Details of the Target

General Information of Target

Target ID LDTP06602
Target Name Gamma-interferon-inducible protein 16 (IFI16)
Gene Name IFI16
Gene ID 3428
Synonyms
IFNGIP1; Gamma-interferon-inducible protein 16; Ifi-16; Interferon-inducible myeloid differentiation transcriptional activator
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKFRGDA
GLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVKTEGA
EATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAPPNSS
STENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQTQFF
HVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIINRAKE
TLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPCEEGD
KLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQRQLPYPSEASTT
FPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIGPAES
HPHTPQMPPSTPSSSFLTTKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIGPAESHPHT
PQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMF
HATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNME
IPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHG
RLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILNPDSSMETS
PDFFF
Target Bioclass
Transcription factor
Family
HIN-200 family
Subcellular location
Cytoplasm; Nucleus
Function
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.; [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome. Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2. Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome. This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1.
Uniprot ID
Q16666
Ensemble ID
ENST00000295809.12
HGNC ID
HGNC:5395

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.D774N .
HCT116 Insertion: p.E85RfsTer34 .
HS936T SNV: p.Y635S DBIA    Probe Info 
HT SNV: p.Q408P DBIA    Probe Info 
LNCaP clone FGC Insertion: p.I227NfsTer42 DBIA    Probe Info 
NCIH661 SNV: p.T212R .
SW480 SNV: p.L426R .
SW620 SNV: p.L426R .
WM1552C SNV: p.L210R DBIA    Probe Info 
ZR751 SNV: p.F440L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y334(15.60); Y635(7.37); Y645(7.13); Y20(5.87)  LDD0260  [1]
STPyne
 Probe Info  		K140(6.88); K190(10.00); K443(10.00); K64(7.74)  LDD0277  [2]
BTD
 Probe Info  		C679(0.88)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C637(2.16)  LDD0169  [4]
HHS-475
 Probe Info  		Y413(0.69)  LDD0264  [5]
DBIA
 Probe Info  		C637(1.19); C679(0.88)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C637(0.00); C679(0.00); C366(0.00); C737(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C637(0.00); C679(0.00); C737(0.00); C727(0.00)  LDD0036  [7]
IPIAA_L
 Probe Info  		C727(0.00); C737(0.00); C351(0.00); C679(0.00)  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C637(0.00); C679(0.00); C366(0.00); C737(0.00)  LDD0037  [7]
Compound 10
 Probe Info  		C191(0.00); C637(0.00); C679(0.00); C727(0.00)  LDD2216  [9]
Compound 11
 Probe Info  		C191(0.00); C637(0.00); C679(0.00)  LDD2213  [9]
IPM
 Probe Info  		C679(0.00); C191(0.00); C637(0.00)  LDD0147  [10]
PF-06672131
 Probe Info  		N.A.  LDD0152  [11]
TFBX
 Probe Info  		C679(0.00); C637(0.00); C737(0.00); C191(0.00)  LDD0148  [10]
Acrolein
 Probe Info  		C727(0.00); C679(0.00); C737(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		C737(0.00); C727(0.00)  LDD0218  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C727(0.70); C679(0.69)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C737(0.92); C727(0.91); C679(0.99); C191(1.03)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C737(1.28); C727(1.17); C679(0.76)  LDD2117  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C737(0.51); C727(0.66)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C727(0.59); C191(0.96)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C191(1.00)  LDD2131  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C637(2.16)  LDD0169  [4]
 LDCM0214  AC1 PaTu 8988t C679(0.24); C351(0.60); C356(0.60)  LDD1093  [6]
 LDCM0215  AC10 PaTu 8988t C679(0.87); C637(0.96); C351(1.06); C356(1.06)  LDD1094  [6]
 LDCM0216  AC100 PaTu 8988t C637(1.60); C351(1.04); C356(1.04)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C637(1.57); C351(0.98); C356(0.98)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C637(1.73); C351(1.06); C356(1.06)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C637(1.15); C351(0.92); C356(0.92)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C637(1.05); C351(1.07); C356(1.07)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C637(1.07); C351(0.99); C356(0.99)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C637(1.11); C351(0.96); C356(0.96)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C637(1.33); C351(1.19); C356(1.19)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C637(1.45); C351(0.80); C356(0.80)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C637(1.55); C351(0.92); C356(0.92)  LDD1104  [6]
 LDCM0226  AC11 PaTu 8988t C679(0.83); C637(0.94); C351(1.09); C356(1.09)  LDD1105  [6]
 LDCM0227  AC110 PaTu 8988t C637(2.30); C351(0.74); C356(0.74)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C637(1.46); C351(0.94); C356(0.94)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C637(1.61); C351(0.85); C356(0.85)  LDD1108  [6]
 LDCM0230  AC113 PaTu 8988t C637(0.91); C351(1.13); C356(1.13)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C637(0.77); C351(1.29); C356(1.29)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C637(0.92); C351(1.19); C356(1.19)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C637(0.81); C351(1.18); C356(1.18)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C637(0.84); C351(1.26); C356(1.26)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C637(1.22); C351(1.06); C356(1.06)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C637(0.81); C351(0.94); C356(0.94)  LDD1115  [6]
 LDCM0237  AC12 PaTu 8988t C679(0.84); C637(1.39); C351(0.95); C356(0.95)  LDD1116  [6]
 LDCM0238  AC120 PaTu 8988t C637(0.88); C351(1.07); C356(1.07)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C637(0.75); C351(1.25); C356(1.25)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C637(1.06); C351(1.21); C356(1.21)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C637(1.18); C351(1.02); C356(1.02)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C637(1.27); C351(1.24); C356(1.24)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C637(1.30); C351(0.95); C356(0.95)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C637(1.03); C351(1.16); C356(1.16)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C637(0.85); C351(1.01); C356(1.01)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C679(0.88); C637(0.81); C351(1.05); C356(1.05)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C679(0.90); C637(1.17); C351(0.91); C356(0.91)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C679(1.03); C637(1.12); C351(1.07); C356(1.07)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C679(1.25); C637(1.10); C351(0.99); C356(0.99)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C679(1.01); C637(1.24); C351(1.08); C356(1.08)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C679(0.88); C637(1.05); C351(0.92); C356(0.92)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C679(1.09); C637(1.10); C351(0.96); C356(0.96)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C679(0.84); C637(1.07); C351(0.88); C356(0.88)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C679(0.89); C637(0.72); C351(1.05); C356(1.05)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C679(0.67); C637(0.84); C351(1.07); C356(1.07)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C679(1.09); C637(1.13); C351(0.79); C356(0.79)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C679(1.58); C637(0.75); C351(1.10); C356(1.10)  LDD1137  [6]
 LDCM0259  AC14 PaTu 8988t C679(0.93); C637(0.91); C351(1.04); C356(1.04)  LDD1138  [6]
 LDCM0260  AC140 PaTu 8988t C679(0.79); C637(1.07); C351(0.94); C356(0.94)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C679(0.87); C637(1.34); C351(0.99); C356(0.99)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C679(0.86); C637(1.28); C351(0.82); C356(0.82)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C737(0.96); C637(0.97); C351(0.88); C356(0.88)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C737(0.90); C637(0.58); C351(0.95); C356(0.95)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C737(0.71); C637(1.14); C351(0.90); C356(0.90)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C737(0.77); C637(1.07); C351(0.81); C356(0.81)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C737(0.89); C637(1.27); C351(1.03); C356(1.03)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C737(0.84); C637(0.66); C351(0.84); C356(0.84)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C737(0.79); C637(0.58); C351(0.91); C356(0.91)  LDD1148  [6]
 LDCM0270  AC15 PaTu 8988t C679(0.75); C637(0.84); C351(0.98); C356(0.98)  LDD1149  [6]
 LDCM0271  AC150 PaTu 8988t C737(0.63); C637(1.04); C351(1.11); C356(1.11)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C737(0.57); C637(1.44); C351(1.13); C356(1.13)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C737(0.73); C637(0.52); C351(1.16); C356(1.16)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C737(0.62); C637(1.09); C351(0.99); C356(0.99)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C737(0.58); C637(0.85); C351(1.10); C356(1.10)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C737(0.60); C637(0.91); C351(0.97); C356(0.97)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C737(0.67); C637(0.55); C351(1.16); C356(1.16)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C737(0.58); C637(1.02); C351(1.03); C356(1.03)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C737(0.94); C679(0.99); C637(1.50); C351(1.03)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C737(0.76); C679(0.84); C637(1.08); C351(1.01)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C737(0.99); C679(1.06); C637(1.15); C351(0.99)  LDD1157  [6]
 LDCM0279  AC2 PaTu 8988t C679(0.25); C351(0.57); C356(0.57)  LDD1158  [6]
 LDCM0280  AC20 PaTu 8988t C737(0.84); C679(0.91); C637(1.05); C351(1.09)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C737(0.81); C679(0.88); C637(1.22); C351(1.04)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C737(0.79); C679(0.89); C637(1.22); C351(1.11)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C737(0.77); C679(0.89); C637(1.26); C351(1.03)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C737(0.81); C679(0.92); C637(1.27); C351(1.07)  LDD1163  [6]
 LDCM0285  AC25 PaTu 8988t C637(1.03); C351(0.98); C356(0.98)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C637(1.14); C351(1.10); C356(1.10)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C637(1.09); C351(1.00); C356(1.00)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C637(1.27); C351(0.83); C356(0.83)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C637(1.02); C351(0.92); C356(0.92)  LDD1168  [6]
 LDCM0290  AC3 PaTu 8988t C679(0.21); C351(0.53); C356(0.53)  LDD1169  [6]
 LDCM0291  AC30 PaTu 8988t C637(0.97); C351(0.91); C356(0.91)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C637(0.91); C351(0.95); C356(0.95)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C637(1.51); C351(0.94); C356(0.94)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C637(1.46); C351(0.94); C356(0.94)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C637(1.45); C351(0.92); C356(0.92)  LDD1174  [6]
 LDCM0296  AC35 PaTu 8988t C679(0.86); C637(1.32); C351(0.97); C356(0.97)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C679(0.69); C637(1.53); C351(0.85); C356(0.85)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C679(0.91); C637(1.34); C351(0.86); C356(0.86)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C679(1.11); C637(1.56); C351(0.95); C356(0.95)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C679(0.90); C637(2.54); C351(0.84); C356(0.84)  LDD1179  [6]
 LDCM0301  AC4 PaTu 8988t C679(0.25); C351(0.58); C356(0.58)  LDD1180  [6]
 LDCM0302  AC40 PaTu 8988t C679(0.78); C637(2.66); C351(0.91); C356(0.91)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C679(1.18); C637(1.97); C351(0.82); C356(0.82)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C679(1.00); C637(1.42); C351(0.91); C356(0.91)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C679(1.04); C637(1.51); C351(0.92); C356(0.92)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C679(0.90); C637(2.11); C351(1.02); C356(1.02)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C679(0.89); C637(1.58); C351(0.84); C356(0.84)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C679(1.50); C637(1.11); C351(1.03); C356(1.03)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C679(1.59); C637(1.16); C351(1.11); C356(1.11)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C679(1.43); C637(1.01); C351(1.12); C356(1.12)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C679(1.29); C637(1.55); C351(1.11); C356(1.11)  LDD1190  [6]
 LDCM0312  AC5 PaTu 8988t C679(0.22); C351(0.57); C356(0.57)  LDD1191  [6]
 LDCM0313  AC50 PaTu 8988t C679(1.26); C637(1.38); C351(1.04); C356(1.04)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C679(1.32); C637(1.40); C351(0.74); C356(0.74)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C679(1.07); C637(1.35); C351(0.99); C356(0.99)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C679(1.16); C637(1.47); C351(1.24); C356(1.24)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C679(1.06); C637(1.48); C351(1.23); C356(1.23)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C679(1.09); C637(1.30); C351(1.28); C356(1.28)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C679(1.28); C637(1.28); C351(1.02); C356(1.02)  LDD1198  [6]
 LDCM0320  AC57 PaTu 8988t C679(0.85); C637(1.15); C351(0.84); C356(0.84)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C679(0.86); C637(1.25); C351(0.95); C356(0.95)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C679(0.93); C637(1.04); C351(1.01); C356(1.01)  LDD1201  [6]
 LDCM0323  AC6 PaTu 8988t C679(0.95); C637(1.34); C351(1.03); C356(1.03)  LDD1202  [6]
 LDCM0324  AC60 PaTu 8988t C679(0.85); C637(1.01); C351(1.06); C356(1.06)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C679(0.96); C637(0.88); C351(0.94); C356(0.94)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C679(0.90); C637(0.95); C351(0.93); C356(0.93)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C679(0.91); C637(0.88); C351(0.95); C356(0.95)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C679(1.02); C637(0.92); C351(0.95); C356(0.95)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C679(1.09); C637(1.04); C351(0.96); C356(0.96)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C679(0.84); C637(1.02); C351(1.02); C356(1.02)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C679(0.96); C637(0.82); C351(0.95); C356(0.95)  LDD1210  [6]
 LDCM0332  AC68 PaTu 8988t C737(1.16); C351(1.15); C356(1.15)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C737(1.06); C351(1.08); C356(1.08)  LDD1212  [6]
 LDCM0334  AC7 PaTu 8988t C679(0.84); C637(1.23); C351(1.02); C356(1.02)  LDD1213  [6]
 LDCM0335  AC70 PaTu 8988t C737(1.14); C351(1.17); C356(1.17)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C737(1.21); C351(1.19); C356(1.19)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C737(1.34); C351(0.99); C356(0.99)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C737(1.29); C351(1.02); C356(1.02)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C737(1.17); C351(1.01); C356(1.01)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C737(1.05); C351(1.15); C356(1.15)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C737(1.09); C351(1.06); C356(1.06)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C737(1.17); C351(1.30); C356(1.30)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C737(1.24); C351(0.96); C356(0.96)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C737(1.17); C351(1.15); C356(1.15)  LDD1223  [6]
 LDCM0345  AC8 PaTu 8988t C679(1.03); C637(0.87); C351(1.17); C356(1.17)  LDD1224  [6]
 LDCM0346  AC80 PaTu 8988t C737(1.24); C351(1.02); C356(1.02)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C737(1.18); C351(1.07); C356(1.07)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C737(1.20); C351(1.02); C356(1.02)  LDD1227  [6]
 LDCM0349  AC83 PaTu 8988t C679(1.12); C637(0.90); C351(1.18); C356(1.18)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C679(1.04); C637(0.67); C351(1.15); C356(1.15)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C679(1.19); C637(0.58); C351(1.35); C356(1.35)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C679(1.21); C637(0.60); C351(1.18); C356(1.18)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C679(1.10); C637(0.45); C351(1.35); C356(1.35)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C679(1.06); C637(1.31); C351(1.13); C356(1.13)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C679(1.19); C637(1.00); C351(1.13); C356(1.13)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C679(1.10); C637(1.12); C351(1.04); C356(1.04)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C679(1.03); C637(0.97); C351(1.22); C356(1.22)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C679(1.13); C637(1.06); C351(1.21); C356(1.21)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C679(1.20); C637(0.60); C351(1.25); C356(1.25)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C679(1.16); C637(1.03); C351(1.35); C356(1.35)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C679(1.22); C637(1.04); C351(1.27); C356(1.27)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C679(1.15); C637(1.40); C351(1.26); C356(1.26)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C679(1.19); C637(1.30); C351(1.07); C356(1.07)  LDD1243  [6]
 LDCM0365  AC98 PaTu 8988t C637(1.52); C351(1.11); C356(1.11)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C637(1.16); C351(1.06); C356(1.06)  LDD1245  [6]
 LDCM0545  Acetamide MDA-MB-231 C679(0.24); C191(0.58)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C679(1.08)  LDD2113  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C679(0.89); C637(0.84); C351(1.18); C356(1.18)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C679(0.97); C637(1.02); C351(1.13); C356(1.13)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C679(0.89); C637(0.88); C351(1.03); C356(1.03)  LDD1154  [6]
 LDCM0020  ARS-1620 HCC44 C637(1.19); C679(0.88)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C727(0.69); C191(0.75)  LDD2091  [3]
 LDCM0630  CCW28-3 231MFP C637(1.84)  LDD2214  [14]
 LDCM0108  Chloroacetamide HeLa C727(0.00); C737(0.00); C679(0.00)  LDD0222  [12]
 LDCM0367  CL1 PaTu 8988t C737(0.97); C637(1.23); C351(1.10); C356(1.10)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C737(0.69); C637(0.88); C351(1.21); C356(1.21)  LDD1247  [6]
 LDCM0369  CL100 PaTu 8988t C679(0.23); C351(0.63); C356(0.63)  LDD1248  [6]
 LDCM0370  CL101 PaTu 8988t C679(1.23); C637(1.08); C351(0.97); C356(0.97)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C679(0.79); C637(1.61); C351(0.99); C356(0.99)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C679(0.93); C637(1.59); C351(1.04); C356(1.04)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C679(1.02); C637(1.31); C351(1.02); C356(1.02)  LDD1252  [6]
 LDCM0374  CL105 PaTu 8988t C737(0.83); C679(0.98); C637(1.16); C351(0.95)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C737(0.93); C679(0.97); C637(1.41); C351(0.96)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C737(0.97); C679(1.09); C637(1.02); C351(1.11)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C737(0.88); C679(1.00); C637(1.03); C351(1.03)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C737(0.84); C679(1.01); C637(1.16); C351(1.04)  LDD1257  [6]
 LDCM0379  CL11 PaTu 8988t C737(0.90); C637(0.76); C351(1.01); C356(1.01)  LDD1258  [6]
 LDCM0380  CL110 PaTu 8988t C737(0.71); C679(0.91); C637(1.00); C351(1.16)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C737(0.67); C679(0.98); C637(1.11); C351(1.09)  LDD1260  [6]
 LDCM0382  CL112 PaTu 8988t C637(1.09); C351(0.95); C356(0.95)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C637(1.06); C351(0.85); C356(0.85)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C637(1.35); C351(0.81); C356(0.81)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C637(1.10); C351(0.82); C356(0.82)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C637(1.31); C351(1.35); C356(1.35)  LDD1265  [6]
 LDCM0387  CL117 PaTu 8988t C679(0.99); C637(2.02); C351(0.90); C356(0.90)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C679(1.18); C637(1.96); C351(1.12); C356(1.12)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C679(0.82); C637(1.78); C351(0.94); C356(0.94)  LDD1268  [6]
 LDCM0390  CL12 PaTu 8988t C737(0.88); C637(0.85); C351(0.91); C356(0.91)  LDD1269  [6]
 LDCM0391  CL120 PaTu 8988t C679(0.72); C637(2.25); C351(0.95); C356(0.95)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C679(1.11); C637(1.05); C351(1.08); C356(1.08)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C679(1.17); C637(1.37); C351(1.04); C356(1.04)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C679(1.07); C637(1.28); C351(1.06); C356(1.06)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C679(1.35); C637(1.03); C351(0.97); C356(0.97)  LDD1274  [6]
 LDCM0396  CL125 PaTu 8988t C679(0.92); C637(0.96); C351(0.96); C356(0.96)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C679(0.88); C637(1.03); C351(0.96); C356(0.96)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C679(0.91); C637(1.25); C351(0.90); C356(0.90)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C679(1.03); C637(1.04); C351(0.99); C356(0.99)  LDD1278  [6]
 LDCM0400  CL13 PaTu 8988t C737(0.74); C637(0.95); C351(1.25); C356(1.25)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C737(0.66); C637(1.18); C351(1.26); C356(1.26)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C737(0.77); C637(1.24); C351(0.92); C356(0.92)  LDD1281  [6]
 LDCM0403  CL16 PaTu 8988t C351(1.17); C356(1.17)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C351(0.89); C356(0.89)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C351(0.92); C356(0.92)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C351(0.92); C356(0.92)  LDD1285  [6]
 LDCM0407  CL2 PaTu 8988t C737(0.85); C637(1.45); C351(0.92); C356(0.92)  LDD1286  [6]
 LDCM0408  CL20 PaTu 8988t C351(1.16); C356(1.16)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C351(0.97); C356(0.97)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C351(1.02); C356(1.02)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C351(0.98); C356(0.98)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C351(0.95); C356(0.95)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C351(0.85); C356(0.85)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C351(0.95); C356(0.95)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C351(1.02); C356(1.02)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C351(1.08); C356(1.08)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C351(1.06); C356(1.06)  LDD1296  [6]
 LDCM0418  CL3 PaTu 8988t C737(0.85); C637(1.14); C351(1.25); C356(1.25)  LDD1297  [6]
 LDCM0419  CL30 PaTu 8988t C351(0.87); C356(0.87)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C637(0.52); C351(0.98); C356(0.98)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C637(0.38); C351(1.00); C356(1.00)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C637(0.90); C351(0.86); C356(0.86)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C637(0.56); C351(0.94); C356(0.94)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C637(0.75); C351(0.94); C356(0.94)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C637(0.88); C351(0.51); C356(0.51)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C637(0.32); C351(1.06); C356(1.06)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C637(0.50); C351(0.95); C356(0.95)  LDD1307  [6]
 LDCM0429  CL4 PaTu 8988t C737(0.89); C637(1.18); C351(1.10); C356(1.10)  LDD1308  [6]
 LDCM0430  CL40 PaTu 8988t C637(0.78); C351(0.99); C356(0.99)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C637(0.65); C351(0.91); C356(0.91)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C637(0.78); C351(1.01); C356(1.01)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C637(0.44); C351(1.00); C356(1.00)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C637(0.56); C351(0.95); C356(0.95)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C637(0.74); C351(0.86); C356(0.86)  LDD1314  [6]
 LDCM0436  CL46 PaTu 8988t C637(0.87); C351(0.90); C356(0.90)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C637(1.23); C351(0.90); C356(0.90)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C637(1.43); C351(1.00); C356(1.00)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C637(1.13); C351(0.92); C356(0.92)  LDD1318  [6]
 LDCM0440  CL5 PaTu 8988t C737(0.73); C637(1.30); C351(1.33); C356(1.33)  LDD1319  [6]
 LDCM0441  CL50 PaTu 8988t C637(1.08); C351(0.95); C356(0.95)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C637(0.73); C351(0.92); C356(0.92)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C637(0.94); C351(0.91); C356(0.91)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C637(0.73); C351(0.97); C356(0.97)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C637(0.79); C351(0.89); C356(0.89)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C637(1.18); C351(0.98); C356(0.98)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C637(0.70); C351(0.60); C356(0.60)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C637(1.13); C351(0.92); C356(0.92)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C637(1.16); C351(0.93); C356(0.93)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C637(1.07); C351(0.92); C356(0.92)  LDD1329  [6]
 LDCM0451  CL6 PaTu 8988t C737(0.75); C637(1.46); C351(1.07); C356(1.07)  LDD1330  [6]
 LDCM0452  CL60 PaTu 8988t C637(1.06); C351(0.88); C356(0.88)  LDD1331  [6]
 LDCM0453  CL61 PaTu 8988t C737(0.78); C637(0.88); C351(1.02); C356(1.02)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C737(1.07); C637(1.49); C351(0.93); C356(0.93)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C737(0.97); C637(0.94); C351(0.97); C356(0.97)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C737(0.82); C637(0.90); C351(0.93); C356(0.93)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C737(0.83); C637(1.03); C351(0.90); C356(0.90)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C737(0.79); C637(0.81); C351(0.89); C356(0.89)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C737(0.64); C637(0.92); C351(1.01); C356(1.01)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C737(0.77); C637(0.76); C351(1.01); C356(1.01)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C737(0.81); C637(0.88); C351(0.99); C356(0.99)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C737(0.75); C637(1.51); C351(1.12); C356(1.12)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C737(0.78); C637(0.49); C351(1.01); C356(1.01)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C737(1.14); C637(1.02); C351(0.96); C356(0.96)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C737(1.65); C637(0.77); C351(1.10); C356(1.10)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C737(0.77); C637(1.03); C351(0.95); C356(0.95)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C737(0.78); C637(0.89); C351(1.08); C356(1.08)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C737(0.97); C679(1.00); C637(0.87); C351(0.92)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C737(0.78); C679(1.23); C637(1.15); C351(0.85)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C737(1.21); C679(0.94); C637(1.01); C351(0.93)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C737(1.32); C679(0.92); C637(1.29); C351(0.93)  LDD1351  [6]
 LDCM0473  CL8 PaTu 8988t C737(0.75); C637(1.13); C351(0.92); C356(0.92)  LDD1352  [6]
 LDCM0474  CL80 PaTu 8988t C737(0.77); C679(1.08); C637(1.05); C351(0.88)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C737(0.91); C679(1.16); C637(1.20); C351(0.77)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C737(0.85); C679(1.09); C637(0.68); C351(0.82)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C737(1.18); C679(1.23); C637(0.96); C351(0.92)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C737(1.13); C679(0.91); C637(1.49); C351(0.89)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C737(0.86); C679(1.03); C637(1.82); C351(0.83)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C737(0.71); C679(0.86); C637(1.50); C351(0.83)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C737(0.82); C679(1.12); C637(1.55); C351(0.88)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C737(0.77); C679(1.05); C637(1.24); C351(0.79)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C737(0.78); C679(1.17); C637(1.88); C351(0.91)  LDD1362  [6]
 LDCM0484  CL9 PaTu 8988t C737(0.76); C637(1.14); C351(0.92); C356(0.92)  LDD1363  [6]
 LDCM0485  CL90 PaTu 8988t C737(1.08); C679(1.09); C637(1.70); C351(0.69)  LDD1364  [6]
 LDCM0486  CL91 PaTu 8988t C679(0.29); C351(0.61); C356(0.61)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C679(0.26); C351(0.54); C356(0.54)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C679(0.26); C351(0.56); C356(0.56)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C679(0.27); C351(0.54); C356(0.54)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C679(0.23); C351(0.48); C356(0.48)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C679(0.28); C351(0.51); C356(0.51)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C679(0.28); C351(0.54); C356(0.54)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C679(0.21); C351(0.63); C356(0.63)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C679(0.23); C351(0.58); C356(0.58)  LDD1373  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C637(1.82); C737(1.75); C727(1.43); C191(1.06)  LDD1702  [3]
 LDCM0625  F8 Ramos C737(1.05); C679(1.29); C727(1.12); C637(0.51)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C737(0.68); C679(1.01); C727(0.64)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C737(0.21); C679(1.26); C727(0.61); C637(0.45)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C737(0.86); C679(0.83); C727(0.63)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C737(0.90); C679(0.99); C727(1.15)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C737(1.01); C679(1.02); C727(0.34); C637(0.79)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C737(0.73); C679(0.61); C727(0.47)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C737(0.95); C679(0.92); C727(0.79)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C737(0.50); C679(0.45); C727(0.45)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C737(0.81); C679(0.83); C727(1.06)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C737(0.67); C679(0.28); C727(0.77); C637(0.57)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C737(0.88); C679(1.14); C727(1.28)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C737(0.97); C679(0.95); C727(0.81)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C737(0.74); C679(0.82); C727(0.68)  LDD2201  [15]
 LDCM0468  Fragment33 PaTu 8988t C737(0.82); C637(1.15); C351(0.91); C356(0.91)  LDD1347  [6]
 LDCM0596  Fragment38 Ramos C737(0.84); C679(0.87); C727(0.97)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C737(1.14); C679(0.92); C727(0.78); C637(0.78)  LDD2184  [15]
 LDCM0427  Fragment51 PaTu 8988t C637(0.88); C351(0.88); C356(0.88)  LDD1306  [6]
 LDCM0610  Fragment52 Ramos C737(0.94); C679(1.14); C727(1.22)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C737(0.90); C679(1.52); C727(1.12)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C737(0.87); C679(0.85); C727(0.60); C637(0.58)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C737(0.75); C679(0.88); C727(0.56)  LDD2188  [15]
 LDCM0116  HHS-0101 DM93 Y413(0.69)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y413(0.76)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y413(0.44)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y413(0.61)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y413(1.01)  LDD0268  [5]
 LDCM0107  IAA HeLa C727(0.00); C737(0.00)  LDD0221  [12]
 LDCM0022  KB02 T cell-activated C351, C356, C366(5.92)  LDD1708  [16]
 LDCM0023  KB03 MDA-MB-231 C637(4.11); C737(3.86); C679(2.55); C727(2.34)  LDD1701  [3]
 LDCM0024  KB05 G361 C191(3.98); C679(3.61); C737(3.35)  LDD3311  [17]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C737(0.72); C727(0.75)  LDD2102  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C679(0.45)  LDD2121  [3]
 LDCM0109  NEM HeLa N.A.  LDD0224  [12]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C679(0.32); C191(0.86)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C727(0.79); C679(1.15)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C727(0.64)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C737(1.16)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C737(0.80); C727(1.09); C637(1.80)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C727(0.80); C679(0.38); C191(0.08)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C727(0.49); C679(0.47)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C737(1.26); C727(0.85); C679(0.60)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C727(0.73); C679(0.85); C191(0.75)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C679(0.93)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C737(0.55); C727(0.64); C679(0.83); C191(0.88)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C737(1.02); C679(1.04)  LDD2105  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C727(0.48); C191(1.11)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C737(1.33); C727(1.18); C679(0.87)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C737(0.63); C727(0.76); C191(0.81)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C737(0.71); C727(0.57); C679(0.52)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C191(0.62)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C737(1.09)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C679(1.04); C191(1.17)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C679(0.54)  LDD2115  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C727(0.93); C679(0.69); C191(0.16)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C737(1.35)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C679(0.79); C191(0.93)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C727(0.63); C679(0.77); C191(0.13)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C737(0.82); C727(0.83); C679(0.57)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C727(0.76); C679(0.67); C191(0.12)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C737(0.95); C679(0.51)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C737(1.58); C727(1.04); C679(0.68); C191(0.11)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C737(1.07); C727(1.17); C679(0.79)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C191(0.42)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C737(1.30); C727(0.89)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C679(0.90)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C737(0.71); C679(0.40)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C737(1.51); C679(1.10)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C679(0.90)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C727(1.01); C679(0.88); C637(1.13)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C679(0.88)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C737(0.89); C727(0.84); C679(0.41)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C727(0.78); C679(0.79); C191(0.92)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C191(0.43)  LDD2143  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C679(5.24)  LDD2145  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C191(0.64)  LDD2147  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C679(0.85); C191(0.15)  LDD2149  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C679(0.26); C191(0.18)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C191(0.23)  LDD2151  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C679(1.33); C191(6.89); C637(1.22)  LDD2153  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DHX58 (DHX58) Helicase family Q96C10
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840