Details of the Target

General Information of Target

Target ID LDTP08054
Target Name FMR1-interacting protein NUFIP2 (NUFIP2)
Gene Name NUFIP2
Gene ID 57532
Synonyms
KIAA1321; FMR1-interacting protein NUFIP2; 82 kDa FMRP-interacting protein; 82-FIP; Cell proliferation-inducing gene 1 protein; FMRP-interacting protein 2; Nuclear FMR1-interacting protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEKPGQPQPQHHHSHHHPHHHPQQQQQQPHHHHHYYFYNHSHNHHHHHHHQQPHQYLQH
GAEGSPKAQPKPLKHEQKHTLQQHQETPKKKTGYGELNGNAGEREISLKNLSSDEATNPI
SRVLNGNQQVVDTSLKQTVKANTFGKAGIKTKNFIQKNSMDKKNGKSYENKSGENQSVDK
SDTIPIPNGVVTNNSGYITNGYMGKGADNDGSGSESGYTTPKKRKARRNSAKGCENLNIV
QDKIMQQETSVPTLKQGLETFKPDYSEQKGNRVDGSKPIWKYETGPGGTSRGKPAVGDML
RKSSDSKPGVSSKKFDDRPKGKHASAVASKEDSWTLFKPPPVFPVDNSSAKIVPKISYAS
KVKENLNKTIQNSSVSPTSSSSSSSSTGETQTQSSSRLSQVPMSALKSVTSANFSNGPVL
AGTDGNVYPPGGQPLLTTAANTLTPISSGTDSVLQDMSLTSAAVEQIKTSLFIYPSNMQT
MLLSTAQVDLPSQTDQQNLGDIFQNQWGLSFINEPSAGPETVTGKSSEHKVMEVTFQGEY
PATLVSQGAEIIPSGTEHPVFPKAYELEKRTSPQVLGSILKSGTTSESGALSLEPSHIGD
LQKADTSSQGALVFLSKDYEIESQNPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRA
AIVYHTKEMESIWNLQKQDPKRIITYNEAMDSPDQ
Target Bioclass
Other
Subcellular location
Nucleus
Function Binds RNA.
Uniprot ID
Q7Z417
Ensemble ID
ENST00000225388.9
HGNC ID
HGNC:17634

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.R224GfsTer16 DBIA    Probe Info 
A2058 Insertion: p.A328GfsTer11 DBIA    Probe Info 
HCC1395 SNV: p.R645T .
JURKAT SNV: p.A421T Compound 10    Probe Info 
LNCaP clone FGC SNV: p.S311G; p.L601P; p.A660V DBIA    Probe Info 
MEWO SNV: p.P475S .
NCIH2286 SNV: p.M160V DBIA    Probe Info 
OAW42 SNV: p.V353A DBIA    Probe Info 
REH SNV: p.K146E DBIA    Probe Info 
TE4 Deletion: p.H13_H22del DBIA    Probe Info 
U2OS Deletion: p.I356Ter .
VCAP SNV: p.T584A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.56  LDD0066  [1]
STPyne
 Probe Info  		K146(0.56); K314(10.00); K322(6.67); K361(1.44)  LDD0277  [2]
Probe 1
 Probe Info  		Y218(46.03); Y282(27.01); Y358(29.61); Y619(7.26)  LDD3495  [3]
m-APA
 Probe Info  		12.25  LDD0403  [4]
BTD
 Probe Info  		C234(1.03)  LDD2100  [5]
AHL-Pu-1
 Probe Info  		C234(3.07)  LDD0171  [6]
HHS-475
 Probe Info  		Y282(0.19); Y565(0.95); Y358(1.02); Y540(1.08)  LDD0264  [7]
DBIA
 Probe Info  		C234(1.06)  LDD0078  [8]
5E-2FA
 Probe Info  		H597(0.00); H558(0.00)  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0025  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
NAIA_5
 Probe Info  		N.A.  LDD2224  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
ENE
 Probe Info  		N.A.  LDD0006  [13]
SF
 Probe Info  		N.A.  LDD0028  [15]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
HHS-482
 Probe Info  		Y265(0.62); Y282(0.78)  LDD2239  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C234(0.92)  LDD2112  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C234(3.07)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C234(0.97)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C234(1.43)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C234(0.93)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C234(0.96)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C234(0.97)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C234(1.21)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C234(1.01)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C234(1.29)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C234(1.31)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C234(1.18)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C234(0.96)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C234(0.80)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C234(1.20)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C234(1.00)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C234(1.02)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C234(1.05)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C234(0.81)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C234(0.97)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C234(1.11)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C234(1.11)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C234(0.87)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C234(0.93)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C234(1.11)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C234(0.91)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C234(0.91)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C234(1.02)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C234(0.88)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C234(1.06)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C234(0.87)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C234(1.01)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C234(1.18)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C234(1.03)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C234(0.79)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C234(0.69)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C234(0.84)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C234(0.74)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C234(0.72)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C234(0.77)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C234(0.90)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C234(0.83)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C234(0.77)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C234(0.69)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C234(0.77)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C234(0.80)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C234(0.97)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C234(0.76)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C234(0.79)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C234(0.69)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C234(1.27)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C234(1.52)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C234(1.21)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C234(1.44)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C234(1.37)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C234(1.90)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C234(1.57)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C234(0.80)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C234(1.14)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C234(1.22)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C234(1.58)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C234(2.19)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C234(1.65)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C234(1.65)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C234(1.18)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C234(1.28)  LDD2161  [8]
 LDCM0276  AC17 PaTu 8988t C234(1.02)  LDD1155  [8]
 LDCM0277  AC18 PaTu 8988t C234(1.69)  LDD1156  [8]
 LDCM0278  AC19 PaTu 8988t C234(1.41)  LDD1157  [8]
 LDCM0279  AC2 HCT 116 C234(0.95)  LDD0596  [8]
 LDCM0280  AC20 PaTu 8988t C234(1.38)  LDD1159  [8]
 LDCM0281  AC21 PaTu 8988t C234(1.45)  LDD1160  [8]
 LDCM0282  AC22 PaTu 8988t C234(1.34)  LDD1161  [8]
 LDCM0283  AC23 PaTu 8988t C234(1.70)  LDD1162  [8]
 LDCM0284  AC24 PaTu 8988t C234(1.76)  LDD1163  [8]
 LDCM0285  AC25 HCT 116 C234(1.33)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C234(1.06)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C234(1.22)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C234(1.32)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C234(1.21)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C234(0.85)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C234(1.02)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C234(1.15)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C234(1.51)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C234(1.29)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C234(1.29)  LDD0612  [8]
 LDCM0296  AC35 PaTu 8988t C234(1.65)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C234(2.24)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C234(1.71)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C234(2.34)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C234(2.31)  LDD1179  [8]
 LDCM0301  AC4 HCT 116 C234(0.94)  LDD0618  [8]
 LDCM0302  AC40 PaTu 8988t C234(2.06)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C234(1.49)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C234(1.36)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C234(1.91)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C234(1.81)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C234(1.46)  LDD1186  [8]
 LDCM0308  AC46 HCT 116 C234(1.21)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C234(0.94)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C234(0.96)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C234(1.04)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C234(0.86)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C234(0.84)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C234(0.83)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C234(1.08)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C234(1.17)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C234(0.94)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C234(1.22)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C234(0.87)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C234(1.14)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C234(1.28)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C234(1.35)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C234(0.98)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C234(1.30)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C234(1.25)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C234(1.11)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C234(1.24)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C234(1.30)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C234(0.97)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C234(0.84)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C234(0.90)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C234(1.11)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C234(1.41)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C234(1.04)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C234(1.40)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C234(1.05)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C234(1.51)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C234(1.79)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C234(1.64)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C234(1.81)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C234(1.33)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C234(1.46)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C234(1.47)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C234(1.31)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C234(0.93)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C234(1.37)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C234(1.28)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C234(1.73)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C234(1.30)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C234(1.12)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C234(1.11)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C234(1.22)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C234(1.01)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C234(1.15)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C234(1.03)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C234(1.20)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C234(1.17)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C234(1.12)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C234(1.13)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C234(1.19)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C234(1.19)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C234(1.08)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C234(1.33)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C234(1.64)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C234(0.97)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C234(0.59)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C234(1.11)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C234(1.08)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C234(1.05)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.25  LDD0403  [4]
 LDCM0020  ARS-1620 HCC44 C234(1.06)  LDD0078  [8]
 LDCM0630  CCW28-3 231MFP C234(0.69)  LDD2214  [19]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0367  CL1 HCT 116 C234(0.92)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C234(1.21)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C234(1.14)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C234(0.99)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C234(0.92)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C234(0.90)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C234(1.02)  LDD0690  [8]
 LDCM0374  CL105 PaTu 8988t C234(1.15)  LDD1253  [8]
 LDCM0375  CL106 PaTu 8988t C234(1.15)  LDD1254  [8]
 LDCM0376  CL107 PaTu 8988t C234(1.14)  LDD1255  [8]
 LDCM0377  CL108 PaTu 8988t C234(1.20)  LDD1256  [8]
 LDCM0378  CL109 PaTu 8988t C234(1.36)  LDD1257  [8]
 LDCM0379  CL11 HCT 116 C234(1.15)  LDD0696  [8]
 LDCM0380  CL110 PaTu 8988t C234(1.37)  LDD1259  [8]
 LDCM0381  CL111 PaTu 8988t C234(2.15)  LDD1260  [8]
 LDCM0382  CL112 HCT 116 C234(1.06)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C234(1.34)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C234(0.98)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C234(2.14)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C234(1.35)  LDD0703  [8]
 LDCM0387  CL117 PaTu 8988t C234(1.46)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C234(1.06)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C234(1.69)  LDD1268  [8]
 LDCM0390  CL12 HCT 116 C234(1.11)  LDD0707  [8]
 LDCM0391  CL120 PaTu 8988t C234(2.03)  LDD1270  [8]
 LDCM0392  CL121 HCT 116 C234(1.24)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C234(0.89)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C234(0.90)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C234(0.86)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C234(0.92)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C234(1.06)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C234(1.20)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C234(1.19)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C234(1.16)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C234(1.13)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C234(1.04)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C234(1.16)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C234(1.05)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C234(1.27)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C234(1.09)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C234(0.97)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C234(1.23)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C234(1.04)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C234(0.85)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C234(1.00)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C234(1.14)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C234(1.01)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C234(1.20)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C234(1.07)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C234(1.14)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C234(1.07)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C234(1.07)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C234(1.02)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C234(1.03)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C234(1.09)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C234(1.06)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C234(1.10)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C234(1.07)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C234(1.05)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C234(1.20)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C234(1.09)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C234(1.02)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C234(1.20)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C234(1.22)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C234(1.03)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C234(1.08)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C234(1.10)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C234(1.16)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C234(0.98)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C234(0.93)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C234(0.97)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C234(1.00)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C234(1.03)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C234(0.95)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C234(1.00)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C234(0.96)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C234(0.93)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C234(0.88)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C234(0.93)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C234(0.92)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C234(1.02)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C234(0.94)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C234(0.93)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C234(1.02)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C234(0.94)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C234(0.93)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C234(0.94)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C234(0.92)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C234(1.07)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C234(0.88)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C234(0.96)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C234(0.94)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C234(1.01)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C234(1.01)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C234(1.13)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C234(1.02)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C234(0.96)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C234(1.04)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C234(1.10)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C234(0.94)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C234(1.07)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C234(0.97)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C234(1.03)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C234(1.22)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C234(1.27)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C234(1.01)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C234(1.00)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C234(1.18)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C234(1.20)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C234(1.10)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C234(0.96)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C234(0.95)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C234(1.00)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C234(1.09)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C234(1.05)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C234(1.07)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C234(0.94)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C234(1.08)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C234(1.07)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C234(0.84)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C234(1.18)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C234(0.93)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C234(0.97)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C234(0.87)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C234(1.20)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C234(1.00)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C234(1.09)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C234(1.62)  LDD1702  [5]
 LDCM0625  F8 Ramos C234(1.25)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C234(0.91)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C234(3.56)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C234(0.64)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C234(0.98)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C234(0.82)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C234(0.54)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C234(0.97)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C234(0.88)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C234(0.77)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C234(1.06)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C234(1.04)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C234(0.86)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C234(1.03)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C234(1.02)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C234(0.86)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C234(0.81)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C234(1.18)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C234(1.02)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C234(1.26)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C234(1.10)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C234(0.64)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y282(0.19); Y565(0.95); Y358(1.02); Y540(1.08)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y282(0.42); Y358(0.84); Y540(0.98); Y265(1.85)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y282(0.48); Y540(0.64); Y358(0.95); Y565(1.69)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y282(0.60); Y540(0.86); Y358(0.95); Y265(1.96)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y282(0.09); Y358(1.02); Y565(1.86); Y265(2.11)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C234(1.57)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C234(1.02)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C234(1.24)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C234(1.03)  LDD2100  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C234(1.51)  LDD2105  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C234(0.90)  LDD2114  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C234(1.12)  LDD2116  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C234(1.01)  LDD2136  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C234(0.76)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C234(0.60)  LDD2141  [5]
 LDCM0131  RA190 MM1.R C234(1.26)  LDD0304  [22]
 LDCM0021  THZ1 HCT 116 C234(1.12)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Plasma alpha-L-fucosidase (FUCA2) Glycosyl hydrolase 29 family Q9BTY2
Proprotein convertase subtilisin/kexin type 5 (PCSK5) Peptidase S8 family Q92824
Peroxiredoxin-5, mitochondrial (PRDX5) Peroxiredoxin family P30044
Phospholipid scramblase 1 (PLSCR1) Phospholipid scramblase family O15162
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
MyoD family inhibitor (MDFI) MDFI family Q99750
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 49 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Fibulin-5 (FBLN5) Fibulin family Q9UBX5
Progranulin (GRN) Granulin family P28799
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 1-5 (KRTAP1-5) KRTAP type 1 family Q9BYS1
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6
Keratin-associated protein 4-1 (KRTAP4-1) KRTAP type 4 family Q9BYQ7
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 4-4 (KRTAP4-4) KRTAP type 4 family Q9BYR3
Keratin-associated protein 4-5 (KRTAP4-5) KRTAP type 4 family Q9BYR2
Keratin-associated protein 5-11 (KRTAP5-11) KRTAP type 5 family Q6L8G4
Keratin-associated protein 5-2 (KRTAP5-2) KRTAP type 5 family Q701N4
Keratin-associated protein 5-3 (KRTAP5-3) KRTAP type 5 family Q6L8H2
Keratin-associated protein 5-4 (KRTAP5-4) KRTAP type 5 family Q6L8H1
Keratin-associated protein 5-6 (KRTAP5-6) KRTAP type 5 family Q6L8G9
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Keratin-associated protein 9-4 (KRTAP9-4) KRTAP type 9 family Q9BYQ2
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Late cornified envelope protein 1B (LCE1B) LCE family Q5T7P3
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Late cornified envelope protein 2D (LCE2D) LCE family Q5TA82
Multiple epidermal growth factor-like domains protein 11 (MEGF11) MEGF family A6BM72
Platelet endothelial aggregation receptor 1 (PEAR1) MEGF family Q5VY43
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Cartilage oligomeric matrix protein (COMP) Thrombospondin family P49747
Endothelial cell-specific molecule 1 (ESM1) . Q9NQ30
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Galactoside-binding soluble lectin 13 (LGALS13) . Q9UHV8
Keratinocyte proline-rich protein (KPRP) . Q5T749
Protein kinase C-binding protein NELL2 (NELL2) . Q99435
Regulator of G-protein signaling 17 (RGS17) . Q9UGC6
Regulator of G-protein signaling 19 (RGS19) . P49795
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.