General Information of Target

Target ID LDTP10832
Target Name RNA-binding protein 15 (RBM15)
Gene Name RBM15
Gene ID 64783
Synonyms
OTT; OTT1; RNA-binding protein 15; One-twenty two protein 1; RNA-binding motif protein 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGN
GEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKL
ALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQ
DDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEE
TPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLP
ENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSS
HEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQ
EEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNI
ITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS
LDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDA
QRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQS
VKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASE
NTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPR
ISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPK
GKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLP
NHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKK
KERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCIS
YRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRA
AAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSD
TDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFV
ETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSED
DELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQ
PARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAI
ENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQ
L
Target Bioclass
Other
Family
RRM Spen family
Subcellular location
Nucleus speckle
Function
RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation. Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation. Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen. Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL. May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.
Uniprot ID
Q96T37
Ensemble ID
ENST00000369784.9
HGNC ID
HGNC:14959

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.A759V .
HCT116 SNV: p.R122H DBIA    Probe Info 
HT115 SNV: p.D626N .
J82 SNV: p.Y608Ter .
JURKAT SNV: p.R661H .
MCC13 SNV: p.P736L DBIA    Probe Info 
MDAMB453 SNV: p.R520Q .
MFE319 Deletion: p.P284LfsTer98 DBIA    Probe Info 
MKN1 SNV: p.E187D DBIA    Probe Info 
NB4 Deletion: p.R30_T32del .
NCIH1793 SNV: p.S765Y DBIA    Probe Info 
PF382 Deletion: p.E746del DBIA    Probe Info 
REH SNV: p.V220A DBIA    Probe Info 
TF1 SNV: p.S708G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
14.70  LDD0402  [1]
STPyne
 Probe Info 
K450(10.00)  LDD0277  [2]
Probe 1
 Probe Info 
Y336(11.66); Y416(7.40); Y608(7.88)  LDD3495  [3]
DBIA
 Probe Info 
C926(1.82)  LDD0080  [4]
ATP probe
 Probe Info 
N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info 
N.A.  LDD0038  [6]
IA-alkyne
 Probe Info 
N.A.  LDD0165  [7]
Lodoacetamide azide
 Probe Info 
N.A.  LDD0037  [6]
NAIA_4
 Probe Info 
N.A.  LDD2226  [8]
1d-yne
 Probe Info 
N.A.  LDD0356  [9]
IPM
 Probe Info 
C926(0.00); C667(0.00)  LDD0005  [10]
SF
 Probe Info 
Y416(0.00); Y336(0.00); Y302(0.00); Y894(0.00)  LDD0028  [11]
VSF
 Probe Info 
N.A.  LDD0007  [10]
Acrolein
 Probe Info 
N.A.  LDD0217  [12]
W1
 Probe Info 
N.A.  LDD0236  [13]
NAIA_5
 Probe Info 
N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C296
 Probe Info 
11.71  LDD1966  [14]
FFF probe11
 Probe Info 
20.00  LDD0472  [15]
FFF probe13
 Probe Info 
13.61  LDD0475  [15]
FFF probe2
 Probe Info 
20.00  LDD0463  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C926(0.89)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C926(1.15)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C926(0.74)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C926(0.85)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C926(0.70)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C926(1.25)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C926(0.73)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C926(0.63)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C926(1.01)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C926(1.18)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C926(0.57)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C926(0.70)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C926(1.40)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C926(1.06)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C926(1.00)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C926(0.77)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C926(0.96)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C926(0.94)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C926(1.09)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C926(1.05)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C926(1.09)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C926(1.08)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C926(0.99)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C926(1.15)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C926(1.08)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C926(0.96)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C926(0.83)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C926(1.08)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C926(0.75)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C926(1.01)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C926(1.01)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C926(1.40)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C926(1.05)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C926(0.73)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C926(0.91)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C926(0.80)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C926(0.97)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C926(0.96)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C926(1.10)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C926(1.22)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C926(1.34)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C926(1.32)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C926(1.09)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C926(1.03)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C926(1.14)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C926(1.22)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C926(1.11)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C926(0.75)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C926(1.00)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C926(0.98)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C926(1.00)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C926(1.21)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C926(0.96)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C926(1.24)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C926(1.25)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C926(1.21)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C926(1.10)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C926(1.24)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C926(1.13)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C926(1.33)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C926(1.13)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C926(1.10)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C926(1.27)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C926(1.12)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C926(1.05)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C926(1.07)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C926(0.93)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C926(1.08)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C926(0.98)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C926(1.04)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C926(0.92)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C926(0.96)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C926(1.05)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C926(1.21)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C926(1.37)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C926(1.37)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C926(1.37)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C926(1.06)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C926(0.99)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C926(1.43)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C926(1.40)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C926(1.43)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C926(1.10)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C926(1.49)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C926(1.10)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C926(1.00)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C926(0.81)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C926(1.11)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C926(1.18)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C926(1.05)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C926(1.22)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C926(1.13)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C926(1.27)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C926(1.06)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C926(1.19)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C926(1.24)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C926(0.74)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C926(0.77)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C926(0.87)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C926(1.03)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C926(1.02)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C926(0.99)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C926(0.74)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C926(0.78)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C926(0.85)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C926(0.87)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C926(0.90)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C926(1.20)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C926(1.85)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C926(1.56)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C926(1.66)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C926(1.21)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C926(1.94)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C926(1.84)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C926(2.84)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C926(1.80)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C926(1.97)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C926(1.39)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C926(1.39)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C926(1.71)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C926(1.16)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C926(1.29)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C926(1.23)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C926(1.26)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C926(1.32)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C926(1.20)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C926(1.70)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C926(1.36)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C926(1.40)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C926(1.32)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C926(1.61)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C926(1.11)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C926(1.02)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C926(1.07)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C926(1.31)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C926(1.26)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C926(1.52)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C926(0.76)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C926(0.88)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C926(0.70)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C926(0.90)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C926(0.71)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C926(1.01)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C926(0.77)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C926(0.76)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C926(0.84)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C926(0.76)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C926(0.97)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C926(0.62)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C926(0.83)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C926(0.80)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C926(0.73)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C926(0.86)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C926(0.97)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C926(1.15)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C926(1.30)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C926(1.41)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.91  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C926(0.72)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C926(0.95)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C926(0.89)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C926(1.05)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C926(1.37)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C926(1.14)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C926(1.27)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C926(1.04)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C926(1.06)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C926(1.05)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C926(0.97)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C926(1.12)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C926(0.99)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C926(0.90)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C926(0.96)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C926(0.96)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C926(1.17)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C926(1.19)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C926(1.03)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C926(1.05)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C926(1.43)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C926(1.63)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C926(1.19)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C926(1.06)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C926(0.95)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C926(1.02)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C926(0.80)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C926(0.91)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C926(0.88)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C926(0.91)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C926(1.28)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C926(0.87)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C926(1.14)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C926(1.44)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C926(0.90)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C926(0.92)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C926(0.88)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C926(0.93)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C926(0.87)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C926(0.99)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C926(1.07)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C926(1.08)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C926(1.08)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C926(1.00)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C926(1.31)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C926(1.23)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C926(1.07)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C926(1.13)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C926(1.10)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C926(1.10)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C926(1.16)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C926(1.09)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C926(0.86)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C926(1.02)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C926(0.96)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C926(1.06)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C926(0.96)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C926(1.10)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C926(0.98)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C926(1.11)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C926(1.09)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C926(1.09)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C926(1.00)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C926(1.07)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C926(1.10)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C926(1.02)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C926(1.17)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C926(1.00)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C926(0.94)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C926(0.85)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C926(0.89)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C926(0.87)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C926(0.93)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C926(0.93)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C926(0.92)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C926(0.97)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C926(0.84)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C926(0.87)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C926(0.86)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C926(0.85)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C926(0.90)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C926(0.95)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C926(0.87)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C926(0.94)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C926(1.04)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C926(0.88)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C926(1.07)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C926(1.17)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C926(1.12)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C926(1.29)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C926(1.08)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C926(1.37)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C926(1.36)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C926(1.10)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C926(1.00)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C926(0.94)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C926(1.10)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C926(1.19)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C926(1.10)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C926(1.17)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C926(1.24)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C926(1.00)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C926(1.43)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C926(1.23)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C926(1.45)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C926(1.29)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C926(1.42)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C926(1.06)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C926(1.48)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C926(1.30)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C926(1.33)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C926(1.20)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C926(1.20)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C926(1.06)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C926(1.42)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C926(1.46)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C926(1.01)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C926(1.33)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C926(1.07)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C926(0.99)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C926(0.87)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C926(1.05)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C926(1.31)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C926(1.07)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C926(1.16)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C926(0.96)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C926(1.23)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C667(0.88); C926(1.12); C785(0.95)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C667(1.00)  LDD1702  [17]
 LDCM0625  F8 Ramos C667(2.76); C926(1.06)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C667(1.55)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C667(0.38); C926(5.96)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C667(1.02)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C667(2.19); C926(0.30)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C667(0.94); C926(1.05)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C667(1.13); C926(0.93)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C667(1.02)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C667(1.41); C926(1.08)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C667(1.26); C926(0.52)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C667(0.63)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C667(2.13); C926(0.51)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C667(1.11); C926(1.37)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C667(1.72)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C926(1.14)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C667(2.36); C926(0.41)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C667(1.01); C926(0.77)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C926(1.22)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C667(1.24)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C667(1.59); C926(0.63)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C667(0.99); C926(1.08)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C667(1.18)  LDD2188  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C926(1.82)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C926(4.64)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C926(1.27)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX17 (DDX17) DEAD box helicase family Q92841
Neuron navigator 2 (NAV2) Nav/unc-53 family Q8IVL1
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Testis-specific Y-encoded-like protein 2 (TSPYL2) Nucleosome assembly protein (NAP) family Q9H2G4
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578