Details of the Target

General Information of Target

Target ID LDTP16728
Target Name Eukaryotic translation initiation factor 3 subunit C-like protein (EIF3CL)
Gene Name EIF3CL
Gene ID 728689
Synonyms
Eukaryotic translation initiation factor 3 subunit C-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENLPFPLKLLSASSLNTPSSTPWVLDIFLTLVFALGFFFLLLPYFSYLRCDNPPSPSPK
KRKRHLVSQRPAGRRGRPRGRMKNHSLRACRECPRGLEETWDLLSQLQSLLGPHLEKGDF
GQLSGPDPPGEVGKRTPDGASRSSHEPTEDAAPIVSPLASPDPRTKHPQDLASTPPPGPM
TTSVSSLSASQPPEPSLLLEHPSPEPPALFPHPPRTPDPLACSPPPPKGFTPPPLRDSTL
LTPSHCDSVALPLDTVPQSLSPREDLAASVPGISGLGGSNSQVSALSWSQETTKTWCVFN
SSVQQDHLSRQRDTTMSPLLFQAQPLSHLEPESQPFISSTPQFWPTPMAQAEAQAHLQSS
FPVLSPAFLSPMKNTGVACPASQNKVQALSLPETQHPERPLLKKQLEGGLALPSRVQKSQ
DVFSVSTPNLPQERLTSILPENFPVSPELWRQLEQHMGQRGRIQESLDLMQLQDELPGTS
QAKGKPRPWQSSTSTGESSKEAQTVKFQLERDPCPHLGQILGETPQNLSRGMESFPGKVL
GATSEESERNLRKPLRSDSGSDLLRRTERNHIENILKAHMSRKLGQTNEGLIPVSVRRSW
LAVNQAFPVSNTHVKTSNLAAPKSRKACVNTAQVLSFLEPCTQQVLGAHIVRFWAKHRWG
LPLRVLKPIQCFQLEKVSSLSLIQLAGPSSDTCESGAGSKVEVATFLGEPPMASLRKQVL
TKPSVHMPERLQASSPACKQFQRAPRGIPSSNDHGSLKAPTAGQEGRWPSKPLTYSLTGS
TQQSRSLGAQSSRAGETREAVPQPTVPLGTCMRANLQATSEDVRGFKAPGASKSSLLPRM
SVSQDPRKLCLMEEAVSEFEPGKATKSETQPQVSATVVLLPDGQASVVPHASENLASQVP
QGHLQSMPTGNMQASQELCDLMSARRSNMGHKEPRNPNCQGSCKSQSPMFPPTHKRENSR
KPNLEKHEEMFQGLRTPQLTPGRKTEDTRQNEGVQLLPSKKQPPSISHFGENIKQFFQTI
FSKKERKPAPVTAESQKTVKNRSCVYGSSAEAERLMTAVGQILEENMSLCHARHASKVNQ
QRQQFQAPVCGFPCNHRHPFYSEHSRMLSYAASSQQATLKNQSRPNRDRQIRDQ
Target Bioclass
Other
Family
EIF-3 subunit C family
Subcellular location
Cytoplasm
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Uniprot ID
B5ME19
Ensemble ID
ENST00000380876.5
HGNC ID
HGNC:26347

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y885(16.83)  LDD3495  [1]
AHL-Pu-1
 Probe Info  		C444(2.39)  LDD0168  [2]
HHS-475
 Probe Info  		Y882(0.81); Y885(0.93)  LDD0264  [3]
HHS-465
 Probe Info  		Y882(10.00); Y885(10.00)  LDD2237  [4]
DBIA
 Probe Info  		C444(0.95); C620(0.85)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C79(0.00); C444(0.00); C501(0.00); C481(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C79(0.00); C444(0.00); C501(0.00); C481(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C79(0.00); C444(0.00); C501(0.00); C481(0.00)  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
TFBX
 Probe Info  		C501(0.00); C753(0.00)  LDD0027  [7]
WYneN
 Probe Info  		C79(0.00); C444(0.00)  LDD0021  [8]
WYneO
 Probe Info  		C753(0.00); C501(0.00)  LDD0022  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
SF
 Probe Info  		Y882(0.00); K99(0.00); K333(0.00); Y159(0.00)  LDD0028  [9]
Ox-W18
 Probe Info  		W121(0.00); W767(0.00)  LDD2175  [10]
1c-yne
 Probe Info  		K878(0.00); K644(0.00); K863(0.00)  LDD0228  [11]
m-APA
 Probe Info  		N.A.  LDD0404  [12]
NAIA_5
 Probe Info  		C79(0.00); C444(0.00); C753(0.00); C620(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		6.04  LDD0464  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C444(2.39)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C444(2.39)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C444(1.20); C481(1.11); C501(2.18); C568(1.73)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C444(1.10); C481(1.16); C501(0.98); C620(1.02)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C444(1.02); C481(0.85); C501(1.21); C620(0.71)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C444(0.80); C481(0.81); C501(0.85); C620(0.65)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C444(1.12); C481(0.83); C501(0.94); C620(0.64)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C444(1.46); C481(0.83); C501(0.83); C620(0.65)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C444(0.96); C481(0.81); C501(1.09); C620(0.65)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C444(0.94); C481(0.84); C501(0.93); C620(0.64)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C444(1.14); C481(0.84); C501(0.92); C620(0.65)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C444(1.06); C481(0.89); C501(0.89); C620(0.68)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C444(0.94); C481(0.89); C501(1.04); C620(0.70)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C444(0.89); C481(0.84); C501(0.90); C620(0.71)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C444(1.11); C481(1.10); C501(1.29); C620(0.96)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C444(0.95); C481(0.81); C501(0.92); C620(0.69)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C444(0.90); C481(0.72); C501(0.82); C620(0.64)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C444(1.14); C481(0.70); C501(0.73); C620(0.57)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C444(1.18); C481(1.10); C501(1.28); C620(1.10)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C444(1.14); C481(1.07); C501(1.15); C620(0.99)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C444(1.33); C481(0.99); C501(1.03); C620(1.01)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C444(1.29); C481(1.01); C501(1.16); C620(1.02)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C444(1.06); C481(0.97); C501(1.45); C620(1.28)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C444(1.14); C481(1.00); C501(1.34); C620(1.20)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C444(1.26); C481(1.03); C501(1.09); C620(1.07)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C444(1.13); C481(1.16); C501(1.35); C620(1.00)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C444(1.22); C481(0.88); C501(0.97); C620(0.89)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C444(1.10); C481(0.95); C501(1.57); C620(1.29)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C444(1.21); C481(0.99); C501(1.15); C620(0.97)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C444(1.01); C481(0.96); C501(1.39); C620(1.09)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C444(1.11); C481(1.02); C501(1.41); C620(1.23)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C444(1.19); C481(1.23); C501(1.17); C620(0.92)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C444(1.28); C481(1.12); C501(1.42); C620(0.96)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C444(1.30); C481(1.14); C501(1.50); C620(1.10)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C444(1.46); C481(1.52); C501(1.17); C620(1.41)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C444(2.01); C481(1.41); C501(1.13); C620(1.43)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C444(1.46); C481(1.27); C501(1.01); C620(1.25)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C444(1.04); C481(1.17); C501(1.16); C620(1.17)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C444(1.29); C481(1.33); C501(1.13); C620(1.23)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C444(1.44); C481(1.26); C501(0.99); C620(1.22)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C444(1.40); C481(1.23); C501(0.88); C620(1.09)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C444(1.43); C481(1.32); C501(1.11); C620(1.14)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C444(1.27); C481(1.19); C501(1.08); C620(1.10)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C444(1.17); C481(1.15); C501(1.03); C620(1.13)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C444(1.50); C481(1.27); C501(1.10); C620(1.06)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C444(1.60); C481(1.19); C501(1.02); C620(1.09)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C444(1.06); C481(1.00); C501(1.17); C620(1.00)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C444(1.54); C481(1.47); C501(1.17); C620(1.12)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C444(1.82); C481(1.34); C501(0.91); C620(1.11)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C444(1.15); C481(1.42); C501(1.06); C620(1.19)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C444(1.03); C481(0.99); C501(0.85); C568(0.95)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C501(0.88); C79(0.92); C753(0.93); C620(0.94)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C501(0.63); C79(0.84); C568(0.86); C572(0.86)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C501(0.58); C79(0.86); C620(0.90); C568(0.94)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C620(0.86); C501(0.90); C568(0.96); C572(0.96)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C501(0.63); C79(0.75); C481(0.81); C620(1.05)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C501(0.63); C79(0.80); C620(0.86); C481(0.87)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C501(0.82); C753(0.93); C620(1.00); C79(1.03)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C501(0.80); C79(0.88); C620(0.90); C481(0.91)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C620(0.83); C753(0.84); C79(0.89); C501(1.00)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C501(0.63); C620(0.87); C79(0.92); C481(0.95)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C79(0.76); C501(0.89); C481(0.99); C620(1.04)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C444(1.32); C481(0.97); C501(0.60); C568(1.20)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C444(1.19); C481(0.96); C501(0.73); C568(0.75)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C444(0.96); C481(0.96); C501(0.76); C568(0.91)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C444(0.89); C481(0.98); C501(0.58); C568(0.84)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C79(0.77); C481(0.98); C501(1.01); C753(1.04)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C79(0.60); C501(0.86); C481(0.98); C620(0.99)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C79(0.65); C753(0.96); C501(0.98); C481(0.98)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C620(1.06); C753(1.08); C481(1.09); C568(1.19)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C79(0.75); C501(0.79); C481(0.83); C620(0.96)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C79(0.74); C620(0.95); C501(0.96); C481(1.00)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C79(0.79); C481(0.95); C501(0.98); C620(0.99)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C79(0.68); C501(0.94); C620(0.97); C481(0.99)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C79(0.86); C481(0.89); C501(0.90); C753(1.00)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C753(0.68); C481(0.91); C79(0.95); C620(1.01)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C753(0.70); C481(0.83); C79(0.84); C620(0.99)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C753(0.75); C79(0.77); C481(0.92); C620(0.94)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C753(0.71); C79(0.79); C481(0.88); C620(0.91)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C753(0.68); C79(0.74); C501(0.74); C481(0.82)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C620(1.12); C444(1.13); C753(1.15); C481(1.21)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C753(0.68); C501(0.75); C481(0.76); C79(0.77)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C481(0.80); C753(0.81); C79(0.84); C620(1.05)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C753(0.71); C79(0.75); C481(0.80); C501(0.87)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C79(0.66); C753(0.67); C501(0.74); C481(0.79)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C79(0.59); C753(0.67); C481(0.81); C501(0.86)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C444(0.83); C620(0.98); C481(1.02); C501(1.05)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C620(0.92); C481(0.93); C444(0.96); C501(0.98)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C444(0.90); C481(1.02); C79(1.05); C501(1.07)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C501(0.84); C444(0.86); C620(0.92); C481(0.95)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C620(0.98); C481(1.01); C444(1.02); C501(1.04)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C620(1.17); C753(1.21); C481(1.26); C444(1.38)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C79(0.74); C501(0.95); C481(1.01); C753(1.03)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C501(0.87); C620(0.97); C444(1.01); C79(1.02)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C501(0.80); C620(0.96); C481(1.00); C444(1.02)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C501(0.82); C620(0.94); C481(0.95); C444(1.01)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C501(0.91); C79(0.96); C444(1.01); C481(1.02)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C79(0.83); C501(0.97); C481(1.08); C444(1.16)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C568(0.83); C572(0.83); C753(0.91); C501(0.96)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C753(0.91); C568(0.99); C572(0.99); C79(1.02)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C568(0.86); C572(0.86); C753(0.90); C620(1.07)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C568(0.75); C572(0.75); C79(0.81); C620(1.06)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C620(1.19); C481(1.30); C444(1.30); C753(1.32)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C568(0.64); C572(0.64); C79(0.79); C753(1.03)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C568(0.75); C572(0.75); C753(0.94); C620(0.96)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C568(0.73); C572(0.73); C79(0.99); C620(1.00)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C568(0.74); C572(0.74); C753(0.90); C79(0.92)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C568(0.80); C572(0.80); C79(0.88); C753(0.97)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C79(0.80); C568(0.92); C572(0.92); C753(0.97)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C568(0.68); C572(0.68); C79(0.80); C753(1.17)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C79(0.51); C753(0.94); C481(1.02); C620(1.04)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C79(0.59); C481(0.93); C753(0.94); C620(1.02)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C79(0.50); C753(0.88); C501(0.98); C481(1.08)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C501(0.84); C753(0.86); C79(0.89); C620(0.96)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C79(0.69); C753(0.85); C501(0.86); C620(1.04)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C753(0.94); C481(0.98); C79(1.05); C620(1.06)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C79(0.48); C753(0.89); C501(1.17); C481(1.17)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C79(0.67); C753(0.90); C620(1.12); C481(1.14)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C79(0.53); C753(0.93); C620(1.15); C481(1.31)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C79(0.69); C753(0.90); C501(1.10); C481(1.17)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C79(0.73); C753(0.91); C481(1.14); C501(1.19)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C79(0.44); C753(0.89); C481(1.16); C620(1.25)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C79(0.82); C501(0.86); C620(0.93); C481(0.94)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C79(0.79); C481(1.00); C620(1.04); C501(1.06)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C481(0.97); C501(0.99); C620(1.00); C753(1.00)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C79(0.67); C620(0.91); C481(1.09); C501(1.14)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C79(0.99); C620(1.00); C444(1.04); C501(1.08)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C79(0.81); C620(0.99); C501(1.00); C481(1.13)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C79(0.72); C501(0.87); C753(1.00); C620(1.12)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C79(0.73); C620(1.15); C753(1.21); C501(1.30)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C79(0.63); C501(0.86); C753(1.09); C620(1.34)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C79(0.70); C501(1.00); C620(1.08); C753(1.20)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C79(0.71); C501(0.85); C620(0.96); C481(1.01)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C481(0.92); C620(0.93); C501(0.98); C753(1.05)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C79(0.82); C501(0.84); C620(0.95); C753(1.05)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C501(0.89); C753(0.92); C620(0.93); C79(1.04)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C79(0.77); C620(0.98); C753(1.09); C481(1.14)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C444(0.89); C620(0.95); C79(1.03); C501(1.10)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C79(0.68); C753(1.10); C620(1.14); C501(1.21)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C444(0.82); C753(0.90); C79(0.90); C620(0.93)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C79(0.87); C444(0.87); C620(0.91); C753(0.94)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C620(0.84); C753(0.89); C444(0.92); C481(1.03)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C753(0.79); C501(0.80); C620(0.85); C444(0.90)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C620(0.90); C753(0.91); C481(0.93); C501(0.94)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C501(0.84); C753(0.86); C620(0.88); C481(0.94)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C501(0.76); C753(0.79); C620(0.87); C444(0.91)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C753(0.83); C444(0.92); C501(0.94); C481(0.97)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C79(0.82); C753(0.89); C620(0.93); C501(1.00)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C79(0.76); C753(0.89); C620(0.94); C444(0.97)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C501(0.83); C753(0.84); C620(0.85); C481(0.88)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C501(0.74); C481(0.88); C79(0.93); C620(0.99)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C501(0.84); C620(0.87); C753(0.88); C481(0.98)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C501(0.83); C79(0.84); C620(0.91); C444(0.92)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C753(0.69); C620(0.81); C501(0.82); C79(0.85)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C79(0.26); C620(0.73); C753(0.78); C501(0.82)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C79(0.64); C753(0.71); C620(0.74); C481(0.75)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C444(1.03); C481(1.12); C501(1.18); C620(1.01)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C753(0.85); C620(0.97); C481(1.03); C444(1.05)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C79(0.66); C501(0.89); C753(0.96); C620(1.04)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [12]
 LDCM0020  ARS-1620 HCC44 C444(0.95); C620(0.85)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C501(0.80); C79(0.90); C444(0.90); C620(0.90)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C501(0.93); C753(0.94); C620(1.01); C481(1.05)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C620(1.04); C753(1.09); C444(1.12); C481(1.14)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C753(0.85); C501(0.90); C620(0.93); C481(0.98)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C481(0.81); C753(0.87); C620(1.02); C444(1.06)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C753(0.91); C620(0.98); C79(0.98); C444(1.07)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C753(0.87); C620(0.92); C444(0.98); C79(1.01)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C79(0.58); C753(0.93); C501(0.99); C481(0.99)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C79(0.49); C481(1.14); C501(1.16); C753(1.18)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C79(0.44); C501(0.94); C481(1.04); C753(1.06)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C79(0.37); C501(1.04); C481(1.04); C620(1.11)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C79(0.64); C501(0.78); C753(0.88); C481(0.91)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C753(1.01); C501(1.02); C79(1.06); C620(1.11)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C79(0.51); C501(0.87); C753(0.92); C620(0.92)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C79(0.70); C501(0.77); C481(0.88); C753(0.89)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C753(0.75); C481(0.89); C620(0.90); C444(0.92)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C753(0.65); C79(0.73); C501(0.81); C481(0.81)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C753(0.62); C501(0.69); C481(0.72); C79(0.89)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C501(0.66); C481(0.72); C753(0.76); C79(0.79)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C753(0.69); C481(0.78); C501(0.79); C79(0.88)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C79(0.72); C501(1.08); C620(1.14); C481(1.20)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C79(0.99); C620(1.02); C501(1.05); C444(1.06)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C79(0.97); C620(0.97); C444(0.99); C481(0.99)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C501(0.92); C753(0.98); C620(1.19); C481(1.22)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C501(0.80); C620(0.94); C753(1.00); C481(1.01)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C753(0.74); C620(0.77); C568(0.78); C572(0.78)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C568(0.77); C572(0.77); C620(0.96); C753(0.97)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C568(0.78); C572(0.78); C79(0.81); C753(0.87)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C568(0.57); C572(0.57); C79(0.80); C753(0.93)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C79(0.90); C753(0.91); C501(1.02); C620(1.07)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C79(0.68); C481(0.87); C753(0.87); C501(0.98)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C79(0.84); C753(0.85); C620(0.98); C481(1.01)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C79(0.55); C753(0.90); C481(1.03); C620(1.07)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C501(0.93); C753(0.97); C620(1.04); C444(1.12)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C753(0.85); C620(1.01); C444(1.01); C501(1.03)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C753(0.90); C501(0.95); C620(1.01); C444(1.04)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C481(0.75); C753(0.86); C620(0.89); C79(0.94)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C501(0.77); C620(0.87); C444(0.93); C79(0.96)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C620(0.87); C481(0.90); C753(1.02); C444(1.10)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C620(0.88); C753(0.94); C79(0.96); C444(0.99)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C481(0.91); C79(0.95); C444(0.98); C620(0.99)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C501(0.71); C79(0.72); C620(0.92); C753(0.99)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C79(0.67); C620(0.95); C753(0.96); C501(0.99)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C79(0.72); C481(0.95); C501(0.99); C753(1.04)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C79(0.73); C753(0.84); C481(0.84); C620(0.88)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C79(0.71); C753(0.88); C620(1.00); C501(1.15)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C444(1.16); C481(0.97); C501(1.33); C620(0.93)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C444(1.00); C481(0.94); C501(1.06); C620(0.85)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C444(1.12); C481(1.18); C501(0.92); C620(0.99)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C444(1.05); C481(1.29); C501(0.99); C620(0.86)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C444(1.14); C481(1.21); C501(0.79); C620(0.94)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C444(1.02); C481(1.04); C501(0.94); C620(1.03)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C444(1.07); C481(0.96); C501(1.31); C620(0.97)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C444(0.98); C481(0.88); C501(1.08); C620(0.88)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C444(1.03); C481(0.88); C501(0.93); C620(0.87)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C444(1.09); C481(0.88); C501(0.99); C620(0.74)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C444(1.21); C481(1.05); C501(0.96); C620(0.95)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C444(1.14); C481(0.98); C501(0.96); C620(0.94)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C444(1.18); C481(0.97); C501(0.95); C620(0.93)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C444(1.25); C481(1.10); C501(0.92); C620(1.00)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C444(1.35); C481(1.00); C501(0.93); C620(0.94)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C444(0.98); C481(1.07); C501(0.88); C620(0.94)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C444(1.17); C481(0.95); C501(0.75); C620(0.91)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C444(1.17); C481(0.95); C501(0.73); C620(0.93)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C444(1.90); C481(1.23); C501(0.95); C620(1.11)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C444(1.32); C481(1.13); C501(0.90); C620(1.00)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C444(1.20); C481(0.99); C501(0.94); C620(0.90)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C444(1.39); C481(1.03); C501(0.95); C620(0.94)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C444(0.94); C481(0.99); C501(1.06); C620(1.03)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C444(0.99); C481(0.95); C501(1.12); C620(0.99)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C444(1.04); C481(1.01); C501(0.98); C620(1.10)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C444(1.04); C481(1.16); C501(1.50); C620(1.16)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C444(1.08); C481(1.10); C501(1.03); C620(1.12)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C444(0.96); C481(0.99); C501(0.96); C620(1.07)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C444(0.99); C481(1.07); C501(1.24); C620(1.06)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C444(0.87); C481(1.09); C501(0.90); C620(0.95)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C444(1.05); C481(0.97); C501(0.90); C620(0.94)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C444(0.92); C481(0.97); C501(1.07); C620(0.93)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C444(1.01); C481(1.06); C501(0.92); C620(1.08)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C444(1.14); C481(1.07); C501(1.37); C620(0.97)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C444(0.94); C481(0.96); C501(1.02); C620(0.96)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C444(1.04); C481(1.00); C501(1.11); C620(1.05)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C444(1.08); C481(1.13); C501(1.27); C620(1.01)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C444(1.06); C481(1.11); C501(0.88); C620(1.00)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C444(0.91); C481(0.98); C501(0.98); C620(0.99)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C444(1.11); C481(1.00); C501(0.80); C568(0.75)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C444(1.32); C481(0.98); C501(0.78); C568(0.77)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C444(1.26); C481(1.03); C501(0.72); C568(0.98)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C444(1.24); C481(1.10); C501(0.73); C568(0.95)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C444(1.33); C481(1.02); C501(1.13); C568(1.32)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C444(1.48); C481(1.16); C501(0.73); C568(0.94)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C444(1.36); C481(1.06); C501(0.78); C568(1.04)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C444(1.21); C481(0.95); C501(0.95); C568(1.05)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C444(1.08); C481(1.05); C501(0.64); C568(1.00)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C444(1.18); C481(1.39); C501(1.00); C620(1.13)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C444(1.25); C481(1.00); C501(0.88); C568(1.16)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C444(1.30); C481(1.00); C501(1.16); C568(0.87)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C444(1.18); C481(0.89); C501(0.85); C568(1.09)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C444(1.15); C481(0.99); C501(0.88); C568(1.08)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C444(1.24); C481(1.05); C501(0.74); C568(1.16)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C444(1.11); C481(0.76); C501(0.79); C568(1.21)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C444(1.12); C481(0.96); C501(0.89); C568(1.46)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C444(1.36); C481(0.96); C501(1.14); C568(1.16)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C444(1.48); C481(0.88); C501(0.87); C568(1.03)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C444(1.45); C481(1.09); C501(0.87); C620(1.02)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C444(1.20); C481(0.94); C501(0.95); C568(1.09)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C444(1.24); C481(0.92); C501(0.85); C568(0.91)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C444(1.58); C481(0.97); C501(1.05); C568(1.30)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C444(1.79); C481(0.90); C501(0.82); C568(1.08)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C444(2.04); C481(0.78); C501(0.92); C568(1.07)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C444(1.60); C481(0.81); C501(0.90); C568(1.14)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C444(1.36); C481(0.84); C501(1.03); C568(1.14)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C444(1.29); C481(0.83); C501(0.90); C568(1.09)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C444(1.46); C481(0.86); C501(0.95); C568(1.43)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C444(2.08); C481(0.93); C501(1.40); C568(1.71)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C444(1.16); C481(0.99); C501(0.93); C620(0.98)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C444(1.18); C481(0.83); C501(0.71); C568(1.29)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C444(1.17); C481(1.03); C501(1.24); C568(1.18)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C444(1.12); C481(0.96); C501(0.88); C568(1.33)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C444(1.14); C481(1.03); C501(1.30); C568(1.95)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C444(1.09); C481(0.94); C501(1.63); C568(1.28)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C444(1.18); C481(0.93); C501(1.09); C568(1.54)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C444(1.23); C481(1.06); C501(1.23); C568(1.64)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C444(1.14); C481(1.02); C501(1.28); C568(2.10)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C444(1.15); C481(1.10); C501(1.60); C568(1.32)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C444(1.19); C481(1.10); C501(2.01); C568(1.94)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C501(1.23); C481(0.96); C620(1.10); C444(0.92)  LDD1698  [15]
 LDCM0625  F8 Ramos C501(0.78); C444(0.80); C79(0.56); C753(1.16)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C501(0.35); C444(0.93); C79(0.52); C753(1.37)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C501(0.04); C444(0.03); C79(0.57); C753(0.26)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C501(0.40); C444(0.85); C79(0.92); C753(1.04)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C501(0.55); C444(0.95); C79(1.19); C753(1.34)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C501(0.69); C444(0.90); C79(0.94); C753(1.96)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C501(0.27); C444(0.72); C79(0.68); C753(1.22)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C501(0.51); C444(1.00); C79(0.77); C753(0.88)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C501(0.62); C444(0.98); C79(0.68); C753(0.48)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C501(0.59); C444(1.12); C79(0.56); C753(1.14)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C501(0.38); C444(0.87); C79(1.03); C753(0.73)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C501(1.01); C444(0.80); C79(1.01); C753(1.16)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C501(1.01); C444(1.21); C79(1.20); C753(1.25)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C501(0.42); C444(0.67); C79(0.44); C753(0.94)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C444(1.25); C481(0.89); C501(1.24); C568(0.94)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C501(0.83); C444(0.67); C79(1.18); C753(1.42)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C501(0.73); C444(1.00); C79(0.65); C753(1.07)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C444(1.60); C481(1.19); C501(0.98); C620(1.05)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C501(1.03); C444(0.88); C79(1.61); C753(1.58)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C501(1.49); C444(0.94); C79(1.20); C753(1.21)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C501(0.53); C444(0.76); C79(0.62); C753(1.38)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C501(0.31); C444(0.94); C79(0.50); C753(0.92)  LDD2188  [16]
 LDCM0116  HHS-0101 DM93 Y882(0.81); Y885(0.93)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y882(0.57); Y885(0.78)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y882(0.64); Y885(0.71)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y882(0.60); Y885(0.65)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y882(0.73); Y885(0.74)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C753(2.24); C444(3.24); C620(1.77)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C753(2.44); C444(1.72); C620(2.86)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C753(3.54); C444(2.18); C620(1.74)  LDD0082  [5]
 LDCM0131  RA190 MM1.R C753(1.65); C444(1.36)  LDD0304  [17]
 LDCM0021  THZ1 HCT 116 C444(1.17); C620(1.01); C481(1.03); C568(1.45)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit H (EIF3H) EIF-3 subunit H family O15372

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.