Details of the Target

General Information of Target

Target ID LDTP04691
Target Name Laminin subunit beta-2 (LAMB2)
Gene Name LAMB2
Gene ID 3913
Synonyms
LAMS; Laminin subunit beta-2; Laminin B1s chain; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-laminin subunit beta; S-LAM beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELTSRERGRGQPLPWELRLGLLLSVLAATLAQAPAPDVPGCSRGSCYPATGDLLVGRAD
RLTASSTCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRR
AAWWQSENGIPAVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSY
DCGADFPGVPLAPPRHWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSRIQNLL
KITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYELVVRGNCFCYGHASECAPAPGAPA
HAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDM
AVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDG
GRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPG
STPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQ
CHCRQHMVGRRCEQVQPGYFRPFLDHLIWEAEDTRGQVLDVVERLVTPGETPSWTGSGFV
RLQEGQTLEFLVASVPKAMDYDLLLRLEPQVPEQWAELELIVQRPGPVPAHSLCGHLVPK
DDRIQGTLQPHARYLIFPNPVCLEPGISYKLHLKLVRTGGSAQPETPYSGPGLLIDSLVL
LPRVLVLEMFSGGDAAALERQATFERYQCHEEGLVPSKTSPSEACAPLLISLSTLIYNGA
LPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGYYGFGPTGCQACQCSHEGALS
SLCEKTSGQCLCRTGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDHT
GGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGY
TGLRCEACAPGHFGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCA
HCKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCA
PNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQC
HACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARGFSGIFPACHPCHACFGDWDRV
VQDLAARTQRLEQRAQELQQTGVLGAFESSFWHMQEKLGIVQGIVGARNTSAASTAQLVE
ATEELRREIGEATEHLTQLEADLTDVQDENFNANHALSGLERDRLALNLTLRQLDQHLDL
LKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSASARHRTEALMDAQKEDFN
SKHMANQRALGKLSAHTHTLSLTDINELVCGAPGDAPCATSPCGGAGCRDEDGQPRCGGL
SCNGAAATADLALGRARHTQAELQRALAEGGSILSRVAETRRQASEAQQRAQAALDKANA
SRGQVEQANQELQELIQSVKDFLNQEGADPDSIEMVATRVLELSIPASAEQIQHLAGAIA
ERVRSLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGI
AQGAIRGAVADTRDTEQTLYQVQERMAGAERALSSAGERARQLDALLEALKLKRAGNSLA
ASTAEETAGSAQGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVLAAQARAEQLRDEARD
LLQAAQDKLQRLQELEGTYEENERALESKAAQLDGLEARMRSVLQAINLQVQIYNTCQ
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Uniprot ID
P55268
Ensemble ID
ENST00000305544.9
HGNC ID
HGNC:6487
ChEMBL ID
CHEMBL2364187

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1720(2.17)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K1720(5.02)  LDD3494  [2]
Probe 1
 Probe Info  		Y1640(33.25)  LDD3495  [3]
HHS-482
 Probe Info  		Y48(0.99)  LDD0285  [4]
HHS-465
 Probe Info  		Y48(1.19)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
DBIA
 Probe Info  		C321(1.04); C324(1.04)  LDD0078  [7]
IA-alkyne
 Probe Info  		C905(0.00); C1155(0.00); C407(0.00)  LDD0162  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C182(0.60); C423(0.30); C438(0.30); C47(0.82)  LDD1093  [7]
 LDCM0215  AC10 PaTu 8988t C47(1.15)  LDD1094  [7]
 LDCM0216  AC100 HCT 116 C47(0.84)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C47(1.08)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C47(1.01)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C47(1.16)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C47(1.03)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C47(1.19)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C47(0.93)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C47(0.67)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C47(1.41)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C47(1.26)  LDD0542  [7]
 LDCM0226  AC11 PaTu 8988t C47(0.99)  LDD1105  [7]
 LDCM0227  AC110 HCT 116 C47(1.43)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C47(1.06)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C47(0.69)  LDD0546  [7]
 LDCM0230  AC113 PaTu 8988t C47(0.82)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C47(0.93)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C47(1.02)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C47(0.95)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C47(1.27)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C47(1.12)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C47(1.24)  LDD1115  [7]
 LDCM0237  AC12 PaTu 8988t C47(0.97)  LDD1116  [7]
 LDCM0238  AC120 PaTu 8988t C47(0.95)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C47(1.17)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C47(0.82)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C47(0.82)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C47(0.88)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C47(1.03)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C47(1.03)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C47(1.15)  LDD1124  [7]
 LDCM0246  AC128 PaTu 8988t C423(1.05); C438(1.05)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C423(0.91); C438(0.91)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C423(0.91); C438(0.91)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C423(0.77); C438(0.77)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C423(1.00); C438(1.00)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C423(0.94); C438(0.94)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C423(0.95); C438(0.95)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C423(0.94); C438(0.94)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C423(1.17); C438(1.17)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C423(0.90); C438(0.90)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C423(0.75); C438(0.75)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C423(1.04); C438(1.04)  LDD1137  [7]
 LDCM0259  AC14 PaTu 8988t C47(1.03)  LDD1138  [7]
 LDCM0260  AC140 PaTu 8988t C423(1.01); C438(1.01)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C423(0.97); C438(0.97)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C423(0.77); C438(0.77)  LDD1141  [7]
 LDCM0270  AC15 PaTu 8988t C47(1.14)  LDD1149  [7]
 LDCM0276  AC17 HCT 116 C47(0.88)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C47(1.77)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C47(1.30)  LDD0595  [7]
 LDCM0279  AC2 PaTu 8988t C182(0.63); C423(0.39); C438(0.39); C47(0.87)  LDD1158  [7]
 LDCM0280  AC20 HCT 116 C47(1.26)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C47(1.18)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C47(1.10)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C47(1.31)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C47(0.91)  LDD0601  [7]
 LDCM0285  AC25 PaTu 8988t C321(1.14); C324(1.14); C182(0.73); C423(1.38)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C321(0.89); C324(0.89); C182(0.90); C423(1.41)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C321(0.83); C324(0.83); C182(0.75); C423(1.14)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C321(0.90); C324(0.90); C182(0.89); C423(1.12)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C321(0.79); C324(0.79); C182(0.71); C423(1.15)  LDD1168  [7]
 LDCM0290  AC3 PaTu 8988t C182(0.75); C423(0.35); C438(0.35); C47(1.14)  LDD1169  [7]
 LDCM0291  AC30 PaTu 8988t C321(0.80); C324(0.80); C182(0.63); C423(0.98)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C321(0.59); C324(0.59); C182(0.74); C423(1.35)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C321(0.64); C324(0.64); C182(0.54); C423(0.98)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C321(1.08); C324(1.08); C182(0.72); C423(1.37)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C321(0.69); C324(0.69); C182(0.59); C423(1.14)  LDD1174  [7]
 LDCM0296  AC35 HCT 116 C47(0.92)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C47(0.99)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C47(1.15)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C47(0.91)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C47(1.16)  LDD0617  [7]
 LDCM0301  AC4 PaTu 8988t C182(0.83); C423(0.37); C438(0.37); C47(0.72)  LDD1180  [7]
 LDCM0302  AC40 HCT 116 C47(1.22)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C47(1.11)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C47(1.15)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C47(0.89)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C47(1.17)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C47(1.34)  LDD0624  [7]
 LDCM0308  AC46 HEK-293T C344(0.95); C407(1.05); C202(1.03); C749(1.03)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C344(0.99); C407(1.09); C202(0.98); C749(1.23)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C344(0.95); C407(1.00); C202(1.02); C749(0.87)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C344(1.04); C407(1.12); C202(1.08); C749(1.04)  LDD1550  [11]
 LDCM0312  AC5 PaTu 8988t C182(0.65); C423(0.32); C438(0.32); C47(0.62)  LDD1191  [7]
 LDCM0313  AC50 HEK-293T C344(1.02); C407(1.07); C202(0.97); C749(0.90)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C344(1.06); C407(1.02); C202(1.06); C749(0.95)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C344(1.03); C407(1.07); C202(0.94); C749(0.99)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C344(0.97); C407(1.09); C202(1.14); C749(0.99)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C344(0.96); C407(0.94); C202(1.06); C749(0.97)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C344(0.99); C407(1.05); C202(0.86); C749(1.10)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C344(1.02); C407(1.05); C202(1.15); C749(0.90)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C344(0.97); C407(1.11); C202(1.04); C749(1.01)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C344(1.05); C407(1.08); C202(1.02); C749(0.96)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C344(0.96); C407(1.05); C202(1.10); C749(0.92)  LDD1561  [11]
 LDCM0323  AC6 PaTu 8988t C47(1.09)  LDD1202  [7]
 LDCM0324  AC60 HEK-293T C344(0.95); C407(1.06); C202(0.96); C749(0.98)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C344(1.08); C407(1.07); C202(1.06); C749(1.04)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C344(0.99); C407(1.05); C202(0.89); C749(0.93)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C344(1.02); C407(1.10); C202(0.90); C749(0.97)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C344(0.94); C407(1.11); C202(1.06); C749(0.90)  LDD1567  [11]
 LDCM0332  AC68 PaTu 8988t C47(1.03)  LDD1211  [7]
 LDCM0333  AC69 PaTu 8988t C47(1.17)  LDD1212  [7]
 LDCM0334  AC7 PaTu 8988t C47(1.00)  LDD1213  [7]
 LDCM0335  AC70 PaTu 8988t C47(1.21)  LDD1214  [7]
 LDCM0336  AC71 PaTu 8988t C47(1.03)  LDD1215  [7]
 LDCM0337  AC72 PaTu 8988t C47(1.13)  LDD1216  [7]
 LDCM0338  AC73 PaTu 8988t C47(0.94)  LDD1217  [7]
 LDCM0339  AC74 PaTu 8988t C47(1.11)  LDD1218  [7]
 LDCM0340  AC75 PaTu 8988t C47(1.48)  LDD1219  [7]
 LDCM0341  AC76 PaTu 8988t C47(1.22)  LDD1220  [7]
 LDCM0342  AC77 PaTu 8988t C47(1.14)  LDD1221  [7]
 LDCM0343  AC78 PaTu 8988t C47(1.15)  LDD1222  [7]
 LDCM0344  AC79 PaTu 8988t C47(1.15)  LDD1223  [7]
 LDCM0345  AC8 PaTu 8988t C47(1.04)  LDD1224  [7]
 LDCM0346  AC80 PaTu 8988t C47(1.26)  LDD1225  [7]
 LDCM0347  AC81 PaTu 8988t C47(1.17)  LDD1226  [7]
 LDCM0348  AC82 PaTu 8988t C47(1.11)  LDD1227  [7]
 LDCM0349  AC83 PaTu 8988t C182(0.85); C423(1.33); C438(1.33)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C182(0.88); C423(1.16); C438(1.16)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C182(0.74); C423(1.19); C438(1.19)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C182(0.95); C423(1.31); C438(1.31)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C182(1.22); C423(1.18); C438(1.18)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C182(0.83); C423(1.16); C438(1.16)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C182(0.84); C423(0.97); C438(0.97)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C182(1.10); C423(1.28); C438(1.28)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C182(1.01); C423(1.24); C438(1.24)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C182(0.98); C423(1.20); C438(1.20)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C182(0.88); C423(0.95); C438(0.95)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C182(0.74); C423(1.14); C438(1.14)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C182(0.89); C423(1.09); C438(1.09)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C182(0.89); C423(1.43); C438(1.43)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C182(0.70); C423(1.06); C438(1.06)  LDD1243  [7]
 LDCM0365  AC98 HCT 116 C47(1.42)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C47(0.98)  LDD0683  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C47(1.09)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C47(1.33)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C47(1.28)  LDD1154  [7]
 LDCM0020  ARS-1620 HCC44 C321(1.04); C324(1.04)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HCT 116 C47(0.94)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C47(0.86)  LDD0685  [7]
 LDCM0369  CL100 PaTu 8988t C182(0.69); C423(0.40); C438(0.40); C47(0.61)  LDD1248  [7]
 LDCM0370  CL101 PaTu 8988t C47(1.12)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C47(1.05)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C47(1.15)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C47(1.03)  LDD1252  [7]
 LDCM0374  CL105 HCT 116 C47(1.51)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C47(1.45)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C47(1.55)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C47(1.86)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C47(1.64)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C47(0.75)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C47(1.84)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C47(1.33)  LDD0698  [7]
 LDCM0382  CL112 PaTu 8988t C321(0.65); C324(0.65); C182(0.70); C423(0.93)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C321(0.79); C324(0.79); C182(0.73); C423(1.00)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C321(0.59); C324(0.59); C182(0.49); C423(1.00)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C321(0.68); C324(0.68); C182(0.76); C423(0.95)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C321(0.82); C324(0.82); C182(1.25); C423(1.26)  LDD1265  [7]
 LDCM0387  CL117 HCT 116 C47(1.41)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C47(1.01)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C47(1.18)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C47(0.79)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C47(1.31)  LDD0708  [7]
 LDCM0392  CL121 HEK-293T C344(0.93); C407(1.04); C202(1.05); C749(0.88)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C344(0.97); C407(1.02); C202(1.14); C749(0.99)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C344(1.00); C407(0.99); C202(0.90); C749(0.92)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C344(0.98); C407(1.06); C202(0.98); C749(0.95)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C344(0.98); C407(1.11); C202(0.99); C749(0.90)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C344(0.99); C407(1.08); C202(1.07); C749(1.00)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C344(0.96); C407(1.10); C202(0.97); C749(0.97)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C344(0.96); C407(1.03); C202(1.02); C749(1.01)  LDD1603  [11]
 LDCM0400  CL13 HCT 116 C47(0.88)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C47(0.81)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C47(0.86)  LDD0719  [7]
 LDCM0403  CL16 PaTu 8988t C321(0.76); C324(0.76)  LDD1282  [7]
 LDCM0404  CL17 PaTu 8988t C321(0.47); C324(0.47)  LDD1283  [7]
 LDCM0405  CL18 PaTu 8988t C321(0.65); C324(0.65)  LDD1284  [7]
 LDCM0406  CL19 PaTu 8988t C321(1.10); C324(1.10)  LDD1285  [7]
 LDCM0407  CL2 HCT 116 C47(0.84)  LDD0724  [7]
 LDCM0408  CL20 PaTu 8988t C321(0.98); C324(0.98)  LDD1287  [7]
 LDCM0409  CL21 PaTu 8988t C321(0.65); C324(0.65)  LDD1288  [7]
 LDCM0410  CL22 PaTu 8988t C321(0.72); C324(0.72)  LDD1289  [7]
 LDCM0411  CL23 PaTu 8988t C321(0.66); C324(0.66)  LDD1290  [7]
 LDCM0412  CL24 PaTu 8988t C321(0.84); C324(0.84)  LDD1291  [7]
 LDCM0413  CL25 PaTu 8988t C321(0.55); C324(0.55)  LDD1292  [7]
 LDCM0414  CL26 PaTu 8988t C321(0.59); C324(0.59)  LDD1293  [7]
 LDCM0415  CL27 PaTu 8988t C321(0.71); C324(0.71)  LDD1294  [7]
 LDCM0416  CL28 PaTu 8988t C321(0.72); C324(0.72)  LDD1295  [7]
 LDCM0417  CL29 PaTu 8988t C321(0.88); C324(0.88)  LDD1296  [7]
 LDCM0418  CL3 HCT 116 C47(0.77)  LDD0735  [7]
 LDCM0419  CL30 PaTu 8988t C321(0.84); C324(0.84)  LDD1298  [7]
 LDCM0420  CL31 HCT 116 C47(1.12)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C47(0.98)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C47(0.81)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C47(1.26)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C47(1.25)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C47(1.16)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C47(1.00)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C47(1.01)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C47(0.76)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C47(1.10)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C47(1.03)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C47(1.12)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C47(0.92)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C47(1.29)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C47(1.08)  LDD0752  [7]
 LDCM0436  CL46 PaTu 8988t C321(0.80); C324(0.80); C47(1.16)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C321(0.70); C324(0.70); C47(1.50)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C321(1.18); C324(1.18); C47(0.98)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C321(0.98); C324(0.98); C47(2.81)  LDD1318  [7]
 LDCM0440  CL5 HCT 116 C47(1.03)  LDD0757  [7]
 LDCM0441  CL50 PaTu 8988t C321(0.86); C324(0.86); C47(1.23)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C321(0.77); C324(0.77); C47(1.15)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C321(0.92); C324(0.92); C47(1.19)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C321(1.07); C324(1.07); C47(1.67)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C321(0.77); C324(0.77); C47(2.75)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C321(1.34); C324(1.34); C47(1.30)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C321(0.79); C324(0.79); C47(0.50)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C321(0.82); C324(0.82); C47(1.64)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C321(1.26); C324(1.26); C47(1.21)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C321(1.11); C324(1.11); C47(2.14)  LDD1329  [7]
 LDCM0451  CL6 HCT 116 C47(0.93)  LDD0768  [7]
 LDCM0452  CL60 PaTu 8988t C321(1.00); C324(1.00); C47(1.44)  LDD1331  [7]
 LDCM0453  CL61 HCT 116 C47(0.82)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C47(0.87)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C47(1.37)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C47(1.24)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C47(1.11)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C47(1.18)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C47(1.07)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C47(1.31)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C47(1.22)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C47(1.03)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C47(1.38)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C47(0.95)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C47(0.94)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C47(1.37)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C47(1.28)  LDD0784  [7]
 LDCM0469  CL76 PaTu 8988t C47(1.21)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C47(1.53)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C47(1.88)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C47(1.92)  LDD1351  [7]
 LDCM0473  CL8 HCT 116 C47(1.07)  LDD0790  [7]
 LDCM0474  CL80 PaTu 8988t C47(1.49)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C47(1.87)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C47(1.23)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C47(2.45)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C47(2.05)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C47(1.75)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C47(1.59)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C47(1.57)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C47(1.73)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C47(1.27)  LDD1362  [7]
 LDCM0484  CL9 HCT 116 C47(0.88)  LDD0801  [7]
 LDCM0485  CL90 PaTu 8988t C47(1.48)  LDD1364  [7]
 LDCM0486  CL91 PaTu 8988t C182(0.41); C423(0.28); C438(0.28); C47(0.61)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C182(0.40); C423(0.25); C438(0.25); C47(0.53)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C182(0.54); C423(0.30); C438(0.30); C47(0.73)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C182(0.44); C423(0.25); C438(0.25); C47(0.60)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C182(0.46); C423(0.23); C438(0.23); C47(1.57)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C182(0.48); C423(0.30); C438(0.30); C47(0.93)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C182(0.57); C423(0.36); C438(0.36); C47(0.83)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C182(0.75); C423(0.39); C438(0.39); C47(0.69)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C182(0.42); C423(0.29); C438(0.29); C47(0.82)  LDD1373  [7]
 LDCM0634  CY-0357 Hep-G2 C47(1.32)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C344(1.14); C407(0.99); C202(0.96); C749(0.95)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C47(0.98)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C47(0.76)  LDD0744  [7]
 LDCM0123  JWB131 DM93 Y48(0.99)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y48(2.35)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y48(1.36)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y48(5.05)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y48(1.55)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y48(2.50)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y48(1.24)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y48(1.06)  LDD0292  [4]
 LDCM0022  KB02 HEK-293T C905(1.03); C1155(1.07); C344(0.99); C407(1.02)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C905(1.07); C1155(1.10); C344(0.99); C407(1.00)  LDD1497  [11]
 LDCM0024  KB05 HEK-293T C905(1.02); C1155(1.03); C344(1.05); C407(1.07)  LDD1502  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-rRNA-processing protein TSR2 homolog (TSR2) TSR2 family Q969E8

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402