Details of the Target

General Information of Target

Target ID LDTP04073
Target Name Chromobox protein homolog 5 (CBX5)
Gene Name CBX5
Gene ID 23468
Synonyms
HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP
ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG
LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED
AENKEKETAKS
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Uniprot ID
P45973
Ensemble ID
ENST00000209875.9
HGNC ID
HGNC:1555
ChEMBL ID
CHEMBL3826867

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K32(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y37(30.43); Y177(13.93)  LDD3495  [3]
BTD
 Probe Info  		C133(0.87)  LDD2109  [4]
AHL-Pu-1
 Probe Info  		C160(2.15)  LDD0168  [5]
HHS-475
 Probe Info  		Y177(0.34)  LDD0265  [6]
DBIA
 Probe Info  		C133(1.02)  LDD0078  [7]
5E-2FA
 Probe Info  		H48(0.00); H175(0.00)  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C160(0.00); C133(0.00); C59(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C160(0.00); C59(0.00); C133(0.00)  LDD0032  [10]
IPIAA_H
 Probe Info  		C59(0.00); C160(0.00)  LDD0030  [11]
IPIAA_L
 Probe Info  		C59(0.00); C160(0.00)  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C59(0.00); C133(0.00); C160(0.00)  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [12]
JW-RF-010
 Probe Info  		C160(0.00); C133(0.00)  LDD0026  [13]
NAIA_4
 Probe Info  		C133(0.00); C160(0.00)  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		C133(0.00); C59(0.00)  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		K102(0.00); K74(0.00)  LDD0010  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		C59(0.00); C133(0.00); H48(0.00); H175(0.00)  LDD0217  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
MPP-AC
 Probe Info  		N.A.  LDD0428  [20]
NAIA_5
 Probe Info  		C160(0.00); C133(0.00); C59(0.00)  LDD2223  [14]
TER-AC
 Probe Info  		N.A.  LDD0426  [20]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C207
 Probe Info  		18.13  LDD1882  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C160(2.15)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C160(2.18); C133(2.60)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C133(1.12)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C133(1.28)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C133(1.06)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C133(0.86)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C133(0.80)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C133(0.98)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C133(0.96)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C133(0.90)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C133(0.85)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C133(0.98)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C133(0.91)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C133(0.73)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C133(1.24)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C133(0.88)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C133(0.83)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C133(0.90)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C133(1.06); C160(1.13)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C133(0.99); C160(1.16)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C133(1.08); C160(0.99)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C133(1.00); C160(0.99)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C133(1.06); C160(0.98)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C133(0.91); C160(1.07)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C133(1.00); C160(1.08)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C133(1.09)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C133(1.05); C160(1.23)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C133(1.01); C160(0.85)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C133(0.94); C160(1.15)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C133(0.91); C160(0.97)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C133(0.89); C160(0.98)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C133(0.93); C160(1.15)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C133(0.87); C160(1.23)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C133(0.97); C160(0.95)  LDD0562  [7]
 LDCM0246  AC128 HEK-293T C133(1.10)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C133(1.18)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C133(1.07)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C133(1.12)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C133(1.02)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C133(0.97)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C133(1.01)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C133(0.98)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C133(0.99)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C133(1.17)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C133(0.99)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C133(1.19)  LDD0856  [7]
 LDCM0259  AC14 HCT 116 C133(1.15)  LDD0576  [7]
 LDCM0260  AC140 HEK-293T C133(1.10)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C133(1.10)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C133(1.14)  LDD0860  [7]
 LDCM0263  AC143 HCT 116 C133(1.09)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C133(1.18)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C133(1.11)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C133(1.18)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C133(1.26)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C133(1.54)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C133(1.14)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C133(1.21)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C133(1.05)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C133(0.98)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C133(1.22)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C133(1.62)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C133(1.15)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C133(1.13)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C133(0.93)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C133(1.00)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C133(1.09)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C133(1.24)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C133(1.12)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C133(1.12)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C133(1.21)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C133(1.19)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C133(1.05)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C133(0.97)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C133(1.07)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C133(0.97); C160(1.00)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C160(1.01); C133(1.16)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C160(0.89); C133(1.15)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C160(0.88); C133(1.12)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C160(0.92); C133(1.14)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C133(1.06)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C160(1.08); C133(1.19)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C160(1.07); C133(1.16)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C160(0.96); C133(1.23)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C160(1.05); C133(1.13)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C160(1.00); C133(1.30)  LDD0612  [7]
 LDCM0296  AC35 HEK-293T C160(0.57)  LDD0894  [7]
 LDCM0297  AC36 HEK-293T C160(0.84)  LDD0895  [7]
 LDCM0298  AC37 HEK-293T C160(1.04)  LDD0896  [7]
 LDCM0299  AC38 HEK-293T C160(1.13)  LDD0897  [7]
 LDCM0300  AC39 HEK-293T C160(0.74)  LDD0898  [7]
 LDCM0301  AC4 HCT 116 C133(1.17)  LDD0618  [7]
 LDCM0302  AC40 HEK-293T C160(1.25)  LDD0900  [7]
 LDCM0303  AC41 HEK-293T C160(1.11)  LDD0901  [7]
 LDCM0304  AC42 HEK-293T C160(0.78)  LDD0902  [7]
 LDCM0305  AC43 HEK-293T C160(0.80)  LDD0903  [7]
 LDCM0306  AC44 HEK-293T C160(1.25)  LDD0904  [7]
 LDCM0307  AC45 HEK-293T C160(1.09)  LDD0905  [7]
 LDCM0308  AC46 HCT 116 C133(1.06); C160(1.23)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C160(0.97); C133(1.05)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C160(0.96); C133(1.16)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C160(1.05); C133(1.36)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C133(1.11)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C160(1.03); C133(1.30)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C133(0.90); C160(0.99)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C133(0.98); C160(1.01)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C160(1.02); C133(1.18)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C160(0.94); C133(1.04)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C160(0.98); C133(1.22)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C160(0.89); C133(1.49)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C133(1.18)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C133(1.15)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C133(1.16)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C133(1.22)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C133(1.17)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C133(1.06)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C133(1.19)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C133(1.04)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C133(1.24)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C133(1.16)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C133(1.17)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C133(1.20)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C160(0.85); C133(1.18)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C160(0.84); C133(1.10)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C133(1.04)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C160(0.80); C133(1.11)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C160(0.91); C133(1.03)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C160(0.94); C133(1.16)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C160(0.70); C133(1.03)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C160(0.85); C133(0.96)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C160(0.68); C133(1.14)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C160(0.86); C133(1.01)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C160(0.83); C133(1.20)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C160(0.81); C133(1.02)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C160(0.97); C133(1.07)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C133(1.24)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C160(0.82); C133(0.97)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C160(0.66); C133(1.04)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C160(0.57); C133(1.05)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C160(0.90); C133(1.31)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C160(1.06); C133(1.25)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C160(0.87); C133(1.18)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C160(0.82); C133(1.03)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C160(0.94); C133(0.97)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C160(0.97); C133(1.08)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C160(0.82); C133(1.18)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C160(0.87); C133(0.89)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C160(1.09); C133(1.40)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C160(0.97); C133(1.26)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C160(0.98); C133(1.10)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C133(1.09); C160(1.09)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C160(0.89); C133(1.02)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C160(1.08); C133(1.15)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C160(0.92); C133(1.18)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C133(0.75)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C133(0.93)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C133(1.01)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C133(1.00)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C133(1.89)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 13.68  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C133(1.02)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa C133(0.00); H48(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C133(1.73); C133(0.67)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C133(0.84); C160(1.25)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C133(1.15); C160(1.27)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C133(1.12)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C133(1.24)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C133(1.06)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C133(1.05)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C133(1.07)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C133(1.22)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C133(1.36)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C133(1.35)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C133(1.38)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C133(1.18)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C133(1.25); C160(1.50)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C133(1.14)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C133(1.20)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C133(0.98); C160(1.03)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C160(1.10); C133(1.15)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C133(1.09); C160(1.13)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C133(1.14); C160(1.33)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C133(1.09); C160(1.18)  LDD0703  [7]
 LDCM0387  CL117 HEK-293T C160(0.71)  LDD0985  [7]
 LDCM0388  CL118 HEK-293T C160(0.85)  LDD0986  [7]
 LDCM0389  CL119 HEK-293T C160(1.22)  LDD0987  [7]
 LDCM0390  CL12 HCT 116 C133(1.29); C160(1.39)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C160(1.22)  LDD0989  [7]
 LDCM0392  CL121 HCT 116 C160(1.02); C133(1.44)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C160(0.91); C133(1.08)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C160(0.86); C133(1.08)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C160(1.03); C133(1.35)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C133(0.96)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C133(0.94)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C133(1.06)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C133(1.18)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C133(1.15); C160(1.37)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C133(0.94); C160(1.27)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C160(1.06); C133(1.09)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C133(1.08)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C133(1.02)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C133(1.18)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C133(1.28)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C160(0.83); C133(0.90)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C133(1.38)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C133(1.43)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C133(1.83)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C133(1.25)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C133(1.44)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C133(1.34)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C133(1.26)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C133(1.14)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C133(1.43)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C133(1.30)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C133(1.03); C160(0.86)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C133(1.18)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C133(1.09); C160(1.32)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C133(1.25); C160(1.31)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C133(1.01); C160(1.56)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C133(1.51); C160(1.08)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C133(1.41); C160(2.06)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C133(1.12); C160(1.12)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C133(1.45); C160(2.45)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C133(1.27); C160(1.01)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C133(0.94); C160(1.20)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C133(1.15); C160(1.36)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C133(1.23); C160(1.18)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C133(1.67); C160(0.67)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C133(1.51); C160(1.49)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C133(1.24); C160(1.16)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C133(1.49); C160(0.77)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C133(0.92)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C133(0.92)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C133(0.92)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C133(0.98)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C133(0.98); C160(1.07)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C133(0.91)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C133(0.88)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C133(1.00)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C133(0.90)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C133(0.89)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C133(0.89)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C133(1.00)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C133(0.95)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C133(1.01)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C133(0.93)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C133(1.00); C160(0.98)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C133(0.94)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C133(1.03)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C133(1.00)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C133(0.99)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C133(1.15)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C133(1.04)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C133(1.22)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C133(1.16)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C133(1.02)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C133(1.01)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C133(1.12); C160(0.89)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C133(1.03)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C133(1.07)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C133(1.00)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C133(1.14)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C133(1.03)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C133(1.14)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C133(1.24)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C133(1.09)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C133(1.34)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C133(1.19); C160(0.93)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C133(1.07)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C133(1.18)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C133(1.44)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C133(1.31)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C133(1.50)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C133(1.31)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C133(1.12)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C133(1.17)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C133(1.39)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C133(1.73)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C133(1.05); C160(0.88)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C133(1.03)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C133(1.14)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C133(1.11)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C133(1.06)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C133(1.09)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C133(1.20)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C133(1.13)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C133(1.14)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C133(1.15)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C133(1.14)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C133(1.30)  LDD2228  [14]
 LDCM0495  E2913 HEK-293T C59(1.00); C160(0.96); C133(0.85)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C133(1.33)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C133(1.10)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C133(1.44); C160(0.71)  LDD0744  [7]
 LDCM0117  HHS-0201 DM93 Y177(0.34)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y177(1.06)  LDD0266  [6]
 LDCM0120  HHS-0701 DM93 Y177(0.39)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C133(1.15)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C133(1.08)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C133(1.12)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C133(0.87)  LDD2109  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C133(0.92)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C133(0.86)  LDD2127  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C59(1.45)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C133(0.85)  LDD2137  [4]
 LDCM0131  RA190 MM1.R C59(1.19); C133(1.13)  LDD0304  [24]
 LDCM0021  THZ1 HCT 116 C133(1.21)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase NSD3 (NSD3) Histone-lysine methyltransferase family Q9BZ95
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
ATP-dependent RNA helicase DDX19B (DDX19B) DEAD box helicase family Q9UMR2
Delta(14)-sterol reductase LBR (LBR) ERG4/ERG24 family Q14739
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN) Helicase family Q14191
Sentrin-specific protease 7 (SENP7) Peptidase C48 family Q9BQF6
Cytosol aminopeptidase (LAP3) Peptidase M17 family P28838
GPI mannosyltransferase 2 (PIGV) PIGV family Q9NUD9
Transcriptional regulator ATRX (ATRX) SNF2/RAD54 helicase family P46100
Transcription intermediary factor 1-beta (TRIM28) TRIM/RBCC family Q13263
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Choline transporter-like protein 5 (SLC44A5) CTL (choline transporter-like) family Q8NCS7
Major facilitator superfamily domain-containing protein 10 (MFSD10) Major facilitator superfamily Q14728
Peroxisome proliferator-activated receptor alpha (PPARA) Nuclear hormone receptor family Q07869
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Activity-dependent neuroprotector homeobox protein (ADNP) . Q9H2P0
Methyl-CpG-binding domain protein 1 (MBD1) . Q9UIS9
Myc proto-oncogene protein (MYC) . P01106
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Zinc finger protein 280C (ZNF280C) . Q8ND82
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromatin assembly factor 1 subunit A (CHAF1A) CHAF1A family Q13111
Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1) G-alpha family P09471
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Histone H3.1t (H3-4) Histone H3 family Q16695
Histone H3.3 (H3-3A; H3-3B) Histone H3 family P84243
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Inner centromere protein (INCENP) INCENP family Q9NQS7
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) LRIF1 family Q5T3J3
Shugoshin 1 (SGO1) Shugoshin family Q5FBB7
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Chromobox protein homolog 5 (CBX5) . P45973
Kinetochore-associated protein NSL1 homolog (NSL1) . Q96IY1
Ligand of Numb protein X 2 (LNX2) . Q8N448
Proline-rich protein 14 (PRR14) . Q9BWN1
Telethonin (TCAP) . O15273
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.