Details of the Target

General Information of Target

Target ID LDTP11559
Target Name Protein Niban 1 (NIBAN1)
Gene Name NIBAN1
Gene ID 116496
Synonyms
C1orf24; FAM129A; NIBAN; Protein Niban 1; Cell growth-inhibiting gene 39 protein; Protein FAM129A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
YAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLI
HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGR
VVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKA
RNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
EYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSL
NSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNPN
VSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
Target Bioclass
Other
Family
Niban family
Subcellular location
Cytoplasm
Function Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response.
Uniprot ID
Q9BZQ8
Ensemble ID
ENST00000367511.4
HGNC ID
HGNC:16784

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K124(10.00); K303(9.09); K328(6.46); K412(6.67)  LDD0277  [2]
BTD
 Probe Info  		C516(1.17)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C891(2.08)  LDD0169  [4]
HHS-475
 Probe Info  		Y322(0.93)  LDD0264  [5]
IPM
 Probe Info  		C516(6.64); C409(2.39); C891(1.35)  LDD1701  [3]
DBIA
 Probe Info  		C891(1.64)  LDD0080  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
NAIA_4
 Probe Info  		C339(0.00); C891(0.00)  LDD2226  [8]
TFBX
 Probe Info  		C194(0.00); C516(0.00); C409(0.00)  LDD0148  [9]
Acrolein
 Probe Info  		C194(0.00); C891(0.00)  LDD0217  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C516(0.84)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C516(0.78); C194(1.13)  LDD2117  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C516(1.00)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C516(0.58)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C516(0.71)  LDD2131  [3]
 LDCM0025  4SU-RNA DM93 C891(4.58)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C891(2.08)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C194(1.16); C409(0.87)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C194(0.93)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C194(0.95)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C194(0.97)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C194(1.01)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C194(0.98)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C194(1.12)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C194(1.07)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C194(1.05)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C194(0.81)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C194(0.85)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C194(0.78)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C194(0.86)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C194(1.07)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C194(0.88)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C194(0.91)  LDD0546  [6]
 LDCM0230  AC113 PaTu 8988t C409(2.07); C41(1.12); C194(1.00)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C409(1.87); C41(1.07); C194(0.88)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C409(1.05); C41(0.96); C194(1.02)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C409(1.23); C41(1.06); C194(1.02)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C409(1.95); C41(1.04); C194(1.06)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C409(1.17); C41(1.19); C194(0.98)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C409(0.96); C41(1.00); C194(0.97)  LDD1115  [6]
 LDCM0237  AC12 HCT 116 C194(0.97)  LDD0554  [6]
 LDCM0238  AC120 PaTu 8988t C409(2.02); C41(1.11); C194(1.18)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C409(2.10); C41(1.07); C194(1.14)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C409(2.22); C41(1.05); C194(1.04)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C409(1.35); C41(1.19); C194(0.98)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C409(1.16); C41(1.33); C194(1.01)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C409(1.04); C41(1.13); C194(0.99)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C409(0.88); C41(1.23); C194(1.16)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C409(1.62); C41(1.22); C194(1.13)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C177(1.15); C409(1.11); C41(0.90); C194(0.99)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C177(1.14); C409(0.82); C41(1.01); C194(0.97)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C177(1.10); C409(1.23); C41(0.93); C194(0.88)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C177(1.22); C409(1.84); C41(1.02); C194(0.94)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C177(1.20); C409(1.22); C41(1.08); C194(0.97)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C177(1.59); C409(0.95); C41(1.05); C194(1.26)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C177(1.45); C409(1.65); C41(1.06); C194(1.07)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C177(1.62); C409(0.75); C41(1.07); C194(1.34)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C177(1.48); C409(1.28); C41(0.87); C194(1.16)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C177(1.45); C409(1.25); C41(1.01); C194(1.19)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C177(1.17); C409(1.27); C41(0.97); C194(1.03)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C177(1.26); C409(1.39); C41(0.86); C194(1.15)  LDD1137  [6]
 LDCM0259  AC14 HCT 116 C194(0.93)  LDD0576  [6]
 LDCM0260  AC140 PaTu 8988t C177(1.27); C409(1.07); C41(0.84); C194(1.11)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C177(1.22); C409(1.11); C41(0.95); C194(0.98)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C177(1.30); C409(1.01); C41(0.95); C194(1.07)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C891(1.39); C763(0.98); C41(0.82); C194(1.11)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C891(1.50); C763(0.86); C41(0.88); C194(0.87)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C891(1.31); C763(0.72); C41(0.84); C194(0.93)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C891(1.61); C763(1.60); C41(1.06); C194(0.83)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C891(1.32); C763(0.84); C41(0.86); C194(0.93)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C891(1.71); C763(1.94); C41(0.95); C194(0.96)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C891(2.01); C763(3.14); C41(0.83); C194(1.05)  LDD1148  [6]
 LDCM0270  AC15 HCT 116 C194(0.95)  LDD0587  [6]
 LDCM0271  AC150 PaTu 8988t C891(2.12); C763(1.13); C41(0.85); C194(0.92)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C891(3.78); C763(2.48); C41(1.03); C194(1.10)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C891(2.07); C763(1.29); C41(0.81); C194(1.00)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C891(2.77); C763(1.41); C41(0.94); C194(1.00)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C891(3.09); C763(2.67); C41(0.90); C194(1.05)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C891(2.77); C763(1.34); C41(0.89); C194(0.98)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C891(2.63); C763(1.07); C41(0.81); C194(1.02)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C891(2.60); C763(1.51); C41(0.88); C194(1.03)  LDD2169  [6]
 LDCM0276  AC17 HCT 116 C409(0.90)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C409(0.91)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C409(0.94)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C409(0.85); C194(1.12)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C409(0.87)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C409(0.98)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C409(0.90)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C409(0.87)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C409(0.90)  LDD0601  [6]
 LDCM0285  AC25 PaTu 8988t C891(1.01); C763(1.54); C177(0.85); C41(0.93)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C891(1.15); C763(1.61); C177(0.90); C41(0.78)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C891(1.41); C763(1.41); C177(0.99); C41(0.82)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C891(1.98); C763(1.93); C177(0.94); C41(0.81)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C891(1.21); C763(1.05); C177(0.92); C41(0.79)  LDD1168  [6]
 LDCM0290  AC3 HCT 116 C409(0.87); C194(1.08)  LDD0607  [6]
 LDCM0291  AC30 PaTu 8988t C891(1.01); C763(0.86); C177(0.91); C41(0.89)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C891(1.37); C763(1.49); C177(0.87); C41(0.88)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C891(1.45); C763(1.21); C177(0.91); C41(0.85)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C891(1.90); C763(1.58); C177(0.93); C41(0.95)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C891(1.18); C763(1.71); C177(1.03); C41(0.99)  LDD1174  [6]
 LDCM0296  AC35 HCT 116 C194(1.19)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C194(1.44)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C194(1.15)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C194(1.28)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C194(1.31)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C409(0.95); C194(1.19)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C194(1.35)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C194(1.10)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C194(1.19)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C194(1.31)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C194(1.30)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C194(1.23)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C194(1.08)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C194(1.07)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C194(1.09)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C194(1.17)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C409(0.96); C194(1.26)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C194(1.14)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C194(1.07)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C194(1.05)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C194(1.13)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C194(1.11)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C194(1.25)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C194(1.38)  LDD0636  [6]
 LDCM0320  AC57 PaTu 8988t C891(1.66); C409(0.95); C516(0.91); C41(1.10)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C891(1.68); C409(0.97); C516(0.97); C41(1.19)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C891(1.34); C409(0.88); C516(0.99); C41(0.89)  LDD1201  [6]
 LDCM0323  AC6 HCT 116 C194(1.05)  LDD0640  [6]
 LDCM0324  AC60 PaTu 8988t C891(1.53); C409(1.00); C516(1.09); C41(0.91)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C891(1.02); C409(0.99); C516(1.11); C41(0.74)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C891(1.07); C409(0.98); C516(0.99); C41(0.86)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C891(0.85); C409(0.94); C516(0.95); C41(0.83)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C891(0.91); C409(0.93); C516(1.02); C41(0.73)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C891(0.92); C409(0.99); C516(0.92); C41(0.91)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C891(0.97); C409(0.98); C516(1.03); C41(0.91)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C891(0.96); C409(0.92); C516(0.92); C41(0.77)  LDD1210  [6]
 LDCM0332  AC68 PaTu 8988t C891(1.00); C409(0.83); C516(0.96); C41(0.83)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C891(1.13); C409(0.87); C516(1.01); C41(0.77)  LDD1212  [6]
 LDCM0334  AC7 HCT 116 C194(1.00)  LDD0651  [6]
 LDCM0335  AC70 PaTu 8988t C891(1.00); C409(0.80); C516(0.94); C41(0.83)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C891(0.99); C409(0.88); C516(0.96); C41(0.78)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C891(0.91); C409(0.91); C516(1.07); C41(0.83)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C891(0.98); C409(0.82); C516(1.00); C41(0.80)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C891(1.09); C409(0.79); C516(0.89); C41(0.82)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C891(1.13); C409(0.80); C516(0.88); C41(0.74)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C891(1.05); C409(0.84); C516(0.93); C41(0.76)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C891(1.03); C409(0.85); C516(0.93); C41(0.81)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C891(1.01); C409(0.79); C516(0.94); C41(0.89)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C891(1.09); C409(0.75); C516(0.92); C41(0.74)  LDD1223  [6]
 LDCM0345  AC8 HCT 116 C194(0.82)  LDD0662  [6]
 LDCM0346  AC80 PaTu 8988t C891(0.94); C409(0.78); C516(0.92); C41(0.91)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C891(1.06); C409(0.82); C516(0.96); C41(0.82)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C891(1.06); C409(0.77); C516(0.95); C41(0.78)  LDD1227  [6]
 LDCM0349  AC83 PaTu 8988t C891(0.90); C177(0.99)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C891(0.84); C177(0.85)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C891(0.89); C177(0.98)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C891(0.90); C177(1.00)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C891(0.87); C177(0.91)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C891(0.86); C177(0.93)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C891(0.84); C177(0.93)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C891(0.87); C177(0.91)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C891(0.85); C177(1.04)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C891(0.81); C177(1.00)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C891(0.76); C177(0.95)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C891(0.83); C177(1.01)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C891(0.91); C177(0.84)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C891(0.72); C177(1.18)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C891(0.82); C177(1.03)  LDD1243  [6]
 LDCM0365  AC98 HCT 116 C194(1.08)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C194(0.91)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C516(0.31)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C194(1.08)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C194(0.89)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C194(1.09)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.74  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C516(0.43)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 PaTu 8988t C891(0.89); C763(0.84); C409(1.05); C516(0.98)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C891(1.49); C763(1.75); C409(0.72); C516(0.87)  LDD1247  [6]
 LDCM0369  CL100 HCT 116 C409(0.88); C194(1.18)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C194(0.93)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C194(0.96)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C194(0.91)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C194(0.84)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C409(0.81)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C409(1.02)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C409(0.93)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C409(0.97)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C409(0.90)  LDD0695  [6]
 LDCM0379  CL11 PaTu 8988t C891(0.90); C763(1.09); C409(0.88); C516(0.92)  LDD1258  [6]
 LDCM0380  CL110 HCT 116 C409(0.96)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C409(0.98)  LDD0698  [6]
 LDCM0382  CL112 PaTu 8988t C891(1.27); C763(1.69); C177(0.87); C41(0.84)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C891(1.14); C763(1.28); C177(0.83); C41(0.82)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C891(1.52); C763(1.45); C177(0.81); C41(0.97)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C891(1.15); C763(1.87); C177(0.85); C41(0.90)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C891(1.48); C763(1.85); C177(0.89); C41(0.78)  LDD1265  [6]
 LDCM0387  CL117 HCT 116 C194(1.58)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C194(1.35)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C194(1.31)  LDD0706  [6]
 LDCM0390  CL12 PaTu 8988t C891(0.93); C763(1.18); C409(1.02); C516(0.95)  LDD1269  [6]
 LDCM0391  CL120 HCT 116 C194(1.13)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C194(1.09)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C194(1.13)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C194(1.01)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C194(1.12)  LDD0712  [6]
 LDCM0396  CL125 PaTu 8988t C891(1.10); C409(0.86); C516(1.08); C41(0.85)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C891(1.01); C409(0.84); C516(0.84); C41(0.82)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C891(1.17); C409(0.95); C516(0.99); C41(0.87)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C891(1.37); C409(0.93); C516(0.89); C41(0.93)  LDD1278  [6]
 LDCM0400  CL13 PaTu 8988t C891(2.10); C763(2.36); C409(0.90); C516(1.09)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C891(2.15); C763(1.57); C409(0.85); C516(1.02)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C891(1.18); C763(1.32); C409(0.83); C516(1.04)  LDD1281  [6]
 LDCM0403  CL16 HCT 116 C194(0.91)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C194(1.03)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C194(0.92)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C194(1.04)  LDD0723  [6]
 LDCM0407  CL2 PaTu 8988t C891(0.99); C763(1.11); C409(0.77); C516(0.86)  LDD1286  [6]
 LDCM0408  CL20 HCT 116 C194(1.07)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C194(1.18)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C194(1.50)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C194(1.05)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C194(1.15)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C194(0.98)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C194(0.99)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C194(1.16)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C194(1.01)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C194(1.16)  LDD0734  [6]
 LDCM0418  CL3 PaTu 8988t C891(1.26); C763(1.32); C409(0.84); C516(0.91)  LDD1297  [6]
 LDCM0419  CL30 HCT 116 C194(0.99)  LDD0736  [6]
 LDCM0420  CL31 PaTu 8988t C177(0.86); C409(0.97); C41(0.71); C194(0.70)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C177(0.88); C409(1.07); C41(0.72); C194(0.69)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C177(0.79); C409(0.99); C41(0.88); C194(0.68)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C177(0.78); C409(0.97); C41(0.71); C194(0.58)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C177(0.77); C409(0.96); C41(0.84); C194(0.64)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C177(0.25); C409(0.68); C41(0.75); C194(0.21)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C177(0.85); C409(1.13); C41(0.85); C194(0.66)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C177(0.80); C409(0.98); C41(0.73); C194(0.69)  LDD1307  [6]
 LDCM0429  CL4 PaTu 8988t C891(1.13); C763(0.99); C409(1.05); C516(1.02)  LDD1308  [6]
 LDCM0430  CL40 PaTu 8988t C177(0.88); C409(1.04); C41(0.95); C194(0.73)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C177(0.88); C409(1.08); C41(0.74); C194(0.69)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C177(0.82); C409(1.05); C41(0.83); C194(0.72)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C177(0.78); C409(1.22); C41(1.12); C194(0.69)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C177(0.82); C409(1.12); C41(0.74); C194(0.70)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C177(0.89); C409(1.02); C41(0.82); C194(0.66)  LDD1314  [6]
 LDCM0436  CL46 HCT 116 C409(0.96)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C409(0.88)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C409(0.89)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C409(1.31)  LDD0756  [6]
 LDCM0440  CL5 PaTu 8988t C891(1.79); C763(1.28); C409(0.93); C516(0.86)  LDD1319  [6]
 LDCM0441  CL50 HCT 116 C409(0.85)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C409(0.82)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C409(0.98)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C409(0.76)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C409(1.05)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C409(1.03)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C409(0.72)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C409(0.57)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C409(0.85)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C409(1.00)  LDD0767  [6]
 LDCM0451  CL6 PaTu 8988t C891(1.47); C763(1.31); C409(0.98); C516(1.05)  LDD1330  [6]
 LDCM0452  CL60 HCT 116 C409(0.84)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C409(1.23)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C409(0.88)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C409(1.05)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C409(1.04)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C409(1.14)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C409(1.14)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C409(1.08)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C409(1.25)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C409(1.08)  LDD0778  [6]
 LDCM0462  CL7 PaTu 8988t C891(1.78); C763(1.56); C409(0.96); C516(0.94)  LDD1341  [6]
 LDCM0463  CL70 HCT 116 C409(1.01)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C409(1.10)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C409(1.01)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C409(1.21)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C409(1.15)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C194(0.96)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C194(0.84)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C194(0.89)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C194(1.11)  LDD0789  [6]
 LDCM0473  CL8 PaTu 8988t C891(1.19); C763(1.22); C409(1.00); C516(0.79)  LDD1352  [6]
 LDCM0474  CL80 HCT 116 C194(1.04)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C194(1.08)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C194(1.22)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C194(0.90)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C194(1.14)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C194(1.01)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C194(1.03)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C194(1.15)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C194(1.10)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C194(1.03)  LDD0800  [6]
 LDCM0484  CL9 PaTu 8988t C891(1.42); C763(1.29); C409(0.80); C516(0.95)  LDD1363  [6]
 LDCM0485  CL90 HCT 116 C194(0.77)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C194(1.19); C409(0.96)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C194(1.09); C409(0.88)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C194(1.19); C409(0.83)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C194(1.05); C409(0.85)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C194(1.25); C409(0.89)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C194(1.07); C409(0.89)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C194(1.18); C409(0.87)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C194(1.04); C409(0.90)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C194(1.05); C409(0.85)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C177(1.03); C516(1.03); C194(0.96); C891(0.88)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C516(2.59); C891(1.13)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C409(1.04)  LDD0785  [6]
 LDCM0427  Fragment51 PaTu 8988t C177(0.86); C409(1.09); C41(0.88); C194(0.64)  LDD1306  [6]
 LDCM0116  HHS-0101 DM93 Y322(0.93)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y322(0.81)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y322(0.72)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y322(0.63)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y322(1.28)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HCT 116 C891(1.64)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C891(1.09)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C891(1.12)  LDD0082  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C516(0.96)  LDD2102  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C516(0.46)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C516(1.01)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C516(0.96)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C516(0.86)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C516(0.93)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C516(0.52)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C516(0.65)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C516(0.79)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C516(0.94)  LDD2101  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C516(1.11)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C516(0.80)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C516(0.69); C194(0.68)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C516(0.83)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C516(0.46)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C516(0.62)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C516(0.71)  LDD2118  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C516(0.83)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C516(0.61)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C516(0.73); C194(0.99)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C516(0.58)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C516(0.61); C409(0.96)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C516(0.94)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C516(0.99)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C516(0.96)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C516(0.76)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C516(0.58)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C516(0.54)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C516(0.91)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C516(1.22)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C516(1.00); C194(0.97); C41(2.28); C409(1.02)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C516(1.17)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C516(0.51)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C516(1.08)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C516(3.31)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C516(0.75)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C516(2.82)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C516(0.53)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C516(0.31)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C516(0.56)  LDD2151  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C516(1.42)  LDD2153  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Nucleophosmin (NPM1) Nucleoplasmin family P06748
Four and a half LIM domains protein 2 (FHL2) . Q14192

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402