Details of the Target

General Information of Target

Target ID LDTP01607
Target Name Poly(A)-specific ribonuclease PARN (PARN)
Gene Name PARN
Gene ID 5073
Synonyms
DAN; Poly(A)-specific ribonuclease PARN; EC 3.1.13.4; Deadenylating nuclease; Deadenylation nuclease; Polyadenylate-specific ribonuclease
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKH
SMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQG
FDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKF
IDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIV
ISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQF
YCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKV
ESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFN
KLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTS
AFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLN
PQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEP
LSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW
Target Bioclass
Enzyme
Family
CAF1 family
Subcellular location
Nucleus
Function
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability.
Uniprot ID
O95453
Ensemble ID
ENST00000341484.11
HGNC ID
HGNC:8609
ChEMBL ID
CHEMBL3616362

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.E52D DBIA    Probe Info 
DU145 SNV: p.S530I DBIA    Probe Info 
HCC1395 SNV: p.N197I DBIA    Probe Info 
KMS27 SNV: p.K58R DBIA    Probe Info 
MEWO SNV: p.L343I DBIA    Probe Info 
RT112 SNV: p.D292Y DBIA    Probe Info 
SW403 SNV: p.Y161D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y432(5.85)  LDD0260  [3]
Probe 1
 Probe Info  		Y146(64.26); Y238(13.95); Y500(35.34)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C543(2.33)  LDD0169  [5]
HHS-475
 Probe Info  		Y552(0.91); Y432(0.93); Y546(0.98); Y161(1.48)  LDD0264  [6]
HHS-465
 Probe Info  		Y553(10.00)  LDD2237  [7]
DBIA
 Probe Info  		C317(1.36); C169(2.03)  LDD0080  [8]
ATP probe
 Probe Info  		K326(0.00); K211(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C169(0.00); C317(0.00); C205(0.00); C302(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C169(0.00); C543(0.00); C302(0.00); C205(0.00)  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
Compound 10
 Probe Info  		C169(0.00); C205(0.00); C543(0.00)  LDD2216  [15]
Compound 11
 Probe Info  		C169(0.00); C543(0.00)  LDD2213  [15]
ENE
 Probe Info  		N.A.  LDD0006  [14]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
NPM
 Probe Info  		N.A.  LDD0016  [14]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Acrolein
 Probe Info  		H275(0.00); C317(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		14.30  LDD0443  [18]
NAIA_5
 Probe Info  		C108(0.00); C543(0.00); C302(0.00)  LDD2223  [19]
HHS-482
 Probe Info  		Y546(1.29)  LDD2239  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C296
 Probe Info  		12.13  LDD1966  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C317(2.82)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C543(2.33)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C108(0.60); C169(1.38); C205(0.91); C317(1.13)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C108(0.89); C169(1.04); C205(0.76); C317(0.99)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C108(0.62); C169(1.03); C205(0.76); C317(0.92)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C108(0.76); C169(1.24); C205(0.66); C317(0.93)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C108(0.63); C169(1.21); C205(0.61); C317(0.99)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C108(0.73); C169(1.27); C205(0.58); C317(1.01)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C108(0.59); C169(1.16); C205(0.57); C317(1.17)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C108(0.66); C169(1.26); C205(0.57); C317(1.46)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C108(0.64); C169(1.21); C205(0.56); C317(0.85)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C108(0.67); C169(1.18); C205(0.57); C317(1.07)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C108(0.55); C169(1.21); C205(0.76); C317(0.83)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C108(0.55); C169(1.13); C205(0.87); C317(0.89)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C108(1.02); C169(1.10); C205(0.69); C317(1.12)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C108(0.62); C169(1.36); C205(0.71); C317(0.84)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C108(0.62); C169(1.32); C205(0.64); C317(0.77)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C108(0.61); C169(1.34); C205(0.60); C317(1.04)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C169(1.20); C205(1.17); C317(1.01)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C169(1.27); C205(1.13); C317(1.11)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C169(1.26); C205(0.79); C317(1.09)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C169(1.57); C205(0.90); C317(1.26)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C169(1.03); C205(1.05); C317(1.19)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C169(1.41); C205(1.24); C317(1.10)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C169(1.42); C205(0.94); C317(1.22)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C108(0.94); C169(0.95); C205(0.93); C317(1.29)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C169(1.16); C205(0.87); C317(1.31)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C169(1.37); C205(1.34); C317(1.11)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C169(1.31); C205(1.01); C317(1.45)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C169(1.12); C205(1.17); C317(1.21)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C169(1.04); C205(1.23); C317(1.07)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C169(1.30); C205(1.16); C317(1.24)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C169(1.15); C205(1.10); C317(1.23)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C169(1.46); C205(1.19); C317(1.26)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C169(1.42); C205(1.60); C317(1.38)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C169(0.77); C205(1.46); C317(1.01)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C169(1.20); C205(1.53); C317(0.91)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C169(0.83); C205(1.13); C317(0.73)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C169(1.06); C205(1.00); C317(0.86)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C169(1.17); C205(1.20); C317(1.12)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C169(1.26); C205(0.85); C317(1.38)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C169(1.27); C205(1.10); C317(1.05)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C169(1.22); C205(0.96); C317(1.21)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C169(1.08); C205(0.93); C317(1.09)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C169(1.21); C205(0.83); C317(1.10)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C169(1.25); C205(0.82); C317(1.10)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C108(0.93); C169(1.00); C205(0.92); C317(1.04)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C169(1.22); C205(0.78); C317(1.22)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C169(1.15); C205(0.84); C317(1.21)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C169(0.98); C205(1.08); C317(1.01)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C205(0.87); C169(1.13); C317(1.16)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C169(0.93); C205(0.95); C317(1.24)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C205(0.69); C169(1.08); C317(1.19)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C205(0.89); C169(0.94); C317(1.33)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C205(0.83); C317(1.16); C169(1.20)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C169(0.81); C205(0.90); C317(1.72)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C205(0.84); C169(0.86); C317(1.49)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C205(0.90); C317(0.93); C108(0.97); C169(1.05)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C205(0.89); C169(0.94); C317(1.16)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C169(0.81); C205(0.95); C317(1.13)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C169(0.88); C205(0.89); C317(1.32)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C169(0.77); C205(0.95); C317(1.65)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C169(0.88); C205(0.83); C317(1.12)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C169(0.83); C205(0.90); C317(1.25)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C169(1.01); C205(0.94); C317(1.22)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C169(0.87); C205(1.10); C317(1.00)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C317(0.98); C205(1.01); C169(1.07)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C205(0.60); C317(1.24); C169(1.72)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C205(0.88); C317(1.08); C169(1.18)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C108(0.81); C205(1.02); C317(1.26); C169(1.29)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C205(0.97); C317(1.04); C169(1.11)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C205(0.80); C169(1.03); C317(1.11)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C317(0.98); C205(1.00); C169(1.02)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C205(0.84); C169(0.95); C317(1.02)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C317(0.89); C205(1.01); C169(1.05)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C205(0.80); C108(0.82); C317(1.10); C169(1.15)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C108(0.78); C205(0.85); C317(1.27); C169(1.27)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C205(0.79); C108(0.81); C317(1.26); C169(1.33)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C108(0.71); C205(0.80); C317(1.18); C169(1.31)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C108(0.72); C205(0.82); C317(1.09); C169(1.25)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C108(0.97); C317(1.08); C205(1.16); C169(1.22)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C205(0.72); C108(0.80); C317(1.15); C169(1.36)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C108(0.61); C205(0.75); C317(1.11); C169(1.37)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C205(0.70); C108(0.71); C317(1.35); C169(1.59)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C205(0.66); C108(0.73); C317(1.15); C169(1.29)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C205(0.61); C108(0.86); C317(1.23); C169(1.39)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C317(0.88); C169(0.91); C205(1.16); C108(1.33)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C169(0.94); C317(0.95); C108(1.13); C205(1.49)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C108(0.93); C317(0.93); C169(0.95); C205(1.21)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C317(0.77); C205(0.96); C169(0.98); C108(1.11)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C317(0.90); C169(0.96); C205(1.11); C108(1.19)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C108(0.80); C205(1.16); C317(1.18); C169(1.30)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C317(0.88); C169(1.12); C108(1.18); C205(1.26)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C317(0.84); C169(0.97); C205(0.98); C108(1.17)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C317(0.94); C205(0.95); C169(1.00); C108(1.17)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C317(0.85); C169(0.96); C205(0.97); C108(1.09)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C317(0.92); C169(1.00); C205(1.33); C108(1.42)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C317(0.94); C108(1.04); C169(1.06); C205(1.19)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C205(0.88); C108(0.96); C169(1.04); C317(1.36)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C205(0.89); C169(0.90); C108(0.91); C317(0.97)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C108(0.77); C205(0.85); C169(0.96); C317(1.00)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C205(0.73); C108(0.88); C317(1.14); C169(1.19)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C108(0.88); C205(1.05); C317(1.24); C169(1.37)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C205(0.72); C108(0.84); C169(1.03); C317(1.11)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C169(0.89); C108(0.98); C317(1.06); C205(1.08)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C169(0.87); C205(0.88); C108(1.04); C317(1.06)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C205(0.77); C317(1.00); C169(1.05); C108(1.07)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C205(0.77); C317(0.88); C108(1.04); C169(1.09)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C205(0.83); C108(1.09); C169(1.15); C317(1.42)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C205(0.75); C108(0.84); C317(1.15); C169(1.18)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C205(0.96); C108(1.11); C317(1.20); C169(1.23)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C205(0.83); C317(1.02); C108(1.21); C169(1.44)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C205(0.74); C317(1.21); C108(1.22); C169(1.32)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C205(0.80); C108(0.83); C317(1.05); C169(1.23)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C205(0.67); C108(0.88); C317(1.17); C169(1.26)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C108(0.78); C205(0.85); C317(1.28); C169(1.31)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C205(0.79); C108(1.23); C169(1.38); C317(1.38)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C205(0.67); C108(0.94); C169(1.21); C317(1.28)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C205(0.72); C108(1.08); C317(1.31); C169(1.41)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C205(0.84); C108(1.21); C317(1.32); C169(1.58)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C205(0.82); C317(1.09); C108(1.20); C169(1.46)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C205(0.65); C108(1.05); C317(1.31); C169(1.55)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C205(1.03); C317(1.13)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C205(0.96); C317(0.97)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C108(0.89); C205(0.91); C169(0.98); C317(1.02)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C205(0.95); C317(1.17)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C205(1.04); C317(1.04)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C205(1.13); C317(1.16)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C205(1.05); C317(1.29)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C205(0.95); C317(1.31)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C205(1.05); C317(1.14)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C205(1.00); C317(1.20)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C205(1.03); C317(1.06)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C317(0.92); C205(1.06)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C317(0.96); C205(1.21)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C205(0.79); C108(0.96); C317(1.02); C169(1.04)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C205(0.88); C317(0.93)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C317(0.93); C205(1.14)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C317(1.08); C205(1.09)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C205(0.59); C317(1.40); C169(1.50)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C205(0.61); C169(1.25); C317(1.40)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C205(0.64); C169(1.23); C317(1.45)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C205(0.67); C169(1.26); C317(1.41)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C205(0.77); C169(0.94); C317(1.21)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C205(0.69); C169(1.09); C317(1.27)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C205(0.63); C169(1.23); C317(1.38)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C205(1.09); C169(1.12); C317(1.23)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C205(0.78); C169(1.52); C317(1.73)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C205(0.69); C169(1.42); C317(1.51)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C205(0.64); C169(1.03); C317(1.36)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C205(0.92); C169(1.16); C317(1.21)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C205(0.70); C169(1.07); C317(1.16)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C205(0.94); C169(1.28); C317(1.43)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C205(0.63); C169(1.32); C317(1.42)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C108(0.47); C205(0.48); C317(1.00); C169(1.28)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C108(0.60); C205(0.73); C317(0.84); C169(1.19)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C108(0.87); C169(1.04); C205(1.08); C317(0.97)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C205(0.80); C108(0.87); C169(0.98); C317(1.23)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C205(0.78); C108(0.89); C317(0.95); C169(1.34)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.78  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C169(0.97); C317(0.89)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa C317(0.00); C205(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C543(0.73)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C108(0.87); C169(1.00); C317(1.07); C205(1.14)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C205(0.55); C108(0.74); C317(1.23); C169(1.27)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C205(0.74); C108(0.76); C317(1.01); C169(1.44)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C205(0.83); C317(0.86); C108(0.93); C169(1.17)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C317(0.81); C205(0.95); C108(1.02); C169(1.03)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C108(0.89); C317(0.90); C169(0.96); C205(1.07)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C108(0.86); C317(0.90); C169(1.00); C205(1.06)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C205(0.78); C317(1.09); C169(1.18)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C205(0.63); C317(1.05); C169(1.23)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C205(0.73); C317(1.11); C169(1.20)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C205(0.88); C317(1.34); C169(1.63)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C205(0.81); C169(1.11); C317(1.18)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C205(0.61); C108(0.78); C317(1.15); C169(1.28)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C205(0.82); C317(1.35); C169(1.62)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C205(0.64); C169(1.11); C317(1.12)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C108(0.68); C205(0.97); C317(1.02); C169(1.24)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C205(0.70); C108(0.83); C169(1.34); C317(1.38)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C108(0.66); C205(0.80); C317(1.25); C169(1.29)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C205(0.73); C108(0.76); C317(0.99); C169(1.31)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C108(0.79); C205(0.80); C317(1.18); C169(1.33)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C317(0.79); C205(0.90); C108(1.06); C169(1.30)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C317(0.80); C169(1.00); C205(1.09); C108(1.24)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C317(0.91); C169(1.00); C205(1.06); C108(1.52)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C205(0.73); C108(0.93); C317(1.16); C169(1.33)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C317(0.90); C169(0.93); C205(1.01); C108(1.10)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C108(0.53); C205(0.74); C317(0.96); C169(0.98)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C205(0.80); C108(0.95); C317(1.05); C169(1.09)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C205(0.79); C108(0.99); C169(1.16); C317(1.41)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C205(0.76); C108(0.90); C169(1.10); C317(1.11)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C205(1.01); C169(1.03); C108(1.28); C317(1.42)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C205(0.91); C169(1.10); C317(1.17); C108(1.23)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C205(0.88); C108(1.04); C317(1.04); C169(1.06)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C205(0.92); C317(1.22); C108(1.31); C169(1.41)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C205(0.53); C108(0.86); C317(1.04); C169(1.24)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C108(0.88); C205(0.92); C169(1.08); C317(1.23)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C205(0.70); C108(0.77); C169(1.07); C317(1.11)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C169(0.98); C108(1.05); C317(1.20)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C108(0.95); C317(1.02); C169(1.25)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C108(0.67); C169(1.14); C317(1.33)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C108(0.95); C317(1.22); C169(1.22)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C317(0.92); C169(0.96); C108(1.02); C205(1.06)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C108(1.05); C317(1.37); C169(1.41)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C108(0.93); C317(1.37); C169(1.60)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C108(1.01); C169(1.61); C317(1.67)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C108(1.14); C169(1.17); C317(1.34)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C108(0.98); C169(1.33); C317(1.46)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C108(0.75); C169(1.32); C317(1.33)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C108(0.93); C169(1.14); C317(1.32)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C108(1.12); C169(1.24); C317(1.25)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C108(0.87); C169(1.23); C317(1.35)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C108(1.01); C169(1.36); C317(1.45)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C108(0.86); C169(0.92); C205(0.80); C317(0.91)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C108(0.74); C169(1.09); C317(1.15)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C169(0.95); C317(0.98)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C169(1.02); C317(1.09)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C169(1.06); C317(1.08)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C169(1.08); C317(1.22)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C169(0.93); C317(1.19)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C169(1.12); C317(1.05)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C169(0.97); C317(1.19)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C169(0.94); C317(1.26)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C108(0.92); C169(1.03); C205(0.98); C317(0.94)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C169(1.13); C317(1.14)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C169(0.88); C317(1.16)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C169(0.87); C317(1.34)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C169(1.00); C317(1.18)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C169(0.97); C317(1.11)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C169(1.03); C317(1.34)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C169(1.05); C205(0.99); C317(0.89)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C169(1.01); C205(0.79); C317(0.85)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C169(1.17); C205(1.01); C317(0.87)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C169(0.93); C205(1.15); C317(0.87)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C108(0.88); C169(0.99); C205(0.76); C317(0.89)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C169(1.00); C205(1.06); C317(0.85)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C169(1.05); C205(1.02); C317(0.81)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C169(1.18); C205(0.86); C317(0.94)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C169(1.28); C205(0.58); C317(0.92)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C169(1.09); C205(0.78); C317(0.99)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C169(1.06); C205(0.76); C317(0.79)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C169(0.98); C205(0.79); C317(0.87)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C169(1.00); C205(0.86); C317(0.85)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C169(0.98); C205(1.04); C317(0.79)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C169(1.00); C205(0.93); C317(0.89)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C108(0.79); C169(1.18); C205(0.75); C317(1.10)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C169(0.99); C205(1.16); C317(0.86)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C108(0.97); C169(1.12); C205(1.02); C317(1.13)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C108(0.86); C169(1.10); C205(1.06); C317(1.18)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C108(0.77); C169(1.29); C205(1.01); C317(1.05)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C108(0.95); C169(1.40); C205(1.02); C317(1.13)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C108(0.78); C169(1.23); C205(0.96); C317(1.10)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C108(0.90); C169(1.55); C205(1.01); C317(1.21)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C108(0.97); C169(1.34); C205(0.88); C317(1.12)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C108(0.68); C169(1.22); C205(0.70); C317(1.06)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C108(0.70); C169(1.13); C205(0.98); C317(0.99)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C108(0.92); C169(1.21); C205(0.75); C317(1.22)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C108(0.70); C169(1.23); C205(0.82); C317(1.10)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C108(1.04); C169(1.22); C205(0.80); C317(1.30)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C108(0.71); C169(1.10); C205(0.88); C317(1.06)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C108(0.78); C169(1.22); C205(0.89); C317(1.04)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C108(0.91); C169(1.33); C205(0.89); C317(1.09)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C108(0.80); C169(1.13); C205(0.71); C317(1.40)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C108(0.80); C169(1.20); C205(0.82); C317(1.24)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C108(0.93); C169(1.13); C205(0.91); C317(1.03)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C108(1.01); C169(1.29); C205(0.76); C317(1.07)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C108(0.89); C169(1.43); C205(0.70); C317(1.12)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C108(0.75); C169(1.13); C205(0.94); C317(1.13)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C108(0.99); C169(1.11); C205(1.01); C317(1.01)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C108(1.05); C169(1.48); C205(0.66); C317(1.08)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C108(0.89); C169(1.54); C205(0.68); C317(1.06)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C108(1.12); C169(1.73); C205(0.66); C317(0.96)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C108(1.02); C169(1.18); C205(0.82); C317(1.35)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C108(0.97); C169(1.02); C205(0.94); C317(1.14)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C108(1.21); C169(1.17); C205(0.96); C317(1.05)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C108(1.05); C169(1.21); C205(0.69); C317(1.17)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C108(0.99); C169(1.79); C205(0.66); C317(1.33)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C108(0.93); C169(1.19); C205(0.69); C317(0.98)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C108(0.99); C169(0.96); C205(1.04); C317(1.03)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C108(1.02); C169(1.19); C205(1.16); C317(1.04)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C108(0.97); C169(1.20); C205(0.98); C317(0.84)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C108(0.77); C169(1.25); C205(1.12); C317(0.81)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C108(0.86); C169(1.50); C205(0.94); C317(0.93)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C108(0.79); C169(1.64); C205(0.98); C317(1.38)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C108(0.91); C169(1.23); C205(1.09); C317(0.86)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C108(0.84); C169(1.27); C205(1.01); C317(1.11)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C108(0.91); C169(1.36); C205(0.98); C317(1.29)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C108(0.85); C169(1.40); C205(0.82); C317(1.07)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C169(1.08); C317(0.95); C543(1.01); C302(0.94)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C169(1.00)  LDD1702  [22]
 LDCM0625  F8 Ramos C543(1.80); C169(1.12)  LDD2187  [23]
 LDCM0573  Fragment11 Ramos C543(4.16)  LDD2190  [23]
 LDCM0575  Fragment13 Ramos C169(0.92)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C543(0.90); C169(0.95)  LDD2193  [23]
 LDCM0580  Fragment21 Ramos C169(0.90)  LDD2195  [23]
 LDCM0578  Fragment27 Ramos C169(1.72)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C543(0.79); C169(0.84)  LDD2198  [23]
 LDCM0589  Fragment31 Ramos C169(1.02)  LDD2200  [23]
 LDCM0468  Fragment33 HCT 116 C108(0.88); C169(1.22); C205(0.94); C317(1.07)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C169(0.81)  LDD2203  [23]
 LDCM0427  Fragment51 HCT 116 C169(0.85); C317(1.18)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C169(2.14)  LDD2204  [23]
 LDCM0569  Fragment7 Ramos C543(1.72)  LDD2186  [23]
 LDCM0116  HHS-0101 DM93 Y552(0.91); Y432(0.93); Y546(0.98); Y161(1.48)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y546(0.64); Y552(0.85); Y432(0.88)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y432(0.79); Y552(0.89); Y546(0.91)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y552(0.73); Y432(0.92); Y546(0.93); Y161(9.44)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y432(0.90); Y552(1.08); Y546(1.23); Y161(2.15)  LDD0268  [6]
 LDCM0022  KB02 HCT 116 C317(1.36); C169(2.03)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C317(1.46); C169(1.99)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C317(2.24); C169(1.76)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0021  THZ1 HCT 116 C169(0.97); C317(0.89)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BRCA1-associated RING domain protein 1 (BARD1) . Q99728
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear cap-binding protein subunit 1 (NCBP1) NCBP1 family Q09161
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cleavage stimulation factor subunit 2 (CSTF2) . P33240

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578