Details of the Target

General Information of Target

Target ID LDTP05425
Target Name Neurogenic locus notch homolog protein 2 (NOTCH2)
Gene Name NOTCH2
Gene ID 4853
Synonyms
Neurogenic locus notch homolog protein 2; Notch 2; hN2) [Cleaved into: Notch 2 extracellular truncation; N2ECD; Notch 2 intracellular domain; N2ICD)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE
YCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGT
CHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE
TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTG
DFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD
ECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF
SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECA
MANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTC
LCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP
CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYM
GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICM
DGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQ
VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYR
CTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPN
PCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECP
PGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKN
GGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGS
FCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQ
KKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLG
YTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGG
TCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGER
CEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCA
VASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCAS
SPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCD
EACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNS
KTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQ
DARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAG
SKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERTQLLY
LLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNL
SVQVSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIR
RTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIIT
DLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAA
DAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSA
LHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITD
HMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMG
KKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTY
VSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPS
VSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHP
GIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMY
QIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAER
TPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMS
EPPHNNMQVYA
Target Type
Clinical trial
Target Bioclass
Other
Family
NOTCH family
Subcellular location
Nucleus; Cell membrane
Function
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells.
TTD ID
T88656
Uniprot ID
Q04721
DrugMap ID
TT82FVD
Ensemble ID
ENST00000256646.7
HGNC ID
HGNC:7882
ChEMBL ID
CHEMBL3407320

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.77  LDD0402  [1]
STPyne
 Probe Info  		K1705(1.02); K1725(5.88); K2095(0.75)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K693(1.50); K1058(1.50); K1350(2.12); K1353(7.44)  LDD3494  [3]
AHL-Pu-1
 Probe Info  		C1829(2.08)  LDD0169  [4]
DBIA
 Probe Info  		C412(0.89); C419(0.89); C1235(0.86); C1241(0.86)  LDD0078  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
IA-alkyne
 Probe Info  		C264(0.00); C1060(0.00); C1829(0.00)  LDD0165  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
IPM
 Probe Info  		N.A.  LDD0147  [9]
PF-06672131
 Probe Info  		N.A.  LDD0017  [10]
TFBX
 Probe Info  		C1250(0.00); C1366(0.00); C1357(0.00); C1829(0.00)  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		12.00  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		8.28  LDD1850  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1829(2.02)  LDD0371  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1829(2.08)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C1067(0.89)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1229(0.97); C1632(0.89); C1639(0.89)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1049(0.89); C1051(0.89); C1060(0.80); C1067(0.80)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1049(0.79); C1051(0.79); C1060(0.96); C1067(0.96)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1049(0.84); C1051(0.84); C1060(0.78); C1067(0.78)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1049(0.95); C1051(0.95); C1060(0.99); C1067(0.99)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1049(0.95); C1051(0.95); C1060(1.01); C1067(1.01)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1049(1.21); C1051(1.21); C1060(1.00); C1067(1.00)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1049(1.07); C1051(1.07); C1060(1.00); C1067(1.00)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1049(1.04); C1051(0.90); C1060(0.81); C1067(0.99)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1049(0.68); C1051(0.72); C1060(0.89); C1067(0.86)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1049(1.32); C1051(0.89); C1060(1.08); C1067(0.91)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1229(0.92); C1632(0.90); C1639(0.90)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1049(0.74); C1051(0.84); C1060(1.07); C1067(0.77)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1049(0.76); C1051(0.82); C1060(0.83); C1067(0.73)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1049(0.89); C1051(0.85); C1060(0.85); C1067(0.94)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1049(0.93); C1051(0.93); C1060(0.82); C1067(0.82)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1049(1.17); C1051(1.17); C1060(1.02); C1067(0.97)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1049(1.24); C1051(1.24); C1060(0.99); C1067(0.83)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1049(1.25); C1051(1.25); C1060(0.82); C1067(0.88)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1049(1.09); C1051(1.09); C1060(0.82); C1067(0.94)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1049(1.10); C1051(1.10); C1060(0.93); C1067(0.89)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1049(1.26); C1051(1.26); C1060(0.94); C1067(0.97)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1229(0.93); C1632(1.01); C1639(1.01)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1049(1.30); C1051(1.30); C1060(1.12); C1067(0.87)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1049(1.14); C1051(1.14); C1060(1.03); C1067(1.03)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1049(1.26); C1051(1.26); C1060(1.02); C1067(1.16)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1049(1.11); C1051(1.11); C1060(1.08); C1067(1.18)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1049(1.17); C1051(1.17); C1060(0.89); C1067(1.11)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1049(1.21); C1051(1.21); C1060(0.97); C1067(1.15)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1049(1.39); C1051(1.39); C1060(1.13); C1067(1.15)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1049(1.25); C1051(1.25); C1060(0.96); C1067(1.18)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1049(1.18); C1051(1.18); C1632(1.24); C1639(1.24)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1049(0.75); C1051(0.75); C1632(1.18); C1639(1.18)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1049(1.00); C1051(1.00); C1632(0.84); C1639(0.84)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1049(0.83); C1051(0.83); C1632(1.11); C1639(1.11)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1049(0.79); C1051(0.79); C1632(0.71); C1639(0.71)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1049(0.93); C1051(0.93); C1632(0.77); C1639(0.77)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1049(0.86); C1051(0.86); C1632(0.76); C1639(0.76)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1049(0.83); C1051(0.83); C1632(0.70); C1639(0.70)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1049(0.78); C1051(0.78); C1632(0.64); C1639(0.64)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1049(0.88); C1051(0.88); C1632(0.83); C1639(0.83)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1049(0.81); C1051(0.81); C1632(0.87); C1639(0.87)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1049(0.79); C1051(0.79); C1632(0.65); C1639(0.65)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1229(0.90); C1632(1.20); C1639(1.20)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1049(0.85); C1051(0.85); C1632(0.66); C1639(0.66)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1049(0.97); C1051(0.97); C1632(0.63); C1639(0.63)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1049(0.68); C1051(0.68); C1632(0.73); C1639(0.73)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C1049(0.84); C1051(0.84); C1060(1.09); C1067(1.09)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C1049(1.11); C1051(1.11); C1060(1.63); C1067(1.63)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C1049(1.07); C1051(1.07); C1060(1.23); C1067(1.23)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C1049(0.91); C1051(0.91); C1060(1.37); C1067(1.37)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C1049(1.16); C1051(1.16); C1060(1.27); C1067(1.27)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C1049(1.37); C1051(1.37); C1060(2.15); C1067(2.15)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C1049(0.98); C1051(0.98); C1060(1.71); C1067(1.71)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C1229(0.85); C1632(1.06); C1639(1.06)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C1049(0.97); C1051(0.97); C1060(1.03); C1067(1.03)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C1049(1.08); C1051(1.08); C1060(1.14); C1067(1.14)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C1060(1.11); C1067(1.11); C1049(1.23); C1051(1.23)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1049(1.44); C1051(1.44); C1060(1.96); C1067(1.96)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1049(1.18); C1051(1.18); C1060(2.21); C1067(2.21)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1049(1.20); C1051(1.20); C1060(1.48); C1067(1.48)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1049(0.98); C1051(0.98); C1060(1.04); C1067(1.04)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1049(1.01); C1051(1.01); C1060(1.66); C1067(1.66)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1366(0.84); C1229(0.86); C1632(1.15); C1639(1.15)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1366(0.99); C1632(1.06); C1639(1.06); C1229(1.09)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1366(1.04); C1632(1.19); C1639(1.19); C1229(1.28)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1067(2.05)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C1366(0.68); C1229(0.85); C1632(1.12); C1639(1.12)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1229(0.88); C1366(0.99); C1632(1.17); C1639(1.17)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1366(0.82); C1632(0.96); C1639(0.96); C1229(1.00)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1229(0.79); C1366(0.80); C1632(0.95); C1639(0.95)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1229(0.81); C1366(0.91); C1632(1.23); C1639(1.23)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C1632(0.97); C1639(0.97); C362(1.03); C364(1.11)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C1632(0.61); C1639(0.61); C362(1.18); C364(1.23)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C1632(0.82); C1639(0.82); C362(1.14); C364(1.23)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C1632(0.62); C1639(0.62); C362(1.17); C364(1.26)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1632(0.61); C1639(0.61); C362(1.21); C364(1.30)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C1067(1.35)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1632(0.67); C1639(0.67); C362(1.34); C364(1.48)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C1632(0.63); C1639(0.63); C362(1.27); C364(1.29)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1632(0.57); C1639(0.57); C362(1.47); C364(1.61)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1632(0.91); C1639(0.91); C362(1.32); C364(1.41)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1632(1.17); C1639(1.17); C364(1.29); C362(1.31)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C362(0.97); C364(1.06); C1632(1.17); C1639(1.17)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1632(0.89); C1639(0.89); C362(0.96); C364(1.17)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C364(0.87); C362(0.87); C1632(1.22); C1639(1.22)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C364(0.87); C362(0.94); C1632(1.13); C1639(1.13)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1632(1.00); C1639(1.00); C362(1.03); C364(1.07)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C1067(1.10)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C1632(0.89); C1639(0.89); C362(1.07); C364(1.25)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C1632(0.86); C1639(0.86); C362(0.94); C364(1.04)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1632(0.77); C1639(0.77); C362(0.95); C364(0.98)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C1632(0.80); C1639(0.80); C362(1.03); C364(1.07)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C1632(1.11); C1639(1.11); C362(1.14); C364(1.22)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C1632(1.07); C1639(1.07); C362(1.09); C364(1.14)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C1632(0.56); C1639(0.56); C364(0.59); C362(0.82)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C1632(0.69); C1639(0.69); C364(0.73); C362(0.82)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C364(0.50); C1632(0.67); C1639(0.67); C362(0.69)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C1632(0.51); C1639(0.51); C364(0.86); C362(1.03)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C1067(1.05)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C364(0.53); C1632(0.59); C1639(0.59); C362(0.78)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C364(0.50); C1632(0.69); C1639(0.69); C362(0.75)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C1632(0.58); C1639(0.58); C364(0.63); C362(0.81)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C364(0.61); C1632(0.64); C1639(0.64); C362(0.79)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C364(0.56); C1632(0.69); C1639(0.69); C362(0.81)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C1632(0.75); C1639(0.75); C364(0.90); C362(0.93)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C1632(0.61); C1639(0.61); C362(0.98); C364(1.01)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1060(1.27); C1067(1.27)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1060(1.38); C1067(1.38)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1060(1.48); C1067(1.48)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C1632(0.90); C1639(0.90); C1229(0.94)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1060(1.58); C1067(1.58)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1060(1.61); C1067(1.61)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1060(1.52); C1067(1.52)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1060(1.47); C1067(1.47)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1060(1.50); C1067(1.50)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C1060(1.05); C1067(1.05)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1060(1.10); C1067(1.10)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1060(1.02); C1067(1.02)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1060(0.83); C362(1.01); C364(1.01); C1049(1.15)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1060(0.90); C1049(1.04); C1051(1.04); C1632(1.04)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C1632(0.88); C1639(0.88); C1229(0.93)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C1632(0.88); C1639(0.88); C362(1.05); C364(1.05)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C362(0.84); C364(0.84); C1060(0.99); C1632(1.11)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C1632(0.89); C1639(0.89); C1049(0.95); C1051(0.95)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C1632(0.89); C1639(0.89); C1060(1.27); C362(1.32)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1060(0.89); C1632(1.23); C1639(1.23); C1049(1.35)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C1632(0.85); C1639(0.85); C1060(1.08); C1049(1.41)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C362(0.90); C364(0.90); C1060(1.06); C1632(1.18)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1060(0.90); C362(0.92); C364(0.92); C1632(0.94)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C362(0.88); C364(0.88); C1049(0.96); C1051(0.96)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C362(0.95); C364(0.95); C1632(0.98); C1639(0.98)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C1632(0.85); C1639(0.85); C1229(1.00)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C362(0.96); C364(0.96); C1049(1.00); C1051(1.00)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C1049(0.73); C1051(0.73); C362(0.87); C364(0.87)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C1060(1.18); C1632(1.33); C1639(1.33); C1049(1.50)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C1632(0.80); C1639(0.80); C1229(1.14); C1067(1.32)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C1632(0.71); C1639(0.71); C1067(1.27); C1060(1.36)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1632(0.65); C1639(0.65); C1229(1.18); C1049(1.40)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1632(0.80); C1639(0.80); C1229(1.11); C1049(1.24)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1229(0.94); C1632(0.94); C1639(0.94); C1049(1.05)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C1632(0.84); C1639(0.84); C1229(1.21); C362(1.25)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C1632(0.87); C1639(0.87); C1229(1.19); C1049(1.28)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C1632(0.85); C1639(0.85); C1229(1.15); C362(1.20)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C1632(0.79); C1639(0.79); C1229(0.80); C1049(1.44)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C1632(0.80); C1639(0.80); C1229(1.01); C1049(1.57)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1632(0.91); C1639(0.91); C1229(1.07); C1067(1.33)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1632(0.70); C1639(0.70); C1229(0.88); C1060(1.21)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1632(0.88); C1639(0.88); C1229(1.01); C362(1.13)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C1632(0.82); C1639(0.82); C1229(0.92); C364(1.49)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C1632(0.82); C1639(0.82); C1229(1.22); C1049(1.63)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C1632(0.70); C1639(0.70); C1060(0.92); C1067(0.92)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C1632(0.73); C1639(0.73); C1060(0.76); C1067(0.76)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C1229(0.91); C1632(1.02); C1639(1.02)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C1229(0.87); C1632(0.94); C1639(0.94)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C1632(0.89); C1639(0.89); C1229(0.94)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C412(0.89); C419(0.89); C1235(0.86); C1241(0.86)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C1829(2.93); C2085(1.02)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C1632(1.14); C1639(1.14); C1366(1.17)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C1366(0.86); C1632(1.25); C1639(1.25)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C1067(1.76)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C1229(0.89); C1632(1.04); C1639(1.04)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C1229(0.90); C1632(1.16); C1639(1.16)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C1229(0.86); C1632(1.07); C1639(1.07)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C1229(0.96); C1632(1.17); C1639(1.17)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1366(0.78); C1229(0.98); C1632(1.40); C1639(1.40)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1366(0.72); C1632(0.93); C1639(0.93); C1229(1.05)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1366(0.97); C1632(1.02); C1639(1.02); C1229(1.09)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1366(0.77); C1229(1.27); C1632(1.32); C1639(1.32)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1366(0.96); C1632(0.97); C1639(0.97); C1229(1.01)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1366(1.11); C1632(1.34); C1639(1.34)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C1366(0.90); C1229(1.04); C1632(1.18); C1639(1.18)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1366(0.90); C1229(1.03); C1632(1.09); C1639(1.09)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C1632(0.81); C1639(0.81); C362(1.15); C364(1.21)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1632(0.64); C1639(0.64); C362(1.30); C364(1.36)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1632(0.75); C1639(0.75); C362(1.14); C364(1.16)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C1632(0.75); C1639(0.75); C364(1.37); C362(1.40)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1632(0.95); C1639(0.95); C362(1.31); C364(1.35)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C362(0.84); C1632(0.93); C1639(0.93); C364(0.96)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1632(0.91); C1639(0.91); C364(0.96); C362(0.98)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1632(0.84); C1639(0.84); C362(1.03); C364(1.04)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C1632(1.24); C1639(1.24); C1366(1.31)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C1632(0.76); C1639(0.76); C362(0.99); C364(1.12)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C1632(0.79); C1639(0.79); C364(0.80); C362(0.87)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C364(0.71); C362(0.86); C1632(0.87); C1639(0.87)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C364(0.73); C362(0.81); C1632(0.90); C1639(0.90)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C1632(0.62); C1639(0.62); C362(1.05); C364(1.13)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C1060(1.39); C1067(1.39)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1060(1.37); C1067(1.37)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1060(1.44); C1067(1.44)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1060(1.53); C1067(1.53)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C1632(1.14); C1639(1.14); C1366(1.59)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C1632(1.08); C1639(1.08); C1366(1.66)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C1632(1.20); C1639(1.20); C1366(1.73)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C1632(1.12); C1639(1.12); C1060(1.18); C1067(1.18)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C1060(0.97); C1067(0.97); C364(1.04); C362(1.14)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C364(1.04); C362(1.04); C1060(1.10); C1067(1.10)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1060(0.96); C1067(0.96); C1632(1.08); C1639(1.08)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1632(1.01); C1639(1.01); C1366(1.41)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1060(0.97); C1067(0.97); C1632(0.98); C1639(0.98)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C1060(0.79); C1067(0.79); C1632(0.79); C1639(0.79)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1060(0.76); C1067(0.76); C364(0.94); C1632(0.96)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C1632(0.95); C1639(0.95); C364(0.95); C362(1.13)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C364(0.90); C362(0.98); C1632(1.08); C1639(1.08)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1060(1.20); C1067(1.20); C1632(0.88); C1639(0.88)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1060(1.30); C1067(1.30); C1632(0.94); C1639(0.94)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1060(1.33); C1067(1.33); C1632(0.86); C1639(0.86)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1060(1.46); C1067(1.46); C1632(0.96); C1639(0.96)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1060(1.36); C1067(1.36); C1632(0.95); C1639(0.95)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1366(1.23); C1632(1.18); C1639(1.18)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1060(1.32); C1067(1.32); C1632(0.87); C1639(0.87)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1229(0.83); C1632(0.96); C1639(0.96)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1229(0.94); C1632(1.01); C1639(1.01)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1229(0.91); C1632(0.94); C1639(0.94)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1229(0.77); C1632(0.93); C1639(0.93)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1229(1.11); C1632(1.01); C1639(1.01)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1229(0.90); C1632(0.92); C1639(0.92)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1229(0.89); C1632(1.06); C1639(1.06)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1229(0.74); C1632(0.97); C1639(0.97)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1366(1.02); C1632(1.21); C1639(1.21)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1229(0.90); C1632(0.94); C1639(0.94)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1229(0.89); C1632(0.86); C1639(0.86)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1229(0.82); C1632(1.15); C1639(1.15)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1229(0.70); C1632(1.03); C1639(1.03)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1229(0.67); C1632(0.96); C1639(0.96)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1229(0.70); C1632(0.99); C1639(0.99)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1229(0.89); C1366(1.02); C1632(0.87); C1639(0.87)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1229(1.39); C1366(1.49); C1632(0.85); C1639(0.85)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1229(1.04); C1366(1.13); C1632(0.85); C1639(0.85)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1229(0.74); C1366(0.98); C1632(0.99); C1639(0.99)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1366(1.19); C1632(0.96); C1639(0.96)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1229(0.84); C1366(0.97); C1632(0.91); C1639(0.91)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1229(0.95); C1366(0.79); C1632(1.13); C1639(1.13)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1229(1.06); C1366(1.02); C1632(0.92); C1639(0.92)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1229(0.64); C1366(0.94); C1632(0.82); C1639(0.82)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1229(0.84); C1366(1.05); C1632(1.03); C1639(1.03)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1229(0.56); C1366(0.91); C1632(1.01); C1639(1.01)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1229(0.81); C1366(0.82); C1632(1.10); C1639(1.10)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1229(0.78); C1366(0.85); C1632(1.01); C1639(1.01)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1229(0.75); C1366(1.22); C1632(1.11); C1639(1.11)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1229(0.80); C1366(0.91); C1632(1.16); C1639(1.16)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1366(1.69); C1632(1.09); C1639(1.09)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1229(0.91); C1366(1.16); C1632(1.02); C1639(1.02)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1060(1.26); C1067(1.26); C1632(0.84); C1639(0.84)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1060(1.43); C1067(1.43); C1632(0.85); C1639(0.85)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1060(0.94); C1067(0.94); C1632(0.94); C1639(0.94)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1060(1.17); C1067(1.17); C1632(0.97); C1639(0.97)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1060(0.98); C1067(0.98); C1632(0.96); C1639(0.96)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1060(1.26); C1067(1.26); C1632(0.96); C1639(0.96)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1060(1.04); C1067(1.04); C1632(0.98); C1639(0.98)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1060(0.92); C1067(0.92); C1632(1.04); C1639(1.04)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1060(1.13); C1067(1.13); C1632(1.06); C1639(1.06)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1366(2.22); C1632(1.20); C1639(1.20)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1060(1.03); C1067(1.03); C1632(0.93); C1639(0.93)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1060(1.26); C1067(1.26); C1632(0.86); C1639(0.86)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1060(1.02); C1067(1.02); C1632(0.89); C1639(0.89)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1060(1.08); C1067(1.08); C1632(0.86); C1639(0.86)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1060(1.07); C1067(1.07); C1632(0.85); C1639(0.85)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1049(0.87); C1051(0.87); C362(0.98); C364(1.00)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1049(0.83); C1051(0.83); C362(0.95); C364(0.98)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1049(0.98); C1051(0.98); C362(1.00); C364(1.19)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1049(0.95); C1051(0.95); C362(0.99); C364(0.99)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1366(0.92); C1632(1.11); C1639(1.11)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1049(0.94); C1051(0.94); C362(0.97); C364(0.94)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1049(0.82); C1051(0.82); C362(1.07); C364(0.97)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1049(0.80); C1051(0.80); C362(0.92); C364(1.00)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1049(0.92); C1051(0.92); C362(0.98); C364(1.13)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1049(0.73); C1051(0.73); C362(1.01); C364(0.95)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1049(0.82); C1051(0.82); C362(0.93); C364(1.12)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1049(0.74); C1051(0.74); C362(0.89); C364(0.88)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1049(0.87); C1051(0.87); C362(0.94); C364(1.07)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1049(0.75); C1051(0.75); C362(0.91); C364(0.79)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1049(0.91); C1051(0.91); C362(0.97); C364(1.12)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1366(1.30); C1632(1.13); C1639(1.13)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1049(0.61); C1051(0.61); C362(0.51); C364(0.95)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1067(1.42)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1067(0.89)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1067(1.55)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1067(1.75)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1067(0.96)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1067(1.31)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1067(1.24)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1067(0.90)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1067(0.99)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C264(1.80)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C264(1.40); C1250(0.92); C1509(1.22); C1252(1.07)  LDD1698  [16]
 LDCM0468  Fragment33 HCT 116 C1060(1.15); C1067(1.15); C1632(0.93); C1639(0.93)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C1229(0.79); C1632(1.05); C1639(1.05)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C1632(4.46); C1639(4.46); C480(4.86); C482(4.86)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C1632(3.78); C1639(3.78); C480(3.02); C482(3.02)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C1632(5.99); C1639(5.99); C480(4.89); C482(4.89)  LDD0082  [5]
 LDCM0021  THZ1 HCT 116 C1250(1.37); C362(1.08); C364(1.08); C1366(1.10)  LDD2173  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tarextumab Monoclonal antibody D01QLP

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402