Details of the Target

General Information of Target

Target ID LDTP09391
Target Name Ceramide kinase (CERK)
Gene Name CERK
Gene ID 64781
Synonyms
KIAA1646; Ceramide kinase; hCERK; EC 2.7.1.138; Acylsphingosine kinase; Lipid kinase 4; LK4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAV
EETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLR
EMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETL
YEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGS
TDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDS
EKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQ
LEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDL
ILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRF
GHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS
Target Type
Literature-reported
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides. Binds phosphoinositides.
TTD ID
T40243
Uniprot ID
Q8TCT0
DrugMap ID
TT9XRNV
Ensemble ID
ENST00000216264.13
HGNC ID
HGNC:19256
ChEMBL ID
CHEMBL1764936

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.D265GfsTer37 .
HCC1143 SNV: p.A28S .
MFE319 Insertion: p.K477GfsTer75 .
SNGM SNV: p.S229G .
WM115 SNV: p.S489C .
WM2664 SNV: p.S489C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C400(5.08)  LDD0515  [1]
DBIA
 Probe Info  		C517(1.17)  LDD0532  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C156
 Probe Info  		7.21  LDD1836  [4]
C159
 Probe Info  		18.38  LDD1839  [4]
C160
 Probe Info  		23.43  LDD1840  [4]
C161
 Probe Info  		21.56  LDD1841  [4]
C310
 Probe Info  		12.82  LDD1977  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C21(1.05); C385(0.94); C50(1.02)  LDD1507  [5]
 LDCM0215  AC10 HCT 116 C517(1.17)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C517(1.06)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C400(0.91)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C400(0.93)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C400(0.97)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C400(0.96)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C400(1.09)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C400(1.00)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C400(1.14)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C517(1.25)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C400(1.06)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C400(0.79)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C400(0.95)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C400(0.72)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C400(0.92)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C400(0.81)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C400(0.75)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C400(0.90)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C517(1.24)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C400(0.94)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C400(0.99)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C400(0.90)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C400(0.98)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C400(0.90)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C400(0.82)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C400(0.87)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C517(1.19)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C400(0.97)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C400(1.02)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C400(0.88)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C400(1.01)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C400(0.87)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C400(1.05)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C400(0.95)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C400(0.83)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C400(0.99); C517(1.01)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C400(0.97); C517(1.04)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C517(0.93); C400(1.05)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C21(0.93)  LDD1518  [5]
 LDCM0280  AC20 HCT 116 C517(0.96); C400(0.99)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C400(0.85); C517(0.86)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C517(0.95); C400(1.04)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C400(0.98); C517(0.98)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C517(0.95); C400(1.03)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C517(0.84)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C517(0.94)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C517(0.95)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C517(0.91)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C517(0.88)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C21(1.09); C385(0.87); C50(0.86); C517(1.02)  LDD1529  [5]
 LDCM0291  AC30 HCT 116 C517(0.97)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C517(1.05)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C517(1.13)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C517(0.95)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C517(1.05)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C517(0.81)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C517(0.93)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C517(0.96)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C517(0.97)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C517(1.09)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C21(1.10); C385(0.91); C50(1.42)  LDD1540  [5]
 LDCM0302  AC40 HCT 116 C517(1.24)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C517(1.01)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C517(1.13)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C517(1.10)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C517(1.08)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C517(1.26)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C21(1.24); C385(0.95)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C385(0.90); C50(1.07)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C21(1.26); C385(1.04); C50(0.90)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C21(1.11); C385(0.87); C50(0.94)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C21(1.12); C385(1.31)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C21(1.02)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C21(0.93); C385(0.87); C50(0.93); C517(1.05)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C21(1.06); C385(0.99); C50(1.46)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C21(1.03); C385(1.05)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C21(1.09); C385(0.94)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C385(0.96); C50(0.91)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C21(1.15); C385(0.94); C50(1.12)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C21(1.02); C385(1.14); C50(1.03)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C21(0.96)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C21(1.05); C385(1.01); C50(1.12); C517(0.98)  LDD1561  [5]
 LDCM0323  AC6 HCT 116 C517(1.11)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C21(0.90); C385(0.93); C50(1.45)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C21(0.95); C385(0.92)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C21(1.15); C385(0.85)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C385(1.05); C50(0.95)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C21(1.06); C385(0.97); C50(0.90)  LDD1567  [5]
 LDCM0334  AC7 HCT 116 C517(1.19)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C517(1.11)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C400(0.74)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C400(0.82)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C400(0.90)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C400(0.89)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C400(0.90)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C400(0.70)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C400(0.77)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C400(0.95)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C400(0.75)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C400(0.80)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C400(0.94)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C400(0.91)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C400(1.34)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C400(0.98)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C400(0.77)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C517(1.24)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C517(1.14)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C517(1.47)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C400(2.04)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C400(4.14)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C21(0.93); C517(1.04)  LDD1573  [5]
 LDCM0370  CL101 HCT 116 C517(1.13)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C517(1.28)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C517(1.18)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C517(1.11)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C517(1.02); C400(1.05)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C517(1.16); C400(1.22)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C400(1.10); C517(1.16)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C400(1.06); C517(1.28)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C517(1.08); C400(1.37)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C400(1.65)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C517(1.09); C400(1.32)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C517(1.05); C400(1.20)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C517(0.88)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C517(1.01)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C517(1.02)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C517(1.01)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C517(1.23)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C517(1.63)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C517(1.02)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C517(1.02)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C400(2.00)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C517(1.02)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C21(1.08); C50(0.97)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C21(1.15); C385(1.03)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C385(1.05); C193(0.72)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C21(1.12); C517(1.14)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C21(0.95); C50(0.88)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C21(0.99); C385(1.23)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C385(1.04); C193(1.12)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C21(1.06); C517(1.12)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C400(1.18)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C400(2.12)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C400(1.59)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C21(1.02); C517(1.11)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C21(1.14); C385(0.88); C50(0.97)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C21(1.09)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C21(1.24); C385(1.15); C50(0.98); C517(1.13)  LDD1610  [5]
 LDCM0407  CL2 HCT 116 C400(0.74)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C21(1.07); C385(1.05); C50(1.31)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C21(1.33); C385(1.03)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C21(1.50); C385(1.01)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C385(1.26); C50(0.97)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C21(1.15); C385(1.27); C50(0.97)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C21(1.07); C50(0.96)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C21(1.01); C385(1.25)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C385(1.07); C193(0.90)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C21(1.09); C517(1.10)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C21(1.35); C385(0.85); C50(1.06)  LDD1621  [5]
 LDCM0418  CL3 HCT 116 C400(1.19)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C21(1.07)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C21(1.23); C385(1.00); C50(0.89); C517(1.17)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C21(1.15); C385(1.06); C50(1.60)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C21(1.41); C385(1.32)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C21(1.26); C385(0.92)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C385(1.23); C50(1.05)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C21(1.19); C385(1.39); C50(1.21)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C21(1.08); C50(0.96)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C385(1.03); C193(1.14)  LDD1632  [5]
 LDCM0429  CL4 HCT 116 C400(2.17)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C21(1.02); C517(1.06)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C21(1.30); C385(0.88); C50(1.00)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C21(1.01)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C21(1.09); C385(1.13); C50(0.96); C517(1.07)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C21(1.17); C385(0.97); C50(1.13)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C21(1.32); C385(0.93)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C21(1.25); C385(1.11)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C385(1.24); C50(1.06)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C21(1.22); C385(1.10); C50(1.32)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C21(1.03); C50(0.91)  LDD1643  [5]
 LDCM0440  CL5 HCT 116 C400(0.94)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C21(1.10); C385(0.98)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C21(1.06); C517(1.23)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C21(1.32); C385(0.96); C50(1.13)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C21(1.17)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C21(1.10); C385(0.95); C50(0.96); C517(1.18)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C21(1.03); C385(1.16); C50(1.17)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C21(1.24); C385(1.31)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C21(1.27); C385(1.20)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C385(1.20); C50(1.07)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C400(2.35)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C21(1.15); C385(1.16); C50(1.70)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C21(1.04); C50(1.20)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C21(1.09); C385(0.95)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C385(1.02); C193(0.82)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C21(1.15); C517(1.07)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C21(1.16); C385(0.94); C50(1.02)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C21(1.18)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C21(1.07); C385(1.05); C50(0.87); C517(1.29)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C21(1.05); C385(1.04); C50(1.17)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C21(1.11); C385(1.01)  LDD1664  [5]
 LDCM0462  CL7 HCT 116 C400(1.32)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C21(1.29); C385(1.33)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C385(1.10); C50(1.12)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C21(1.12); C385(1.74); C50(1.05)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C21(1.05); C50(0.84)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C21(1.00); C385(1.30)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C21(0.96); C517(1.09)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C21(1.13); C385(1.03); C50(1.30)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C21(1.10)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C21(1.20); C385(0.92); C50(1.03); C517(1.10)  LDD1675  [5]
 LDCM0473  CL8 HCT 116 C400(3.82)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C21(1.17); C385(0.88); C50(1.40)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C21(1.15); C385(0.87)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C21(1.04); C385(1.03)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C385(1.10); C50(1.02)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C21(1.20); C385(1.26); C50(1.05)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C21(0.93); C50(0.93)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C21(1.04); C385(1.40)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C385(1.14); C193(1.08)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C21(0.94); C517(1.12)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C21(0.96); C385(0.92); C50(0.88)  LDD1686  [5]
 LDCM0484  CL9 HCT 116 C400(1.36)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C21(1.78)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C21(1.23); C385(1.21); C50(1.40); C517(1.23)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C21(1.22); C385(0.91); C50(1.53)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C21(1.07); C385(1.14)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C21(1.07); C385(1.01)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C385(1.35); C50(1.26)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C21(1.22); C385(1.05); C50(1.05)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C21(1.07); C50(1.14)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C21(1.02); C385(1.14)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C385(0.95); C193(0.90)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C385(1.03); C193(1.17)  LDD1698  [5]
 LDCM0201  EV-3 T cell C400(5.08)  LDD0515  [1]
 LDCM0468  Fragment33 HEK-293T C385(1.09); C193(1.13)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C21(1.13); C385(1.08)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C21(0.88)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C21(1.10)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C21(0.91)  LDD1502  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-crystallin A3 (CRYBA1) Beta/gamma-crystallin family P05813
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Protein Mis18-beta (OIP5) Mis18 family O43482
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
NHL-repeat-containing protein 4 (NHLRC4) . P0CG21
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nvp 231 Small molecular drug D0S9JG

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402