Details of the Target

General Information of Target

Target ID LDTP10503
Target Name N-terminal kinase-like protein (SCYL1)
Gene Name SCYL1
Gene ID 57410
Synonyms
CVAK90; GKLP; NTKL; TAPK; TEIF; TRAP; N-terminal kinase-like protein; Coated vesicle-associated kinase of 90 kDa; SCY1-like protein 1; Telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; Teratoma-associated tyrosine kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSC
TDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIA
PNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCED
RCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPC
QNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSP
GYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLY
GIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD
CDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGV
DCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAE
RCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGIC
ECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVC
PSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHN
GAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGF
MGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLN
SLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMR
VVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFV
NLKNVNPGKRGPVGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSN
CSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPT
VSVVQGVFSNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE
Target Bioclass
Enzyme
Family
Protein kinase superfamily
Subcellular location
Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.; Isoform 6 acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
Uniprot ID
Q96KG9
Ensemble ID
ENST00000270176.10
HGNC ID
HGNC:14372

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.G756V DBIA    Probe Info 
CCSW1 SNV: p.A775V DBIA    Probe Info 
G415 SNV: p.E55K DBIA    Probe Info 
HCT116 SNV: p.G194D DBIA    Probe Info 
HT115 SNV: p.K292Q .
JHH6 SNV: p.D758Y DBIA    Probe Info 
JHH7 SNV: p.E55K .
LNCaP clone FGC SNV: p.F68I; p.L131M DBIA    Probe Info 
MCC26 SNV: p.L398M DBIA    Probe Info 
MFE319 SNV: p.W727Ter DBIA    Probe Info 
REH SNV: p.Q183Ter DBIA    Probe Info 
SKN SNV: p.K234E DBIA    Probe Info 
YSCCC SNV: p.D758Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
STPyne
 Probe Info  		K339(6.25); K349(6.25); K356(3.15); K410(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y184(27.79); Y346(8.43); Y458(34.64)  LDD3495  [3]
BTD
 Probe Info  		C261(0.81); C241(1.35)  LDD2090  [4]
AHL-Pu-1
 Probe Info  		C241(2.63)  LDD0169  [5]
DBIA
 Probe Info  		C241(1.04); C88(0.89); C309(0.86)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C88(0.00); C512(0.00); C210(0.00); C241(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C88(0.00); C512(0.00); C210(0.00); C309(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C210(0.00); C241(0.00); C512(0.00)  LDD2226  [9]
TFBX
 Probe Info  		C512(0.00); C241(0.00); C446(0.00); C309(0.00)  LDD0027  [10]
Compound 10
 Probe Info  		C241(0.00); C88(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		C309(0.00); C241(0.00); C261(0.00)  LDD0147  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
Acrolein
 Probe Info  		C241(0.00); C309(0.00); C512(0.00)  LDD0217  [13]
Methacrolein
 Probe Info  		C241(0.00); C512(0.00); C309(0.00)  LDD0218  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		7.80  LDD0443  [15]
NAIA_5
 Probe Info  		C503(0.00); C88(0.00); C512(0.00); C210(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C241(1.08)  LDD2103  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C241(2.63)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C241(0.85); C309(0.97); C446(1.02); C451(0.99)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C309(1.10); C446(1.08); C451(1.00); C88(0.84)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C241(0.81); C309(0.77); C446(1.13); C451(1.13)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C241(0.79); C309(0.83); C446(0.85); C451(0.85)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C241(0.84); C309(0.91); C446(0.79); C451(0.79)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C241(0.73); C309(0.81); C446(0.92); C451(0.92)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C241(0.88); C309(0.80); C446(0.80); C451(0.80)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C241(0.72); C309(0.78); C446(0.85); C451(0.85)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C241(0.70); C309(0.83); C446(0.85); C451(0.85)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C241(0.99); C309(0.90); C446(0.94); C451(0.94)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C241(0.77); C309(1.10); C446(0.85); C451(0.85)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C241(0.72); C309(1.10); C446(0.87); C451(0.87)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C309(0.95); C446(0.97); C451(0.98); C88(0.91)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C241(0.70); C309(1.10); C446(0.88); C451(0.88)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C241(0.74); C309(1.02); C446(0.83); C451(0.83)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C241(0.83); C309(0.90); C446(0.84); C451(0.84)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C241(0.90); C309(0.95); C446(0.81); C451(0.81)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C241(0.86); C309(1.01); C446(1.06); C451(1.01)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C241(0.85); C309(0.93); C446(1.12); C451(1.09)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C241(0.73); C309(0.94); C446(0.93); C451(0.93)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C241(0.87); C309(0.90); C446(0.93); C451(0.90)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C241(0.88); C309(1.00); C446(1.01); C451(0.93)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C241(0.83); C309(0.98); C446(0.89); C451(0.87)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C309(0.99); C446(1.07); C451(1.03); C88(1.07)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C241(1.06); C309(0.96); C446(0.94); C451(0.92)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C241(0.83); C309(0.95); C446(0.94); C451(0.87)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C241(0.93); C309(1.01); C446(1.10); C451(1.02)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C241(0.97); C309(0.97); C446(0.79); C451(0.76)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C241(0.97); C309(0.97); C446(1.01); C451(0.99)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C241(0.84); C309(1.04); C446(1.02); C451(1.03)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C241(0.91); C309(1.03); C446(1.04); C451(0.99)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C241(0.85); C309(1.03); C446(0.98); C451(0.87)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C241(0.83); C309(1.28); C446(1.41); C451(1.41)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C241(0.76); C309(1.05); C446(1.19); C451(1.19)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C241(0.82); C309(1.29); C446(1.33); C451(1.33)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C241(0.94); C309(1.20); C446(1.27); C451(1.27)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C241(0.97); C309(1.11); C446(1.13); C451(1.13)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C241(0.87); C309(1.29); C446(1.11); C451(1.11)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C241(0.88); C309(1.26); C446(1.65); C451(1.65)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C241(0.90); C309(1.12); C446(1.51); C451(1.51)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C241(1.00); C309(1.49); C446(1.03); C451(1.03)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C241(0.96); C309(1.28); C446(1.24); C451(1.24)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C241(1.09); C309(1.36); C446(1.38); C451(1.38)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C241(1.11); C309(1.31); C446(1.11); C451(1.11)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C309(0.97); C446(0.87); C451(0.87); C88(1.08)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C241(1.06); C309(1.27); C446(1.31); C451(1.31)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C241(0.93); C309(1.38); C446(1.50); C451(1.50)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C241(0.93); C309(1.25); C446(1.56); C451(1.56)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C241(0.91); C446(0.92); C451(0.92); C309(0.92)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C451(1.13); C241(1.15); C446(1.24); C309(1.32)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C309(1.10); C241(1.11); C446(1.27); C451(1.47)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C309(0.85); C451(1.15); C446(1.18); C241(1.21)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C241(1.16); C446(1.30); C309(1.62); C451(1.63)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C451(1.21); C309(1.27); C446(1.33); C241(1.52)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C309(1.00); C451(1.12); C446(1.32); C241(1.43)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C451(0.91); C446(0.93); C309(1.02); C88(1.06)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C451(0.90); C446(1.00); C309(1.12); C241(1.14)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C451(0.96); C309(0.99); C446(1.11); C241(1.26)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C309(1.01); C451(1.05); C446(1.21); C241(1.29)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C309(1.12); C241(1.60); C451(1.77); C446(1.83)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C241(1.37); C309(0.95); C446(1.26); C451(1.06)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C241(1.39); C309(1.22); C446(1.10); C451(0.85)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C241(1.37); C309(0.88); C446(1.20); C451(1.00)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C241(1.37); C309(0.91); C446(1.40); C451(1.25)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C512(0.84); C446(0.93); C451(0.93); C309(0.94)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C512(0.84); C241(0.99); C446(1.00); C451(1.00)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C241(0.81); C309(0.85); C512(0.91); C446(0.97)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C241(0.81); C503(0.88); C451(0.90); C446(0.91)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C241(0.95); C446(0.98); C451(0.98); C512(0.98)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C512(0.83); C309(0.88); C88(0.97); C241(0.99)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C512(0.85); C309(0.89); C241(0.94); C446(0.96)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C512(0.73); C241(0.81); C309(0.99); C446(0.99)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C512(0.86); C241(0.86); C309(0.91); C446(0.92)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C241(0.82); C309(1.02); C446(1.12); C88(1.13)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C241(0.85); C309(1.03); C88(1.11); C446(1.13)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C241(0.95); C446(0.95); C309(1.01); C88(1.20)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C241(0.98); C446(1.01); C88(1.03); C309(1.04)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C241(0.85); C446(0.93); C309(1.03); C451(1.17)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C241(0.86); C446(0.90); C503(0.91); C451(0.91)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C241(0.97); C446(1.00); C309(1.04); C451(1.19)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C241(0.94); C309(0.99); C446(1.01); C88(1.12)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C241(0.94); C446(1.03); C309(1.10); C451(1.21)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C241(0.94); C446(1.00); C309(1.04); C451(1.07)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C309(1.02); C446(1.02); C88(1.02); C241(1.18)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C446(0.99); C451(1.03); C309(1.07); C241(1.09)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C446(0.95); C451(0.96); C309(1.01); C241(1.04)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C241(0.94); C446(0.98); C309(1.00); C451(1.04)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C446(0.91); C451(0.93); C309(0.95); C241(1.00)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C446(1.00); C451(1.06); C241(1.06); C309(1.10)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C241(0.93); C503(0.98); C446(0.98); C451(0.99)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C309(1.00); C241(1.04); C446(1.11); C451(1.18)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C241(0.94); C309(0.97); C446(1.00); C451(1.04)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C241(0.93); C309(0.98); C446(0.99); C451(1.03)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C241(0.88); C309(1.00); C446(1.06); C451(1.07)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C241(0.92); C309(1.05); C451(1.05); C446(1.06)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C241(0.87); C446(1.07); C451(1.08); C309(1.11)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C309(0.97); C241(1.05); C446(1.12); C451(1.12)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C241(0.81); C309(0.98); C88(1.09); C446(1.10)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C241(0.86); C309(1.07); C446(1.11); C451(1.11)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C241(1.12); C446(1.18); C451(1.18); C309(1.22)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C503(0.91); C309(0.95); C241(0.96); C446(0.98)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C241(0.90); C309(1.05); C446(1.23); C451(1.23)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C241(1.00); C309(1.14); C446(1.16); C451(1.16)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C241(0.92); C309(1.00); C88(1.12); C446(1.13)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C241(0.83); C309(1.02); C446(1.06); C451(1.06)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C446(1.04); C451(1.04); C241(1.05); C309(1.07)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C241(0.90); C309(1.17); C446(1.22); C451(1.22)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C241(1.08); C309(1.30); C446(1.39); C451(1.39)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C88(0.93); C446(1.05); C309(1.05); C451(1.08)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C309(1.02); C451(1.05); C446(1.08); C88(1.12)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C88(0.98); C446(0.98); C451(1.00); C309(1.02)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C451(0.96); C309(1.03); C88(1.03); C446(1.08)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C88(0.92); C446(0.97); C309(1.01); C451(1.04)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C88(0.87); C309(1.02); C451(1.11); C446(1.22)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C88(0.90); C309(0.99); C451(1.14); C446(1.16)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C88(0.81); C309(0.99); C451(1.02); C446(1.09)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C88(1.02); C309(1.06); C446(1.09); C451(1.12)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C88(1.12); C309(1.15); C451(1.24); C446(1.29)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C88(0.98); C309(1.09); C451(1.16); C446(1.16)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C88(0.90); C309(1.19); C451(1.22); C446(1.30)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C241(0.85); C88(0.93); C309(0.98); C446(1.12)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C241(0.93); C88(1.06); C309(1.09); C512(1.22)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C309(0.98); C451(1.00); C446(1.08); C88(1.17)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C88(0.94); C241(0.96); C309(1.01); C512(1.13)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C241(0.84); C88(0.88); C309(1.03); C512(1.14)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C88(0.94); C241(0.97); C309(1.03); C512(1.12)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C88(0.88); C241(0.94); C309(1.24); C446(1.60)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C88(0.85); C241(0.92); C309(1.18); C446(1.36)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C241(0.82); C88(0.92); C309(1.30); C446(1.56)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C241(0.80); C88(0.87); C309(1.03); C512(1.22)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C88(0.92); C241(0.95); C309(1.04); C512(1.26)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C241(0.93); C512(1.01); C309(1.02); C446(1.10)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C88(0.96); C241(0.98); C309(1.05); C446(1.14)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C309(1.02); C451(1.03); C446(1.03); C88(1.06)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C88(0.87); C241(0.98); C309(1.04); C446(1.14)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C512(0.72); C241(0.81); C88(0.85); C446(0.97)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C241(0.91); C88(0.97); C309(1.31); C512(1.50)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C503(0.83); C309(1.09); C241(1.21); C446(1.50)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C503(0.81); C309(1.18); C241(1.27); C446(1.37)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C503(0.68); C446(0.97); C451(0.97); C309(1.07)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C503(0.87); C309(0.94); C241(0.94); C446(1.16)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C503(0.77); C241(1.02); C309(1.07); C446(1.19)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C309(1.01); C241(1.04); C446(1.07); C451(1.07)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C503(0.76); C241(0.94); C309(0.95); C446(1.27)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C503(0.77); C241(0.84); C309(1.13); C446(1.18)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C503(0.72); C241(1.07); C309(1.15); C446(1.28)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C503(0.65); C241(1.02); C309(1.05); C446(1.53)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C503(0.75); C241(1.02); C309(1.03); C446(1.13)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C503(0.72); C309(1.03); C446(1.05); C451(1.05)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C503(0.82); C241(0.90); C309(0.91); C446(0.92)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C503(0.63); C241(0.97); C309(0.98); C446(1.04)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C503(0.66); C309(1.04); C241(1.12); C446(1.19)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C512(0.71); C309(0.87); C446(0.93); C451(0.93)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C512(0.64); C241(0.85); C309(0.89); C446(0.96)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C261(0.82)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C309(1.04); C446(0.90); C451(0.91); C88(1.07)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C446(0.91); C451(0.91); C309(1.00); C88(1.07)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C451(1.08); C88(1.14); C446(1.16); C309(1.18)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C241(1.04); C88(0.89); C309(0.86)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C512(0.00); C309(0.00); C241(0.00)  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C88(20.00); C241(1.71); C512(1.65); C512(1.57)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C309(0.96); C512(1.03); C241(1.05); C446(1.07)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C241(0.88); C512(1.01); C446(1.01); C451(1.01)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C241(0.80); C503(0.90); C309(0.92); C446(0.96)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C451(0.90); C446(0.93); C309(0.94); C88(1.01)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C446(0.85); C451(0.90); C88(0.96); C309(1.07)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C446(0.90); C451(0.96); C88(1.02); C309(1.11)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C451(0.87); C446(0.96); C309(1.02); C88(1.21)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C512(0.86); C309(0.91); C241(0.95); C446(0.98)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C88(1.00); C512(1.01); C241(1.04); C309(1.05)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C512(0.97); C309(0.97); C241(0.98); C446(1.06)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C309(0.97); C512(1.01); C446(1.06); C451(1.06)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C512(0.83); C241(0.87); C309(0.90); C446(0.96)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C241(0.85); C446(1.11); C451(1.11); C512(1.14)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C512(0.86); C88(0.95); C309(0.95); C241(0.96)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C512(0.81); C309(0.93); C446(0.97); C451(0.97)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C88(0.89); C241(0.97); C446(1.06); C309(1.09)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C241(1.00); C446(1.02); C309(1.06); C88(1.09)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C88(0.97); C241(0.97); C446(1.01); C309(1.05)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C446(0.87); C241(0.93); C451(1.02); C309(1.07)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C241(0.94); C446(0.95); C309(1.08); C451(1.13)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C446(1.23); C241(1.23); C309(1.29); C451(1.30)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C309(0.92); C241(0.94); C446(0.96); C451(0.97)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C241(0.89); C309(0.98); C446(0.99); C451(1.05)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C241(0.88); C446(1.11); C451(1.11); C512(1.14)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C241(0.87); C309(1.08); C446(1.08); C451(1.13)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C309(0.85); C241(0.87); C446(1.29); C451(1.29)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C446(1.07); C451(1.07); C309(1.08); C241(1.16)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C241(0.99); C309(1.08); C446(1.26); C451(1.26)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C241(0.97); C309(1.12); C446(1.25); C451(1.25)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C446(0.90); C309(0.98); C451(0.98); C88(1.02)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C309(0.91); C446(0.92); C451(0.92); C88(0.95)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C451(0.93); C446(0.96); C88(0.97); C309(1.03)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C309(0.97); C451(1.03); C446(1.04); C88(1.07)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C446(0.90); C451(0.90); C309(1.00); C241(1.03)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C446(0.84); C451(0.84); C241(0.86); C512(0.97)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C446(0.88); C451(0.88); C241(0.89); C512(1.01)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C241(0.77); C309(0.89); C512(1.01); C446(1.01)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C446(0.77); C451(0.77); C512(0.83); C241(0.86)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C446(0.70); C451(0.70); C512(0.82); C88(0.87)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C446(0.79); C451(0.79); C309(0.90); C88(0.90)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C446(0.91); C451(0.91); C512(1.00); C241(1.03)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C88(0.87); C241(0.90); C512(0.90); C446(0.94)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C241(0.79); C446(0.93); C451(0.93); C309(0.95)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C241(1.03); C88(1.25); C309(1.26); C512(1.28)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C446(0.83); C451(0.83); C512(0.86); C88(0.93)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C241(0.79); C309(1.05); C446(1.13); C451(1.13)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C241(0.77); C309(1.05); C446(1.02); C451(1.02)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C241(0.84); C309(1.00); C446(0.99); C451(0.99)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C241(0.91); C309(1.03); C446(0.82); C451(0.82)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C241(0.82); C309(1.01); C446(0.89); C451(0.89)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C241(0.75); C309(0.96); C446(0.94); C451(0.94)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C241(1.19); C309(1.07); C446(0.92); C451(0.92)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C241(0.72); C309(0.94); C446(0.85); C451(0.85)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C241(1.01); C309(1.01); C446(1.01); C451(0.96)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C241(1.04); C309(0.84); C446(0.85); C451(0.86)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C241(1.00); C309(0.86); C446(0.94); C451(0.95)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C241(0.92); C309(0.98); C446(1.13); C451(1.20)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C241(1.25); C309(0.88); C446(1.10); C451(1.11)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C241(1.12); C309(0.95); C446(1.06); C451(1.02)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C241(1.12); C309(1.14); C446(1.15); C451(1.11)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C241(1.10); C309(1.10); C446(1.26); C451(1.26)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C241(0.95); C309(1.08); C446(0.82); C451(0.82)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C241(1.18); C309(0.90); C446(1.16); C451(1.09)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C241(1.19); C309(0.82); C446(1.03); C451(1.01)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C241(1.42); C309(1.16); C446(1.25); C451(1.19)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C241(1.20); C309(1.01); C446(1.14); C451(1.12)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C241(1.04); C309(0.95); C446(1.03); C451(1.04)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C241(1.08); C309(1.01); C446(1.04); C451(1.08)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C241(0.80); C309(1.01); C446(1.08); C451(1.08)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C241(0.87); C309(1.09); C446(0.94); C451(0.94)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C241(0.77); C309(0.99); C446(1.12); C451(1.12)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C241(0.83); C309(1.14); C446(0.95); C451(0.95)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C241(0.91); C309(1.07); C446(0.93); C451(0.93)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C241(0.86); C309(1.12); C446(1.14); C451(1.14)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C241(0.79); C309(1.08); C446(0.96); C451(0.96)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C241(0.84); C309(1.05); C446(0.98); C451(0.98)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C241(1.04); C309(1.03); C446(0.98); C451(0.98)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C241(0.76); C309(1.18); C446(1.01); C451(1.01)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C241(0.82); C309(1.11); C446(0.97); C451(0.97)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C241(0.95); C309(1.07); C446(1.10); C451(1.10)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C241(0.92); C309(1.03); C446(0.93); C451(0.93)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C241(0.80); C309(0.99); C446(1.08); C451(1.08)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C241(0.85); C309(0.99); C446(0.94); C451(0.94)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C241(0.82); C309(1.02); C446(0.84); C451(0.84)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C241(0.78); C309(1.03); C446(0.87); C451(0.87)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C241(1.06); C309(1.00); C446(0.96); C451(0.94)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C241(0.94); C309(1.06); C446(1.01); C451(1.01)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C241(1.00); C309(0.97); C446(1.00); C451(1.03)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C241(1.06); C309(0.95); C446(0.99); C451(0.98)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C241(1.05); C309(1.03); C446(0.98); C451(0.97)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C241(0.96); C309(1.05); C446(1.05); C451(1.07)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C241(0.98); C309(1.00); C446(0.97); C451(0.96)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C241(1.42); C309(0.96); C446(0.93); C451(0.91)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C241(1.10); C309(0.92); C446(0.85); C451(0.86)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C241(0.80); C309(1.14); C446(1.00); C451(1.00)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C241(0.97); C309(0.97); C446(0.96); C451(0.95)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C241(1.05); C309(1.09); C446(1.03); C451(1.02)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C241(1.04); C309(1.12); C446(1.01); C451(0.99)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C241(1.10); C309(1.08); C446(0.89); C451(0.87)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C241(1.16); C309(1.00); C446(0.91); C451(0.91)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C241(1.22); C309(0.96); C446(0.96); C451(0.96)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C241(1.26); C309(0.92); C446(0.99); C451(0.99)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C241(0.99); C309(0.96); C446(1.25); C451(1.25)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C241(1.19); C309(1.05); C446(1.30); C451(1.30)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C241(0.97); C309(1.14); C446(1.06); C451(1.06)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C241(1.17); C309(0.98); C446(0.93); C451(0.93)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C241(0.99); C309(1.06); C446(1.25); C451(1.25)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C241(1.22); C309(1.15); C446(1.38); C451(1.38)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C241(1.11); C309(1.08); C446(1.36); C451(1.36)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C241(1.30); C309(1.15); C446(1.37); C451(1.37)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C241(1.39); C309(1.06); C446(1.09); C451(1.09)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C241(1.35); C309(1.01); C446(0.96); C451(0.96)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C241(1.50); C309(1.02); C446(1.16); C451(1.16)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C241(1.64); C309(1.12); C446(1.19); C451(1.19)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C241(1.26); C309(1.26); C446(1.35); C451(1.35)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C241(0.99); C309(1.02); C446(0.94); C451(0.94)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C241(1.00); C309(0.96); C446(1.05); C451(1.05)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C241(0.90); C309(0.95); C446(0.96); C451(0.95)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C241(0.87); C309(1.01); C446(1.00); C451(0.97)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C241(0.75); C309(0.95); C446(1.09); C451(1.02)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C241(0.89); C309(0.87); C446(0.86); C451(0.87)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C241(0.91); C309(0.86); C446(0.88); C451(0.90)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C241(1.04); C309(0.87); C446(0.92); C451(0.93)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C241(0.88); C309(0.89); C446(0.90); C451(0.91)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C241(0.91); C309(0.98); C446(0.99); C451(0.99)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C241(0.90); C309(0.97); C446(0.95); C451(0.94)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C241(0.94); C309(1.01); C503(1.04); C88(0.90)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C88(1.15); C261(0.83); C241(0.38)  LDD1702  [4]
 LDCM0573  Fragment11 Ramos C88(6.91)  LDD2190  [17]
 LDCM0576  Fragment14 Ramos C88(0.83)  LDD2193  [17]
 LDCM0586  Fragment28 Ramos C88(1.37)  LDD2198  [17]
 LDCM0468  Fragment33 HCT 116 C241(1.05); C309(0.98); C446(0.97); C451(0.95)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C241(1.19); C309(1.01); C446(1.52); C451(1.42)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C309(2.62); C88(1.88)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C309(3.54); C88(2.05)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C309(3.28); C88(1.40)  LDD0082  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C241(2.50)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C261(1.01)  LDD2121  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C261(0.81); C241(1.35)  LDD2090  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C241(1.82)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C241(0.55)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C261(0.92); C241(1.00)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C261(1.15)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C241(1.23)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C241(1.00)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C241(1.94)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C241(1.21)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C261(1.12)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C261(0.65)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C241(1.93)  LDD2110  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C241(0.83)  LDD2114  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C261(1.04)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C261(1.37)  LDD2125  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C261(1.63)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C261(1.16)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C261(0.75); C241(1.05)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C241(0.65)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C261(2.26)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C241(1.00)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C261(0.70)  LDD2150  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C261(1.67); C241(2.36)  LDD2153  [4]
 LDCM0021  THZ1 HCT 116 C241(0.89); C309(1.17)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit beta (AP2B1) Adaptor complexes large subunit family P63010
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Axin-1 (AXIN1) . O15169
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Grn163l . DB05036

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578