0.97)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C234(0.95); C100(0.95)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C100(0.93); C234(0.93)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C100(0.96); C234(0.78)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C100(0.96); C234(0.93)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C100(0.85); C234(1.22)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C100(0.88); C234(1.03)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C100(0.85); C234(1.07)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C100(0.89); C234(0.91)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C100(0.88); C234(0.81)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C100(0.89); C234(1.04)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C100(1.25)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C100(1.22)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C100(1.16)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C100(1.16)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C100(1.01)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C100(1.12)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C100(1.25)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C100(0.85); C234(1.25)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C100(1.03)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C100(1.03)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C100(1.04)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C100(1.13)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C100(1.05)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C100(1.03)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C100(0.92); C234(0.78)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C100(0.88); C234(0.76)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C100(0.93); C234(0.92)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C100(0.94); C234(0.80)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C100(1.01); C234(0.99)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C100(1.01); C234(1.03)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C100(1.02); C234(0.87)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C100(0.99); C234(0.87)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C100(0.97); C234(1.12)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C100(0.99); C234(0.94)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C100(0.82); C234(0.82)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C100(1.06); C234(0.84)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C100(0.97); C234(1.18)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C100(0.96); C234(0.90)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C100(0.98); C234(0.86)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C100(0.94); C234(1.01)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C100(0.95); C234(0.88)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C100(0.85)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C100(0.84)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C100(0.88)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C100(1.06)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C100(0.93)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C100(0.91)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C100(0.90)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C100(1.12)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C100(0.98)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C100(1.05); C234(1.08)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C100(1.07)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C100(1.10)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C100(1.02)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C100(0.96)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C100(0.95)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C100(0.95); C234(1.15)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C100(0.99); C234(1.21)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C100(0.98); C234(1.31)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C100(1.00); C234(1.15)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C100(1.03); C234(1.12)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C100(0.99); C234(1.33)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C100(0.93); C234(1.11)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C100(1.00); C234(1.18)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C100(1.03); C234(1.17)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C100(1.12); C234(1.26)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C100(1.11); C234(1.46)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C100(1.01); C234(1.17)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C100(0.95); C234(1.21)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C100(1.00); C234(1.04)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C100(0.98); C234(1.05)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C100(1.12); C234(1.25)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C100(0.92); C234(0.98)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C234(1.15)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C234(0.96)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C234(1.02)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C234(1.08)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C234(0.91)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C234(0.94)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C234(0.82)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C234(0.89)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C234(1.03)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C234(1.05); C100(0.87)  LDD1698  [21]
 LDCM0625  F8 Ramos C100(2.07)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C100(0.60)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C100(0.47)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C100(0.52)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C100(0.96)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C100(0.61)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C100(0.35)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C100(0.94)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C100(1.43)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C100(1.72)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C100(0.65)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C100(1.39)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C100(0.81)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C100(0.82)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C100(1.03)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C100(1.40)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C100(0.64)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C100(0.83)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C100(0.76)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C100(1.07)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C100(0.50)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C100(0.42)  LDD2188  [22]
 LDCM0116  HHS-0101 DM93 Y279(0.77)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y279(0.86)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y279(1.20)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y279(1.06)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y279(1.01)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C100(1.36); C234(1.29)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C100(1.49); C234(1.39)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C100(1.30); C234(1.07)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C100(1.25)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C100(0.88)  LDD2107  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C100(0.08)  LDD2122  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C100(1.03)  LDD2125  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C100(1.21)  LDD2136  [6]
 LDCM0021  THZ1 HCT 116 C100(1.35)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) RNA polymerase beta' chain family P24928
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (RPAP2) RPAP2 family Q8IXW5
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
High mobility group protein 20A (HMG20A) . Q9NP66
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Borealin (CDCA8) Borealin family Q53HL2
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Prefoldin subunit 6 (PFDN6) Prefoldin subunit beta family O15212
STING ER exit protein (STEEP1) STEEP1 family Q9H5V9
Regulation of nuclear pre-mRNA domain-containing protein 1A (RPRD1A) UPF0400 (RTT103) family Q96P16
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Bridging integrator 3 (BIN3) . Q9NQY0
Nuclear transport factor 2 (NUTF2) . P61970
Ras association domain-containing protein 3 (RASSF3) . Q86WH2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578