Details of the Target

General Information of Target

Target ID LDTP11545
Target Name Ubiquitin-like protein 5 (UBL5)
Gene Name UBL5
Gene ID 59286
Synonyms
Ubiquitin-like protein 5
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV
EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQ
QGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPV
SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLL
ATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEA
KQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPT
GNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASF
DSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSY
RGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins. Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair pathway by interacting with FANCI component and subsequently mediating the formation of FANCI homodimers. Plays also a protective role against ER stress-induced apoptosis.
Uniprot ID
Q9BZL1
Ensemble ID
ENST00000358666.7
HGNC ID
HGNC:13736

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K29(1.96)  LDD0277  [1]
IPM
 Probe Info  		C18(0.00); C6(0.00)  LDD0241  [2]
BTD
 Probe Info  		C18(1.36)  LDD1700  [3]
DBIA
 Probe Info  		C18(1.39)  LDD0613  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C18(0.00); C6(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		C18(0.00); C6(0.00)  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
NPM
 Probe Info  		N.A.  LDD0016  [8]
PF-06672131
 Probe Info  		N.A.  LDD0152  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
W1
 Probe Info  		N.A.  LDD0236  [2]
NAIA_5
 Probe Info  		C18(0.00); C6(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C18(0.42)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C18(0.93)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C18(0.53)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C18(0.97)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C18(0.90)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C18(1.28)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C18(1.08)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C18(0.31)  LDD2132  [3]
 LDCM0214  AC1 HEK-293T C18(0.85); C6(1.08)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C18(0.96); C6(0.97)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C18(1.01); C6(1.00)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C18(1.22); C6(0.98)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C18(1.04); C6(1.03)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C18(1.11); C6(0.97)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C18(0.96); C6(0.96)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C18(1.00); C6(0.99)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C18(0.97); C6(0.94)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C18(0.82); C6(0.86)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C18(1.04); C6(1.10)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C18(1.10); C6(0.93)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C18(1.05); C6(1.08)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C18(0.99); C6(0.96)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C18(0.99); C6(0.99)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C18(0.93); C6(0.90)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C18(1.00); C6(0.94)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C18(1.02); C6(0.98)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C18(1.09); C6(1.00)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C18(1.07); C6(1.04)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C18(0.92); C6(1.02)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C18(1.13); C6(1.17)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C18(1.04); C6(0.91)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C18(1.04); C6(0.94)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C18(0.99); C6(0.92)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C18(0.94); C6(0.98)  LDD1534  [12]
 LDCM0296  AC35 HCT 116 C18(1.39)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C18(1.44)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C18(1.22)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C18(1.48)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C18(1.04)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C18(1.01); C6(1.00)  LDD1540  [12]
 LDCM0302  AC40 HCT 116 C18(0.91)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C18(1.13)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C18(1.26)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C18(1.34)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C18(0.96)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C18(0.75)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C18(0.99)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C18(0.82)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C18(1.18)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C18(0.26)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C18(1.03); C6(1.05)  LDD1551  [12]
 LDCM0313  AC50 HCT 116 C18(0.34)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C18(2.93)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C18(0.79)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C18(0.50)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C18(0.62)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C18(0.36)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C18(0.17)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C18(0.90); C6(0.91)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C18(0.95); C6(0.97)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C18(0.92); C6(0.99)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C18(1.03); C6(1.01)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C18(0.91); C6(0.92)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C18(0.98); C6(0.92)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C18(0.95); C6(0.96)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C18(1.01); C6(0.99)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C18(1.06); C6(1.04)  LDD1567  [12]
 LDCM0332  AC68 HCT 116 C18(1.02)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C18(0.78)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C18(1.01); C6(0.96)  LDD1568  [12]
 LDCM0335  AC70 HCT 116 C18(0.50)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C18(1.21)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C18(0.82)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C18(0.30)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C18(0.36)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C18(0.23)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C18(0.77)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C18(0.60)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C18(1.17)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C18(0.87)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C18(0.99); C6(1.03)  LDD1569  [12]
 LDCM0346  AC80 HCT 116 C18(0.66)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C18(0.74)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C18(0.17)  LDD0665  [4]
 LDCM0545  Acetamide MDA-MB-231 C18(0.51)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C18(0.83)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C18(1.02); C6(1.06)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C18(0.96); C6(1.00)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C18(1.04); C6(1.04)  LDD1514  [12]
 LDCM0498  BS-3668 MDA-MB-231 C18(0.46)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C18(0.94); C6(0.91)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C18(1.07); C6(0.93)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C18(0.97); C6(0.87)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C18(1.18); C6(1.03)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C18(1.05); C6(0.90)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C18(1.04); C6(0.91)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C18(1.00); C6(0.95)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C18(1.14); C6(1.03)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C18(1.16); C6(1.00)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C18(1.12); C6(0.90)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C18(1.07); C6(0.91)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C18(1.05); C6(0.86)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C18(1.09); C6(0.98)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C18(1.07); C6(0.92)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C18(1.04); C6(0.92)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C18(1.04); C6(0.93)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C18(1.19); C6(0.98)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C18(1.04); C6(0.95)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C18(0.83); C6(1.02)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C18(0.97); C6(0.98)  LDD1590  [12]
 LDCM0387  CL117 HCT 116 C18(0.36)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C18(1.32)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C18(1.01)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C18(1.14); C6(1.02)  LDD1594  [12]
 LDCM0391  CL120 HCT 116 C18(1.50)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C18(0.95)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C18(0.72)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C18(0.60)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C18(0.41)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C18(0.96); C6(0.97)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C18(1.11); C6(1.06)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C18(0.99); C6(0.98)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C18(0.99); C6(0.94)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C18(0.90); C6(1.01)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C18(1.14); C6(1.01)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C18(0.79); C6(0.85)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C18(1.24); C6(0.97)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C18(0.95); C6(0.90)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C18(1.07); C6(0.92)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C18(1.11); C6(0.98)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C18(1.11); C6(0.96)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C18(1.37); C6(1.06)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C18(1.11); C6(0.98)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C18(1.23); C6(1.06)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C18(1.13); C6(1.10)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C18(1.29); C6(1.09)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C18(1.02); C6(0.93)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C18(1.19); C6(1.05)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C18(1.12); C6(0.95)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C18(1.05); C6(0.89)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C18(1.07); C6(0.93)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C18(1.04); C6(0.90)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C18(1.19); C6(0.96)  LDD1623  [12]
 LDCM0420  CL31 HCT 116 C18(0.85)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C18(0.85)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C18(0.72)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C18(0.38)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C18(0.44)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C18(0.50)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C18(0.47)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C18(0.47)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C18(1.02); C6(1.01)  LDD1633  [12]
 LDCM0430  CL40 HCT 116 C18(0.64)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C18(0.77)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C18(0.21)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C18(0.33)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C18(0.79)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C18(0.52)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C18(1.43); C6(1.14)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C18(1.03); C6(1.05)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C18(1.47); C6(0.99)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C18(1.09); C6(1.18)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C18(0.96); C6(0.98)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C18(1.21); C6(0.98)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C18(1.16); C6(1.05)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C18(1.06); C6(0.90)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C18(1.15); C6(0.83)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C18(1.14); C6(1.12)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C18(1.19); C6(1.07)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C18(1.28); C6(1.14)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C18(1.46); C6(1.09)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C18(1.18); C6(1.10)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C18(0.86); C6(0.88)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C18(1.42); C6(1.00)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C18(0.98); C6(0.99)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C18(1.14); C6(0.98)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C18(1.08); C6(0.96)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C18(1.05); C6(1.05)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C18(0.99); C6(1.05)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C18(1.02); C6(0.96)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C18(1.10); C6(1.09)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C18(1.14); C6(1.09)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C18(1.31); C6(1.19)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C18(0.94); C6(1.04)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C18(1.23); C6(1.08)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C18(1.14); C6(0.96)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C18(1.26); C6(1.11)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C18(1.01); C6(1.01)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C18(1.09); C6(0.92)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C18(1.12); C6(1.02)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C18(0.94); C6(0.96)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C18(1.01); C6(1.00)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C18(1.16); C6(1.14)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C18(1.02); C6(0.79)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C18(1.36); C6(1.07)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C18(1.35); C6(1.12)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C18(1.33); C6(1.06)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C18(1.11); C6(1.16)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C18(1.22); C6(1.14)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C18(0.93); C6(0.99)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C18(0.89); C6(1.06)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C18(1.07); C6(1.02)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C18(1.01); C6(0.83)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C18(0.96); C6(1.01)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C18(1.22); C6(1.10)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C18(0.89); C6(0.83)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C18(1.03); C6(1.02)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C18(1.20); C6(0.94)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C18(1.14); C6(1.06)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C18(1.18); C6(1.11)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C18(0.98); C6(0.83)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C18(1.01); C6(1.12)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C18(1.06); C6(0.97)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C18(1.13); C6(1.02)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C18(1.19); C6(0.90)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C18(0.96); C6(0.99)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C18(1.67)  LDD1702  [3]
 LDCM0625  F8 Ramos C6(0.96); C18(0.93)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C6(0.52); C18(0.59)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C6(1.18); C18(0.52)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C6(0.72); C18(0.61)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C6(0.88); C18(0.73)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C6(1.17); C18(1.32)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C6(0.55); C18(0.57)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C6(0.90); C18(0.67)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C6(0.27); C18(0.21)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C6(0.87); C18(0.66)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C6(0.80); C18(0.71)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C6(0.90); C18(0.85)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C6(0.92); C18(0.77)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C6(0.55); C18(0.53)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C18(0.99); C6(0.97)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C6(0.91); C18(0.62)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C6(0.82); C18(0.81)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C18(0.29)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C6(1.00); C18(0.72)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C6(0.96); C18(0.91)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C6(0.73); C18(0.75)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C6(0.55); C18(0.46)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C18(0.76); C6(0.97)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C18(1.06); C6(0.98)  LDD1497  [12]
 LDCM0024  KB05 MEL167 C6(2.37)  LDD3316  [14]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C18(1.04)  LDD2102  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C18(0.58)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C18(0.99)  LDD2089  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C18(1.20)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C18(0.74)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C18(3.24)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C18(0.32)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C18(0.77)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C18(1.08)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C18(0.99)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C18(0.90)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C18(0.60)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C18(2.77)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C18(0.94)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C18(0.38)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C18(0.75)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C18(0.80)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C18(0.64)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C18(0.51)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C18(0.70)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C18(0.74)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C18(2.49)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C18(0.90)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C18(0.60)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C18(0.40)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C18(0.86)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C18(0.42)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C18(1.08)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C18(0.69)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C18(0.97)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C18(0.69); C6(1.15)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C18(0.55)  LDD2134  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C18(0.88)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C18(0.96)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C18(1.36)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C18(0.72)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C18(0.44)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C18(0.95)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C18(3.10)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C18(2.19)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C18(0.87)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C18(3.38)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C18(0.75)  LDD2148  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C18(0.82)  LDD2149  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C18(0.29)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C18(0.54)  LDD2151  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C18(0.80)  LDD2206  [15]
 LDCM0131  RA190 MM1.R C6(1.13)  LDD0304  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 8 (PRMT8) Protein arginine N-methyltransferase family Q9NR22
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Phosphatase and actin regulator 3 (PHACTR3) Phosphatase and actin regulator family Q96KR7
Nuclear receptor-interacting protein 3 (NRIP3) . Q9NQ35
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox expressed in ES cells 1 (HESX1) ANF homeobox family Q9UBX0
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 41 homolog (ZFP41) Krueppel C2H2-type zinc-finger protein family Q8N8Y5
Zinc finger protein 618 (ZNF618) Krueppel C2H2-type zinc-finger protein family Q5T7W0
HMG domain-containing protein 4 (HMGXB4) . Q9UGU5
THAP domain-containing protein 3 (THAP3) . Q8WTV1
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Protein HID1 (HID1) Hid-1 family Q8IV36
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Proteasome activator complex subunit 2 (PSME2) PA28 family Q9UL46
PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) PINX1 family Q96BK5
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
U4/U6.U5 tri-snRNP-associated protein 1 (SART1) SNU66/SART1 family O43290
Sperm protein associated with the nucleus on the X chromosome B1 (SPANXB1) SPAN-X family Q9NS25
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Bridging integrator 3 (BIN3) . Q9NQY0
Germinal center-associated signaling and motility-like protein (GCSAML) . Q5JQS6
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.