Details of the Target

General Information of Target

Target ID LDTP00403
Target Name Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
Gene Name ADAM10
Gene ID 102
Synonyms
KUZ; MADM; Disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; EC 3.4.24.81; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD antigen CD156c
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
Target Type
Clinical trial
Target Bioclass
Enzyme
Subcellular location
Cell membrane
Function
Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA. Enhances the cleavage of CHL1 by BACE1. Cleaves NRCAM. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain. Involved in the development and maturation of glomerular and coronary vasculature. During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions. May regulate the EFNA5-EPHA3 signaling. Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells.; (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores.
TTD ID
T31902
Uniprot ID
O14672
DrugMap ID
TTOMWSY
Ensemble ID
ENST00000260408.8
HGNC ID
HGNC:188
ChEMBL ID
CHEMBL5028

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.R74Q DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.M271L DBIA    Probe Info 
JURKAT SNV: p.C222Y .
MCC26 SNV: p.E89Q DBIA    Probe Info 
MDST8 SNV: p.N429K DBIA    Probe Info 
SKHEP1 SNV: p.S521P DBIA    Probe Info 
SNU1 SNV: p.R738Ter DBIA    Probe Info 
SUPT1 SNV: p.V641A DBIA    Probe Info 
SW756 SNV: p.S54Ter .
TF1 SNV: p.R274C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y741(17.55)  LDD0260  [1]
STPyne
 Probe Info  		K410(1.30); K721(10.00)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K431(0.41); K601(0.81); K410(1.52); K273(2.98)  LDD3494  [3]
m-APA
 Probe Info  		10.70  LDD0403  [4]
BTD
 Probe Info  		C435(0.94)  LDD2093  [5]
AHL-Pu-1
 Probe Info  		C632(2.80)  LDD0170  [6]
Acrolein
 Probe Info  		N.A.  LDD0222  [7]
DBIA
 Probe Info  		C173(0.84); C435(1.07)  LDD0531  [8]
CY4
 Probe Info  		M743(0.00); M746(0.00); Y741(0.00)  LDD0247  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C530(0.00); C435(0.00); C607(0.00); C222(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C435(0.00); C607(0.00); C222(0.00); C530(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C435(0.00); C607(0.00); C222(0.00)  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
AOyne
 Probe Info  		14.80  LDD0443  [13]
NAIA_5
 Probe Info  		C435(0.00); C639(0.00); C222(0.00); C399(0.00)  LDD2223  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C173(0.41)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C173(0.54)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C435(0.51)  LDD2117  [5]
 LDCM0025  4SU-RNA DM93 C632(2.80)  LDD0170  [6]
 LDCM0214  AC1 HCT 116 C173(0.84); C435(1.07)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C173(0.88); C435(1.35)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C173(0.92); C435(1.04)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C173(0.92); C435(0.99)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C173(0.94); C435(0.93)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C173(1.15); C435(1.03)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C173(1.03); C435(1.00)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C173(1.14); C435(1.03)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C173(1.20); C435(1.09)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C173(1.00); C435(1.03)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C173(0.93); C435(0.98)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C173(1.12); C435(0.79)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C173(1.16); C435(1.18)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C173(0.96); C435(0.87)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C173(0.99); C435(0.92)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C173(1.10); C435(1.12)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C173(1.00); C222(0.78); C435(0.97)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C173(1.08); C222(0.60); C435(1.04)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C173(1.07); C222(0.57); C435(1.36)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C173(1.09); C222(0.72); C435(1.36)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C173(0.96); C222(0.65); C435(1.02)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C173(0.97); C222(0.76); C435(1.16)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C173(1.01); C222(0.82); C435(1.18)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C173(1.12); C435(1.16)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C173(0.98); C222(0.88); C435(1.12)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C173(1.04); C222(0.83); C435(1.01)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C173(1.08); C222(0.73); C435(1.07)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C173(0.90); C222(0.79); C435(1.02)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C173(0.99); C222(0.70); C435(1.11)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C173(0.97); C222(0.91); C435(1.05)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C173(1.12); C222(0.69); C435(1.24)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C173(1.21); C222(0.74); C435(1.50)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C173(0.91); C435(1.34)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C173(1.07); C435(0.97)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C173(1.17); C435(1.02)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C173(0.95); C435(0.99)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C173(1.13); C435(1.03)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C173(0.96); C435(1.17)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C173(1.17); C435(1.21)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C173(1.14); C435(1.13)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C173(1.13); C435(1.35)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C173(1.11); C435(1.25)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C173(1.13); C435(1.27)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C173(1.21); C435(1.18)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C173(0.92); C435(0.94)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C173(1.28); C435(1.39)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C173(1.09); C435(1.37)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C173(1.16); C435(1.12)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C173(1.11); C435(1.19)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C435(1.16); C173(1.17)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C173(1.21); C435(1.23)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C173(1.16); C435(1.21)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C435(1.11); C173(1.33)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C173(1.13); C435(1.40)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C435(1.10); C173(1.31)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C435(1.09); C173(1.26)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C173(1.06); C435(1.19)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C435(1.11); C173(1.13)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C173(1.06); C435(1.08)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C173(1.25); C435(1.42)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C173(1.07); C435(1.35)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C173(1.28); C435(1.28)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C173(1.19); C435(1.20)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C173(1.11); C435(1.29)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C173(0.87); C222(1.12); C435(1.18)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C173(1.07); C435(1.10); C222(1.24)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C173(1.00); C222(1.08); C435(1.21)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C173(1.01); C435(1.01)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C435(1.03); C173(1.13); C222(1.14)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C173(1.02); C222(1.13); C435(1.15)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C173(0.88); C222(1.10); C435(1.15)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C173(0.93); C222(1.11); C435(1.21)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C173(0.91); C222(1.03); C435(1.06)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C222(0.75); C173(0.97); C435(0.97); C639(1.57)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C173(0.81); C222(0.83); C435(1.07); C639(1.79)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C222(0.84); C173(0.94); C435(1.06); C639(2.21)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C222(0.87); C173(1.05); C435(1.18); C639(1.44)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C173(0.77); C222(0.98); C435(1.17); C639(1.90)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C435(0.95); C173(0.96)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C222(0.93); C173(0.95); C435(1.16); C639(2.16)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C222(0.82); C173(0.91); C435(1.25); C639(1.54)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C173(0.90); C222(0.93); C435(1.35); C639(2.29)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C222(0.90); C173(1.04); C435(1.37); C639(1.57)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C222(0.85); C173(0.88); C435(1.25); C639(1.51)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C639(0.72); C435(1.02); C173(1.06)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C639(0.87); C173(1.03); C435(1.10)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C639(0.89); C435(0.98); C173(1.05)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C639(0.93); C173(1.07); C435(1.14)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C173(1.06); C435(1.10); C639(1.22)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C173(0.86); C435(1.13)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C173(0.89); C435(1.09); C639(1.20)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C173(0.91); C435(1.20); C639(1.34)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C173(1.03); C435(1.07); C639(1.11)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C639(0.83); C173(0.93); C435(1.03)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C173(0.96); C435(1.08); C639(1.97)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C639(0.95); C173(0.95); C435(1.09)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C639(0.78); C173(0.89); C435(0.93); C222(0.94)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C222(0.82); C173(0.97); C639(1.10); C435(1.22)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C639(0.74); C222(0.79); C173(0.81); C435(1.22)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C173(0.89); C222(0.98); C639(1.18); C435(1.40)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C173(0.87); C435(1.22)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C222(0.99); C173(1.02); C639(1.23); C435(1.41)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C173(0.81); C222(0.86); C639(0.92); C435(1.11)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C173(0.76); C222(0.83); C639(0.89); C435(1.14)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C173(0.81); C222(0.97); C639(1.03); C435(1.04)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C222(0.82); C173(0.92); C639(0.96); C435(1.48)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C222(0.85); C639(0.86); C173(1.04); C435(1.37)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C222(0.73); C639(0.74); C173(0.80); C435(1.23)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C639(0.85); C435(1.15); C173(1.24)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C435(1.03); C173(1.30); C639(2.13)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C639(1.02); C173(1.21); C435(1.27)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C173(1.08); C435(1.17)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C173(1.14); C435(1.34); C639(1.36)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C639(0.62); C435(1.13); C173(1.25)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C639(0.66); C435(1.13); C173(1.32)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C639(1.11); C435(1.21); C173(1.24)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C639(1.15); C435(1.25); C173(1.33)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C639(0.66); C173(1.17); C435(1.40)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C639(0.94); C173(1.30); C435(1.38)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C639(0.56); C173(1.22); C435(1.52)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C173(0.91); C435(0.98)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C173(0.84); C435(0.92)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C173(0.80); C435(1.06)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C173(0.98); C435(1.07)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C173(0.89); C435(1.06)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C173(0.93); C435(1.14)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C173(0.91); C435(1.22)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C173(1.00); C435(1.07)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C173(0.90); C435(1.12)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C173(0.96); C435(1.05)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C173(0.85); C435(1.10)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C173(0.86); C435(0.99)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C435(1.01); C173(1.16)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C173(1.04); C435(1.06)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C173(0.97); C435(0.99)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C435(1.02); C173(1.23)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C173(0.93); C435(1.12)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C639(1.31); C222(1.36); C435(1.65)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C639(1.11); C222(1.41); C435(1.50)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C222(1.24); C435(1.44); C639(1.53)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C639(1.19); C435(1.24); C222(1.34)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C435(1.09); C222(1.12); C639(1.12)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C639(0.80); C222(1.12); C435(1.24)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C639(1.10); C222(1.15); C435(1.35)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C222(1.06); C639(1.11); C435(1.19)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C639(1.07); C222(1.23); C435(1.69)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C639(1.13); C222(1.25); C435(1.65)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C639(0.99); C222(1.16); C435(1.38)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C435(1.28); C639(1.33); C222(1.35)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C639(0.96); C435(1.18); C222(1.24)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C639(1.00); C222(1.17); C435(1.32)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C222(1.26); C639(1.41); C435(1.53)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C435(0.94); C173(0.96)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C435(0.87); C173(0.99)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C435(0.68)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C173(0.86); C435(1.05)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C173(1.01); C435(1.05)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C173(0.94); C435(1.10)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 10.70  LDD0403  [4]
 LDCM0020  ARS-1620 HCC44 C639(1.14); C173(0.90); C530(1.08); C562(1.09)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C173(0.81); C435(0.81); C222(1.10)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C173(0.73); C435(0.97); C222(1.14)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C173(0.84); C435(1.11)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C173(0.92); C435(0.97)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C435(0.97); C173(1.06)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C173(0.82); C435(1.02)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C173(0.96); C435(1.01)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C173(1.14); C435(1.20); C222(1.35)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C173(0.86); C435(1.42); C222(1.42)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C173(1.19); C222(1.27); C435(1.49)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C173(0.99); C435(1.28); C222(1.89)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C173(0.96); C222(1.06); C435(1.23)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C173(0.62); C222(1.06); C435(1.09)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C173(0.79); C222(1.12); C435(1.47)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C173(0.80); C435(1.09); C222(1.17)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C173(0.89); C222(0.91); C435(0.95); C639(1.43)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C222(0.89); C173(0.93); C435(1.21); C639(1.46)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C222(0.91); C173(0.95); C435(1.17); C639(1.74)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C222(0.99); C173(1.02); C435(1.22); C639(1.50)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C222(0.84); C173(1.01); C435(1.14); C639(2.07)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C173(0.93); C435(1.06); C639(1.26)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C435(1.07); C173(1.12); C639(1.40)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C639(0.87); C173(0.97); C435(1.04)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C173(0.52); C222(1.06); C435(1.19)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C173(0.91); C639(1.04); C435(1.06)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C222(0.73); C173(0.93); C639(1.04); C435(1.41)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C222(0.76); C639(1.02); C173(1.21); C435(1.24)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C222(0.64); C173(0.64); C639(0.71); C435(1.32)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C222(0.67); C639(0.84); C173(1.01); C435(1.10)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C639(0.76); C435(1.02); C173(1.65)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C639(0.48); C173(1.12); C435(1.18)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C639(0.64); C435(1.03); C173(1.28)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C639(0.82); C435(1.29); C173(1.30)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C173(0.66); C435(1.13); C222(1.26)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C173(0.77); C435(1.01); C222(1.08)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C173(0.58); C222(0.90); C435(1.30)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C173(0.79); C435(1.02); C222(1.16)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C173(0.52); C222(0.99); C435(1.10)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C173(0.68); C435(1.09); C222(1.10)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C173(0.66); C435(1.03); C222(1.05)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C173(0.81); C435(0.84); C222(0.98)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C173(0.82); C435(1.07); C222(1.18)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C173(0.85); C435(0.99); C222(1.03)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C173(0.75); C222(0.86); C435(0.95)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C173(0.72); C222(0.89); C435(1.13)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C173(0.69); C222(1.03); C435(1.04)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C173(0.87); C222(0.90); C435(1.07)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C173(0.65); C222(1.01); C435(1.20)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C173(0.83); C222(1.11); C435(1.01)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C173(0.72); C222(1.12); C435(1.08)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C173(0.72); C222(1.09); C435(1.01)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C173(0.59); C222(1.08); C435(0.92)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C173(0.78); C222(0.98); C435(1.05)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C222(0.99); C435(0.89)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C173(1.00); C222(1.16); C435(1.00)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C173(0.76); C222(1.58); C435(1.07)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C173(0.85); C222(1.20); C435(0.68)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C173(1.02); C222(1.06); C435(0.97)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C173(0.79); C222(1.20); C435(0.88)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C173(0.83); C222(1.04); C435(0.94)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C173(0.88); C222(1.19); C435(1.05)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C173(0.66); C222(1.10); C435(0.81)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C173(0.88); C222(1.16); C435(0.89)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C173(0.80); C222(0.98); C435(0.79)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C173(0.58); C222(0.82); C435(0.98)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C173(0.90); C222(1.11); C435(0.87)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C173(0.97); C222(1.28); C435(0.82)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C173(0.93); C222(1.12); C435(0.84)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C173(0.76); C435(1.19)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C173(0.76); C435(1.12)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C173(0.77); C435(1.06)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C173(0.82); C435(0.95)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C173(0.77); C222(1.13); C435(1.01)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C173(0.79); C435(1.00)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C173(0.88); C435(1.00)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C173(0.83); C435(1.08)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C173(1.01); C435(1.07)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C173(0.82); C435(1.08)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C173(0.78); C435(1.01)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C173(0.92); C435(1.10)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C173(0.80); C435(1.01)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C173(0.71); C435(1.01)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C173(0.94); C435(0.99)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C173(0.76); C222(1.26); C435(1.02)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C173(0.78); C435(1.13)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C173(0.90); C435(1.15)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C173(0.99); C435(1.22)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C173(0.97); C435(1.27)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C173(0.97); C435(1.22)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C173(1.04); C435(1.19)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C173(1.04); C435(1.31)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C173(0.97); C435(1.35)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C173(1.15); C435(1.22)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C173(0.95); C435(1.27)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C173(0.71); C222(1.18); C435(1.12)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C173(0.94); C435(1.26)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C173(1.00); C435(1.35)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C173(0.82); C435(1.19)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C173(0.99); C435(1.11)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C173(1.15); C435(1.31)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C173(1.13); C222(1.09); C435(0.95)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C173(0.82); C222(1.37); C435(1.30)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C173(1.00); C222(1.02); C435(0.98)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C173(0.90); C222(1.09); C435(1.17)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C173(0.87); C222(1.05); C435(1.05)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C173(1.00); C222(0.92); C435(1.11)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C173(1.12); C222(1.03); C435(1.07)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C173(1.12); C222(0.93); C435(1.15)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C173(1.04); C222(0.97); C435(1.24)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C173(1.19); C222(0.96); C435(1.38)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C173(0.93); C222(0.99); C435(1.02)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C173(1.04); C222(1.03); C435(0.95)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C173(1.02); C222(1.06); C435(1.11)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C173(0.97); C222(0.92); C435(1.34)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C173(1.09); C222(0.84); C435(1.44)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C173(0.70); C222(1.12); C435(1.03)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C173(0.94); C222(1.05); C435(0.83)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C173(0.92); C435(1.03)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C173(0.87); C435(0.96)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C173(0.87); C435(0.94)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C173(0.84); C435(0.93)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C173(0.84); C435(1.05)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C173(0.86); C435(0.91)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C173(1.17); C435(0.95)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C173(1.02); C435(0.89)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C173(0.94); C435(1.10)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C173(1.01); C313(1.03); C344(1.12); C435(1.11)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C699(2.54); C435(0.76)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C173(1.09); C435(1.34)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C173(0.84); C222(0.81); C435(0.66)  LDD0744  [8]
 LDCM0022  KB02 HEK-293T C699(1.05); C435(0.90); C222(1.04); C173(0.90)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C699(1.07); C435(1.02); C222(1.13); C173(1.01)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C435(2.56); C173(2.31)  LDD3310  [16]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C435(0.94)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C435(0.96)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C173(0.41)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C173(0.49)  LDD2104  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C173(0.30)  LDD2106  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C173(0.45)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C435(1.04)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C435(0.72)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C435(0.42)  LDD2115  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C435(1.11)  LDD2123  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C435(0.67)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C435(1.00)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C435(0.95)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C435(0.83)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C632(0.94)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C435(0.46)  LDD2140  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C173(0.13)  LDD2145  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C435(0.74)  LDD2148  [5]
 LDCM0021  THZ1 HCT 116 C639(1.14); C173(0.90); C530(1.08); C562(1.09)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-secretase 1 (BACE1) Peptidase A1 family P56817
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Tyrosine-protein kinase HCK (HCK) Tyr protein kinase family P08631
Tyrosine-protein kinase Lck (LCK) Tyr protein kinase family P06239
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Sorting nexin-18 (SNX18) Sorting nexin family Q96RF0
CD81 antigen (CD81) Tetraspanin (TM4SF) family P60033
CD9 antigen (CD9) Tetraspanin (TM4SF) family P21926
Tetraspanin-12 (TSPAN12) Tetraspanin (TM4SF) family O95859
Tetraspanin-14 (TSPAN14) Tetraspanin (TM4SF) family Q8NG11
Tetraspanin-15 (TSPAN15) Tetraspanin (TM4SF) family O95858
Tetraspanin-33 (TSPAN33) Tetraspanin (TM4SF) family Q86UF1
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-A2 (SH3GL1) Endophilin family Q99961
GRB2-related adapter protein (GRAP) GRB2/sem-5/DRK family Q13588
GRB2-related adapter protein 2 (GRAP2) GRB2/sem-5/DRK family O75791
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) PACSIN family Q9BY11
Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) PACSIN family Q9UNF0
Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3) PACSIN family Q9UKS6
Tetraspanin-5 (TSPAN5) Tetraspanin (TM4SF) family P62079

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aderbasib Small molecular drug D02CZF
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Iai-100 Small molecular drug D06EHW
Xl784 . DB04991

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840