Details of the Target

General Information of Target

Target ID LDTP16090
Target Name Centromere protein M (CENPM)
Gene Name CENPM
Gene ID 79019
Synonyms
C22orf18; ICEN39; PANE1; Centromere protein M; CENP-M; Interphase centromere complex protein 39; Proliferation-associated nuclear element protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQKERSTADTLPDLEEWKSAAGLRWWQTAVVDGSGSGNEVIEGPQNARVLKGSQARFNC
TVSQGWKLIMWALSDMVVLSVRPMEPIITNDRFTSQRYDQGGNFTSEMIIHNVEPSDSGN
IRCSLQNSRLHGSAYLTVQVMGELFIPSVNLVVAENEPCEVTCLPSHWTRLPDISWELGL
LVSHSSYYFVPEPSDLQSAVSILALTPQSNGTLTCVATWKSLKARKSATVNLTVIRCPQD
TGGGINIPGVLSSLPSLGFSLPTWGKVGLGLAGTMLLTPTCTLTIRCCCCRRRCCGCNCC
CRCCFCCRRKRGFRIQFQKKSEKEKTNKETETESGNENSGYNSDEQKTTDTASLPPKSCE
SSDPEQRNSSCGPPHQRADQRPPRPASHPQASFNLASPEKVSNTTVV
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.
Uniprot ID
Q9NSP4
Ensemble ID
ENST00000215980.10
HGNC ID
HGNC:18352

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HLF Deletion: p.T17del DBIA    Probe Info 
JURKAT SNV: p.V88M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C110(6.88)  LDD0171  [1]
DBIA
 Probe Info  		C40(4.11)  LDD0209  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C131(0.00); C98(0.00); C153(0.00); C110(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C131(0.00); C153(0.00); C98(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C131(0.00); C153(0.00); C110(0.00)  LDD0037  [3]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C110(6.88)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C40(1.21); C98(1.00)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C98(0.81)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C98(0.63)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C98(0.80)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C98(0.88)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C98(0.91)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C98(0.78)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C98(0.81)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C98(1.01)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C98(1.08)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C98(0.88)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C98(0.76)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C98(0.68)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C98(0.68)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C98(0.82)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C98(0.81)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C98(1.02)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C98(1.02)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C98(1.39)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C98(1.32)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C98(1.08)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C98(1.20)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C98(1.12)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C98(0.73)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C98(1.07)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C98(1.20)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C98(0.99)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C98(0.93)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C98(0.84)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C98(0.97)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C98(1.24)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C98(1.19)  LDD0562  [8]
 LDCM0246  AC128 HEK-293T C40(0.72); C98(0.97)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C40(0.66); C98(1.05)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C40(0.84); C98(0.90)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C40(1.06); C98(1.57)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C40(1.10); C98(0.95)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C40(0.75); C98(1.87)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C40(0.82); C98(1.29)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C40(0.99); C98(0.92)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C40(0.85); C98(1.78)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C40(0.85); C98(0.94)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C40(0.94); C98(1.07)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C40(1.02); C98(1.37)  LDD0856  [8]
 LDCM0259  AC14 HCT 116 C98(0.87)  LDD0576  [8]
 LDCM0260  AC140 HEK-293T C40(0.77); C98(0.84)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C40(1.01); C98(1.06)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C40(1.13); C98(0.96)  LDD0860  [8]
 LDCM0263  AC143 HCT 116 C98(1.25)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C98(1.07)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C98(1.02)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C98(1.20)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C98(0.98)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C98(1.25)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C98(1.17)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C98(0.90)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C98(0.93)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C98(1.07)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C98(0.97)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C98(1.33)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C98(1.12)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C98(1.15)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C98(1.12)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C98(1.03)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C98(0.81); C40(0.96)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C98(0.92); C40(0.94)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C98(1.01); C40(1.01)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C98(1.10); C40(1.14)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C98(0.78); C40(1.02)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C98(0.71); C40(0.97)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C98(0.79); C40(1.00)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C98(0.78); C40(0.92)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C98(0.81); C40(0.98)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C98(0.63); C40(0.91)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C98(0.81); C40(1.03)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C98(1.03); C40(1.10)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C98(0.76); C40(0.89)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C98(0.88); C40(1.02)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C98(0.96); C40(1.16)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C98(0.92); C40(1.05)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C98(0.59); C40(0.90)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C98(0.89); C40(1.11)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C40(0.88); C98(0.92)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C98(0.81); C40(1.37)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C40(0.93); C98(1.06)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C98(0.89); C40(0.98)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C40(0.94); C98(1.41)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C98(0.89); C40(1.08)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C40(0.95); C98(1.03)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C98(0.91); C40(1.07)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C40(0.96); C98(1.38)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C40(1.08); C98(1.16)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C40(0.99); C98(1.29)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C98(0.91); C40(1.21)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C40(0.86); C98(1.27)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C40(0.88); C98(1.44)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C98(0.96); C40(1.27)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C98(0.89); C40(0.99)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C98(0.97); C40(1.10)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C98(0.85); C40(1.09)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C98(1.11); C40(1.19)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C98(1.27); C40(1.29)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C98(1.00); C40(1.03)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C40(0.97); C98(1.10)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C98(0.68); C40(1.09)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C98(1.04); C40(1.08)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C98(0.50); C40(1.04)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C98(0.87); C40(1.18)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C98(0.89); C40(1.02)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C40(0.90); C98(1.22)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C40(0.85); C98(1.36)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C98(0.78)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C98(1.05); C40(1.09)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C98(0.96); C40(1.12)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C40(1.10); C98(1.19)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C40(0.91); C98(1.03)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C98(1.09); C40(1.24)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C40(0.84); C98(1.22)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C40(0.79); C98(1.21)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C40(0.90); C98(1.11)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C40(0.59)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C40(0.52)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C98(0.80)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C40(0.72)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C40(0.86)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C40(0.83)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C40(0.82)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C40(1.08)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C40(0.74)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C40(0.82)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C40(0.74)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C40(0.67)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C40(0.69)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C98(0.69)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C40(0.81)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C40(0.62)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C40(0.66)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C98(1.26); C40(1.31)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C98(1.17); C40(1.31)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C98(1.04); C40(1.35)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C98(1.27); C40(1.38)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C98(1.13); C40(1.32)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C98(1.22); C40(1.47)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C98(0.99); C40(1.41)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C98(1.47); C40(1.51)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C98(1.17); C40(1.22)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C98(1.31); C40(1.31)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C98(1.08); C40(1.21)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C98(1.01); C40(1.30)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C98(1.12); C40(1.54)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C98(1.14); C40(1.34)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C98(1.07); C40(1.49)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C98(0.81)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C98(0.83)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C98(0.72)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C98(0.73)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C98(0.92)  LDD0592  [8]
 LDCM0367  CL1 HCT 116 C40(0.83); C98(0.92)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C98(0.89); C40(0.94)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C40(1.08); C98(1.12)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C98(0.82)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C98(0.69)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C98(1.81)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C98(1.00)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C98(0.86); C40(0.94)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C98(0.83); C40(0.92)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C98(0.82); C40(0.96)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C40(0.98); C98(0.99)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C98(0.69); C40(1.01)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C98(0.78); C40(0.79)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C98(0.81); C40(0.96)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C98(0.81); C40(1.05)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C98(0.61); C40(1.03)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C98(0.81); C40(1.14)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C98(0.70); C40(0.83)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C98(0.84); C40(1.05)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C98(0.92); C40(1.06)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C40(1.05); C98(1.09)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C98(1.12); C40(1.12)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C98(0.93); C40(1.10)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C98(0.78); C40(1.00)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C98(1.06); C40(1.17)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C98(0.76); C40(1.03)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C98(0.67); C40(1.04)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C98(0.88); C40(1.06)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C98(0.83); C40(1.03)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C98(0.87); C40(1.17)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C40(0.81); C98(1.03)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C40(0.92); C98(0.97)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C40(1.05); C98(1.08)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C98(0.75); C40(0.89)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C98(0.78); C40(0.97)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C98(0.82); C40(0.97)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C98(0.81); C40(1.20)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C98(0.84); C40(0.90)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C98(0.88); C40(1.04)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C98(0.88); C40(1.04)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C98(0.76); C40(0.90)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C98(0.86); C40(1.05)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C40(0.99); C98(1.07)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C40(1.00); C98(1.07)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C98(0.91); C40(1.00)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C98(1.03); C40(1.10)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C40(0.98); C98(0.98)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C40(1.09); C98(0.91)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C40(1.10); C98(0.83)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C40(1.10); C98(0.91)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C40(1.14); C98(0.84)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C40(0.86); C98(0.67)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C40(1.01); C98(0.77)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C40(1.40); C98(0.66)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C40(1.22); C98(0.67)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C40(1.00); C98(0.81)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C40(1.23); C98(0.67)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C40(1.11); C98(0.90)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C40(1.19); C98(0.80)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C40(1.24); C98(0.75)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C40(1.02); C98(0.81)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C40(0.85); C98(1.01)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C40(1.12); C98(0.80)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C40(1.35); C98(0.67)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C40(1.43); C98(0.83)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C40(1.26); C98(0.87)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C40(1.11); C98(0.88)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C40(1.29); C98(0.95)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C98(1.06)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C98(1.03)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C98(1.00)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C98(0.92)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C40(0.97); C98(0.80)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C98(0.96)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C98(1.01)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C98(0.96)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C98(0.85)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C98(0.87)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C98(0.89)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C98(0.92)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C98(0.89)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C98(0.99)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C98(0.97)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C40(0.95); C98(0.66)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C98(0.95)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C40(0.91)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C40(0.88)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C40(0.89)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C40(1.03)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C40(0.99)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C40(0.96)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C40(0.95)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C40(0.86)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C40(0.83)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C40(1.02); C98(0.72)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C40(0.95)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C40(0.91)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C40(1.00)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C40(0.90)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C40(0.93)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C40(0.84); C98(0.86)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C40(0.68); C98(0.83)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C40(1.35); C98(0.94)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C40(1.36); C98(0.97)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C40(0.90); C98(1.12)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C40(0.92); C98(0.84)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C40(1.34); C98(0.86)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C40(1.98); C98(1.18)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C40(0.97); C98(0.99)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C40(1.46); C98(1.09)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C40(0.94); C98(0.96)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C40(0.94); C98(0.89)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C40(1.16); C98(0.98)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C40(1.34); C98(0.91)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C40(1.26); C98(1.18)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C40(0.98); C98(0.86)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C40(0.75); C98(0.92)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C40(1.11); C98(1.05)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C40(0.99); C98(0.97)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C40(0.95); C98(0.85)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C40(0.82); C98(0.87)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C40(0.98); C98(0.99)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C40(1.09); C98(1.11)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C40(1.05); C98(1.08)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C40(1.17); C98(0.96)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C40(1.28); C98(0.93)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C98(0.88); C131(1.06); C153(1.02)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C110(2.58)  LDD1702  [10]
 LDCM0625  F8 Ramos C110(3.45); C98(0.82); C131(0.77)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C98(0.41); C131(1.07)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C110(0.59); C98(0.20); C131(0.12)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C98(0.42); C131(1.64)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C98(0.76)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C110(0.87); C98(0.40); C131(0.47); C153(0.35)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C131(1.58)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C98(0.62); C131(8.13)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C98(0.66); C131(1.93)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C98(0.73); C131(5.37)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C110(0.59); C98(0.94); C131(1.31); C153(0.58)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C98(0.61); C131(0.94)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C98(0.93); C131(0.83)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C98(0.39); C131(1.69)  LDD2201  [11]
 LDCM0468  Fragment33 HCT 116 C40(0.99)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C98(0.69); C131(5.20)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C110(1.14); C98(0.89); C131(0.71); C153(0.65)  LDD2184  [11]
 LDCM0427  Fragment51 HCT 116 C40(1.56); C98(0.94)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C98(0.90); C131(0.60)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C98(0.84); C131(1.58)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C110(1.66); C98(0.55); C131(0.54); C153(0.27)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C98(0.45); C131(2.11)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C40(0.97); C110(0.87)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C40(4.11)  LDD0209  [2]
 LDCM0024  KB05 COLO792 C98(2.42)  LDD3310  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C131(0.88)  LDD2206  [13]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.